Article
Orthopedics
Joon-Kiong Lee, Azlina A. Abbas, Tien-Eang Cheah, Ruslan Nazaruddin Simanjuntak, Sargunan Sockalingam, Sharifah Roohi
Summary: Osteoarthritis (OA) is a significant burden in many populations, with its prevalence expected to rise due to aging and increase in risk factors. Topical NSAIDs are recommended as an early treatment option for managing OA pain, but their use in Malaysia is low and not preferred by prescribers. This consensus recommendation provides guidance for healthcare practitioners on the use of topical NSAIDs in managing OA pain, emphasizing their efficacy, safety, and ease of use. It is recommended to advocate for early use of topical NSAIDs over oral NSAIDs for mild-to-moderate OA pain while involving patients in the decision-making process for optimal outcomes.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Review
Primary Health Care
Dylan G. Wolff, Christy Christophersen, Symone M. Brown, Mary K. Mulcahey
Summary: Topical NSAIDs are effective in reducing pain and improving physical function in patients with knee osteoarthritis, with diclofenac and ketoprofen being the most studied and effective options. The choice of carrier for delivering the NSAID can impact the safety profile of the medication.
PHYSICIAN AND SPORTSMEDICINE
(2021)
Article
Pharmacology & Pharmacy
Bangtao Yao, Fei Wang, Xiaogui Zhao, Bei Wang, Xiaoli Yue, Yuhua Ding, Gang Liu
Summary: The study found that topical application of 0.1% pranoprofen effectively reduces the expression of VEGF and COX-2 in primary pterygium, showing potential in prevention of postoperative recurrence for patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Agota Peto, Dora Kosa, Adam Haimhoffer, Palma Feher, Zoltan Ujhelyi, David Sinka, Ferenc Fenyvesi, Judit Varadi, Miklos Vecsernyes, Alexandra Gyongyosi, Istvan Lekli, Peter Szentesi, Annamaria Marton, Imre Gombos, Barbara Dukic, Laszlo Vigh, Ildiko Bacskay
Summary: The study formulated 10% BGP-15 creams with different penetration enhancers to investigate its potential anti-inflammatory effects in vivo. The results showed a reduction in local inflammation in mice, but the exact mechanism of action remains unknown. Further pharmacological studies are needed to clarify the mechanism of action.
Review
Orthopedics
Nelson F. Athow, Patrick M. Morgan, Gregory A. Brown
Summary: The study found that hip and/or knee osteoarthritis is associated with an increased risk of cardiovascular disease morbidity and mortality, but did not show a link between nonselective NSAID use and cardiovascular risk. Factors such as the use of walking aids and walking difficulties may increase cardiac risk.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Environmental Sciences
Xiangju Li, Xue Xue, Jia Jia, Xiaocui Zou, Yongjing Guan, Long Zhu, Zaizhao Wang
Summary: The overuse of antimicrobial agents is a key factor in the emergence of antibiotic resistance bacteria (ARB), but it is unclear whether non-antibiotic chemicals like nonsteroidal anti-inflammatory drug (NSAID) can induce ARB. This study investigated whether NSAID diclofenac (DCF) promotes the emergence of antibiotic resistance in Escherichia coli K12 MG1655. The results showed that DCF induced hereditary stable ARB and caused gene variation on the chromosome. DCF also triggered bacterial oxidative stress and SOS response, leading to enhanced expression of antioxidant and SOS system-related genes. However, high-dosage DCF reduced mutation frequency but enhanced mutant resistance.
