Article
Medicine, General & Internal
Iranzu Gonzalez-Borja, Emilia Alors-Perez, Irene Amat, Laura Alonso, Cristina Viyuela-Garcia, Saioa Goni, Jose C. Reyes, Maria Ceballos-Chavez, Irene Hernandez-Garcia, Marina E. Sanchez-Frias, Enrique Santamaria, Socorro Razquin, Alvaro Arjona-Sanchez, Virginia Arrazubi, Jairo Perez-Sanz, Ruth Vera, Joaquin Fernandez-Irigoyen, Justo P. Castano, Antonio Viudez
Summary: CHFR expression intensity and promoter methylation pattern may serve as potential prognostic biomarkers in PDAC, indicating longer disease-free survival and overall survival in patients with higher CHFR expression and lower methylation levels. Further comprehensive studies are warranted to confirm these preliminary findings.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Liwei Cao, Chen Huang, Daniel Cui Zhou, Yingwei Hu, T. Mamie Lih, Sara R. Savage, Karsten Krug, David J. Clark, Michael Schnaubelt, Lijun Chen, Felipe da Veiga Leprevost, Rodrigo Vargas Eguez, Weiming Yang, Jianbo Pan, Bo Wen, Yongchao Dou, Wen Jiang, Yuxing Liao, Zhiao Shi, Nadezhda Terekhanova, Song Cao, Rita Jui-Hsien Lu, Yize Li, Ruiyang Liu, Houxiang Zhu, Peter Ronning, Yige Wu, Matthew A. Wyczalkowski, Hariharan Easwaran, Ludmila Danilova, Arvind Singh Mer, Seungyeul Yoo, Joshua M. Wang, Wenke Liu, Benjamin Haibe-Kains, Mathangi Thiagarajan, Scott D. Jewell, Galen Hostetter, Chelsea J. Newton, Qing Kay Li, Michael H. Roehr, David Fenyo, Pei Wang, Alexey Nesvizhskii, D. R. Mani, Gilbert S. Omenn, Emily S. Boja, Mehdi Mesri, Ana Robles, Henry Rodriguez, Oliver F. Bathe, Daniel W. Chan, Ralph H. Hruban, Li Ding, Bing Zhang, Hui Zhang
Summary: This study conducted comprehensive proteogenomic analysis of PDAC to understand the molecular alterations that drive oncogenesis. Multiple analyses were performed on tissues from patients, providing valuable resources for early detection and identification of therapeutic targets.
Review
Biochemistry & Molecular Biology
Nausika Betriu, Juan Bertran-Mas, Anna Andreeva, Carlos E. Semino
Summary: Syndecans, a subfamily of proteoglycans, play critical roles in various physiological processes and have implications in disease progression. Their interactions with other macromolecules contribute to normal cellular functions and disease pathogenesis.
Review
Oncology
Eleonora Lai, Pina Ziranu, Dario Spanu, Marco Dubois, Andrea Pretta, Simona Tolu, Silvia Camera, Nicole Liscia, Stefano Mariani, Mara Persano, Marco Migliari, Clelia Donisi, Laura Demurtas, Valeria Pusceddu, Marco Puzzoni, Mario Scartozzi
Summary: Despite ongoing research, there is still insufficient data on BRCA1/2-mutant PDAC, and more understanding is needed on the specific landscape of PDAC with BRCA mutations.
BRITISH JOURNAL OF CANCER
(2021)
Article
Gastroenterology & Hepatology
Zhiheng Zhang, Hongzhen Li, Yibin Deng, Kathleen Schuck, Susanne Raulefs, Nadja Maeritz, Yuanyuan Yu, Torsten Hechler, Andreas Pahl, Vanesa Fernandez-Saiz, Yuan Wan, Guosheng Wang, Thomas Engleitner, Rupert Oellinger, Roland Rad, Maximilian Reichert, Kalliope N. Diakopoulos, Verena Weber, Jingjing Li, Shanshan Shen, Xiaoping Zou, Joerg Kleeff, Andre Mihaljevic, Christoph W. Michalski, Hana Alguel, Helmut Friess, Bo Kong
Summary: The study demonstrates that Agr2 is up-regulated during the ADM-to-pancreatic intraepithelial neoplasia transition in the context of inflammation and Kras(G12D) -driven early pancreatic carcinogenesis. Genetic ablation of Agr2 blocks the metaplastic-to-neoplastic process by interfering with the nuclear import of RNAPII. The developed hexapeptide disrupts the Agr2-RNAPII complex, leading to dysfunction of RNAPII and compromised initiation of PDAC.
