Article
Clinical Neurology
Nicolas Lejeune, Eva Petrossova, Ken Steffen Frahm, Andre Mouraux
Summary: This study aimed to compare the nociceptive event-related brain potentials elicited by a high-speed contact-thermode and an infrared CO2 laser stimulator. The results showed that CHEPs were reduced in amplitude and delayed in latency compared to LEPs for 55 degrees C stimuli. When stimuli were perceptually matched, the amplitudes were similar, but CHEPs still had delayed latencies. These differences can be explained by skin thermal inertia and heating profiles at the dermo-epidermal junction. In conclusion, CHEPs could be used as an alternative to LEPs for diagnosing neuropathic pain.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Anesthesiology
Viktor Bublitz, Carlo Jurth, Matthias Kreuzer, Gregor Lichtner, Falk von Dincklage
Summary: This study investigated the potential correlations between electroencephalogram (EEG) band power and behavioral responses to noxious stimulation in critical care patients. The results indicated that specific EEG power bands were associated with behavioral responses preceding and following the stimulation.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Review
Surgery
Bill Hum, Alexa Christophides, Zhaosheng Jin, Murad Elias, Kamil Taneja, Sergio D. Bergese
Summary: Pain is a subjective, unpleasant experience related to illness or injury, while nociception refers to the neural processing of noxious stimuli. The Analgesia Nociception Index (ANI) is a device that aims to objectively measure intra-operative nociception by analyzing heart rate variability. It has potential clinical applications in surgical and non-surgical settings, although more research is needed to determine its clinical benefits.
FRONTIERS IN SURGERY
(2023)
Article
Behavioral Sciences
Lei Jia, Zheng Zheng, Billy Sung, Brian J. Compton, Jun Wang
Summary: Using event-related potentials (ERPs), this study examined whether experienced physicians' state empathy for pain could resist the effects of repeated exposure to depictions of pain. The findings showed that experienced physicians differed from controls in neural processes related to pain empathy. Additionally, it was discovered that experienced physicians with low empathy traits were able to resist the effects of repeated exposure to pain.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Endocrinology & Metabolism
Shiwei Zhuo, Yinhua Zhang, Chennan Lin, Weiwei Peng
Summary: This study investigated the influence of testosterone on pain perception and expectation of electrocutaneous stimulus. The results showed that testosterone enhanced the perception and expectation of pain, supporting its role in cognitive functions.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Neurosciences
Lewis S. Crawford, Emily P. Mills, Theo Hanson, Paul M. Macey, Rebecca Glarin, Vaughan G. Macefield, Kevin A. Keay, Luke A. Henderson
Summary: Perception of pain can be influenced by expectations and beliefs. This study used ultra-high-field fMRI to investigate the brainstem pathways involved in placebo analgesia and nocebo hyperalgesia, revealing differential activation of key pain modulatory nuclei during these phenomena.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Anesthesiology
H. -K Yoon, Y. J. Kim, H. S. Lee, J. -H Seo, H. -S Kim
Summary: This study aimed to investigate the effect of the analgesia nociception index on postoperative pain in women undergoing gynaecological laparotomy. The results showed that maintaining analgesia nociception indices within a certain range did not significantly reduce the proportion of women with pain scores >= 5. There was also no significant difference in the doses of fentanyl administered during recovery and remifentanil doses during the operation between the two groups.