ENVIRONMENTAL POLLUTION
(2023)
Article
Cardiac & Cardiovascular Systems
Anders Holt, Jarl E. Strange, Nina Nouhravesh, Sebastian Kinnberg Nielsen, Mariam Elmegaard Malik, Anne -Marie Schjerning, Lars Kober, Christian Torp-Pedersen, Gunnar H. Gislason, Patricia McGettigan, Morten Schou, Morten Lamberts
Summary: This study found an association between short-term use of NSAIDs and an increased risk of first-time hospitalization for heart failure in patients with type 2 diabetes. Patients in subgroups with advanced age, elevated HbA1c levels, and new users of NSAIDs were particularly susceptible.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Allergy
Lily Li, Jillian Bensko, Kathleen Buchheit, Rebecca R. Saff, Tanya M. Laidlaw
Summary: This study investigated the safety and outcomes of two-step outpatient NSAID challenges for patients with non-aspirin-exacerbated respiratory disease (AERD)-related NSAID hypersensitivity. The results showed that more than 85% of the challenges were negative, allowing patients to use clinically indicated NSAIDs. The challenge reactions were generally mild.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Pharmacology & Pharmacy
Els Mehuys, Tine De Backer, Filip De Keyser, Thierry Christiaens, Thierry Van Hees, Sophie Demarche, Inge Van Tongelen, Koen Boussery
Summary: The concomitant use of NSAIDs and antithrombotic agents increases the risk of bleeding and thromboembolism. In this intervention study, community pharmacists screened for and managed interactions between these drugs. The results showed that most interactions did not result in a change of pharmacotherapy, but in some cases, changes in medication were made.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Barbara Hutka, Anett Varallyay, Szilvia B. Laszlo, Andras S. Toth, Balint Scheich, Sandor Paku, Imre Voros, Zoltan Pos, Zoltan V. Varga, Derek D. Norman, Andrea Balogh, Zoltan Benyo, Gabor Tigyi, Klara Gyires, Zoltan S. Zadori
Summary: Lysophosphatidic acid (LPA) plays an important role in both NSAID-induced gastric injury and small intestinal injury. The signaling pathway of LPAR2 receptor is involved in the development of small intestinal injury, as well as the inflammatory responses associated with ulceration.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Anesthesiology
Chao Li, Hui Wang, Suomao Yuan, Yonghao Tian, Lianlei Wang, Xinyu Liu
Summary: This study demonstrates that postoperative topical nonsteroidal anti-inflammatory drugs (NSAIDs) can effectively alleviate pain, reduce opioid consumption, prolong the time of first analgesic demand, and have minimal side effects after transforaminal lumbar interbody fusion (TLIF) surgery.
Article
Chemistry, Analytical
Ruijuan Zheng, Yingchen Yang, Chang Yang, Yan Xia
Summary: A core-shell material (UiO@TapbTp) has been developed for detecting nonsteroidal anti-inflammatory drugs by MALDI-TOF MS, showing improved enrichment ability and matrix performance. Pre-enrichment under optimized conditions significantly reduces the detection limits of drugs, with good recoveries in complex samples like saliva and environmental water.
Review
Peripheral Vascular Disease
J. David Spence, Tilo Grosser, Garret A. FitzGerald
Summary: Recent studies have questioned the safety of using acetaminophen for pain relief and fever reduction in patients with cardiovascular disease and those taking anticoagulants. The studies suggest that acetaminophen, like most nonsteroidal anti-inflammatory drugs, can increase blood pressure and formulations containing sodium can increase cardiovascular risk. The influence of acetaminophen on coagulation through its effects on vitamin K metabolism is also discussed.
Article
Agriculture, Dairy & Animal Science
Lu Lin, Liguang Xu, Hua Kuang, Jing Xiao, Chuanlai Xu
Summary: A monoclonal antibody selective for 6 oxicam NSAIDs was developed, along with a colloidal gold immunochromatographic strip for on-site detection in milk samples. Results can be obtained within 10 minutes, making it a promising tool for screening oxicam NSAIDs in milk.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Environmental Sciences
Neelam Shivnath, Vineeta Rawat, Sahabjada Siddiqui, Sushma Verma, Pragya Gupta, Juhi Rais, Mohd Sajid Khan, Md Arshad
Summary: The study found that PGP can alleviate collagenase-induced OA in rats by reducing blood ALP levels, inhibiting cartilage erosion, increasing COL-2 gene expression, and decreasing MMP-3 and COX-2 gene expression. PGP's high phenolic and flavonoid content contribute to its strong antioxidant activity, making it a potential preventive treatment for OA that warrants further validation in clinical studies.
ENVIRONMENTAL TOXICOLOGY
(2021)