Article
Cell Biology
Richard L. Kraus, Fuqiang Zhao, Parul S. Pall, Dan Zhou, Joshua D. Vardigan, Andrew Danziger, Yuxing Li, Christopher Daley, Jeanine E. Ballard, Michelle K. Clements, Rebecca M. Klein, Marie A. Holahan, Thomas J. Greshock, Ronald M. Kim, Mark E. Layton, Christopher S. Burgey, Jordi Serra, Darrell A. Henze, Andrea K. Houghton
Summary: Humans with mutations in the Na(v)1.7 channel gene can either be insensitive to pain or suffer from inherited pain syndromes. Clinical studies using Na(v)1.7 inhibitors have not shown significant pain relief, leading researchers to develop rhesus macaque models to measure target modulation and efficacy.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Review
Immunology
Daniel B. Lowy, Preet G. S. Makker, Gila Moalem-Taylor
Summary: Bidirectional interaction between the peripheral immune and nervous systems plays a crucial role in maintaining homeostasis and responding to noxious stimuli. The skin is a highly complex biological structure where sensory nerve terminals and immune cells coexist. Sensory neurons regulate cutaneous immune responses through neuropeptides, while immune cells modulate sensory neurons through mediators.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Carlos H. Hiroki, Nicole Sarden, Mortaza F. Hassanabad, Bryan G. Yipp
Summary: The lungs are exposed to harmful threats from non-sterile air, but have efficient mechanisms to eliminate threats and prevent pathogen invasion. Sensory neurons in the respiratory tract play a crucial role in detecting external stimuli and initiating immune responses. In elderly individuals, sensory nerve function and innate receptors may contribute to respiratory and immunological dysfunction.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Xavier Mas-Orea, Lilian Basso, Catherine Blanpied, Claire Gaveriaux-Ruff, Nicolas Cenac, Gilles Dietrich
Summary: This study identifies the important role of the delta opioid receptor (DOR) in relieving intestinal inflammatory pain and suggests the potential of developing peripherally restricted DOR analgesics for intestinal disorders, which could avoid the side effects associated with drugs targeting the mu opioid receptor (MOR).
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Neurosciences
Yu Zhang, Jun Zhao, Nan Hu, Jing Wang, Xi Chen, Kaiyuan Wang, Yiqing Yin
Summary: This study aimed to observe the effects of intrathecal administration of motilin on pain behavior and expression of motilin/motilin receptor (MTL/MTLR) in the spinal cord of a rat model of acute incisional pain. The results showed that MTL/MTLR are expressed in the rat spinal dorsal horn and their expression is increased in acute pain. Moreover, intrathecal injection of motilin can alleviate pain in rat models of acute incisional pain. These findings suggest that MTL/MTLR could be a novel target for the management of acute pain.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Engineering, Biomedical
Yaodan Xu, Kaichen Wang, Yibin Jin, Fang Qiu, Yang Yao, Lin Xu
Summary: This study systematically investigated the influence of electrode configuration on muscle fiber conduction velocity estimation. It was found that normalized bipolar configuration produced the most accurate estimation.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Neurosciences
Lian Cui, Jeff Guo, Suna L. Cranfill, Mayank Gautam, Janardhan Bhattarai, William Olson, Katherine Beattie, Rosemary C. Challis, Qinxue Wu, Xue Song, Tobias Raabe, Viviana Gradinaru, Minghong Ma, Qin Liu, Wenqin Luo
Summary: This study investigates the role of glutamate and neuropeptide neuromedin B (Nmb) in itch transmission. The results show that glutamate is essential for transmitting itch through MRGPRA3(+) afferents, while Nmb signaling enhances its activities.
Article
Endocrinology & Metabolism
Aleksandra V. Durkina, Olesya G. Bernikova, Mikhail A. Gonotkov, Natalia J. Mikhaleva, Ksenia A. Sedova, Inna A. Malykhina, Vladislav S. Kuzmin, Ilya O. Velegzhaninov, Jan E. Azarov
Summary: Melatonin treatment has been found to reduce the risk of cardiac arrhythmias by enhancing activation spread. This study demonstrated that melatonin treatment shortened ATs and increased conduction velocity, which was achieved through the upregulation of sodium channel proteins expression and sodium current in ventricular myocytes.
JOURNAL OF PINEAL RESEARCH
(2022)
Article
Materials Science, Characterization & Testing
Zhenyu Qiu, Jingxuan Wang, Hualin Fan
Summary: The study investigated the anti-impact behavior and loading rate sensitivity of bamboo fiber reinforced composite beams through low-velocity-impact flexural experiments. Velocity-dependent effects such as impact force, energy absorption, and impact toughness were revealed, showing a nearly linear increase with impact velocity. Linear fitting equations were used to quantitatively express the rate sensitivities, providing a basis for designing shock and explosion resistant BFRC structures.
