Article
Biology
Simon Desch, Petra Schweinhardt, Ben Seymour, Herta Flor, Susanne Becker, Markus Ploner
Summary: Active decision-making and unpredictability enhance the perception of pain relief, and this effect is more pronounced in individuals with high novelty-seeking traits. Dopaminergic signaling plays a key role in modulating the perception of pain relief, while the effect of opioidergic manipulation is not significant.
Article
Clinical Neurology
Aida Marcotti, Jorge Fernandez-Trillo, Alejandro Gonzalez, Marta Vizcaino-Escoto, Pablo Ros-Arlanzon, Luz Romero, Jose Miguel Vela, Ana Gomis, Felix Viana, Elvira de la Pena
Summary: The study reveals that sigma-1 receptor antagonists can regulate TRPA1 channels in nociceptors, reducing pain in a mouse model of oxaliplatin neuropathy. This finding suggests a novel strategy for the treatment of chemotherapy-induced peripheral neuropathy and offers insights for the development of new therapeutics for neuropathic pain.
Article
Multidisciplinary Sciences
Fernando G. Exposto, Miranda Huang, Talita Haasnoot, Michail Koutris, Frank Lobbezoo, Karina H. Bendixen, Peter Svensson
Summary: This study investigates the influence of painful stimuli applied to the temporalis muscle on the location, area, and frequency of referred sensations during palpation of the masseter muscle. The results show that the application of painful stimuli does not alter the location, area, and frequency of referred sensations. However, there seems to be a positive relationship between painful stimuli and the frequency and intensity of referred sensations elicited from the temporalis muscle.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Sergio Varela-Rodriguez, Jose Luis Sanchez-Sanchez, Enrique Velasco, Miguel Delicado-Miralles, Juan Luis Sanchez-Gonzalez
Summary: The study aimed to investigate the effects of percutaneous electrolysis (PE) on endogenous pain modulation and whether dosage of galvanic current plays a role. Results showed that PE intervention could modulate pain processing in local and widespread areas, and the effect was independent of the dosage administered.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Analytical
Noy Turgeman Dahan, Jean-Jacques Vatine, Irit Weissman-Fogel, Hana Karpin, Sharon Shmuely, Tami Bar-Shalita
Summary: This study developed a reliable and valid protocol called Quantitative Dynamic Allodynography (QDA) for measuring Dynamic Mechanical Allodynia (DMA) in a clinical setting. The QDA showed high test-retest and inter-rater reliability, and correlated with other measures of pain and quality of life.
Review
Clinical Neurology
Li-Ling Hope Pan, Rolf-Detlef Treede, Shuu-Jiun Wang
Summary: The review found inconclusive changes to MPT in migraine patients, with the importance of considering measurement methods and well-defined migraine phases for future studies.
FRONTIERS IN NEUROLOGY
(2022)
Article
Nutrition & Dietetics
Kordula Lang-Illievich, Christoph Klivinyi, Gudrun Rumpold-Seitlinger, Christian Dorn, Helmar Bornemann-Cimenti
Summary: This study aimed to investigate the analgesic mechanisms of Palmitoylethanolamide (PEA) and found that PEA significantly reduced heat pain, prolonged cold pain tolerance, increased pressure pain tolerance and conditioned pain modulation, decreased wind-up ratio and average distance of allodynia, and improved heat pain tolerance.
Article
Anesthesiology
Viktor Bublitz, Carlo Jurth, Matthias Kreuzer, Gregor Lichtner, Falk von Dincklage
Summary: This study investigated the potential correlations between electroencephalogram (EEG) band power and behavioral responses to noxious stimulation in critical care patients. The results indicated that specific EEG power bands were associated with behavioral responses preceding and following the stimulation.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Neurosciences
Diba Borgmann, Lionel Rigoux, Bojana Kuzmanovic, Sharmili Edwin Thanarajah, Thomas F. Muente, Henning Fenselau, Marc Tittgemeyer
Summary: Research has shown that transcutaneous auricular vagus nerve stimulation (taVNS) can activate key brainstem regions and have long-lasting effects, which may have potential benefits in modulating vagal afferent signaling.
