Journal
PANCREATOLOGY
Volume 12, Issue 4, Pages 344-349Publisher
ELSEVIER
DOI: 10.1016/j.pan.2012.06.002
Keywords
Smoking; Pancreatic cancer; Fibrosis; Inflammation
Categories
Funding
- NIH grant [K01AA019996]
- Department of Veterans Affairs
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Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease. The prognosis is poor; less than 5% of those diagnosed are still alive five years after diagnosis, and complete remission is still rare. Tobacco smoking is a major risk factor of pancreatic cancer. However, the mechanism(s) through which it causes the disease remains unknown. Accumulating evidence indicates that carcinogenic compounds in cigarette smoke stimulate pancreatic cancer progression through induction of inflammation and fibrosis which act in concert with genetic factors leading to the inhibition of cell death and stimulation of proliferation resulting in the promotion of the PDAC. Copyright (c) 2012, LAP and EPC. Published by Elsevier India, a division of Reed Elsevier India Pvt. Ltd. All rights reserved.
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