Article
Clinical Neurology
Abteen Mostofi, Francesca Morgante, Mark J. Edwards, Peter Brown, Erlick A. C. Pereira
Summary: Pain in Parkinson's disease is often untreated due to lack of understanding of its mechanisms. Deep brain stimulation of the subthalamic nucleus has shown potential in treating pain, but the exact type of pain it benefits and how it interferes with pain processing remain unclear.
Letter
Clinical Neurology
T. J. C. Zoon, V. Mathiopoulou, G. van Rooijen, P. van den Munckhof, D. A. J. P. Denys, P. R. Schuurman, R. M. A. de Bie, M. Bot
Summary: This study used subthalamic nucleus deep brain stimulation (STN DBS) and network analysis to investigate the relationship between the location of active DBS contact points and apathy in Parkinson's disease (PD) patients. The results showed that active contacts in apathy patients were more often positioned in the area with a high density of surrounding projections to associative cortex areas. The study provides insight into the anatomical connectivity substrate for apathy in DBS.
Article
Neurosciences
Yingchuan Chen, Guanyu Zhu, Yuye Liu, Defeng Liu, Tianshuo Yuan, Xin Zhang, Yin Jiang, Tingting Du, Jianguo Zhang
Summary: The study found that changes in brain morphology are associated with the initial motor response to subthalamic nucleus deep brain stimulation in Parkinson's disease patients, and can be used to predict individual initial stimulation-related motor responses.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Review
Behavioral Sciences
Chun-Hwei Tai
Summary: Understanding the pathophysiological mechanism of Parkinson's disease in the subthalamic nucleus is crucial for effective treatment through deep brain stimulation. STN burst firing is considered an electrophysiological signature of the cortico-basal ganglia circuit in PD patients, and plays a significant role in the motor symptoms of PD as well. This review explores the origins of STN bursts, factors influencing their formation, and the potential for interventions to alleviate PD symptoms.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Review
Medicine, General & Internal
Marwan Hariz, Patric Blomstedtl
Summary: Parkinson's disease is a progressive neurodegenerative illness with motor and nonmotor symptoms. Deep brain stimulation is an effective symptomatic treatment that can be tailored to individual patients. DBS has significant effects on tremors, rigidity, and dyskinesias, but less responsive for axial symptoms. Specialized multidisciplinary teams are required for DBS in PD.
JOURNAL OF INTERNAL MEDICINE
(2022)
Review
Clinical Neurology
Thomas J. C. Zoon, Geeske van Rooijen, Georgina M. F. C. Balm, Isidoor O. Bergfeld, Joost G. Daams, Paul Krack, Damiaan A. J. P. Denys, Rob M. A. de Bie
Summary: This meta-analysis found that apathy is increased after STN DBS compared to the pre-operative state and medication only. The difference in severity of apathy remained significant after multiple analyses.
MOVEMENT DISORDERS
(2021)
Article
Medicine, General & Internal
Tianqi Hu, Hutao Xie, Yu Diao, Houyou Fan, Delong Wu, Yifei Gan, Fangang Meng, Yutong Bai, Jianguo Zhang
Summary: This study aimed to investigate the effects of STN-DBS on PD patients with different levels of depression and identify predictors of these effects. The results showed that patients with moderate depression had better improvement, and gender (female) and preoperative HAMA scores were predictors of the effects of STN-DBS on PD depression.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Olga Khazen, Marisa DiMarzio, Kelsey Platanitis, Heather C. Grimaudo, Maria Hancu, Miriam M. Shao, Michael D. Staudt, Lucy Maguire, Vishad V. Sukul, Jennifer Durphy, Era K. Hanspal, Octavian Adam, Eric Molho, Julie G. Pilitsis
Summary: This study evaluated sex-specific differences in pain relief after DBS for PD, showing that males had significantly improved scores on the KPDPS and RODI, while females did not show significant improvements.
JOURNAL OF NEUROSURGERY
(2021)
Article
Neurosciences
Martina Bockova, Eva Vytvarova, Martin Lamos, Petr Klimes, Pavel Jurak, Josef Halamek, Sabina Goldemundova, Marek Balaz, Ivan Rektor
Summary: The response to subthalamic nucleus deep brain stimulation (STN-DBS) varies individually and is difficult to predict. While most patients did not show changes in global network organization, suboptimal responders exhibited decreased global connectivity in the 1-8 Hz frequency range and regional node strength in frontal areas. The supplementary motor area was demonstrated to play an important role in the optimal response to DBS, with good responders showing increased node strength and eigenvector centrality in this brain region.
