Article
Medicine, General & Internal
Eden Engel-Rebitzer, Abby R. Dolan, Shoshana V. Aronowitz, Frances S. Shofer, Max Jordan Nguemeni Tiako, Marilyn M. Schapira, Jeanmarie Perrone, Erik P. Hess, Karin V. Rhodes, Venkatesh R. Bellamkonda, Carolyn C. Cannuscio, Erica Goldberg, Jeffrey Bell, Melissa A. Rodgers, Michael Zyla, Lance B. Becker, Sharon McCollum, Zachary F. Meisel
Summary: Despite additional patient data provided to clinicians, disparities in acute pain management between Black and White patients remained, suggesting that lack of patient information may not be the sole factor associated with opioid prescribing disparities.
Article
Multidisciplinary Sciences
Holly B. Ende, Ruth Landau, Naida M. Cole, Sara M. Burns, Brian T. Bateman, Melissa E. Bauer, Jessica L. Booth, Pamela Flood, Lisa R. Leffert, Timothy T. Houle, Lawrence C. Tsen
Summary: The study found that women with intrapartum cesarean delivery experienced higher pain scores on the day of surgery, increased opioid use after discharge, but similar pain scores at other time points compared to women without labor prior to cesarean delivery.
Article
Neurosciences
Sin Yin Lim, Pelin Cengiz
Summary: Opioid use for pain relief can lead to tolerance and hyperalgesia. There is a need for strategies to mitigate these effects. The BDNF-TrkB signaling pathway shows promise in reducing opioid tolerance and hyperalgesia.
Article
Multidisciplinary Sciences
Marieke Hellinga, Marijke Hyke Algera, Rutger van der Schrier, Elise Sarton, Monique van Velzen, Albert Dahan, Erik Olofsen, Marieke Niesters
Summary: The respiratory parameter _V(E)55 from the hypercapnic ventilatory response (HCVR) is the most sensitive biomarker of opioid-induced respiratory depression (OIRD). This finding can be used for standardized comparison of opioids in assessing their safety.
Article
Behavioral Sciences
Jessica L. Sharp, Tallia Pearson, Mark A. Smith
Summary: Research has shown that there are sex differences in endogenous opioid peptides and receptors, resulting in functional differences in sensitivity to opioid receptor mediated behaviors between males and females. This review focuses on the influence of androgens on these effects and suggests that further investigation may lead to new treatment options for conditions like chronic pain and substance use disorders.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Review
Chemistry, Medicinal
Alok K. Paul, Craig M. Smith, Mohammed Rahmatullah, Veeranoot Nissapatorn, Polrat Wilairatana, Mariana Spetea, Nuri Gueven, Nikolas Dietis
Summary: Opioids are commonly used for pain management but have numerous adverse effects, particularly in older adults. Understanding the mechanisms of opioid-induced adverse reactions can aid in improving pain management strategies.
Article
Plant Sciences
Amanda de Oliveira Marinho, Jessica de Santana Brito, Jainaldo Alves Da Costa, Abdenego Rodrigues Da Silva, Suellen Pedrosa Da Silva, Luciclaudio Cassimiro De Amorim, Maria Tereza dos Santos Correia, Patricia Maria Guedes Paiva, Alisson Macario De Oliveira, Leydianne Leite de Siqueira Patriota, Thiago Henrique Napolea
Summary: The study evaluated the antinociceptive activity of S. terebinthifolia leaf lectin (SteLL) and found that it has both peripheral and central analgesic effects, which are mediated through modulation of opioid receptors without affecting motor coordination in animals.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Eileen Nguyen, Kelly M. Smith, Nathan Cramer, Ruby A. Holland, Isabel H. Bleimeister, Krystal Flores-Felix, Hanna Silberberg, Asaf Keller, Claire E. Le Pichon, Sarah E. Ross
Summary: By using molecular, tracing, and behavioural approaches, Nguyen et al. discovered that neurons containing the kappa-opioid receptor in the rostral ventromedial medulla can robustly modulate itch and pain behaviours bidirectionally, shedding light on a distinct population of neurons that inhibit itch and nociception.
Article
Biochemistry & Molecular Biology
Aina Porta, Laura Rodriguez, Xue Bai, Gerard Batalle, Gerad Roch, Enric Pouso-Vazquez, Gianfranco Balboni, Olga Pol
Summary: This study demonstrates that slow-releasing H2S donors can inhibit allodynia and hyperalgesia, potentiate the analgesic effects and expression of DOR, activate the antioxidant system, and reduce nociceptive and apoptotic pathways in inflammatory pain models. The data also suggest the involvement of potassium channels and the Nrf2 transcription factor signaling pathway in the pain-relieving activities of DADS and P-ITC. Systemic administration of DADS and P-ITC, along with local application of DOR agonists in combination with H2S donors, offer new strategies for the treatment of inflammatory pain.
