Journal
PARASITE IMMUNOLOGY
Volume 36, Issue 11, Pages 583-591Publisher
WILEY
DOI: 10.1111/pim.12133
Keywords
coinfection - disease; complement - immunological terms; human - host species; sarcoptes - parasite; Staphylococcus aureus - bacteria; Streptococcus pyogenes - bacteria
Categories
Funding
- NHMRC Project Grant
- NHMRC Early Career Fellowship
- Australian Research Council Future Fellowship
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Scabies is a ubiquitous and contagious skin disease caused by the parasitic mite Sarcoptes scabiei Epidemiological studies have identified scabies as a causative agent for secondary skin infections caused by Staphylococcus aureus and Streptococcus pyogenes. This is an important notion, as such bacterial infections can lead to serious downstream life-threatening complications. As the complement system is the first line of host defence that confronts invading pathogens, both the mite and bacteria produce a large array of molecules that inhibit the complement cascades. It is hypothesised that scabies mite complement inhibitors may play an important role in providing a favourable micro-environment for the establishment of secondary bacterial infections. This review aims to bring together the current literature on complement inhibition by scabies mites and bacteria associated with scabies and to discuss the proposed molecular link between scabies and bacterial co-infections.
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