HUMAN BRAIN MAPPING
(2021)
Article
Clinical Neurology
Ahro Kim, Han-Joon Kim, Aryun Kim, Yoon Kim, Ahwon Kim, Jed Noel A. Ong, Hye Ran Park, Sun Ha Paek, Beomseok Jeon
Summary: This study aimed to investigate mortality and factors associated with mortality and causes of death after deep brain stimulation of the subthalamic nucleus in patients with Parkinson's disease. The results showed that 18.7% of patients died, with pneumonia being the most common cause of death. Older age, earlier disease onset, higher preoperative falling score while on medication, and higher preoperative total levodopa equivalent daily dose were associated with a higher risk of mortality.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Jeanne Garcia, Cecile Hubsch, Ana Marques, Jean-Marc Gurruchaga, Cedric Lamirel, Emmanuel Roze, Antoine Moulignier
Summary: The study demonstrated that STN-DBS is a safe and effective treatment for PLHIV with Parkinson's disease, significantly improving symptoms without major adverse events; impulse control disorders were fully resolved after surgery.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Lulu Jiang, Wanru Chen, Qiyu Guo, Chao Yang, Jing Gu, Wenbiao Xian, Yanmei Liu, Yifan Zheng, Jing Ye, Shaohua Xu, Yu Hu, Lei Wu, Jie Chen, Hao Qian, Xiaoli Fu, Jinlong Liu, Ling Chen
Summary: The long-term therapeutic efficacy of STN-DBS can be achieved in southern China with relatively low stimulation intensity and medication dosage, maintaining motor improvement and medication reduction through an 8-year follow-up, while improvement in quality of life lasts for only 3 years. No definite changes in nonmotor symptoms were found after STN-DBS.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Clinical Neurology
Danilo Genovese, Francesco Bove, Leonardo Rigon, Tommaso Tufo, Alessandro Izzo, Paolo Calabresi, Anna Rita Bentivoglio, Carla Piano
Summary: This study assessed the clinical safety and efficacy of frameless bilateral subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) patients at 5 years after surgery. The results demonstrate that this technique is safe and well-tolerated, with sustained motor efficacy at 5 years post-surgery.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Jan Hirschmann, Alexandra Steina, Jan Vesper, Esther Florin, Alfons Schnitzler
Summary: This study demonstrates for the first time that neuronal oscillations are predictive of deep brain stimulation (DBS) outcome. Coherence between subthalamic and parietal oscillations are particularly informative.
Review
Clinical Neurology
Yuhan Wang, Chencheng Zhang, Bomin Sun, Dianyou Li, Yiwen Wu
Summary: This study aimed to evaluate optimal stimulation parameters for treating dystonia with STN-DBS. Results showed that the optimal parameters vary among patients, with improvement rate being linearly dependent on stimulation parameters. Adverse effects include dyskinesia and depression.
JOURNAL OF NEUROLOGY
(2022)
Editorial Material
Anesthesiology
Steven P. Cohen, Daniel Ciampi de Andrade
Article
Anesthesiology
Irina Raicher, Alexandra P. Zandonai, Isadora W. Anghinah, Mariana Frassetto, Patrick R. N. A. G. Stump, Maria A. B. Trindade, Simone Harnik, Rodrigo A. Oliveira, Ricardo S. S. Macarenco, Kathrin Doppler, Nurcan Uceyler, Evandro S. Mello, Claudia Sommer, Manoel J. Teixeira, Ricardo Galhardoni, Daniel C. de Andrade
Summary: This study investigated the differences between leprosy patients with and without neuropathic pain (NeP). The results showed that patients with NeP exhibited signs of C-fiber dysfunction and hyperesthesia, while patients without NeP did not. It was also found that the duration of leprosy treatment was associated with the intensity of neuropathy.
