Article
Oncology
Sharavan Ramachandran, Itishree S. Kaushik, Sanjay K. Srivastava
Summary: Pimavanserin, as a novel anti-psychotic drug, shows potential as a treatment option for pancreatic cancer by suppressing the growth of pancreatic tumors through inducing autophagy-mediated apoptosis. The study found that Pimavanserin treatment led to increased autophagy and apoptosis in pancreatic ductal adenocarcinoma cells, supporting its role in tumor growth suppression.
Article
Plant Sciences
Zhu Zhang, Wen-qing Chen, Shi-qing Zhang, Jing-xuan Bai, Bin Liu, Ken Kin-Lam Yung, Joshua Ka-Shun Ko
Summary: The study revealed that isoliquiritigenin (ISL) inhibited the progression of pancreatic cancer by blocking autophagy through the p38 MAPK signaling pathway.
Article
Medicine, Research & Experimental
Aneesha Dasgupta, Paige C. Arneson-Wissink, Rebecca E. Schmitt, Dong Seong Cho, Alexandra M. Ducharme, Tara L. Hogenson, Eugene W. Krueger, William R. Bamlet, Lizhi Zhang, Gina L. Razidlo, Martin E. Fernandez-Zapico, Jason D. Doles
Summary: Approximately 80% of pancreatic cancer patients suffer from cachexia, and one-third die due to cachexia-related complications. However, there are currently no FDA-approved therapies for cachexia. In this study, a aged model of pancreatic cancer cachexia was generated and compared with young tumor-bearing mice. The antiwasting compound, 3-methyladenine (3-MA), was identified and shown to have potential antitumor effects. In addition, the gene Perp was implicated as a target of 3-MA, and its reduction inhibited tumor cell growth.
Review
Chemistry, Medicinal
Nityaa Selvarajoo, Johnson Stanslas, Mohammad Kaisarul Islam, Sreenivasa Rao Sagineedu, Ho Kok Lian, Jonathan Chee Woei Lim
Summary: This review summarizes the regulatory mechanisms of apoptosis and autophagy in pancreatic cancer and the potential drug-like molecules that target these pathways. By targeting apoptosis and autophagy, the effectiveness of pancreatic cancer treatment can be improved. Several drugs have shown synergistic effects when combined with chemotherapy.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2022)
Article
Plant Sciences
Xiang Qian, Qian-Yu Bi, Zeng-Na Wang, Fang Han, Lu-Ming Liu, Li-Bin Song, Chang-Yu Li, Ai-Qin Zhang, Xu-Ming Ji
Summary: This study found that Qingyihuaji Formula (QYHJ) can be effective in treating pancreatic ductal adenocarcinoma (PDAC) and identified its underlying mechanisms using proteomics and network pharmacology-based analysis. The results showed that QYHJ inhibits the growth and metastasis of PDAC by activating STAT 1 and inhibiting the MAPK/ERK and PI3K/Akt/mTOR signaling pathways. Quercetin, a core component of QYHJ, induces apoptosis and autophagy in PDAC cells by inhibiting the activation of ERK1/2.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rulin Sun, Xujun He, Xiaoting Jiang, Houquan Tao
Summary: Pancreatic cancer is often diagnosed at an advanced stage, making chemotherapy the best treatment option. Research suggests that Riluzole may have potential in inhibiting tumors, including pancreatic cancer. Further experiments are needed to confirm the reliability of these findings, but data indicates Riluzole may offer promise for future treatments.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Oncology
Hongcheng Wang, Yongzhi Liu, Yiwei Wang, Ting Xu, Guanggai Xia, Xinyu Huang
Summary: The study found that umbelliprenin has inhibitory effects on pancreatic cancer. It shows anti-tumor effects by inducing apoptosis in both in vitro and in vivo experiments. It also inhibits pancreatic cancer growth and proliferation by blocking autophagy and reducing cancer stem cell characteristics.
Article
Oncology
Jyoti B. Kaushal, Rakesh Bhatia, Ranjana K. Kanchan, Pratima Raut, Surya Mallapragada, Quan P. Ly, Surinder K. Batra, Satyanarayana Rachagani
Summary: The study evaluated the therapeutic efficacy of Niclosamide on pancreatic cancer and found that it induced cell death through mitochondrial stress and mTORC1-dependent autophagy. Niclosamide inhibited the Hedgehog (Hh) signaling pathway and promoted cell death through regulation of p-Gsk3 beta.
Review
Oncology
Wenhao Luo, Lianfang Zheng, Taiping Tai Zhang
Summary: Pancreatic cancer is the most lethal malignancy of the gastrointestinal tract, and lack of effective treatments often leads to poor prognosis for patients. Resistance to apoptosis and autophagy is a key feature of PC, contributing to its invasiveness and resistance to conventional treatment. Natural product extracts show potential in inhibiting PC progression by affecting apoptosis or autophagy.
