Article
Surgery
Shinjiro Kobayashi, Takehito Otsubo, Hiroshi Nakano, Satoshi Koizumi, Kazunari Nakahara
Summary: The study demonstrated that Artery-first approach pancreatoduodenectomy (AFA-PD) with complete lymphadenectomy around the entire superior mesenteric artery (SMA) can prolong overall survival and reduce recurrence rate in pancreatic ductal adenocarcinoma (PDAC) patients.
WORLD JOURNAL OF SURGERY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Francesca Rigiroli, Jocelyn Hoye, Reginald Lerebours, Kyle J. Lafata, Cai Li, Mathias Meyer, Peijie Lyu, Yuqin Ding, Fides R. Schwartz, Niharika B. Mettu, Sabino Zani, Sheng Luo, Desiree E. Morgan, Ehsan Samei, Daniele Marin
Summary: Analyzing radiomic features of preoperative CT images can improve the detection of superior mesenteric artery involvement in patients with pancreatic ductal adenocarcinoma. In a retrospective study, a model with five features showed better performance compared to radiologist assessment.
Article
Oncology
Seiko Hirono, Manabu Kawai, Ken-ichi Okada, Motoki Miyazawa, Yuji Kitahata, Rryohei Kobayashi, Shinya Hayami, Masaki Ueno, Hiroki Yamaue
Summary: The study revealed that locoregional recurrence most commonly occurred around the superior mesenteric artery after upfront pancreatoduodenectomy for pancreatic ductal adenocarcinoma. Lymph node metastasis was identified as an independent risk factor for both locoregional and distant recurrences, while non-completion of postoperative adjuvant therapy was a risk factor for distant recurrence.
Article
Surgery
Yoshihiro Miyazaki, Tatsuya Oda, Osamu Shimomura, Shinji Hashimoto, Manami Doi, Kazuhiro Takahashi, Yohei Owada, Kinji Furuya, Koichi Ogawa, Yusuke Ohara, Yoshimasa Akashi, Tsuyoshi Enomoto
Summary: This study investigated the feasibility of preserving the superior mesenteric artery nerve plexus (PLsma) in pancreaticoduodenectomy (PD) for pancreatic ductal adenocarcinoma (PDAC), and found that PLsma preservation improves patient outcomes in terms of recurrence and overall survival.
WORLD JOURNAL OF SURGERY
(2023)
Review
Endocrinology & Metabolism
Danielle L. Overton, Teresa L. Mastracci
Summary: Diabetes mellitus, affecting nearly 536.6 million people worldwide, is primarily caused by the death or dysfunction of beta cells in the pancreas. Studies suggest that interactions between neighboring cells in the pancreas play a crucial role in supporting beta cell function.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Justin M. Lebenthal, Junting Zheng, Paul M. Glare, Eileen M. O'Reilly, Andrew C. Yang, Andrew S. Epstein
Summary: The Memorial Sloan Kettering Prognostic Score (MPS), consisting of the neutrophil-lymphocyte ratio (NLR) and albumin levels, is a predictive tool for survival in patients with metastatic pancreatic adenocarcinoma (mPDAC) regardless of performance status, disease characteristics, and cancer therapy. Higher MPS scores, liver metastases, radiation therapy, hospital admissions, thromboembolism, and performance status were associated with worse overall survival in this study.
Article
Surgery
Hironori Shiozaki, Yoshihiro Shirai, Machi Suka, Ryoga Hamura, Takashi Horiuchi, Jungo Yasuda, Kenei Furukawa, Shinji Onda, Takeshi Gocho, Toru Ikegami
Summary: This study found that for resectable pancreatic cancer patients without LN enlargement around the SMA, performing LN and nerve plexus dissection around the SMA did not prolong disease-free survival and overall survival. However, it significantly increased the frequency of severe diarrhea.