Letter
Clinical Neurology
Anderson Rodrigues Brandao de Paiva, Andre Luiz Santos Pessoa, Paulo Ribeiro Nobrega, Cristiane Araujo Martins Moreno, David S. Lynch, Lucas Mitsuo Taniguti, Joao Paulo Kitajima, Fernando Freua, Bruno Della-Ripa, Paulina Cunha, Isabella Peixoto de Barcelos, Lucia Ines Macedo-Souza, Carlos Augusto Takeuchi, Antonio Milton Silva Garcia, Flavia Nardes, Ramiro Fontao, Sergio Antonio Antoniuk, Monica Troncoso, Norma Specola, Consuelo Durand, Bianca de Aguiar Coelho Silva Madeiro, Maria Juliana Rodovalho Doriqui, Diane Vergara, Henry Houlden, Fernando Kok
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Artur M. Coutinho, Maria Gabriela Ghilardi, Ana Carolina P. Campos, Elba Etchebehere, Fernanda C. Fonoff, Rubens G. Cury, Rosana L. Pagano, Raquel C. R. Martinez, Erich T. Fonoff
Summary: This study aimed to understand the correlation between disease laterality, DAT-SPECT, cognition, and alpha-synuclein levels in PD. The results showed that alpha-synuclein in the CSF was correlated with global cognition and DAT-SPECT concentration in specific brain regions, thus working as a neurodegenerative biomarker.
Article
Neurosciences
Jennifer S. Lewis, Muhammad Kashif, Aasam Maan, Daniel Ciampi de Andrade, Michelle Casey, Jee Youn Moon, Chih-Peng Lin, Lena Danielsson, Terence Quek, Rodrigo Diez Tafur, Abdelkarim Aloweidi, Frank Birklein, Lone Knudsen, Andreas Goebel
Summary: The aim of the 2021 IASP CRPS SIG Global Series was to facilitate knowledge exchange among clinicians from developing countries and enhance understanding of the clinical presentation of complex regional pain syndrome in regions with less published research. The proceedings include abstracts of online presentations from nine countries across four continents, providing insights into treatments, outcomes, and challenges. Clinicians from Asia, South America, Africa, and Europe shared their experiences in diagnosing and treating CRPS, highlighting its global presence across borders and cultures. These proceedings broaden the international pain community's understanding of and approaches to CRPS.
Article
Clinical Neurology
Luciana Mendonca Barbosa, Fernanda da Valerio, Samira Luisa Apostolos Pereira, Valquiria Aparecida da Silva, Antonia Lilian de Lima Rodrigues, Ricardo Galhardoni, Lin Tchia Yeng, Jefferson Rosi Jr, Adriana Bastos Conforto, Leandro Tavares Lucato, Marcelo Delboni Lemos, Manoel Jacobsen Teixeira, Daniel Ciampi de Andrade
Summary: This study examined the relationships between symptoms and somatosensory profiles in patients with central neuropathic pain (CNP) caused by different types of lesions to the central nervous system. The results suggest that CNP of different etiologies may have different pain descriptors and somatosensory profiles, likely due to differences in lesion locations.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Anesthesiology
Gabriel T. Kubota, Felipe H. C. Soares, Alessandra S. da Fonseca, Talita dos Santos Rosa, Valquiria A. da Silva, Gisele R. Gouveia, Viviane G. Faria, Pedro H. M. da Cunha, Andre R. Brunoni, Manoel J. Teixeira, Daniel C. de Andrade
Summary: This study describes the different temporal evolutions of chronic pain after COVID-19 and reveals its epidemiological and phenotypical features. The results show that COVID-19-related pain usually follows a chronic non-neuropathic course, and its possible courses and phenotypes are associated with specific clinical and epidemiological features.
EUROPEAN JOURNAL OF PAIN
(2023)
Article
Clinical Neurology
Clarice Listik, Eduardo Listik, Flavia de Paiva Santos Rolim, Denise Maria Meneses Cury Portela, Santiago Perez Lloret, Natalia Rebeca de Alves Araujo, Pedro Rubens Araujo Carvalho, Graziele Costa Santos, Joao Carlos Papaterra Limongi, Francisco Cardoso, Veit Mylius, Florian Brugger, Ana Mercia Fernandes, Egberto Reis Barbosa, Manoel Jacobsen Teixeira, Henrique Ballalai Ferraz, Sarah Teixeira Camargos, Rubens Gisbert Cury, Daniel de Ciampi de Andrade
Summary: The aim of this study was to develop a classification and scoring system for chronic pain (CP) in dystonia. The results showed that the developed Dystonia-Pain Classification System (Dystonia-PCS) is a reliable tool for categorizing and quantifying CP impact in dystonia and can help improve clinical trial design and pain management in patients with this disorder.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Luciana Mendonca Barbosa, Fernanda Valerio, Valquiria Aparecida da Silva, Antonia Lilian de Lima Rodrigues, Ricardo Galhardoni, Lin Tchia Yeng, Jefferson Rosi Junir, Adriana Bastos Conforto, Leandro Tavares Lucato, Manoel Jacobsen Teixeira, Daniel Ciampi de Andrade
Summary: Objectives: This study aimed to describe the changes in corticomotor excitability (CE) that are specifically related to central neuropathic pain (CNP). Methods: CE measurements and comprehensive assessments were conducted on patients with CNP associated with brain injury after stroke or spinal cord injury (SCI) due to neuromyelitis optica. Results: Patients with CNP had lower motor evoked potential (MEP) and defective short-interval intracortical inhibition (SICI) compared to patients with non-neuropathic pain and no-pain patients.
NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Marcelo Luiz da Silva, Ana Mercia Fernandes, Valquiria A. Silva, Ricardo Galhardoni, Valter Felau, Joaci O. de Araujo, Jefferson Rosi Jr, Roger S. Brock, Gabriel T. Kubota, Manoel J. Teixeira, Lin T. Yeng, Daniel Ciampi de Andrade
Summary: This study investigated the clinical pain, conditioned pain modulation (CPM), and cortical plastic changes in patients with three types of low-back pain: non-specific LBP, failed back surgery syndrome (FBSS), and sciatica. The results showed that different types of low-back pain were associated with different clinical, CPM, and cortical excitability profiles, emphasizing the need for further characterization of patients with low-back pain in psychophysics and cortical neurophysiology studies.
NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Neurosciences
Enrico De Martino, Adenauer Casali, Silvia Casarotto, Gabriel Hassan, Mario Rosanova, Thomas Graven-Nielsen, Daniel Ciampi de Andrade
Summary: Pain-related changes in cortical excitability were investigated in the dorsolateral prefrontal cortex and primary motor cortex using transcranial magnetic stimulation-electroencephalography. Acute pain decreased peak-to-peak amplitude in both M1 and dorsolateral prefrontal cortex, while only M1 showed a reduction in global-mean field power. Participants with the greatest reduction in local cortical excitability under acute pain showed a negative correlation between dorsolateral prefrontal cortex and M1. These findings highlight the differential effects of acute pain on local and global cortical excitability, as well as individual patterns of cortical excitability changes.
Review
Anesthesiology
Daniel Ciampi de Andrade, Luis Garcia-Larrea
Summary: Repetitive transcranial magnetic stimulation (rTMS) applied to the motor cortex provides supplementary relief for some individuals with chronic pain. However, the efficacy at the group-level does not guarantee individual pain relief. Ongoing attempts in personalized medicine aim to overcome this therapeutic challenge.
EUROPEAN JOURNAL OF PAIN
(2023)
Article
Clinical Neurology
Victor Rossetto Barboza, Gabriel Taricani Kubota, Valquiria Aparecida da Silva, Luciana Mendonca Barbosa, Debora Arnaut, Antonia Lilian de Lima Rodrigues, Ricardo Galhardoni, Rubens Gisbert Cury, Egberto Reis Barbosa, Andre Russowsky Brunoni, Manoel Jacobsen Teixeira, Daniel Ciampi de Andrade
Summary: This study found that Parkinson's disease patients with nociceptive chronic pain may have distinctive somatosensory and corticospinal excitability profiles compared to those with non-nociceptive pain subtypes.
Letter
Clinical Neurology
Paulo Ribeiro Nobrega, Thais de Maria F. Vasconcelos, Anderson Rodrigues Brandao de Paiva, Pedro Lucas Grangeiro de Sa Barreto Lima, Pedro Braga Neto, Thiago Goncalves Guimaraes, Mariana Braatz Krueger
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Daniel Alves de Oliveira, Luziany Carvalho Araujo, Anderson Rodrigues Brandao de Paiva, Eduardo Sousa de Melo
Summary: This article describes a 27-year-old man with a progressive neurological disease characterized by brainstem involvement and symmetrical white matter lesions on MR scanning. After ruling out other potential causes, the patient was confirmed to have Alexander disease with a probable pathogenic variant in the GFAP gene: p.Leu359Pro. Clinicians should consider Alexander disease as a possible diagnosis in individuals with progressive neurological motor decline, pyramidal and bulbar signs, and compatible neuroimaging findings.
PRACTICAL NEUROLOGY
(2023)