Article
Obstetrics & Gynecology
Mary E. Norton, Arianna Cassidy, Steven J. Ralston, Debnath Chatterjee, Diana Farmer, Anitra D. Beasley, Monica Dragoman
Summary: Fetal anesthesia and analgesia in maternal-fetal surgical procedures are primarily used to reduce fetal autonomic responses and minimize fetal movement for safe execution of procedures. Administration of fetal analgesia is not recommended during pregnancy termination due to maternal risk and lack of evidence supporting benefit to the fetus.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Neurosciences
Yan Jing Wu, Qinpu Dang, Zhaoqi Zhang, Haoyun Zhang, Taomei Guo
Summary: The use of two dialects has an impact on executive functions, but the mechanisms underlying the advantages of bilingualism have not been specified. Using multivariate pattern classification methods, the researchers decoded neural signals associated with Flanker task performance in mono-dialectal and bi-dialectal speakers of Chinese. The decoding accuracy of ERPs was reduced in bi-dialectal speakers compared to mono-dialectal speakers, indicating an effect of bidialectalism on attentional deployment rather than inhibitory control.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Psychology, Biological
Di Yang, Jin Jiang, Wanchen Li, Runjie Zhang, Luzhuang Sun, Jing Meng
Summary: This study investigated the effects of priming spicy food pictures on pain perception in female participants. The results showed that priming with spicy food pictures significantly reduced pain perception, especially at high pain intensities. Electrophysiological analysis revealed that the analgesic effects of spicy food pictures were associated with changes in pain-related brain activity.
BIOLOGICAL PSYCHOLOGY
(2023)
Article
Psychology, Multidisciplinary
Xuemei Tang, Lexian Shen, Peng Yang, Yanhong Huang, Shaojuan Huang, Min Huang, Wei Ren
Summary: This study investigated the processing of scientific metaphors in a speaker's native language (L1) and their second language (L2) using event-related potential experimentation. The findings suggest that L2 scientific metaphor comprehension requires more cognitive effort and may involve decreased automaticity and sensitivity to metaphorical meanings compared to L1.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Psychology, Multidisciplinary
Harm Brouwer, Francesca Delogu, Noortje J. Venhuizen, Matthew W. Crocker
Summary: Research has found that expectation-based theories of language comprehension, particularly Surprisal Theory, are effective in explaining the behavioral correlates of word-by-word processing difficulty. However, there is still uncertainty about which component(s) of the Event-Related brain Potential (ERP) signal reflects Surprisal and how these electrophysiological correlates are related to behavioral processing indices. By establishing a neurocomputational model and experimental design, a close link between Surprisal and the P600 component has been identified, providing an integrated explanation for processing difficulty in language comprehension.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Psychology, Multidisciplinary
Reza Pishghadam, Haniyeh Jajarmi, Shaghayegh Shayesteh, Azin Khodaverdi, Hossein Nassaji
Summary: This study investigated the effect of audio-visual vocabulary repetition on L2 sentence comprehension. The results showed that repetition of instructed words did not significantly impact sentence comprehension under multisensory instruction.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Neurosciences
Fedal Saini, Fabio Masina, Jasmine Wells, Richard Rosch, Sarah Hamburg, Carla Startin, Andre Strydom
Summary: Down syndrome (DS) is associated with a high risk of developing Alzheimer's disease (AD). Variability in pre-AD cognitive abilities may help understand cognitive decline in DS population. The study found that reduced MMN amplitude was associated with lower memory scores, while longer MMN latencies were associated with poorer memory, verbal abilities, and attention in adults with DS without AD.
Article
Psychology, Multidisciplinary
Xinmei Deng, Sieun An, Yuanyuan You
Summary: This study examined cross-cultural differences in emotional processing of positive emotions in social contexts. The results showed that Chinese participants had larger neural and behavioral responses to positive emotions in social contexts compared to Caucasians. These findings suggest that cultural background influences how people process positive emotions in social situations.
CURRENT PSYCHOLOGY
(2023)
Article
Oncology
An De Groef, Mira Meeus, Lauren C. Heathcote, Louise Wiles, Mark Catley, Anna Vogelzang, Ian Olver, William B. Runciman, Peter Hibbert, Lore Dams, Bart Morlion, G. Lorimer Moseley
Summary: This paper discusses the growing problem of persistent pain after successful breast cancer treatment and presents recommendations for improving pain-related outcomes. The authors compare the dominant treatment approach for persistent pain post-breast cancer treatment with contemporary treatment approaches for noncancer-related persistent pain. They emphasize the potential role of pain science education in improving pain and disability outcomes after successful breast cancer treatment. The paper also provides research recommendations for adapting pain science education to the post-breast cancer context.