LANGENBECKS ARCHIVES OF SURGERY
(2021)
Review
Immunology
Anne Sofie Bruun-Sorensen, Sarannya Edamana, Frederic H. Login, Signe Borgquist, Lene N. Nejsum
Summary: Aquaporins, proteins that facilitate passive water transport across cellular membranes, are often overexpressed in various cancers, including pancreatic ductal adenocarcinoma. This overexpression of aquaporins, such as aquaporin-1, aquaporin-3, and aquaporin-5, has been linked to metastasis and poor survival in pancreatic cancer, suggesting their potential as diagnostic markers and therapeutic targets.
Article
Surgery
Yoichi Miyata, Naoto Yonamine, Ibuki Fujinuma, Takazumi Tsunenari, Yasuhiro Takihata, Toshimitsu Iwasaki, Takahiro Einama, Hironori Tsujimoto, Hideki Ueno, Junji Yamamoto, Yoji Kishi
Summary: Metastases to LN#14 in pancreatic head cancer patients significantly affect prognosis, with LN#14 + group having worse overall survival compared to LN#14 - group.
WORLD JOURNAL OF SURGERY
(2021)
Article
Surgery
Takafumi Sato, Yosuke Inoue, Atsushi Oba, Yoshihiro Ono, Hiromichi Ito, Yu Takahashi
Summary: This study describes a technique for SMA dissection from the left posterior side. The method allows safe oncologic dissection around SMA avoiding anatomical misorientation during laparoscopic PD.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Takafumi Sato, Yosuke Inoue, Atsushi Oba, Yoshihiro Ono, Hiromichi Ito, Yu Takahashi
Summary: This study describes a method for dissecting the superior mesenteric artery (SMA) from the left side, which is a safe approach for pancreaticoduodenectomy and avoids anatomical misorientation.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Oncology
Ahmad Alkhasawneh, Tasnuva Rashid, Ibraheem Mohammed, Basma Elhaddad, Hassan Al-Balas, Mayur Virarkar, Ziad Awad, Brett Baskovich, Arun Gopinath
Summary: This study evaluated the prognostic significance of duodenal wall invasion in pancreatic adenocarcinoma. It found that duodenal wall invasion is associated with lymph node metastasis but not with disease-free/overall survival.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Review
Endocrinology & Metabolism
Laura Soldovieri, Gianfranco Di Giuseppe, Gea Ciccarelli, Giuseppe Quero, Francesca Cinti, Michela Brunetti, Enrico C. Nista, Antonio Gasbarrini, Sergio Alfieri, Alfredo Pontecorvi, Andrea Giaccari, Teresa Mezza
Summary: In the past few decades, various approaches have been explored to restore sufficient β-cell mass in diabetic patients. Stem cells are an attractive source of new β-cells, while inducing endogenous regeneration is also an alternative option. This review summarizes the latest evidence on physiological and pathological conditions associated with pancreatic regeneration and proliferation, as well as the signaling cascade mediating cell growth.
MOLECULAR METABOLISM
(2023)
Article
Oncology
Ritu R. Singh, Alison P. Klein, Neil R. Sharma, Eileen M. O'Reilly
Summary: This study investigates the incidence of pancreatic ductal adenocarcinoma (PDAC) in patients with non-biliary and non-alcoholic acute pancreatitis (AP), and compares the rates of early-stage diagnosis and surgical resection between patients with and without AP. The results show that the incidence of PDAC is relatively low, but patients with preceding AP are more likely to undergo surgical resection and have a trend towards earlier diagnosis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Francesca Rigiroli, Jocelyn Hoye, Reginald Lerebours, Peijie Lyu, Kyle J. Lafata, Anru R. Zhang, Alaattin Erkanli, Niharika B. Mettu, Desiree E. Morgan, Ehsan Samei, Daniele Marin
Summary: This study developed and evaluated task-based radiomic features extracted from the mesenteric-portal axis for prediction of survival and response to neoadjuvant therapy in patients with pancreatic ductal adenocarcinoma (PDAC). The results suggest that task-based shape radiomic features can predict survival in PDAC patients.
EUROPEAN RADIOLOGY
(2023)