Review
Medicine, General & Internal
Dmitriy Viderman, Karina Tapinova, Fatima Nabidollayeva, Ramil Tankacheev, Yerkin G. Abdildin
Summary: This study compares the use of intravenous and epidural routes for patient-controlled analgesia in abdominal surgery. The results show that there is no significant difference in pain control and side effects between the two methods. However, epidural analgesia is associated with a shorter length of hospital stay, while intravenous analgesia is associated with fewer episodes of hypotension.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Ming Zhang, Ziyan Yang, Jiahui Zhong, Yuqi Zhang, Xiaomin Lin, Huajian Cai, Yazhuo Kong
Summary: Nostalgia, as a positive emotion, has an analgesic effect and may modulate brain activity to reduce pain perception.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Biotechnology & Applied Microbiology
Soraya Babaie, Arezou Taghvimi, Joo-Hyun Hong, Hamed Hamishehkar, Seongpil An, Ki Hyun Kim
Summary: Nanotechnology has shown promising applications in pain management, including nanotechnology-based drug delivery, imaging and diagnostic tools, as well as pain measurement. It has provided acceptable results in pain control and has the potential to revolutionize pain management, but further extensive research is needed.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Miriam S. Martin, Michael D. Kleinhenz, Abbie V. Viscardi, Andrew K. Curtis, Blaine T. Johnson, Shawnee R. Montgomery, Maria E. Lou, Johann F. Coetzee
Summary: This study evaluated the effectiveness of using bupivacaine liposome suspension as a cornual nerve block at the time of dehorning compared to current industry standard analgesic approaches. The results showed that administration of bupivacaine liposome suspension was as effective at controlling pain as a multimodal approach of lidocaine and meloxicam.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Miriam S. Martin, Michael D. Kleinhenz, Abbie V. Viscardi, Andrew K. Curtis, Blaine T. Johnson, Shawnee R. Montgomery, Maria E. Lou, Johann F. Coetzee
Summary: Castration is a common procedure in the beef and dairy industry in the United States, but it causes pain. This study evaluated the effectiveness of bupivacaine liposome suspension as a nerve block during castration and found that it was as effective as a combination of lidocaine and meloxicam in controlling pain. A single injection that alleviates both perioperative and postoperative pain would be an attractive option for livestock producers to alleviate pain at the time of castration.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Anesthesiology
Jin Cao, Yiheng Tu, Courtney Lang, Mark Vangel, Joel Park, Jiao Liu, Georgia Wilson, Randy Gollub, Scott Orr, Jian Kong
Summary: The study found that daily caffeine intake did not influence acupuncture analgesia in healthy subjects. Real acupuncture was shown to increase pain thresholds compared to sham acupuncture.
ANESTHESIA AND ANALGESIA
(2021)
Article
Multidisciplinary Sciences
Holly B. Ende, Ruth Landau, Naida M. Cole, Sara M. Burns, Brian T. Bateman, Melissa E. Bauer, Jessica L. Booth, Pamela Flood, Lisa R. Leffert, Timothy T. Houle, Lawrence C. Tsen
Summary: The study found that women with intrapartum cesarean delivery experienced higher pain scores on the day of surgery, increased opioid use after discharge, but similar pain scores at other time points compared to women without labor prior to cesarean delivery.
Article
Chemistry, Multidisciplinary
Aining Zhang, Yongnian Zeng, Bingrui Xiong, Xue Jiang, Yinli Jin, Siyuan Wang, Yikang Yuan, Wei Li, Mian Peng
Summary: A pH-responsive microneedle (MN) patch has been developed for sustained and personalized analgesia after surgery. The patch intelligently modulates drug release based on the pH value of the surgical incision microenvironment, resulting in a prolonged and individualized analgesic effect. It addresses the limitations of existing invasive treatments in postoperative pain management.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Anesthesiology
Neil Singla, Todd Bertoch, Srinivas Shenoy, Sagar Munjal
Summary: The analgesic efficacy and safety of DFN-15, a new oral liquid formulation of celecoxib, were evaluated in the treatment of acute pain in adult patients after dental surgery. The study showed that DFN-15 was superior to placebo in reducing pain intensity, providing pain relief, increasing treatment satisfaction, and reducing the use of rescue medication, without apparent dose-related effects.
