Article
Sport Sciences
Marcus P. Hannon, Lloyd J. F. Parker, Daniel J. Carney, John Mckeown, John R. Speakman, Catherine Hambly, Barry Drust, Viswanath B. Unnithan, Graeme L. Close, James P. Morton
Summary: The total energy expenditure of male academy soccer players progressively increases as players progress through the academy age groups. In some individuals (evident in all age groups), total energy expenditure was greater than that previously observed in adult EPL soccer players.
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2021)
Article
Oncology
Daniel R. Principe, Murray Korc, Suneel D. Kamath, Hidayatullah G. Munshi, Ajay Rana
Summary: Immunotherapy has revolutionized cancer treatment in the past decade, but has faced exceptional challenges in pancreatic ductal adenocarcinoma. Despite many different immunotherapies being explored in clinical trials, few have shown significant therapeutic efficacy.
Article
Biochemistry & Molecular Biology
Li-Li Zhu, Zheng Wu, Rong-Kun Li, Xin Xing, Yong-Sheng Jiang, Jun Li, Ya-Hui Wang, Li-Peng Hu, Xu Wang, Wei-Ting Qin, Yong-Wei Sun, Zhi-Gang Zhang, Qin Yang, Shu-Heng Jiang
Summary: The study comprehensively analyzed multidimensional omic data of PDAC tumors, revealing molecular events associated with aerobic glycolysis and identifying long non-coding RNAs involved in PDAC aerobic glycolysis. Loss-of-function studies demonstrated that silencing of LINC01559 and UNC5B-AS1 significantly inhibited the glycolytic capacity of PDAC cells, and high expression of these two lncRNAs correlated with poor patient prognosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biology
Peter K. Kim, Christopher J. Halbrook, Samuel A. Kerk, Megan Radyk, Stephanie Wisner, Daniel M. Kremer, Peter Sajjakulnukit, Anthony Andren, Sean W. Hou, Ayush Trivedi, Galloway Thurston, Abhinav Anand, Liang Yan, Lucia Salamanca-Cardona, Samuel D. Welling, Li Zhang, Matthew R. Pratt, Kayvan R. Keshari, Haoqiang Ying, Costas A. Lyssiotis
Summary: The rewired metabolism in pancreatic ductal adenocarcinomas is sustained by cancer cells scavenging nutrients from the tumor microenvironment to maintain glycosylation precursor pools. Hyaluronic acid, a carbohydrate polymer in pancreatic tumors, can refuel the hexosamine biosynthetic pathway beyond its structural and signaling roles, providing energy for PDA metabolism.
Article
Oncology
Elettra Merola, Teresa Alonso Gordoa, Panpan Zhang, Taymeyah Al-Toubah, Eleonora Pelle, Agnieszka Kolasinska-Cwikla, Wouter Zandee, Faidon Laskaratos, Louis De Mestier, Angela Lamarca, Jorge Hernando, Jaroslaw Cwikla, Jonathan Strosberg, Wouter De Herder, Martin Caplin, Mauro Cives, Rachel van Leeuwaarde
Summary: Long-acting somatostatin analogs demonstrate antiproliferative activity in pancreatic NETs with Ki-67 >= 10%, particularly in G2 tumors and when hepatic tumor load is <= 25%.
Review
Oncology
Xinyao Chang, Xingchen Liu, Haoze Wang, Xuan Yang, Yan Gu
Summary: Metabolic reprogramming, specifically the switch from oxidative phosphorylation to glycolysis, promotes the malignant behavior of pancreatic cancer and affects tumor microenvironments. Glycolysis is critical for cancer cells to maintain biosynthesis and promotes tumor initiation, invasion, angiogenesis, and metastasis to distant organs.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Biology
Samuel A. Kerk, Lin Lin, Amy L. Myers, Damien J. Sutton, Anthony Andren, Peter Sajjakulnukit, Li Zhang, Yaqing Zhang, Jennifer A. Jimenez, Barbara S. Nelson, Brandon Chen, Anthony Robinson, Galloway Thurston, Samantha B. Kemp, Nina G. Steele, Megan T. Hoffman, Hui-Ju Wen, Daniel Long, Sarah E. Ackenhusen, Johanna Ramos, Xiaohua Gao, Zeribe C. Nwosu, Stefanie Galban, Christopher J. Halbrook, David B. Lombard, David R. Piwnica-Worms, Haoqiang Ying, Marina Pasca di Magliano, Howard C. Crawford, Yatrik M. Shah, Costas A. Lyssiotis
Summary: Mitochondrial glutamate-oxaloacetate transaminase 2 (GOT2) is a key component of glutamine metabolism in pancreatic ductal adenocarcinoma (PDA). Loss of GOT2 disrupts redox homeostasis and halts proliferation of PDA cells in vitro, but has no effect on tumor growth in vivo due to metabolic plasticity of PDA cells.
