Article
Gastroenterology & Hepatology
Tareq El Menabawey, Raymond McCrudden, Dushyant Shetty, Andrew D. Hopper, Matthew T. Huggett, Noor Bekkali, Nicholas R. Carroll, Elaine Henry, Gavin J. Johnson, Margaret G. Keane, Mark Love, Colin J. McKay, Sally Norton, Kofi Oppong, Ian Penman, Jayapal Ramesh, Barbara Ryan, Keith Siau, Manu Nayar
Summary: The international approach to credentialing individuals in endoscopic ultrasound (EUS) varies, but there is no consensus on this or its implementation. In 2019, the Joint Advisory Group on GI Endoscopy (JAG) commissioned a working group to develop evidence-based recommendations for EUS training and certification. The key recommendations include a minimum of 250 hands-on cases, attendance at a basic EUS course, formative DOPS assessment every 10 cases, competent performance in summative DOPS assessments, and a minimum 12-month mentorship period.
Article
Gastroenterology & Hepatology
Ji Young Park, Tae Joo Jeon
Summary: This study confirms that submucosal saline injection (SSI) can improve the accuracy of endoscopic ultrasonography (EUS) in distinguishing T1a and T1b lesions in early gastric cancer (EGC).
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Yutaka Saito, Shinya Kodashima, Takahisa Matsuda, Koji Matsuda, Mitsuhiro Fujishiro, Kiyohito Tanaka, Kiyonori Kobayashi, Chikatoshi Katada, Takahiro Horimatsu, Manabu Muto, Kazuo Ohtsuka, Ichiro Oda, Masayuki Kato, Mitsuhiro Kida, Shu Hoteya, Hironori Yamamoto, Shomei Ryozawa, Ryuichi Iwakiri, Hiromu Kutsumi, Mototsugu Kato, Ken Haruma, Kazuma Fujimoto, Hiroyasu Iishi, Haruhiko Ogata, Naomi Uemura, Michio Kaminishi, Hisao Tajiri, Haruhiro Inoue
Summary: The study reviewed the first phase data of the Japan Endoscopy Database Project, including the purposes of procedures, diagnostic results, and therapeutic procedures. Screening and fecal immunochemical test positivity were the main reasons for procedures, with a certain rate of complications during treatment.
DIGESTIVE ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Nora D. Hallensleben, Pauline M. C. Stassen, Nicolien J. Schepers, Marc G. Besselink, Marie-Paule G. F. Anten, Olaf J. Bakker, Thomas L. Bollen, David W. da Costa, Sven M. van Dijk, Hendrik M. van Dullemen, Marcel G. W. Dijkgraaf, Brechje van Eijck, Casper H. J. van Eijck, Willemien Erkelens, Nicole S. Erler, Paul Fockens, Erwin-Jan M. van Geenen, Janneke van Grinsven, Wouter L. Hazen, Robbert A. Hollemans, Jeanin E. van Hooft, Jeroen M. Jansen, Frank J. G. M. Kubben, Sjoerd D. Kuiken, Alexander C. Poen, Rutger Quispel, Rogier J. de Ridder, Tessa E. H. Romkens, Erik J. Schoon, Matthijs P. Schwartz, Tom C. J. Seerden, Xavier J. N. M. Smeets, B. W. Marcel Spanier, Adriaan C. I. T. L. Tan, Willem J. Thijs, Robin Timmer, Devica S. Umans, Niels G. Venneman, Robert C. Verdonk, Frank P. Vleggaar, Wim van de Vrie, Roy L. J. van Wanrooij, Ben J. Witteman, Hjalmar C. van Santvoort, Stefan A. W. Bouwense, Marco J. Bruno
Summary: In patients with predicted severe acute biliary pancreatitis without cholangitis, urgent endoscopic ultrasound-guided ERCP with ES did not show any improvement compared to conservative treatment in terms of major complications or mortality.
