Article
Geriatrics & Gerontology
Karlijn J. Joling, Maud ten Koppel, Hein P. J. van Hout, Bregje D. Onwuteaka-Philipsen, Anneke L. Francke, Robert A. Verheij, Jos W. R. Twisk, Rob J. van Marum
Summary: This study examined the prevalence of psychotropic drug prescriptions in primary care among persons with dementia. The results showed a substantial increase in psychotropic drug prescription rates from the first to the eighth year after dementia diagnosis, with the most frequently prescribed drugs being antidepressants, antipsychotics, and antidementia drugs.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Medicine, General & Internal
Theresa E. Matson, Kevin A. Hallgren, Gwen T. Lapham, Malia Oliver, Xiaoming Wang, Emily C. Williams, Katharine A. Bradley
Summary: This study evaluated the psychometric properties of the Substance Use Symptom Checklist (symptom checklist) used in primary care. The results showed that the symptom checklist performed well in assessing the severity of substance use disorders and was applicable to different populations. These findings support the clinical utility of the symptom checklist for standardized and more complete assessment of substance use disorder symptoms in primary care.
Review
Pharmacology & Pharmacy
Mandy Wan, Anish Patel, Jignesh P. Patel, Greta Rait, Stuart Jones, Rukshana Shroff
Summary: Despite the increasing availability of quality assured licensed preparations, food supplements continued to be used interchangeably with licensed preparations to fulfil vitamin D prescriptions. Food supplements, manufactured under less stringent quality standards, showed wide variations between measured and declared vitamin D content, which could lead to the risk of under- and over-dosing.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Psychology, Clinical
Deepiksana Keerthy, Joht Singh Chandan, Juste Abramovaite, Krishna Margadhamane Gokhale, Siddhartha Bandyopadhyay, Ed Day, Steven Marwaha, Matthew R. Broome, Krishnarajah Nirantharakumar, Clara Humpston
Summary: This study investigates the relationship between cannabis exposure and the risks of mental illness diagnoses or treatment and finds that cannabis exposure is associated with an increased risk of developing mental health disorders.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Pediatrics
Nicole Hamp, Sarah L. DeHaan, Celina M. Cerf, Jenny S. Radesky
Summary: The study aimed to explore experiences and needs of pediatric primary care providers (PCPs) regarding the identification and management of autism spectrum disorder (ASD) in toddlers. 28 PCPs were recruited for semi-structured interviews conducted via Zoom. The results suggest a need for targeted improvements in primary care, including increasing PCP capacity and confidence in communicating ASD concerns with families, referring for timely diagnostic evaluations in trusted and easy-to-navigate care systems, and increasing family activation and capacity to follow up on ASD evaluation and treatment services.
Article
Medicine, General & Internal
Alissa Bernstein Sideman, Melissa Ma, Alma Hernandez de Jesus, Cecilia Alagappan, Na'amah Razon, Daniel Dohan, Anna Chodos, Tala Al-Rousan, Loren I. Alving, Freddi Segal-Gidan, Howie Rosen, Katherine P. Rankin, Katherine L. Possin, Soo Borson
Summary: This qualitative study explored the perspectives of primary care practitioners (PCPs) on their role in dementia care. The study found alignment between PCP perspectives and the core values of primary care in diagnosing and providing care for individuals with dementia, but identified a mismatch between these values and the health systems infrastructure for dementia care in their practice environment.
Review
Infectious Diseases
Vania Rocha, Marta Estrela, Vanessa Neto, Fatima Roque, Adolfo Figueiras, Maria Teresa Herdeiro
Summary: Antibiotic resistance is a major global public health problem, and excessive and inappropriate antibiotic use is a key driver. Educational interventions in primary healthcare settings are effective in reducing antibiotic prescription and dispensing, leading to cost savings.