Article
Oncology
Mingyang Song, Qin Lu, Min Xu, Yajie Li, Yawen Zhao, Chen Gong, Xilong Ou
Summary: This study conducted a bibliometric analysis on literature related to autophagy of pancreatic cancer to present the global research features and hotspots, and forecast the emerging trends. China and the United States were the most frequent publishers and collaborators in this field. The research hotspots focused on autophagy mechanisms in tumor onset and progression, the role of autophagy in tumor apoptosis, and autophagy-related drugs in treating pancreatic cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Cheng Qin, Yuanyang Wang, Bangbo Zhao, Zeru Li, Tianyu Li, Xiaoying Yang, Yutong Zhao, Weibin Wang
Summary: Pancreatic cancer is a lethal disease with low survival rate, and chemotherapy resistance is common. Mitochondria, as the energy source in cancer cells, play a role in chemoresistance. STOML2, located in the inner membrane of mitochondria, is highly expressed in cancer cells. This study found that high STOML2 expression correlated with improved survival in patients with pancreatic cancer. STOML2 inhibited cell proliferation and chemoresistance in pancreatic cancer cells, and was associated with mitochondrial mass and mitophagy. STOML2 stabilized PARL and prevented gemcitabine-induced PINK1-dependent mitophagy, suggesting that targeting STOML2 might enhance gemcitabine therapy in the future.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Feng Liang, Ying Lv, Xiao Qiao, Shu Zhang, Shanshan Shen, Changcheng Wang, Guifang Xu, Xiaoping Zou, Lei Wang, Bin Zhang
Summary: This research suggests that cinchonine, a natural compound from cinchona bark, could be a potential anticancer drug for pancreatic cancer. It inhibits the expression of RRP15, leading to the inhibition of autophagy and induction of apoptosis in pancreatic cancer cells. The activation of the Nrf2 axis is involved in this process.
CELL BIOLOGY INTERNATIONAL
(2023)
Review
Gastroenterology & Hepatology
Keisuke Yamamoto, Dosuke Iwadate, Hiroyuki Kato, Yousuke Nakai, Keisuke Tateishi, Mitsuhiro Fujishiro
Summary: Autophagy plays an important role in pancreatic ductal adenocarcinoma (PDAC). In PDAC, autophagy is constitutively active and enables the tumor to survive and thrive in a nutrient-scarce environment. Autophagy promotes PDAC progression through various mechanisms, including metabolic support, resistance to therapy, and immune evasion. Host autophagy also contributes to PDAC progression. There are ongoing clinical trials targeting the autophagy-lysosome pathway in PDAC.
JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Oncology
Yangchun Xie, Jiao Liu, Rui Kang, Daolin Tang
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive solid malignancy with poor response to current therapies and low overall survival rate, often associated with oncogenic KRAS mutations. Autophagy plays a dual role in the regulation of PDAC initiation and progression, while mitophagy is crucial for understanding the occurrence and treatment of PDAC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yixuan Zhang, Jianzhuang Wu, Yao Fu, Ranran Yu, Haochen Su, Qisi Zheng, Hao Wu, Siqi Zhou, Kun Wang, Jing Zhao, Shanshan Shen, Guifang Xu, Lei Wang, Chao Yan, Xiaoping Zou, Ying Lv, Shu Zhang
Summary: This study identified Hesperadin as a potent anti-cancer compound against pancreatic cancer (PC) by inhibiting cell growth and inducing apoptotic cell death. Mechanistic studies revealed that Hesperadin increased GADD45A expression via ATF4, leading to apoptosis. Immunohistochemical staining demonstrated the correlation between ATF4 and GADD45A expression. PC xenograft studies confirmed the inhibitory effect of Hesperadin on PC cell growth in vivo.