Article
Multidisciplinary Sciences
Lena Wiedmann, Francesca De Angelis Rigotti, Nuria Vaquero-Siguero, Elisa Donato, Elisa Espinet, Iris Moll, Elisenda Alsina-Sanchis, Hanibal Bohnenberger, Elena Fernandez-Florido, Ronja Muelfarth, Margherita Vacca, Jennifer Gerwing, Lena-Christin Conradi, Philipp Stroebel, Andreas Trumpp, Carolin Mogler, Andreas Fischer, Juan Rodriguez-Vita
Summary: The presence of peritoneal metastasis in pancreatic cancers is associated with poor prognosis. The authors found that HAPLN1 promotes tumor cell plasticity and pro-tumoral immune microenvironment to facilitate peritoneal dissemination in pancreatic cancers.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Jian Yang, Yongzheng Li, Zhaowei Sun, Hanxiang Zhan
Summary: This review summarizes recent advances in understanding the origin, distribution, and polarization of macrophages in pancreatic cancer, as well as their role in carcinogenesis and development, and potential therapeutic value. Macrophages play a crucial role in creating an immunosuppressive tumor microenvironment, ultimately facilitating tumor initiation and progression in pancreatic cancer.
Article
Multidisciplinary Sciences
Haochen Zhang, Elias-Ramzey Karnoub, Shigeaki Umeda, Ronan Chaligne, Ignas Masilionis, Caitlin A. McIntyre, Palash Sashittal, Akimasa Hayashi, Amanda Zucker, Katelyn Mullen, Jungeui Hong, Alvin Makohon-Moore, Christine A. Iacobuzio-Donahue
Summary: Through an optimized approach, high-throughput single-cell DNA sequencing can be applied to study the genomic evolution patterns of pancreatic ductal adenocarcinoma.
NATURE COMMUNICATIONS
(2023)
Review
Oncology
Hou-Chuan Lai, Yi-Wei Kuo, Yi-Hsuan Huang, Shun-Ming Chan, Kuang- Cheng, Zhi-Fu Wu
Summary: Pancreatic cancer is a deadly disease with a low 5-year survival rate. The interaction between pancreatic tumor cells and the microenvironment plays a crucial role in drug resistance, metastasis, and recurrence. Perioperative factors, including surgical manipulation and anesthesia, can affect the tumor microenvironment and cancer progression. The impact of anesthesia on the pancreatic cancer microenvironment and progression is still limited. Anesthesiologists play an important role in perioperative management and may have an impact on surgical outcomes.
Article
Biotechnology & Applied Microbiology
Meng Wang, Qida Hu, Junmin Huang, Xinyu Zhao, Shiyi Shao, Fu Zhang, Zhuo Yao, Yuan Ping, Tingbo Liang
Summary: The dual-targeting nanomedicine, PG@KMCM, was developed to target tumor-associated macrophages and reprogram the tumor microenvironment, enhancing the therapeutic potential against pancreatic cancer. Combination with PD-L1 immune checkpoint inhibitor further improved the anti-tumoral effect by reprograming the immune-suppressive tumor microenvironment.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jorge Yassen Diaz-Blancas, Ismael Dominguez-Rosado, Carlos Chan-Nunez, Jorge Melendez-Zajgla, Vilma Maldonado
Summary: This study analyzed the effects of platelets on pancreatic cancer cells and found that platelets can increase the proliferation and migration capacity of cancer cells, enhance clonogenicity, and induce higher expression of stem cell markers. Differential expression of microRNAs in platelets from pancreatic cancer patients and healthy subjects was also discovered, with clear differences between the two groups. Furthermore, differences between blood-derived and pancreatic juice-derived platelets in the cancer patients suggest the presence of distinct platelet subpopulations, warranting further analysis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Benedikte Western, Ingrid Demmelmaier, Ingvild Vistad, Bjorge Herman Hansen, Andreas Stenling, Hege Berg Henriksen, Karin Nordin, Rune Blomhoff, Sveinung Berntsen
Summary: The aim of this study was to determine the minimum number of monitoring days required for reliable estimates of different physical activity (PA) intensities in cancer survivors. Results showed that two monitoring days were needed for reliable estimates of light PA, three monitoring days were needed for moderate and moderate-to-vigorous PA. Reliable estimates for vigorous PA could not be obtained for the overall sample, but were obtained for breast cancer survivors. Shorter monitoring periods with wearable devices may provide reliable estimates and reduce participant burden.
Review
Pharmacology & Pharmacy
Xing Huang, Gang Zhang, Tingbo Liang
Summary: The cases and deaths related to pancreatic cancer are on the rise globally, posing a significant global health concern. The heterogeneous nature of pancreatic cancer within and between tumors has been identified as a critical factor contributing to its poor prognosis. However, there is a lack of precise management strategies for this complex disease. Subtyping pancreatic tumors based on their molecular characteristics shows promise in improving the accuracy of treatment decisions, but its feasibility and potential flaws need further exploration.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2022)