Review
Cell Biology
Tianyi Zhang, Yanxian Ren, Pengfei Yang, Jufang Wang, Heng Zhou
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer with a high deposition of extracellular matrix (ECM) and poor prognosis. ECM proteins derived from tumor cells reduce the effectiveness of conventional cancer treatment and contribute to tumor progression and metastasis. Cancer-associated fibroblasts (CAFs) in the ECM are promising targets for novel anti-tumor interventions.
CELL DEATH & DISEASE
(2022)
Editorial Material
Biology
Jessica Castrillon Lal
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with a low survival rate. Understanding the complexity of tumor architecture and identifying targetable cellular phenotypes are major challenges in PDAC. Recent research has found recurrent gene expression patterns in malignant and fibroblast cellular neighborhoods in PDAC tumors that are correlated with treatment outcomes.
COMMUNICATIONS BIOLOGY
(2022)
Review
Oncology
Kongyuan Wei, Thilo Hackert
Summary: Surgery is the main potential cure for pancreatic ductal adenocarcinoma, with advancements in surgical techniques and multimodal approaches. Despite low survival rates, combining surgery with adjuvant therapy can increase five-year survival to around 20%. However, pancreatic resection is complex and high-risk, with ongoing developments in minimally-invasive and robotic approaches.
Review
Oncology
Eric M. Anderson, Shant Thomassian, Jun Gong, Andrew Hendifar, Arsen Osipov
Summary: Pancreatic cancer, with its highly immunosuppressive tumor microenvironment and dense stroma, presents challenges for traditional treatment approaches. Emerging treatment strategies have the potential to significantly improve outcomes for pancreatic cancer patients.
Review
Oncology
Vida Karimnia, Frank J. Slack, Jonathan P. Celli
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer with current clinical trials showing limited improvements in patient survival. Photodynamic therapy (PDT) has emerged as a potential approach for treating pancreatic tumors based on studies indicating its effectiveness in activating photosensitizing agents in target tissues.
Review
Pharmacology & Pharmacy
Delphine Quatannens, Yannick Verhoeven, Peter Van Dam, Filip Lardon, Hans Prenen, Geert Roeyen, Marc Peeters, Evelien L. J. Smits, Jonas Van Audenaerde
Summary: PDAC is a leading cause of cancer related death, with urgent need for effective therapies. Aberrant activation of the Hh signaling pathway in PDAC prompts it as a possible target for treatment, despite ongoing debate on its clinical benefits.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Roman Bubin, Romans Uljanovs, Ilze Strumfa
Summary: The discovery of cancer stem cells (CSCs) in leukemia has led to active research on stemness in neoplastic tissues. CSCs are a subpopulation of malignant cells with unique properties, including a dedifferentiated state, self-renewal, pluripotency, resistance to therapy, epigenetic alterations, and higher tumorigenicity. CSCs have been confirmed in various malignancies, including pancreatic ductal adenocarcinoma, which has a poor prognosis. This review aims to summarize the current knowledge on the markers and molecular features of CSCs in pancreatic ductal adenocarcinoma and the therapeutic options for their elimination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Andreea Rusu, Irina-Draga Caruntu, Ludmila Lozneanu, Delia Gabriela Ciobanu, Cornelia Amalinei, Simona-Eliza Giusca
Summary: This study investigated the expression of Gal8 in PDAC and its correlation with clinicopathological characteristics and survival. The results showed that Gal8 expression was associated with a more aggressive phenotype, suggesting the potential of Gal8 as a prognostic factor in PDAC.
