Article
Immunology
Tianbin Cai, Wenjian Mao, Meiqiong Liu, Jing Zhou, Xinyu Wang, Jing Zhou, Yuxiu Liu, Guangyu Lv, Lu Ke, Youhua Zhang
Summary: This study aimed to assess the association between early mean absolute lymphocyte count (ALC) and the development of infected pancreatic necrosis (IPN) in patients with acute necrotizing pancreatitis (ANP). The results showed that low early mean ALC is an independent risk factor for 90-day IPN, indicating the importance of preventive strategies in patients with reduced ALC.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Gastroenterology & Hepatology
Birte Purschke, Louisa Bolm, Max Nikolaus Meyer, Hiroki Sato
Summary: Acute pancreatitis is a common gastrointestinal disease and can progress to necrotizing pancreatitis, which is associated with infection and increased mortality. Early diagnosis and treatment are crucial for improving patient outcomes. The step-up approach, which includes endoscopic interventions, has shown to decrease multiple-organ failure and intervention-related complications. However, the optimal sequence and timing of interventions remain controversial.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Wenjian Mao, Kang Li, Jing Zhou, Miao Chen, Bo Ye, Gang Li, Vikesh Singh, James Buxbaum, Xiaoyun Fu, Zhihui Tong, Yuxiu Liu, John Windsor, Weiqin Li, Lu Ke, CAPCTG
Summary: This study aimed to assess the performance of the Pancreatitis Activity Scoring System (PASS) and its modifications in predicting infected pancreatic necrosis (IPN) in patients with acute necrotizing pancreatitis. The mPASS-4 model had the best predictive performance and simplified the original PASS, increasing the likelihood of clinical implementation.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qian Liao, Ling Ding, Xin Xu, Chen Yu, Feng Deng, Huifang Xiong, Wenhua He, Liang Xia, Xianjun Zeng, Nonghua Lu, Yin Zhu
Summary: This study investigated the correlation between pancreatic necrosis volume and readmission as well as reintervention. The results showed a significant association between pancreatic necrosis volume and these outcomes. In addition, modified CT severity index and several other factors were also related to readmission and reintervention.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Thomas K. Maatman, Nicholas J. Zyromski
Summary: Operative pancreatic debridement (OPD) is considered an important treatment strategy in modern management of necrotizing pancreatitis, assisting patients in their recovery process.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Gastroenterology & Hepatology
Dingcheng Shen, Qin Wei, Haosu Huang, Caihong Ning, Jiarong Li, Lu Chen, Shuai Zhu, Gengwen Huang
Summary: The study found that patients with synchronous persistent organ failure and infected pancreatic necrosis in critical acute pancreatitis (SCAP) were associated with higher mortality and morbidity. In contrast, patients with metachronous CAP (MCAP) had lower mortality and morbidity rates.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Gastroenterology & Hepatology
Henrik Leonard Husu, Miia Maaria Valkonen, Ari Kalevi Leppaniemi, Panu Juhani Mentula
Summary: IPN in patients with necrotizing SAP is associated with worse outcomes. Risk factors for IPN include extensive anatomical spread of necrotic collections, postinterventional pancreatitis, preceding bacteremia, and preceding open abdomen treatment. Patients with IPN have longer ICU and hospital stays, higher risk for necrosectomy, and higher readmission rate to ICU.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Review
Gastroenterology & Hepatology
Amandeep Singh, Manik Aggarwal, Rajat Garg, Matthew Walsh, Tyler Stevens, Prabhleen Chahal
Summary: Spontaneous internal pancreatic fistula is a rare and complex complication of acute pancreatitis, more common in males, alcoholics, severe AP, and infected necrosis. Diagnosis requires a high index of suspicion, with treatment strategies including medical and nonsurgical interventions, and some cases may require surgical intervention.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Robert A. Moran, Christopher Halloran, Qiang Guo, Chandra Umapathy, Niloofar Y. Jalaly, Saransh Jain, Darren Cowzer, Enrique Perez Cuadrado Robles, Noe Quesada-Vaszquez, Andrea Szentesi, Maria Papp, Tiffany Chua, Katalin Marta, Kartik Sampath, David X. Jin, Shaheel Mohammad Sahebally, Tobias Philipp Kuschnereit, Mouen A. Khashab, Clare Rock, Erika Darvasi, Rebecca Saunders, Guillermo Garcia-Rayado, Yolanda Sanchez Torrijos, Laoise Coady, Georgios I. Papachristou, Julia Mayerle, Justin Geoghegan, Peter A. Banks, Timothy B. Gardner, Aniko Nora Szabo, Tyler Stevens, Tamas Tornai, Emese Toth, Gerry McEntee, Enrique de-Madaria, Pramod K. Garg, Peter Hegyi, Dhiraj Yadav, Weiming Hu, John Neoptolemos, Vikesh K. Singh
Summary: Early infection in infected pancreatic necrosis is associated with increased mortality. Early surgery remains a significant predictor of excess mortality.