Article
Anesthesiology
Sam Singleton, Claire Sneddon, Alice Bakina, Jeremy J. Lambert, Tim G. Hales
Summary: Fragmented maternal care in mice affects pain sensitivity, morphine response, and inflammatory hypersensitivity, resulting in decreased basal sensitivity and enhanced vulnerability to persistent inflammatory hypersensitivity.
Article
Medicine, General & Internal
Nancy E. Morden, Deanna Chyn, Andrew Wood, Ellen Meara
Summary: This study analyzed data from 2016 and 2017 on filled opioid prescriptions for disabled Medicare beneficiaries to compare differences between Black and White patients within the same health systems. The findings showed a 36% lower mean annual opioid dose for Black patients compared to White patients. In 75% of the 310 health systems studied, the mean annual dose was at least 15% higher for White patients than Black patients.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Chemistry, Medicinal
Monica Garcia, Virginia Llorente, Lourdes Garriga, Ute Christmann, Sergi Rodriguez-Escrich, Marina Virgili, Begona Fernandez, Magda Bordas, Eva Ayet, Javier Burgueno, Marta Pujol, Albert Dordal, Enrique Portillo-Salido, Georgia Gris, Jose Miguel Vela, Carmen Almansa
Summary: A new series of propionamide derivatives were developed as dual mu-opioid receptor agonists and sigma(1) receptor antagonists. The lead compound showed good analgesic effects in several animal models of both acute and chronic pain, with reduced gastrointestinal effects compared to oxycodone.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Medicine, General & Internal
Jung Min Koo, Hyung Joo Park, Gong Min Rim, Kwanyong Hyun, Jaewon Huh, Hoon Choi, Yunji Kim, Wonjung Hwang
Summary: This study aimed to identify perioperative factors that influence the requirement for opioids in children undergoing minimally invasive repair of pectus excavatum (MIRPE) surgery with multimodal analgesia. Factors such as the severity of pectus excavatum, Haller index, revised depression index, gender, and the length of pectus bars were found to affect postoperative opioid requirement.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Xue Bai, Gerard Batalle, Gianfranco Balboni, Olga Pol
Summary: Recent studies have shown that hydrogen sulfide (H2S) enhances the analgesic effects of the delta-opioid receptor (DOR) in inflammatory pain. It is still unknown whether two slow-releasing H2S donors, DADS and GYY4137, can improve the analgesic effects of mu-opioid receptor (MOR) and DOR agonists on neuropathic pain. This study found that both DADS and GYY4137 improved the antiallodynic effects of MOR and DOR agonists, possibly by up-regulating MOR and DOR expression in the dorsal root ganglia.
Article
Pharmacology & Pharmacy
Guangchao Zhang, Mengqiao Cui, Ran Ji, Shiya Zou, Lingzhen Song, Bingqian Fan, Li Yang, Di Wang, Suwan Hu, Xiao Zhang, Tantan Fang, Xiaolu Yu, Jun-Xia Yang, Dipesh Chaudhury, He Liu, Ankang Hu, Hai-Lei Ding, Jun-Li Cao, Hongxing Zhang
Summary: Due to the lack of novel mechanism pain medications and the severe adverse effects of opioid analgesics, there is a need to explore non-opioid analgesia and gain a better understanding of pain mechanisms. The study identifies a new neural circuit (PVTGlut -> NAc) for pain sensation and non-opioid analgesia, which involves glutamatergic inputs from the paraventricular thalamic nucleus to the nucleus accumbens. It is shown that inhibiting this circuit in mice has a potent analgesic effect, independent of opioid receptors, making it a valuable target for developing safer pain medications.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Anesthesiology
Joseph L. Riley, Yenisei Cruz-Almeida, Roland Staud, Roger B. Fillingim
Article
Neurosciences
Alisa J. Johnson, Ellen Terry, Emily J. Bartley, Cynthia Garvan, Yenisei Cruz-Almeida, Burel Goodin, Toni L. Glover, Roland Staud, Laurence A. Bradley, Roger B. Fillingim, Kimberly T. Sibille
Article
Anesthesiology
Sonia Snarma, Jean Wactawski-Wende, Michael J. LaMonte, Jiwei Znao, Gary D. Slade, Eric Baire, Joel D. Greenspan, Roger B. Fillingim, William Maixner, Richard Ohrbach
Article
Substance Abuse
