Combination of Hedgehog Signaling Blockage and Chemotherapy Leads to Tumor Reduction in Pancreatic Adenocarcinomas

Sonic Hedgehog Expression Correlates With Distant Metastasis in Pancreatic Adenocarcinoma

(2010) Juntao Dai et al.   PANCREAS

Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer

(2008) G Feldmann et al.   GUT

Fluorouracil vs Gemcitabine Chemotherapy Before and After Fluorouracil-Based Chemoradiation Following Resection of Pancreatic Adenocarcinoma

(2008) William F. Regine et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Hedgehog Drugs Begin To Show Results

(2008) K. Garber   JNCI-Journal of the National Cancer Institute

An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer

(2008) G. Feldmann et al.   MOLECULAR CANCER THERAPEUTICS

The Expression Pattern of PDX-1, SHH, Patched and Gli-1 Is Associated with Pathological and Clinical Features in Human Pancreatic Cancer

(2008) Karl Quint et al.   PANCREATOLOGY

Dose- and Route-Dependent Teratogenicity, Toxicity, and Pharmacokinetic Profiles of the Hedgehog Signaling Antagonist Cyclopamine in the Mouse

(2008) Robert J. Lipinski et al.   TOXICOLOGICAL SCIENCES