Journal
PALLIATIVE MEDICINE
Volume 25, Issue 5, Pages 431-441Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0269216310380763
Keywords
analgesics; central nervous system stimulants; opioid
Categories
Funding
- Cancer research UK
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This is a systematic review examining the management of opioid-induced central side effects. It has been conducted as part of a larger European Palliative Care Research collaborative review into the use and role of opioids in cancer pain. The review process identified 26 studies that met the inclusion criteria. The overall quality of the data was low and the few recommendations that can be made are weak and require confirmatory studies. The main central side effects examined were sedation, cognitive failure, sleep disturbance and myoclonus. Overall there is limited evidence for the use of methylphenidate in counteracting opioid-induced sedation and cognitive disturbance. No clear recommendations can be made concerning other individual drugs for the management of any of the central side effects examined. Given the lack of available data from this review there need to be further prospective controlled trials to confirm or refute these findings.
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