Article
Medicine, General & Internal
Heather Huang, Nicholas Nissen, Christopher T. Lim, Jessica L. Goren, Margaret Spottswood, Hsiang Huang
Summary: Bipolar disorder is a chronic mental illness that is associated with increased risk of comorbid cardiovascular disease, disability burden, and societal costs. Patients often seek treatment in primary care settings but are frequently misdiagnosed. This article provides evidence-based approaches for screening, diagnosing, and pharmacological management of bipolar disorder for primary care providers, as well as guidance for referring patients to higher levels of psychiatric care when necessary.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Infectious Diseases
Laura Dominguez-Dominguez, Alfonso Lopez-Marrufo-Medina, Daniel Cabanillas-Balsera, Maria Carmen Jimenez-Sanchez, Victoria Areal-Quecuty, Jose Lopez-Lopez, Juan. J. Segura-Egea, Jenifer Martin-Gonzalez
Summary: The study aimed to analyze antibiotics prescription habits of Spanish general dental practitioners in the management of endodontic infections. The results showed some inappropriate practices, such as a high proportion of using amoxicillin as the first choice antibiotic and prescribing antibiotics in non-recommended situations. Improvement of antibiotic prescription guidelines for general dentists is necessary.
Review
Public, Environmental & Occupational Health
Grace N. Okoli, Puja Myles, Tarita Murray-Thomas, Hilary Shepherd, Ian C. K. Wong, Duncan Edwards
Summary: The use of primary care databases is important in pharmacoepidemiological studies and pharmacovigilance, providing comprehensive patient data but with limitations due to missing prescribing data in certain scenarios. Awareness of potential missing data and collaboration with primary care clinicians in the UK are crucial for researchers using these databases.
Review
Medicine, General & Internal
Siri Aas Smedemark, Rune Aabenhus, Carl Llor, Anders Fournaise, Ole Olsen, Karsten Juhl Jorgensen
Summary: The use of point-of-care biomarkers, such as C-reactive protein, to guide antibiotic treatment in primary care patients with acute respiratory infections can significantly reduce the number of antibiotic prescriptions, but does not have a significant impact on recovery rates.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Public, Environmental & Occupational Health
Valerie S. Harder, Andrea C. Villanti, Sarah H. Heil, M. Lindsey Smith, Diann E. Gaalema, Marjorie C. Meyer, Nathaniel H. Schafrick, Stacey C. Sigmon
Summary: Despite the effectiveness of medications for treating opioid use disorder, they are underutilized in rural areas. A study in Vermont found that rural primary care practitioners have higher concerns about patients using heroin, fentanyl, and methamphetamine, but there was no difference in comfort treating OUD patients between rural and non-rural PCPs, with male PCPs and those waivered to prescribe buprenorphine showing higher comfort levels. Barriers like lack of training/experience and medication diversion were associated with less comfort, while time constraints were associated with more comfort in treating OUD patients.
PREVENTIVE MEDICINE
(2021)
Article
Health Care Sciences & Services
Lauren Caton, Hannah Cheng, Helene Chokron Garneau, Tammy Fisher, Briana Harris-Mills, Brian Hurley, Sandra Newman, Mark P. McGovern
Summary: With the onset of the COVID-19 crisis, many federal agencies relaxed policies regulating opioid use disorder treatment, leading to adaptations in primary care practices. The majority of clinics shifted to virtual medical and behavioral health visits, with an increase in patient demand for behavioral health services. These adaptations may be temporary and further evaluation is needed to determine their long-term impact on patient outcomes post-COVID-19.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2021)
Review
Medicine, General & Internal
Tina Wu, Jennifer Hu, Dimitry Davydow, Heather Huang, Margaret Spottswood, Hsiang Huang
Summary: Borderline personality disorder is a common mental health diagnosis observed in the primary care population and is associated with various challenges in diagnosis and treatment. This article aims to describe the impact of BPD in primary care, review current knowledge, and provide evidence-based treatment approaches for these patients.
FRONTIERS IN MEDICINE
(2022)
Article
Anthropology
Adam Brisley, Helen Lambert, Carla Rodriguez
Summary: This article explores the issue of antimicrobial resistance and high antibiotic consumption rates in Spain through research findings from Catalonia. The authors argue that antibiotic resistance is connected to broader historical processes and deficiencies in healthcare and social care provision.