Letter
Medicine, General & Internal
Efstathios T. Pavlidis, Theodoros E. Pavlidis
Summary: Necrotizing or severe pancreatitis accounts for approximately 10%-20% of acute pancreatitis. 30%-40% of patients with acute necrotizing pancreatitis (ANP) will develop debris infection through translocation of intestinal microbial flora. Infected ANP is a serious clinical condition with high mortality rates despite progress in intensive care.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Review
Immunology
Yasuo Otsuka, Ken Kamata, Kosuke Minaga, Tomohiro Watanabe, Masatoshi Kudo
Summary: Acute pancreatitis is a common emergent disorder, and a portion of patients develop severe acute pancreatitis (SAP), which is life-threatening. Besides bacterial infection, recent studies have shown a high incidence of fungal infection in SAP patients, and those with fungal infection have a higher mortality rate. Although the pathogenic role of fungal infection in SAP has been supported, the benefits of prophylactic anti-fungal therapy have not been proven.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Infectious Diseases
Supavit Chesdachai, Zachary A. Yetmar, Brian D. Lahr, Santhi Swaroop Vege, Paschalis Vergidis
Summary: This study aimed to compare the clinical characteristics and outcomes of patients with pancreatic fungal infection, pancreatic bacterial infection, and necrotizing pancreatitis without infection. The results showed that nearly half of the patients with necrotizing pancreatitis had pancreatic fungal infection, and there was no significant difference in clinical outcomes between the fungal infection group and non-fungal infection groups.
Article
Gastroenterology & Hepatology
Jiarong Li, Chiayen Lin, Caihong Ning, Qin Wei, Lu Chen, Shuai Zhu, Dingcheng Shen, Gengwen Huang
Summary: Emphysematous pancreatitis (EP) is a subtype of infected pancreatic necrosis (IPN) characterized by the presence of gas in (peri)pancreatic necrosis. The clinical outcomes of EP may be similar to those of non-emphysematous infection, but when EP occurs within 2 weeks from disease onset, the mortality rate is high.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Gastroenterology & Hepatology
Mohamed Ebrahim, Mikkel Parsberg Werge, Amer Hadi, Mariam Lahchich, Zainab Gassem Nagras, Morten Laksafoss Lauritsen, Palle Nordblad Schmidt, Erik Feldager Hansen, Srdan Novovic, John Gasdal Karstensen
Summary: This study reports the experience in managing large walled-off necrosis (WON). Minimally invasive treatment methods are effective in managing large WON, with minimal need for surgery and acceptable rates of morbidity and mortality.
DIGESTIVE ENDOSCOPY
(2022)
Article
Medicine, General & Internal
L. Boxhoorn, S. M. van Dijk, J. van Grinsven, R. C. Verdonk, M. A. Boermeester, T. L. Bollen, S. A. W. Bouwense, M. J. Bruno, V. C. Cappendijk, C. H. C. Dejong, P. van Duijvendijk, C. H. J. van Eijck, P. Fockens, M. F. G. Francken, H. van Goor, M. Hadithi, N. D. L. Hallensleben, J. W. Haveman, M. A. J. M. Jacobs, J. M. Jansen, M. P. M. Kop, K. P. van Lienden, E. R. Manusama, J. S. D. Mieog, I. Q. Molenaar, V. B. Nieuwenhuijs, A. C. Poen, J-W Poley, M. van de Poll, R. Quispel, T. E. H. Romkens, M. P. Schwartz, T. C. Seerden, M. W. J. Stommel, J. W. A. Straathof, H. C. Timmerhuis, N. G. Venneman, R. P. Voermans, W. van de Vrie, B. J. Witteman, M. G. W. Dijkgraaf, H. C. van Santvoort, M. G. Besselink
Summary: This multicenter randomized trial compared the outcomes of immediate drainage versus postponed drainage in patients with infected necrotizing pancreatitis, finding no significant difference in complications between the two groups. Patients in the postponed-drainage group received fewer invasive interventions.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