Article
Medicine, General & Internal
Yu Ji Li, Gil Ho Lee, Min Jae Yang, Jae Chul Hwang, Byung Moo Yoo, Soon Sun Kim, Sun Gyo Lim, Jin Hong Kim
Summary: This study evaluated the capability of ultrasonography for morphological characterization of pancreatic cystic lesions (PCLs), finding that it can successfully delineate PCLs in the pancreas but has limited usefulness in assessing changes in pancreatic duct dilation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Editorial Material
Endocrinology & Metabolism
Martyn E. Caplin, Gowri M. Ratnayake
Summary: Neuroendocrine neoplasms are tumors derived from the diffuse endocrine system, characterized by a diverse range of molecular abnormalities, functionality, and anatomical locations. Key advances in molecular diagnosis, functional imaging, and therapeutic strategies published in 2020 are discussed in this article.
NATURE REVIEWS ENDOCRINOLOGY
(2021)
Review
Oncology
Wei On, Wafaa Ahmed, Simon Everett, Matthew Huggett, Bharat Paranandi
Summary: Endoscopic ultrasound (EUS) plays an important role in the management of patients with pancreatic ductal adenocarcinoma (PDAC), not only for diagnosis but also for therapy. It has become a key tool in managing the clinical effects of PDAC, especially in anatomical areas that are difficult to target. It is increasingly used in situations where conventional endoscopy is not possible or unsuccessful, providing a new dimension for the treatment of PDAC patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Surgery
Yoshiki Tsujii, Yoshito Hayashi, Ryu Ishihara, Shinjiro Yamaguchi, Masashi Yamamoto, Takuya Inoue, Kengo Nagai, Hideharu Ogiyama, Takuya Yamada, Masanori Nakahara, Takashi Kizu, Takashi Kanesaka, Noriko Matsuura, Takashi Ohta, Dai Nakamatsu, Shunsuke Yoshii, Shinichiro Shinzaki, Tsutomu Nishida, Hideki Iijima, Tetsuo Takehara
Summary: The study evaluates the validity of a diagnostic strategy combining conventional endoscopy (CE) and endoscopic ultrasonography (EUS) and determines the additional value of EUS for EGC suspected of submucosal (SM) invasion. The results show that the combination of CE and EUS has a higher diagnostic accuracy compared to CE alone, particularly in differentiating lesion types and low-confidence CE-SM2 lesions.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Gastroenterology & Hepatology
Yugo Suzuki, Kosuke Nomura, Daisuke Kikuchi, Toshiro Iizuka, Mako Koseki, Yusuke Kawai, Takayuki Okamura, Yorinari Ochiai, Junnosuke Hayasaka, Yutaka Mitsunaga, Hiroyuki Odagiri, Satoshi Yamashita, Akira Matsui, Kenichi Ohashi, Shu Hoteya
Summary: This study aimed to compare the diagnostic performance of EUS and ME-NBI for superficial ESCC. The results showed that EUS with the water-filled balloon method had a higher accuracy than ME-NBI, and it had a higher sensitivity for SM2/SM3 lesions.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Oncology
Zhiwen Xiao, Huaxiang Xu, Jonathan R. R. Strosberg, Renquan Lu, Xinzhe Zhu, Shengming Deng, Lei Ding, Quanxing Ni, Andrew L. L. Warshaw, Xianjun Yu, Guopei Luo
Summary: pNENs are heterogeneous tumors with varied clinical presentations. Elevated glycosylation biomarkers were found to be associated with poor prognosis in pNENs and correlated with EGFR overexpression, suggesting EGFR as a potential therapeutic target.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Medicine, General & Internal
Yong-Gang He, Jing Li, Xue-Hui Peng, Jing Wu, Ming-Xun Xie, Yi-Chen Tang, Lu Zheng, Xiao-Bing Huang
