Journal
PARASITE
Volume 15, Issue 4, Pages 573-579Publisher
EDP SCIENCES S A
DOI: 10.1051/parasite/2008154573
Keywords
Schistosoma mansoni; insulin receptor; glucose; tyrosine kinase inhibitor
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Funding
- Institut National de la Sante et de la Recherche Medicale (INSERM-FIOCRUZ program)
- Institut Pasteur de Lille
- Ministere de l'Education Nationale et de la Recherche
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Very little is known about insulin signalling in schistosomes despite its potential importance in host-parasite molecular dialogue and parasite growth and development. The recent characterization of two insulin receptors (SmIR-1 and SmIR-2) in Schistosoma mansoni has led us to reconsider the question of the potential importance of insulin in host-schistosome interactions. In this work, we demonstrated that insulin could regulate glucose uptake in schistosomes and we investigated the implication of SmIR-1 and SmIR-2 in this process. The possibility that specific inhibitors of SmIR-1 and SmIR-2 tyrosine kinase activities could be developed to target schistosomes is discussed.
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