JOURNAL OF CANCER SURVIVORSHIP
(2023)
Review
Rehabilitation
Emma L. Karran, Louise K. Wiles, Dianne J. Wilson, G. Lorimer Moseley
Summary: By reviewing clinical practice guidelines and recent literature, common recommendations for best practice pain care in adults with spinal cord injury (SCI) have been identified. These recommendations can guide consumers, clinicians, researchers, and policy makers in understanding and implementing evidence-based best practice pain management in adults with SCI.
DISABILITY AND REHABILITATION
(2023)
Article
Anesthesiology
Ruth L. Chimenti, Andrew A. Post, Ebonie K. Rio, G. Lorimer Moseley, Megan Dao, Hadley Mosby, Mederic Hall, Cesar de Cesar Netto, Jason M. Wilken, Jessica Danielson, Emine O. Bayman, Kathleen A. Sluka
Summary: Exercise is the standard treatment for Achilles tendinopathy (AT), but a significant number of patients still experience pain after rehabilitation. Adding pain science education (PSE) to an exercise program may improve clinical outcomes, but this has not been studied in AT patients. Moreover, we have limited knowledge about how AT rehabilitation affects fear of movement and central nervous system nociceptive processing.
Article
Clinical Neurology
Diana M. Torta, Elke Meyers, Klaartje Polleunis, Sarah De Wolf, Ann Meulders, Emaneul N. van den Broeke
Summary: It is unclear whether watching others in high pain affects mechanical hypersensitivity induced by pain. In this study, we applied high-frequency electrical stimulation to induce pinprick hypersensitivity in healthy volunteers. Participants were randomly assigned to a low pain group, where they observed a model expressing lower pain scores, or a high pain group, where the model expressed higher scores. The high pain group reported higher pain ratings during the stimulation, suggesting that observing someone in high pain increases one's own pain experience and may contribute to the development of mechanical hypersensitivity.
Article
Clinical Neurology
Aroldo D. S. Aguiar, G. Lorimer Moseley, Cesar Bataglion, Beatriz Azevedo, Thais C. Chaves
Summary: The study aimed to investigate the effect of enhancing conventional care with an individualized contemporary pain science education (PSE) intervention for patients with chronic painful temporomandibular disorders (TMD). A randomized controlled trial was conducted with 148 participants, who were divided into two groups: PSE-enhanced conventional care and Conventional care alone. The results showed that the PSE enhancement had a significant and clinically meaningful effect on disability, but not on pain intensity, post-treatment. Secondary analyses suggested that the PSE enhancement may lead to long-term benefits in pain and disability ratings.
Article
Orthopedics
Benedict M. Wand, Aidan G. Cashin, James H. McAuley, Matthew K. Bagg, Gemma M. Orange, G. Lorimer Moseley
Summary: This article describes a model for understanding the complexity of chronic nonspecific low back pain (LBP) by integrating modifiable factors across the biopsychosocial spectrum. The model suggests that individuals with chronic LBP hold strong and relatively unchangeable internal models of a damaged, fragile, and unhealthy back, and that information supporting these models is more credible and accessible than conflicting information. The article proposes a treatment framework aimed at changing these internal models to view the back as healthy, adaptable, and fit for purpose, while providing precise and trustworthy evidence to support this view and minimizing conflicting information.
Article
Anesthesiology
Hayley B. Leake, G. Lorimer Moseley, Lexa K. Murphy, Caitlin B. Murray, Tonya M. Palermo, Lauren C. Heathcote
Summary: This study examined how young adults with childhood-onset chronic pain understand the biology of pain. The findings revealed that they primarily conceptualize pain in terms of something wrong with the body, unhealed injuries, abnormal neural firing, and an overactive stress system. These insights can inform the development of tailored pain science education interventions for young adults.