Summary: The study retrospectively analyzed the treatment outcomes of 162 patients with pancreatic pseudocysts, finding that sequential therapy with combined ENPD and ERPD is safe and effective in managing these patients.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Review
Oncology
Feng Su, Meiling Zhu, Ru Feng, Yunhong Li
Summary: Magnifying endoscopy with narrow-band imaging (ME-NBI) plus endoscopic ultrasonography (EUS) may be an adequate diagnostic and staging modality for esophageal cancer (EC), but more large-scale, high-quality studies are needed to confirm its diagnostic accuracy.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Review
Medicine, General & Internal
Giuseppinella Melita, Socrate Pallio, Andrea Tortora, Stefano Francesco Crino, Antonio Macri, Gianlorenzo Dionigi
Summary: Pancreatic neuroendocrine neoplasms (PanNENs) are rare but their incidence has increased significantly. Endoscopic ultrasound (EUS) is crucial for diagnosis and prognostic stratification, with a well-demonstrated correlation between Ki-67 proliferation index values and tumor grading on EUS and surgical specimens according to the WHO 2017 classification. EUS also serves as a guide for preoperative sampling and interventions, with the possibility of locoregional ablative treatments in selected patients unfit for surgery.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Guo Tian, Danxia Xu, Yinghua He, Weilu Chai, Zhuang Deng, Chao Cheng, Xinyan Jin, Guyue Wei, Qiyu Zhao, Tianan Jiang
Summary: In recent years, deep learning has played an important role in cancer detection. This study aimed to differentiate pancreatic cancer (PC) or non-pancreatic cancer (NPC) lesions in real-time using endoscopic ultrasonography (EUS) images. By training a model based on EUS images using YOLOv5 algorithm, the study found that the model achieved convergence and showed potential for real-time decision support in distinguishing PC and NPC lesions.
FRONTIERS IN ONCOLOGY
(2022)
Review
Engineering, Biomedical
Faisal Raza, Lauren Evans, Mahzad Motallebi, Hajra Zafar, Miguel Pereira-Silva, Kalsoom Saleem, Diana Peixoto, Abbas Rahdar, Esmaeel Sharifi, Francisco Veiga, Clare Hoskins, Ana Claudia Paiva-Santos
Summary: Pancreatic cancer is a challenging and often considered incurable disease. Liposomes have shown promise as future drug delivery systems for pancreatic cancer treatment due to their versatility, ease of fabrication, and modification. This review explores the various mechanisms of liposomes in treating pancreatic cancer, including chemotherapy, targeted therapy, mRNA therapy, immunotherapy, and photothermal therapy. Although multifunctional liposomal formulations have shown pre-clinical success, none have been clinically approved for pancreatic cancer. This review sheds light on the progress made so far and provides insights for future liposomal therapy and improved patient outcomes.
ACTA BIOMATERIALIA
(2023)
Review
Oncology
Mingzhu Sun, Jayne Moquet, Michele Ellender, Simon Bouffler, Christophe Badie, Rachel Baldwin-Cleland, Kevin Monahan, Andrew Latchford, David Lloyd, Susan Clark, Nicola A. Anyamene, Elizabeth Ainsbury, David Burling
Summary: This review investigates the potential risks of low-dose ionizing radiation to Lynch syndrome patients and explores the impact of CT imaging and radiotherapy. Limited experimental studies suggest that Lynch syndrome cells may be relatively resistant to radiation, but there is a lack of human data to draw firm conclusions.