Article
Pharmacology & Pharmacy
Gianna Giacoletti, Tatum Price, Lucas V. B. Hoelz, Abdulwhab Shremo Msdi, Samantha Cossin, Katerina Vazquez-Falto, Tacio V. Amorim Fernandes, Vinicius Santos de Pontes, Hongbing Wang, Nubia Boechat, Adwoa Nornoo, Tarsis F. Brust
Summary: In this study, the AC1-selective inhibitor ST034307 was found to alleviate pain in mouse models without causing analgesic tolerance. While unable to detect ST034307 in the mouse brain, a significant reduction in cAMP concentration was observed in the dorsal root ganglia of the animals. These results indicate that AC1 inhibitors are a promising class of analgesic agents that effectively treat pain without inducing tolerance.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Noha O. Mansour, Sherif Boraii, Mohamed Hassan Elnaem, Mahmoud E. Elrggal, Tamer Omar, Amr Abdelraouf, Doaa H. Abdelaziz
Summary: This study evaluated the effect of preoperative oral duloxetine on postoperative pain control in patients undergoing laparoscopic cholecystectomy. The results showed that preoperative use of duloxetine significantly reduced postoperative pain and decreased the occurrence of postoperative nausea and vomiting.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Sport Sciences
Jun Seob Song, Yujiro Yamada, Vickie Wong, Zachary W. Bell, Robert W. Spitz, Takashi Abe, Jeremy P. Loenneke
Summary: The study found that isometric handgrip exercise with or without blood flow restriction can induce exercise-induced hypoalgesia at both local and non-local sites. However, discomfort and changes in systolic blood pressure do not explain this response.
JOURNAL OF SPORTS SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Gustavo Lopez-Cordoba, Guadalupe Martinez-Lorenzana, Jair Lozano-Cuenca, Miguel Condes-Lara, Abimael Gonzalez-Hernandez
Summary: Spinal alpha(2)-adrenoceptors induce analgesia by inhibiting primary afferent fibers. The alpha(2A) subtype is involved in acute or tonic nociception, while the alpha(2C) subtype has an opposing effect under tonic nociceptive input.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Valeria Oliva, Rob Gregory, Wendy-Elizabeth Davies, Lee Harrison, Rosalyn Moran, Anthony E. Pickering, Jonathan C. W. Brooks
Summary: Pain can be alleviated by shifting attention elsewhere, and the brainstem regions including locus coeruleus, rostral ventromedial medulla, and periaqueductal grey are involved in attentional analgesia. Functional interactions between these regions and the cortex modulate nociceptive input to reduce pain, particularly in situations requiring conflicting attentional demands.
Article
Medicine, General & Internal
Taima Alrimy, Wadee Alhalabi, Areej Malibari, Fatma Alzahrani, Sharifah Alrajhi, Ayman Yamani, Halah Ahmed, Amro Abduljawad, Essam Nasser, Samar ALattar, Buthinah Alharby, Hasna Khalid, Mohammed Alhalabi, Hunter G. Hoffman, Keira P. Mason
Summary: Although most scald burn injuries involve children under six, there is limited research on the use of VR in this age group due to the challenges of using head mounted displays on young children. A clinical pilot study was conducted to measure the analgesic effectiveness of a new desktop VR system in children under six during burn wound care. The study found that VR significantly reduced the children's pain and anxiety during burn wound care, as measured by nurse's ratings, observational scales, and parent reports.
JOURNAL OF CLINICAL MEDICINE
(2023)