MEDICAL ANTHROPOLOGY
(2023)
Article
Substance Abuse
Sabrina A. Assoumou, Carlos R. Sian, Christina M. Gebel, Benjamin P. Linas, Jeffrey H. Samet, Judith A. Bernstein
Summary: The study found that active substance use was a major barrier to HCV treatment uptake, and patients suggested improvements such as high-intensity wraparound care, same-day/walk-in options, low-barrier access to substance use treatment, and attention to immediate needs.
DRUG AND ALCOHOL DEPENDENCE
(2021)
Review
Anesthesiology
Hailey W. Bulls, Edward Chu, Burel R. Goodin, Jane M. Liebschutz, Antoinette Wozniak, Yael Schenker, Jessica S. Merlin
Summary: This article discusses the issue of opioid stigma faced by cancer patients using prescription opioids for pain management. It proposes the Opioid Stigma Framework (OSF) to understand and improve opioid stigma in this population. The framework covers factors contributing to opioid stigma, intersections of multiple stigmatized identities, manifestations of stigma, immediate and long-term impacts, and provides guidance for future research.
Article
Clinical Neurology
Jody L. Green, Rebekkah S. Robbins, Taryn Dailey-Govoni, Stephen F. Butler
Summary: The study evaluated real-world data on the past 30-day nonmedical use (NMU) and routes of administration of Xtampza ER and comparator oxycodone medications in the US using data from the Addiction Severity Index. Xtampza ER had significantly lower rates of NMU than other oxycodone ER and oxycodone IR, as well as significantly lower rates of non-oral NMU than oxycodone IR.
JOURNAL OF PAIN RESEARCH
(2021)
Review
Substance Abuse
Emily E. Tanner-Smith, Nicholas J. Parr, Maria Schweer-Collins, Richard Saitz
Summary: Brief substance use interventions delivered in general medical settings may lead to small beneficial reductions in alcohol consumption, but evidence regarding drug-targeted interventions is limited.
Editorial Material
Medicine, General & Internal
Jessica L. Taylor, Jeffrey H. Samet
ANNALS OF INTERNAL MEDICINE
(2022)
Article
Substance Abuse
Jan Klimas, Huiru Dong, Michee-Ana Hamilton, Walter Cullen, Jeffrey H. Samet, Evan Wood, Nadia Fairbairn
Summary: The international one-year intensive research training program for addiction medicine physicians had a significant impact on subsequent research involvement and productivity. Physicians who participated in the program had higher publication rates compared to the control group, indicating successful training in recruiting addiction medicine physicians for addiction research.
Review
Substance Abuse
Anees Bahji, Paxton Bach, Marlon Danilewitz, David Crockford, Nady El-Guebaly, Daniel J. Devoe, Richard Saitz
Summary: This study evaluated the comparative performance of pharmacotherapies for alcohol withdrawal and found that some medications, especially benzodiazepines, appear to be safe and effective in reducing certain measures of alcohol withdrawal. However, methodological issues and a high risk of bias prevent a consistent estimate of their comparative performance.
Article
Substance Abuse
Theresa W. Kim, Timothy C. Heeren, Jeffrey H. Samet, Nicolas Bertholet, Christine Lloyd-Travaglini, Michael R. Winter, Kara M. Magane, Natalia Gnatienko, Kendall Bryant, Lindsey J. Rateau, Winnie R. Muyindike, Judith A. Hahn, Elena Blokhina, Richard Saitz
Summary: There is an association between alcohol use and falls, with severity of alcohol use disorder symptoms and heavy alcohol use being potential targets for fall prevention interventions.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Substance Abuse
Esperanza Romero-Rodriguez, Clara A. Chen, Kimberly A. Dukes, Kaitlin Hartlage, Tibor P. Palfai, Kara M. Magane, Jeffrey H. Samet, Richard Saitz
Summary: This study found no significant associations between cannabis and cocaine use, heavy drinking, or quality of life among hospital inpatients with alcohol use disorder (AUD). These findings raise questions about the impact of drug use on AUD and the generalizability of the results to individuals with milder AUD and prospective studies.