Article
Gastroenterology & Hepatology
Giulia Martina Cavestro, Alessandro Mannucci, Francesc Balaguer, Heather Hampel, Sonia S. Kupfer, Alessandro Repici, Andrea Sartore-Bianchi, Toni T. Seppala, Vincenzo Valentini, Clement Richard Boland, Randall E. Brand, Tineke E. Buffart, Carol A. Burke, Riccardo Caccialanza, Renato Cannizzaro, Stefano Cascinu, Andrea Cercek, Emma J. Crosbie, Silvio Danese, Evelien Dekker, Maria Daca-Alvarez, Francesco Deni, Mev Dominguez-Valentin, Cathy Eng, Ajay Goel, Jose G. Guillem, Britt B. S. L. Houwen, Charles Kahi, Matthew F. Kalady, Fay Kastrinos, Florian Kuehn, Luigi Laghi, Andrew Latchford, David Liska, Patrick Lynch, Alberto Malesci, Gianluca Mauri, Elisa Meldolesi, Pal Moller, Kevin J. Monahan, Gabriela Moeslein, Caitlin C. Murphy, Karlijn Nass, Kimmie Ng, Cristina Oliani, Enrico Papaleo, Swati G. Patel, Marta Puzzono, Andrea Remo, Luigi Ricciardiello, Carla Ida Ripamonti, Salvatore Siena, Satish K. Singh, Zsofia K. Stadler, Peter P. Stanich, Sapna Syngal, Stefano Turi, Emanuele Damiano Urso, Laura Valle, Valeria Stella Vanni, Eduardo Vilar, Marco Vitellaro, Yi-Qian Nancy You, Matthew B. Yurgelun, Raffaella Alessia Zuppardo, Elena M. Stoffel
Summary: This study aimed to develop guidelines for early-onset colorectal cancer (eoCRC). The study found that all individuals younger than 50 should undergo CRC risk stratification and newly diagnosed eoCRC patients should receive germline genetic testing. Furthermore, the treatment of early-onset CRC, including endoscopic, surgical, and oncologic treatment, should not differ from later-onset CRC, except for individuals with pathogenic or likely pathogenic germline variants. The study also highlighted areas for future research.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Oncology
Demetra Georgiou, Laura Monje-Garcia, Tracie Miles, Kevin Monahan, Neil A. J. Ryan
Summary: Lynch syndrome is a hereditary condition that increases the risk of various cancers. Early detection is crucial for implementing cancer prevention strategies, but current interventions are invasive and not applicable to all associated cancers. New criteria, including universal screening, have led to an increased diagnosis of Lynch syndrome but also present challenges regarding consent and testing protocols.
CANCER MANAGEMENT AND RESEARCH
(2023)
Review
Oncology
Kevin J. Monahan, Ottilie Swinyard, Andrew Latchford
Summary: Hereditary gastrointestinal cancer, specifically Lynch syndrome (LS) and familial adenomatous polyposis (FAP), has provided valuable insights into sporadic carcinogenesis and has facilitated the development of risk models and preventative strategies. The understanding of neoplasia-immune interaction in LS has led to the advancement of immune mediated therapies for cancer prevention, while chemoprevention with aspirin and nonsteroidal anti-inflammatory drugs has shown efficacy in LS but remains elusive in FAP. Additionally, controversies surrounding gastrointestinal surveillance in LS and FAP, including the limitations and opportunities of upper and lower gastrointestinal endoscopy, are discussed.