Article
Gastroenterology & Hepatology
Gyorgy Biczo, Eszter T. Vegh, Natalia Shalbueva, Olga A. Mareninova, Jason Elperin, Ethan Lotshaw, Sophie Gretler, Aurelia Lugea, Sudarshan R. Malla, David Dawson, Piotr Ruchala, Julian Whitelegge, Samuel W. French, Li Wen, Sohail Z. Husain, Fred S. Gorelick, Peter Hegyi, Zoltan Rakonczay, Ilya Gukovsky, Anna S. Gukovskaya
Article
Gastroenterology & Hepatology
Matthias Sendler, Frank-Ulrich Weiss, Janine Golchert, Georg Homuth, Cindy van den Brandt, Ujjwal M. Mahajan, Lars-Ivo Partecke, Paula Doering, Ilya Gukovsky, Anna S. Gukovskaya, Preshit R. Wagh, Markus M. Lerch, Julia Mayerle
Article
Gastroenterology & Hepatology
Mouad Edderkaoui, Chintan Chheda, Badr Soufi, Fouzia Zayou, Robert W. Hu, V. Krishnan Ramanujan, Xinlei Pan, Laszlo G. Boros, Jian Tajbakhsh, Anisha Madhav, Neil A. Bhowmick, Qiang Wang, Michael Lewis, Richard Tuli, Aida Habtezion, Ramachandran Murali, Stephen J. Pandol
Article
Gastroenterology & Hepatology
Aida Habtezion, Anna S. Gukovskaya, Stephen J. Pandol
Article
Cell Biology
Shaogui Wang, Hong-Min Ni, Xiaojuan Chao, Hua Wang, Brian Bridges, Sean Kumer, Timothy Schmitt, Olga Mareninova, Anna Gukovskaya, Robert C. De Lisle, Andrea Ballabio, Pal Pacher, Wen-Xing Ding
Article
Physiology
Ce Li, Susan Morvaridi, Gloria Lam, Chintan Chheda, Yoshiko Kamata, Makoto Katsumata, Mouad Edderkaoui, Xiaopu Yuan, Nicholas Nissen, Stephen J. Pandol, Qiang Wang
FRONTIERS IN PHYSIOLOGY
(2019)
Review
Gastroenterology & Hepatology
Anna S. Gukovskaya, Fred S. Gorelick, Guy E. Groblewski, Olga A. Mareninova, Aurelia Lugea, Laura Antonucci, Richard T. Waldron, Aida Habtezion, Michael Karin, Stephen J. Pandol, Ilya Gukovsky
Article
Biochemistry & Molecular Biology
Sudarshan R. Malla, Burkhard Krueger, Thomas Wartmann, Matthias Sendler, Ujjwal M. Mahajan, F. Ulrich Weiss, Franziska G. Thiel, Carina De Boni, Fred S. Gorelick, Walter Halangk, Ali A. Aghdassi, Thomas Reinheckel, Anna S. Gukovskaya, Markus M. Lerch, Julia Mayerle
CELLULAR AND MOLECULAR LIFE SCIENCES
(2020)
Review
Gastroenterology & Hepatology
Jami L. Saloman, Kathryn M. Albers, Zobeida Cruz-Monserrate, Brian M. Davis, Mouad Edderkaoui, Guido Eibl, Ariel Y. Epouhe, Jeremy Y. Gedeon, Fred S. Gorelick, Paul J. Grippo, Guy E. Groblewski, Sohail Z. Husain, Keane K. Y. Lai, Stephen J. Pandol, Aliye Uc, Li Wen, David C. Whitcomb
Article
Cell Biology
Olga A. Mareninova, Wenzhuo Jia, Sophie R. Gretler, Conner L. Holthaus, Diana D. H. Thomas, Michael Pimienta, Dustin L. Dillon, Anna S. Gukovskaya, Ilya Gukovsky, Guy E. Groblewski
Article
Oncology
Enes Taylan, Fouzia Zayou, Ramachandran Murali, Beth Y. Karlan, Stephen J. Pandol, Mouad Edderkaoui, Sandra Orsulic
GYNECOLOGIC ONCOLOGY
(2020)
Article
Pharmacology & Pharmacy
Yan Ou, Ruoxiang Wang, Gina Chia-Yi Chu, Omer Hany Miligy Elmadbouh, Adrian Lim, Leland Wei-Kuo Chung, Mouad Edderkaoui, Yi Zhang, Stephen Jacob Pandol
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a disease with no effective therapeutics. A novel targeted therapy drug consisting of a tumor-targeting ligand, near-infrared (NIR) organic heptamethine carbocyanine dye (DZ), and HMG-CoA inhibitor simvastatin (SIM), is developed and its efficacy in PDAC is assessed. The drug significantly inhibits tumor growth, re-sensitizes therapeutically resistant PDAC cells to conventional therapies, and kills cancer cells through unique pathways involving decreasing mitochondrial bioenergetics and increasing ROS production.
ADVANCED THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
John A. Williams, Guy E. Groblewski, Fred S. Gorelick, Julia Mayerle, Minoti Apte, Anna S. Gukovskaya
Article
Gastroenterology & Hepatology
Maisam Abu-El-Haija, Anna S. Gukovskaya, Dana K. Andersen, Timothy B. Gardner, Peter Hegyi, Stephen J. Pandol, Georgios I. Papachristou, Ashok K. Saluja, Vikesh K. Singh, Aliye Uc, Bechien U. Wu
Article
Pathology
Chiara Birtolo, Hung Pham, Susan Morvaridi, Chintan Chheda, Vay Liang W. Go, Andrzej Ptasznik, Mouad Edderkaoui, Michael H. Weisman, Erika Noss, Michael B. Brenner, Brent Larsonr, Maha Guindi, Qiang Wang, Stephen J. Pandol
AMERICAN JOURNAL OF PATHOLOGY
(2017)