Article
Oncology
Hailey W. Bulls, Megan Hamm, Rachel Wasilko, Flor de Abril Cameron, Shane Belin, Burel R. Goodin, Jane M. Liebschutz, Antoinette Wozniak, Lindsay M. Sabik, Jessica S. Merlin, Yael Schenker
Summary: This qualitative study explores the manifestations of opioid stigma in patients with advanced cancer, identifying three primary ways in which it occurs: direct experiences of stigma and discrimination in healthcare settings, concerns about future stigma affecting patient care, and opioid-restricting attitudes and behaviors reflecting internalized stigma and fear of addiction.
JCO ONCOLOGY PRACTICE
(2022)
Article
Medicine, General & Internal
Jules Canfield, Ve Truong, Agata Bereznicka, Carly Bridden, Jane Liebschutz, Daniel P. Alford, Richard Saitz, Jeffrey H. Samet, Alexander Y. Walley, Karsten Lunze
Summary: This study evaluated a student clinical addiction research program by analyzing its components, evaluation survey data, and scientific outputs. The program successfully introduced students to addiction medicine and research, with high peer-reviewed publication productivity. However, it needs to improve equity by increasing the recruitment of trainees from disadvantaged groups and engaging underrepresented faculty.
ANNALS OF MEDICINE
(2023)
Article
Substance Abuse
Miriam T. H. Harris, Shira Goldenberg, Zishan Cui, Nadia Fairbairn, M-J S. Milloy, Kanna Hayashi, Jeffrey H. Samet, Alexander Y. Walley, Seonaid Nolan
Summary: Women who use drugs and engage in sex work have a higher risk of overdose, however, this risk is driven by social-structural factors such as policing and gendered violence rather than sex work itself.
INTERNATIONAL JOURNAL OF DRUG POLICY
(2023)
Article
Substance Abuse
Nicolas Bertholet, Richard Saitz, Judith A. Hahn, Timothy C. Heeren, Nneka I. Emenyonu, Matthew Freiberg, Michael R. Winter, Theresa W. Kim, Kara Magane, Christine Lloyd-Travaglini, Robin Fatch, Kendall Bryant, Leah S. Forman, Lindsey Rateau, Elena Blokhina, Winnie R. Muyindike, Natalia Gnatienko, Jeffrey H. Samet
Summary: This study assessed the association between alcohol use disorder (AUD) severity and HIV viral suppression and CD4 count. The results showed no association between AUD severity and HIV viral suppression or CD4 count in three cohorts.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Substance Abuse
Jane M. Liebschutz, Geetha A. Subramaniam, Rebecca Stone, Noa Appleton, Lillian Gelberg, Travis I. Lovejoy, Amanda M. Bunting, Charles M. Cleland, Karen E. Lasser, Donna Beers, Catherine Abrams, Jennifer Mccormack, Gail E. Potter, Ashley Case, Leslie Revoredo, Eve M. Jelstrom, Margaret M. Kline, Li-Tzy Wu, Jennifer Mcneely
Summary: The STOP trial aims to study the efficacy of a collaborative care intervention to reduce risky opioid use and prevent progression to moderate or severe OUD in adult primary care patients.
ADDICTION SCIENCE & CLINICAL PRACTICE
(2023)
Article
Health Care Sciences & Services
Suzanne K. Vosburg, Taryn Dailey-Govoni, Jared Beaumont, Stephen F. Butler, Jody L. Green
Summary: Web-based surveys successfully recruited individuals who reported nonmedical use of tapentadol, providing background information and individual experiences. The study found that tapentadol was primarily used for pain relief and to produce psychotropic effects, but did not receive a robust pattern of endorsement for nonmedical use.
JMIR FORMATIVE RESEARCH
(2022)