CANCER PREVENTION RESEARCH
(2023)
Article
Medicine, General & Internal
Mev Dominguez-Valentin, Saskia Haupt, Toni T. Seppaelae, Julian R. Sampson, Lone Sunde, Inge Bernstein, Mark A. Jenkins, Christoph Engel, Stefan Aretz, Maartje Nielsen, Gabriel Capella, Francesc Balaguer, Dafydd Gareth Evans, John Burn, Elke Holinski-Feder, Lucio Bertario, Bernardo Bonanni, Annika Lindblom, Zohar Levi, Finlay Macrae, Ingrid Winship, John-Paul Plazzer, Rolf Sijmons, Luigi Laghi, Adriana Della Valle, Karl Heinimann, Tadeusz Debniak, Robert Fruscio, Francisco Lopez-Koestner, Karin Alvarez-Valenzuela, Lor H. Katz, Ido Laish, Elez Vainer, Carlos Vaccaro, Dirce Maria Carraro, Kevin Monahan, Elizabeth Half, Aine Stakelum, Des Winter, Rory Kennelly, Nathan Gluck, Harsh Sheth, Naim Abu-Freha, Marc Greenblatt, Benedito Mauro Rossi, Mabel Bohorquez, Giulia Martina Cavestro, Leonardo S. Lino-Silva, Karoline Horisberger, Maria Grazia Tibiletti, Ivana do Nascimento, Huw Thomas, Norma Teresa Rossi, Leandro Apolinario da Silva, Attila Zarand, Juan Ruiz-Banobre, Vincent Heuveline, Jukka-Pekka Mecklin, Kirsi Pylvaenaeinen, Laura Renkonen-Sinisalo, Anna Lepistoe, Paeivi Peltomaeki, Christina Therkildsen, Mia Gebauer Madsen, Stefan Kobbelgaard Burgdorf, John L. Hopper, Aung Ko Win, Robert W. Haile, Noralane Lindor, Steven Gallinge, Loic Le Marchand, Polly A. Newcomb, Jane Figueiredo, Daniel D. Buchanan, Stephen N. Thibodeau, Magnus von Knebel Doeberitz, Markus Loeffler, Nils Rahner, Evelin Schroeck, Verena Steinke-Lange, Wolff Schmiegel, Deepak Vangala, Claudia Perne, Robert Hueneburg, Silke Redler, Reinhard Buettner, Jurgen Weitz, Marta Pineda, Nuria Duenas, Joan Brunet Vidal, Leticia Moreira, Ariadna Sanchez, Eivind Hovig, Sigve Nakken, Kate Green, Fiona Lalloo, James Hill, Emma Crosbie, Miriam Mints, Yael Goldberg, Douglas Tjandra, Sanne W. ten Broeke, Revital Kariv, Guy Rosner, Suresh H. Advani, Lidiya Thomas, Pankaj Shah, Mithun Shah, Florencia Neffa, Patricia Esperon, Walter Pavicic, Giovana Tardin Torrezan, Thiago Bassaneze, Claudia Alejandra Martin, Gabriela Moslein, Pal Moller
Summary: This study used the latest PLSD cohort to investigate the mortality rates and age of cancer diagnoses in carriers of pathogenic MMR variants. The results showed that non-colorectal Lynch syndrome cancers caused more deaths than colorectal cancers in these carriers. Reducing deaths from non-colorectal cancers is a crucial challenge for the medical care of Lynch syndrome.
Article
Gastroenterology & Hepatology
Laura Monje-Garcia, Timothy Bill, Lindsay Farthing, Nate Hill, Emma Kipps, Angela F. F. Brady, Zoe Kemp, Katie Snape, Alistair Myers, Muti Abulafi, Kevin Monahan
Summary: This study aimed to measure geographic variation in Lynch syndrome (LS) testing among colorectal cancer (CRC) patients within the RM Partners West London cancer alliance and deliver an effective diagnostic pathway. The LS pathway audit revealed that improvement recommendations have been implemented, resulting in significant improvements in the percentage of patients undergoing tumor marker testing (p=0.008), further testing (p=0.03), and referral for genetic testing (p=0.02).
COLORECTAL DISEASE
(2023)
Article
Orthopedics
Shaelyn B. O'Connor, Kyle J. Holmberg, Jon E. Hammarstedt, Jonathan R. Acosta, Kevin Monahan, Ryan D. Sauber, Daniel T. Altman
Summary: The superiority of surgical or conservative treatment for athletes with lumbar disc herniation (LDH) is inconclusive. Surgical treatment may result in a quicker return to sport, but the outcomes vary based on the sport. Further research is needed to assist physicians and athletes in deciding between conservative or surgical treatment in the athletic population.