Review
Neurosciences
Vincent Feuillet, Sophie Ugolini, Ana Reynders
Summary: The nervous and immune systems communicate bidirectionally in various organs, including the skin. The skin, as an epithelial tissue, has sensory and immune functions. The interaction between specialized primary sensory neurons (PSNs) and immune cells in the skin regulates host defense, inflammation, and tissue repair. This review focuses on the cellular and molecular mechanisms involved in this neuroimmune crosstalk, using mouse model studies, and highlights the role of different subsets of PSNs in modulating immune cell function.
TRENDS IN NEUROSCIENCES
(2023)
Article
Materials Science, Composites
Ali Safamanesh, Seyed Mostafa Mousavi, Hamed Khosravi, Esmaeil Tohidlou
Summary: The study evaluated the effects of modified graphene oxide and graphene nanoplatelets on the impact behavior of aramid fiber/epoxy composites. Results showed that adding 0.3% M-GNs in the multiscale specimens produced the highest impact resistance, significantly improving the force and energy absorption of the composite materials.
POLYMER COMPOSITES
(2021)
Article
Pharmacology & Pharmacy
Seckin Tuncer, Ahmet Akkoca, Murat Cenk Celen, Nizamettin Dalkilic
Summary: The study showed that MitoTEMPO can protect against sciatic nerve damage caused by abdominal ischemia-reperfusion (I/R) by preserving nerve conduction velocity and structural integrity, thereby preventing functional nerve damage. MitoTEMPO, which can enter mitochondria and reduce oxidative stress, prevented the contribution of fast-conducting fibers and caused a shift in nerve conduction velocity distribution, ultimately protecting against nerve damage.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Physiology
Matteo Beretta-Piccoli, Massimo Negro, Luca Calanni, Angela Berardinelli, Gabriele Siciliano, Rossella Tupler, Emiliano Soldini, Corrado Cescon, Giuseppe D'Antona
Summary: In this study, a negative correlation was found between conduction velocity during low level contraction and age at onset in FSHD patients. This suggests that assessing conduction velocity during low intensity isometric contractions may be a potentially useful tool to highlight differences in muscle involvement in FSHD patients.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Neurosciences
Jiaqi Li, Shihao Peng, Yiwen Zhang, Junye Ge, Shasha Gao, Yuanyuan Zhu, Yang Bai, Shengxi Wu, Jing Huang
Summary: This study found that neurons in the zona incerta have opposite effects on pain and itch modulation. By manipulating incertal glutamatergic neurons, the researchers demonstrated their role as negative modulators for pain and itch processing. These findings provide insights into the brain mechanisms underlying somatosensory processing and modulation, and offer a potential therapeutic target for chronic pain and itch disorders.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Anesthesiology
Michael Fetell, Manon Sendel, Thomas Li, Leslie Marinelli, Jan Vollert, Elizaeth Ruggerio, George Houk, Marilyn Dockum, Phillip J. Albrecht, Frank L. Rice, Ralf Baron
Summary: Skin biopsies from patients with postherpetic neuralgia (PHN) showed no correlation between nerve fiber density and baseline pain, and concurrent loss of nerve fibers on the affected side was common. The role of Nav1.7 in PHN pain is still unclear.
Article
Sport Sciences
H. Ota, K. Katanosaka, S. Murase, T. Furuyashiki, S. Narumiya, K. Mizumura
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2018)
Article
Neurosciences
Shiori Murase, Etsuji Terazawa, Fernando Queme, Hiroki Ota, Teru Matsuda, Kenji Hirate, Yasuko Kozaki, Kimiaki Katanosaka, Toru Taguchi, Hisako Urai, Kazue Mizumura
JOURNAL OF NEUROSCIENCE
(2010)
Article
Neurosciences
Shiori Murase, Etsuji Terazawa, Kenji Hirate, Hiroki Yamanaka, Hirosato Kanda, Koichi Noguchi, Hiroki Ota, Fernando Queme, Toru Taguchi, Kazue Mizumura
JOURNAL OF PHYSIOLOGY-LONDON
(2013)
Article
Multidisciplinary Sciences
Hiroki Ota, Kimiaki Katanosaka, Shiori Murase, Makiko Kashio, Makoto Tominaga, Kazue Mizumura
Article
Physiology
Hiroki Ota, Haruna Takebe, Kazue Mizumura, Toru Taguchi
Summary: In this study, the characteristics and responsiveness of cutaneous C-fiber afferents in rats subjected to hindlimb cast immobilization for 4 weeks were examined. While the mechanical response of C-fibers appeared to increase in the model, statistical analysis revealed that neither the response threshold nor the response magnitude was altered. The study also showed an increase in the number of microglia and cell diameters in the superficial dorsal horn of the lumbar spinal cord, suggesting that activated microglia-mediated spinal mechanisms are involved in nociceptive hypersensitivity in rats after persistent cast immobilization.
JOURNAL OF PHYSIOLOGICAL SCIENCES
(2021)