Journal
TRANSBOUNDARY AND EMERGING DISEASES
Volume 63, Issue 5, Pages E447-E452Publisher
WILEY
DOI: 10.1111/tbed.12314
Keywords
peste des petits ruminants; inactivated vaccine; goat; experimental infection
Categories
Funding
- Italian Ministry of Health [IZSAM0110RC]
Ask authors/readers for more resources
Four goats were inoculated with an inactivated peste des petits ruminants virus (PPRV) vaccine. Three unvaccinated goats were kept as controls. After 36 days, the four goats were revaccinated. The immune response was monitored by virus neutralization test showing that two doses of the vaccine were able to stimulate strong immune response in all the vaccinated animals. The vaccinated goat and the controls were challenged with virulent PPRV intranasally. After PPRV challenge, the three control goats showed fever, viremia and virus excretion through mucosal surfaces, whereas the vaccinated goats were fully protected against PPRV infection and replication.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available