Article
Oncology
Ailin Wei, Huiling Zhao, Xue Cong, Linyao Wang, Yiyang Chen, Juxiang Gou, Ziyi Hu, Xiuying Hu, Yali Tian, Ka Li, Yufeng Deng, Haojiang Zuo, Mei Rosemary Fu
Summary: This study investigated the association between oral mycobiota and pancreatic ductal adenocarcinoma (PDAC). The findings suggest that PDAC patients have increased fungal abundance and decreased fungal diversity compared to healthy controls. Certain fungal species, such as Aspergillus and Cladosporium, showed high classification powers in distinguishing PDAC patients from healthy controls. The findings highlight the potential of using oral mycobiota as a biomarker for early detection and prevention of PDAC.
Review
Oncology
Rayane Dennaoui, Hridaya Shrestha, Kay-Uwe Wagner
Summary: Pancreatic cancer research has made significant progress in understanding the molecular and developmental processes involved in the genesis of this highly malignant tumor type. Various models, including chemical carcingen-induced and genetically engineered animal models, are being developed and analyzed to study the biological significance of new molecular targets and mechanisms contributing to pancreatic cancer onset and progression.
CANCER AND METASTASIS REVIEWS
(2021)
Article
Virology
Iveta Selingerova, Dalibor Valik, Lenka Gescheidtova, Vladimir Sramek, Zdenka Cermakova, Lenka Zdrazilova-Dubska
Summary: This study found that high-level IgM specimens need to be diluted with negative human plasma, and the measured anti-SARS-CoV-2 IgM/IgG concentrations are substantially higher in the later marketed immunoassay batch. It is not recommended to combine data from different immunoassay batches for observing the informative time-course pattern of antibody production.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Medicine, General & Internal
Radana Dymackova, Iveta Selingerova, Tomas Kazda, Marek Slavik, Jana Halamkova, Michaela Svajdova, Pavel Slampa, Ondrej Slama
Summary: This study demonstrates that acupuncture can significantly reduce pain levels and analgesic consumption in patients undergoing curative and adjuvant (chemo)radiotherapy for head and neck cancer, providing a potential alternative to standard treatment with lower toxicity.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Petr Burkon, Iveta Selingerova, Marek Slavik, Petr Pospisil, Lukas Bobek, Libor Kominek, Pavel Osmera, Tomas Prochazka, Miroslav Vrzal, Tomas Kazda, Pavel Slampa
Summary: The study demonstrates that extracranial stereotactic body radiotherapy is an effective and low-toxic treatment for oligometastatic lymph node involvement, delaying the need for cytotoxic chemotherapy and improving patient quality of life. Further research should aim to identify patients who would benefit the most from this treatment strategy and determine the optimal timing and dosage of SBRT.
FRONTIERS IN ONCOLOGY
(2021)
Article
Computer Science, Interdisciplinary Applications
Iveta Selingerova, Stanislav Katina, Ivanka Horova
Summary: Modeling censored survival data involves estimating the conditional hazard function through parametric or semiparametric models, with the latter allowing for a weaker assumption of hazard proportionality. Kernel estimation can verify assumptions and capture changes in the hazard function over time and covariates.
JOURNAL OF STATISTICAL COMPUTATION AND SIMULATION
(2021)
Article
Oncology
Milos Holanek, Iveta Selingerova, Ondrej Bilek, Tomas Kazda, Pavel Fabian, Lenka Foretova, Maria Zvarikova, Radka Obermannova, Ivana Kolouskova, Oldrich Coufal, Katarina Petrakova, Marek Svoboda, Alexandr Poprach
Summary: Neoadjuvant chemotherapy is a standard treatment for early-stage TNBC, with achieving pCR being a key factor for favorable outcomes. Platinum salts in NACT are linked to higher pCR rates but come with unclear guidelines and increased adverse events. Identifying patients who benefit from platinum NACT remains a challenge.
Article
Medicine, General & Internal
Milos Holanek, Iveta Selingerova, Pavel Fabian, Oldrich Coufal, Ondrej Zapletal, Katarina Petrakova, Tomas Kazda, Roman Hrstka, Alexandr Poprach, Maria Zvarikova, Ondrej Bilek, Marek Svoboda
Summary: This retrospective study suggests that residual cancer burden after neoadjuvant therapy is associated with worse treatment outcomes in breast cancer patients. The study evaluated the dynamics and impact of biomarkers on long-term outcomes in specific breast cancer subtypes. The proliferation index Ki-67 was significantly altered by neoadjuvant therapy and predicted survival outcomes in different subtypes.