EUROPEAN JOURNAL OF PAIN
(2023)
Review
Public, Environmental & Occupational Health
E. L. Karran, A. R. Grant, H. Lee, S. J. Kamper, C. M. Williams, L. K. Wiles, R. Shala, C. V. Poddar, T. Astill, G. L. Moseley
Summary: This study aimed to evaluate the effectiveness of health education interventions in socio-economically disadvantaged populations. A meta-analysis of 96 studies involving over 57,000 participants from 22 countries found inconsistent effects of educational interventions on health behaviors and biomarkers. Continued investment in targeted approaches and further understanding of implementation and evaluation factors are important for reducing health inequalities.
Article
Anesthesiology
Elke Meyers, Johan W. S. Vlaeyen, Emanuel N. van den Broeke, Andreas von Leupoldt, Andrew J. Palmer, Diana M. Torta
Summary: Limited attentional resources are thought to play a role in modulating pain perception. This study aimed to investigate the effects of cognitive load on the development of long-lasting secondary hypersensitivity. The results showed that cognitive load did not reduce hypersensitivity, but pain-related fear and non-pain-related sympathetic arousal were associated with hypersensitivity.
EUROPEAN JOURNAL OF PAIN
(2023)
Article
Clinical Neurology
Elke Meyers, Maryna Alves, Anouk Teugels, Diana M. Torta
Summary: This study shows that the execution of a cognitive task, irrespective of cognitive load or working memory, does not significantly modulate the development of secondary hypersensitivity, heart rate variability, or steady-state evoked potentials. However, higher pain-related fear seems to contribute to greater hypersensitivity.
Letter
Anesthesiology
Brendan Mouatt, Hayley B. Leake, Tasha R. Stanton, G. Lorimer Moseley, Laura E. Simons, Felicity A. Braithwaite
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Clinical Neurology
Coralie English, Dawn B. Simpson, Sandra A. Billinger, Leonid Churilov, Kirsten G. Coupland, Avril Drummond, Annapoorna Kuppuswamy, Mansur A. Kutlubaev, Anners Lerdal, Amreen Mahmood, G. Lorimer Moseley, Quentin J. Pittman, Ellyn A. Riley, Brad A. Sutherland, Connie H. Y. Wong, Dale Corbett, Gillian Mead
Summary: This article presents a research roadmap for post-stroke fatigue, covering key areas such as measurement tools, clinical identification, interventions, and biological mechanisms. The interdisciplinary team synthesized current knowledge to provide recommendations for future research in this field.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Review
Health Care Sciences & Services
Emma L. Karran, Aidan G. Cashin, Trevor Barker, Mark A. Boyd, Alessandro Chiarotto, Omar Dewidar, Vina Mohabir, Jennifer Petkovic, Saurab Sharma, Sinan Tejani, Peter Tugwell, G. Lorimer Moseley
Summary: The objective of this study was to identify and map data related to the social determinants of health in equity-relevant studies using the PROGRESS-Plus framework. A scoping review was conducted, and data from 200 equity-relevant studies were extracted and categorized. The findings showed that there is a limited range of equity-relevant data being collected and reported, highlighting the need for improved and standardized practices.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Article
Multidisciplinary Sciences
Brian W. Pulling, Felicity A. Braithwaite, David S. Butler, Anna R. Vogelzang, G. Lorimer Moseley, Mark J. Catley, Carolyn M. Murray, Tasha R. Stanton
Summary: Many people with osteoarthritis have misconceptions about the role of physical activity in managing their condition. Recent advancements in scientific understanding of osteoarthritis have led to new treatments that aim to change patients' understanding of their condition and the importance of physical activity in managing it. This study aimed to develop an item bank to assess patients' conceptualizations about knee osteoarthritis and the role of physical activity. The study identified issues and made modifications, resulting in a final item bank of 45 items.
Article
Anesthesiology
Joshua W. Pate, Lauren E. Harrison, Courtney W. Hess, G. Lorimer Moseley, Gillian Rush, Lauren C. Heathcote, Laura E. Simons
Summary: This study aimed to characterize the concept of pain in care-seeking youth and their parents, to examine its clinical and demographic correlates, and to identify conceptual gaps.
CLINICAL JOURNAL OF PAIN
(2023)