Risk Predictors of Opioid-Induced Critical Respiratory Events in Children: Naloxone Use as a Quality Measure of Opioid Safety

BackgroundOpioid-induced respiratory depression (OIRD) is a life-threatening complication of opioid therapy in children. Naloxone administration triggered by OIRD has been used to monitor safety of opioid therapy in adults. We used this trigger as a quality measure of opioid safety in hospitalized children to identify risk predictors of OIRD. MethodsWe retrospectively reviewed medical records of 38 patients identified from the hospital risk management database as requiring naloxone for critical respiratory events between January 2010 and June 2012 for demographics, comorbidities, surgery, naloxone event details, and outcomes. These data were compared with baseline prevalence in contemporary patients followed by pain service, who did not receive naloxone, to calculate unadjusted odds ratios. Thematic classification of preventable events was undertaken based on analysis of each event. ResultsThe incidence of naloxone use among hospital inpatients, who received opioids at-least once, was 0.06% compared with 0.23% for patients on the pain service. A majority of naloxone events occurred in postoperative patients (n=27/38, 71.1%) within the first 24 hours of surgery (n=20/27, 75.1%) and in the critical care unit (50%). Patients undergoing airway surgeries had higher risk for OIRD (P=0.01). Patient risk factors for naloxone use included age <1 year (P<0.001), obstructive sleep apnea (P<0.001), obesity (P=0.019), being underweight (P<0.0001), prematurity (P<0.001), and developmental delay (P<0.001). Majority of events (87%) were found to be preventable, which were classified into six main themes based on type of event. ConclusionOIRD is an important, albeit mostly preventable, complication of opioid therapy in children. Naloxone use can be used as a measure to track opioid safety in children, identify contributing factors, and formulate preventive strategies to reduce the risk for OIRD.