Jenna L. McCauley, Stephanie Reyes, Cyril Meyerowitz, Valeria V. Gordan, D. Brad Rindal, Gregg H. Gilbert, Renata S. Leite, Roger B. Fillingim, Kathleen T. Brady
Article
Health Care Sciences & Services
Todd Matthew Manini, Tonatiuh Mendoza, Manoj Battula, Anis Davoudi, Matin Kheirkhahan, Mary Ellen Young, Eric Weber, Roger Benton Fillingim, Parisa Rashidi
JMIR MHEALTH AND UHEALTH
(2019)
Article
Dentistry, Oral Surgery & Medicine
Carolina Beraldo Meloto, Gary D. Slade, Ryan N. Lichtenwalter, Eric Bair, Nuvan Rathnayaka, Luda Diatchenko, Joel D. Greenspan, William Maixner, Roger B. Fillingim, Richard Ohrbach
JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
(2019)
Article
Multidisciplinary Sciences
Hee Jun Kim, Joel D. Greenspan, Richard Ohrbach, Roger B. Fillingim, William Maixner, Cynthia L. Renn, Meg Johantgen, Shijun Zhu, Susan G. Dorsey
Article
Geriatrics & Gerontology
Staja Booker, Josue Cardoso, Yenisel Cruz-Almeida, Kimberly T. Sibille, Ellen L. Terry, Keesha L. Powell-Roach, Joseph L. Riley, Burel R. Goodin, Emily J. Bartley, Adriana Sotolongo Addison, Roland Staud, David Redden, Laurence Bradley, Roger B. Fillingim
EXPERIMENTAL GERONTOLOGY
(2019)
Article
Geriatrics & Gerontology
Yu-Jung Jenny Wei, Laurence Solberg, Cheng Chen, Roger B. Fillingim, Marco Pahor, Steven DeKosky, Almut G. Winterstein
Summary: The study found high percentage agreement for depression and behavioral symptoms between MDS 3.0 assessments and medical records, with higher negative agreement than positive agreement. The data from MDS 3.0 may be useful in ruling out depression and behavioral symptoms, but further confirmation in a representative sample of nursing homes is needed.
AGING & MENTAL HEALTH
(2021)
Article
Health Care Sciences & Services
Mamoun T. Mardini, Subhash Nerella, Matin Kheirkhahan, Sanjay Ranka, Roger B. Fillingim, Yujie Hu, Duane B. Corbett, Erta Cenko, Eric Weber, Parisa Rashidi, Todd M. Manini
Summary: This study examines the temporal association between ecological momentary assessments of pain and GPS metrics in older adults with symptomatic knee osteoarthritis. The findings show that higher intensity knee pain is associated with lower life-space mobility, and the associations between pain intensity and GPS features are more likely to be statistically significant within individuals.
JMIR MHEALTH AND UHEALTH
(2021)
Article
Anesthesiology
Anna Zajacova, Hanna Grol-Prokopczyk, Roger Fillingim
Summary: Previous literature on race/ethnicity and pain has often neglected to include all major US racial groups or consider the impact of different pain operationalizations. This study examines the prevalence of chronic pain in various racial groups and finds that Asian Americans have the lowest pain prevalence, while Native American and multiracial adults have the highest pain prevalence. The study also reveals that racial disparities in pain are larger than previously recognized, and these disparities remain consistent across different definitions of pain.
Letter
Anesthesiology
Anna Zajacova, Hanna Grol-Prokopczyk, Roger Fillingim
Article
Public, Environmental & Occupational Health
Amy LiKamWa, Josue Cardoso, Jill Sonke, Roger B. Fillingim, Staja Q. Booker
Summary: This study investigated the effects of music on acute pain sensitivity and found that singing can increase pain tolerance compared to simply listening to music. Additionally, singing proficiency and musical factors were found to be associated with pain sensitivity.
Article
Geriatrics & Gerontology
Charlotte Rouzaud Laborde, Erta Cenko, Mamoun T. Mardini, Subhash Nerella, Matin Kheirkhahan, Sanjay Ranka, Roger B. Fillingim, Duane B. Corbett, Eric Weber, Parisa Rashidi, Todd Manini
Summary: This study evaluated satisfaction, usability, and compliance with the ROAMM smartwatch app for individuals with knee osteoarthritis. Most participants rated the app positively and were willing to participate in long-term research, indicating that this is a viable approach for remotely collecting health symptoms and behaviors.
Article
Health Care Sciences & Services
Anis Davoudi, Amal Asiri Wanigatunga, Matin Kheirkhahan, Duane Benjamin Corbett, Tonatiuh Mendoza, Manoj Battula, Sanjay Ranka, Roger Benton Fillingim, Todd Matthew Manini, Parisa Rashidi
JMIR MHEALTH AND UHEALTH
(2019)