Article
Biochemistry & Molecular Biology
Andrea Martisova, Lucia Sommerova, Adam Krejci, Iveta Selingerova, Tamara Kolarova, Filip Zavadil Kokas, Milos Holanek, Jan Podhorec, Tomas Kazda, Roman Hrstka
Summary: The TGF-beta signaling pathway and AGR2 downregulation play important roles in focal adhesion formation and cancer cell migration and invasion. In addition, AGR2 is identified as a crucial component of the arachidonic acid metabolic pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Meeting Abstract
Oncology
T. Kazda, P. Fadrus, I Selingerova, R. Jancalek, P. Pospisil, L. Hynkova, J. Garcic, V. Vybihal, I Roskova, R. Belanova, M. Smrcka, M. Svajdova, P. Slampa
Article
Oncology
Lucie Gabrielova, Iveta Selingerova, Jan Zatecky, Ondrej Zapletal, Petr Burkon, Milos Holanek, Oldrich Coufal
Summary: This study compares different localization systems for detecting tumor lesions in the breast and finds apparent differences and small nuances not yet observed in clinical practice.
CLINICAL BREAST CANCER
(2023)
Article
Oncology
Peter Grell, Simona Borilova, Pavel Fabian, Iveta Selingerova, David Novak, Petr Muller, Igor Kiss, Rostislav Vyzula
Summary: Immunotherapy has revolutionized the treatment of malignant melanoma and non-small cell lung cancer in the last decade. However, a significant proportion of patients do not benefit from checkpoint inhibitor treatment, necessitating the search for new biomarkers to predict treatment response. This study aimed to analyze tumor tissue and immune profiles to identify predictive biomarkers for immune checkpoint inhibitor treatment.
Article
Environmental Sciences
Petra Musilova, Dita Kadlcikova, Hana Hradska, Miluse Vozdova, Iveta Selingerova, Halina Cernohorska, Dusan Salat, Jiri Rubes
Summary: This study compared chromosome damage in city policemen from three cities in the Czech Republic and found that air pollution, especially during the winter season, has a negative impact on chromosomes.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2023)
Meeting Abstract
Respiratory System
J. Nevrlka, I. Selingerova, Z. Nevrlkova, K. Ditetova, L. Zdrazilova-Dubska
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Oncology
Michal Rihacek, Iveta Selingerova, Ivo Kocak, Ilona Kocakova, Eva Rihackova, Dalibor Valik, Jaroslav Sterba
Summary: This study retrospectively analyzed the data of adult and pediatric patients treated with sunitinib, and found that sunitinib treatment increased the mean corpuscular volume of erythrocytes. The study also found that the rate of increase was faster in patients who experienced treatment-related adverse events.
Article
Medicine, General & Internal
Marek Slavik, Petr Burkon, Iveta Selingerova, Pavel Krupa, Tomas Kazda, Jaroslava Stankova, Tomas Nikl, Renata Hejnova, Zdenek Rehak, Pavel Osmera, Tomas Prochazka, Eva Dvorakova, Petr Pospisil, Peter Grell, Pavel Slampa, Radka Obermannova
Summary: This study demonstrates the feasibility of increasing the dose to GEJ tumor and involved nodes using PET/CT imaging in radiotherapy. Although there were instances of dose exceedance in certain areas, overall it is an effective approach. Prospective trials are needed to further validate these findings.
MEDICINA-LITHUANIA
(2021)
Article
Oncology
Radka Obermannova, Iveta Selingerova, Zdenek Rehak, Vaclav Jedlicka, Marek Slavik, Pavel Fabian, Ivo Novotny, Milada Zemanova, Hana Studentova, Peter Grell, Lenka Zdrazilova Dubska, Regina Demlova, Tomas Harustiak, Renata Hejnova, Igor Kiss, Rostislav Vyzula
Summary: This study confirms the accuracy of a PET-response-guided treatment algorithm for locally advanced oesophago-gastric junction cancer in a multicenter setting. Preoperative treatment adaptation was found to be feasible and safe for patients.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2021)