CURRENT REVIEWS IN MUSCULOSKELETAL MEDICINE
(2023)
Review
Oncology
Pal Moller, Toni T. Seppala, Aysel Ahadova, Emma J. Crosbie, Elke Holinski-Feder, Rodney Scott, Saskia Haupt, Gabriela Moeslein, Ingrid Winship, Sanne W. Bajwa-ten Broeke, Kelly E. Kohut, Neil Ryan, Peter Bauerfeind, Laura E. Thomas, D. Gareth Evans, Stefan Aretz, Rolf H. Sijmons, Elizabeth Half, Karl Heinimann, Karoline Horisberger, Kevin Monahan, Christoph Engel, Giulia Martina Cavestro, Robert Fruscio, Naim Abu-Freha, Levi Zohar, Luigi Laghi, Lucio Bertario, Bernardo Bonanni, Maria Grazia Tibiletti, Leonardo S. Lino-Silva, Carlos Vaccaro, Adriana Della Valle, Benedito Mauro Rossi, Leandro Apolinario da Silva, Ivana Lucia de Oliveira Nascimento, Norma Teresa Rossi, Tadeusz Debniak, Jukka-Pekka Mecklin, Inge Bernstein, Annika Lindblom, Lone Sunde, Sigve Nakken, Vincent Heuveline, John Burn, Eivind Hovig, Matthias Kloor, Julian R. Sampson, Mev Dominguez-Valentin, Prospective Lynch Syndrome Database, European Hereditary Tumour Grp
Summary: The recognition of hereditary micro-satellite instable (MSI) cancers caused by pathogenic variants in mismatch repair (MMR) genes has changed our understanding of carcinogenesis. The four Lynch syndromes, each caused by loss of function variants in MMR genes, are characterized by different levels and types of cancer. In Lynch syndromes, carcinogenesis follows a linear process with a dynamic balance between MSI production and the host's immune system. Colonoscopy surveillance, aspirin prevention, and immunotherapy are important advancements in preventing and treating hereditary MSI cancer.
HEREDITARY CANCER IN CLINICAL PRACTICE
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Kevin Monahan, Adam C. Shaw, Laura Laura Monje-Garcia, Francesca Faravelli, Simone Gelinas, Frances Elmslie, Adele Tyson, Steven Hardy
Meeting Abstract
Gastroenterology & Hepatology
Laura Monje-Garcia, Jai Vairale, Hilary Watt, Sondus Hassounah, Heidi Lai, Kevin Monahan
Meeting Abstract
Gastroenterology & Hepatology
Laura Monje-Garcia
Meeting Abstract
Gastroenterology & Hepatology
Ottilie Swinyard, Ann-Marie Baker, Kevin Monahan, Marnix Jansen, Calum Gabbutt, Chris Kimberley, Trevor Graham, Jacob Househam, Eszter Lakatos
Meeting Abstract
Gastroenterology & Hepatology
Husam Al Maliki, Kevin J. Monahan
Meeting Abstract
Gastroenterology & Hepatology
Robert Eckersley, Kevin Monahan, Noriko Suzuki
Meeting Abstract
Gastroenterology & Hepatology
G. M. Cavestro, A. Mannucci, F. Balaguer, H. Heather, S. Kupfer, A. Repici, A. Sartore-Bianchi, T. T. Seppala, V. Valentini, C. R. Boland, R. E. Brand, T. Buffart, C. A. Burke, R. Caccialanza, R. Cannizzaro, S. Cascinu, A. Cercek, E. J. Crosbie, S. Danese, E. Dekker, M. Daca-Alvarez, F. Deni, A. Latchford, D. Liska, P. Lynch, A. Malesci, G. Mauri, E. Meldolesi, M. Pal, K. J. Monahan, G. Moslein, C. C. Murphy, K. Nass, K. Ng, C. Oliani, E. Papaleo, S. Patel, M. Puzzono, A. Remo, L. Ricciardiello, C. I. Ripamonti, S. Siena, S. K. Singh, Z. Stadler, P. P. Stanich, S. Syngal, S. Turi, E. D. Urso, L. Valle, V. S. Vanni, E. Vilar, M. Vitellaro, Y. N. You, M. B. Yurgelun, R. A. Zuppardo, E. M. Stoffel
DIGESTIVE AND LIVER DISEASE
(2023)