Article
Immunology
Chia-En Wong, Chia-Ying Hu, Po-Hsuan Lee, Chi-Chen Huang, Han-Wei Huang, Chih-Yuan Huang, Hsin-Tien Lo, Wentai Liu, Jung-Shun Lee
Summary: This study investigated the therapeutic effect of sciatic nerve stimulation (SNS) on acute neuropathic pain (NP) and its underlying mechanism. The results showed that both 2 Hz and 20 Hz SNS could alleviate pain behavior and hyperactivation of pain conducting pathways, reduce neuroinflammation and inflammatory protein expression, suppress astrocytic gliosis and microglia activation, and enhance the activity of the descending pain modulation pathway.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Multidisciplinary Sciences
Zihua Gong, Chunxiao Yang, Wei Dai, Shuai Miao, Yingyuan Liu, Zhiyang Jiao, Bozhi Li, Wei Xie, Wei Zhao, Xun Han, Shengyuan Yu, Zhao Dong
Summary: Medication overuse headache (MOH) is a serious global condition. This study found that medication overuse aggravated induced cutaneous allodynia in a chronic migraine mouse model. The protein ANXA1 had a significant upregulation in the affected mice, suggesting its potential as a therapeutic target for MOH.
Article
Biotechnology & Applied Microbiology
Li Chen, Zhen Zhang, Rui Han, Liyuan Du, Zhenxing Li, Shuiping Liu, Dong Huang, Haocheng Zhou
Summary: This study aimed to evaluate a novel approach combining quantitative sensory testing (QST) with event-related potential measurements for assessment of experimental pain in healthy individuals. The results showed that pain scores and the amplitudes of pain-related potentials increased with the intensity of stimuli. The combination of QST with EEG was feasible for subjective and objective pain assessment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Anesthesiology
Matthew J. Kmiecik, Frank F. Tu, Daniel J. Clauw, Kevin M. Hellman
Summary: Multimodal hypersensitivity (MMH), characterized by increased sensitivity across multiple sensory modalities, is associated with the development of chronic pain. This study examined a cohort of women and found that MMH was a significant predictor of pelvic pain, even after adjusting for baseline pain levels. These findings suggest that MMH may play a crucial role in the long-term risk and development of pelvic pain.
Article
Veterinary Sciences
Xiaoling Huang, Zhenxing Li, Jiahui Ma, Dong Huang, Xuebin Yan, Haocheng Zhou
Summary: The study introduced a novel electrical stimulator for the measurement of orofacial pain in freely behavioral rodents. The results showed that the stimulator accurately assessed both the sensory and affective components of orofacial pain.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Pharmacology & Pharmacy
Wayra Brackx, Rita de Cassia Collaco, Margaux Theys, Jolien Vander Cruyssen, Frank Bosmans
Summary: Voltage-activated Na+ (NaV) channels are important for electrical signaling in the human body and are targeted by therapeutic drugs and toxins. Some NaV channel subtypes play roles in pain and other sensory processes, while the physiological role of NaV1.9 is not well understood. Mutations in NaV1.9 can lead to sensory-related diseases. This review explores the mechanisms of NaV1.9 in pain and discusses the need for comprehensive understanding of NaV1.9-specific pharmacology.
PHARMACOLOGY & THERAPEUTICS
(2023)
Editorial Material
Anesthesiology
P. Hansson, D. Bouhassira
EUROPEAN JOURNAL OF PAIN
(2015)
Article
Anesthesiology
Birgitta Tuveson, Ann-Sofie Leffler, Per Hansson
CLINICAL JOURNAL OF PAIN
(2011)
Article
Anesthesiology
Monika Samuelsson, Ann-Sofie Leffler, Bo Johansson, Per Hansson
EUROPEAN JOURNAL OF PAIN
(2011)
Article
Anesthesiology
Asa H. Landerholm, Per T. Hansson
EUROPEAN JOURNAL OF PAIN
(2011)
Article
Anesthesiology
N. B. Finnerup, J. Scholz, N. Attal, R. Baron, M. Haanpaa, P. Hansson, S. N. Raja, A. S. C. Rice, W. Rief, M. C. Rowbotham, D. M. Simpson, R. -D. Treede
EUROPEAN JOURNAL OF PAIN
(2013)
Article
Anesthesiology
M. Razavi, P. T. Hansson, B. Johansson, A. -S. Leffler
EUROPEAN JOURNAL OF PAIN
(2014)
Article
Anesthesiology
D. Yarnitsky, D. Bouhassira, A. M. Drewes, R. B. Fillingim, M. Granot, P. Hansson, R. Landau, S. Marchand, D. Matre, K. B. Nilsen, A. Stubhaug, R. D. Treede, O. H. G. Wilder-Smith
EUROPEAN JOURNAL OF PAIN
(2015)
Editorial Material
Neurosciences
K. Fried, P. T. Hansson
EXPERIMENTAL NEUROLOGY
(2014)
Article
Surgery
Jessica Gahm, Per Hansson, Yvonne Brandberg, Marie Wickman
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2013)
Review
Anesthesiology
Maija Haanpaa, Nadine Attal, Miroslav Backonja, Ralf Baron, Michael Bennett, Didier Bouhassira, Giorgio Cruccu, Per Hansson, Jennifer A. Haythornthwaite, Gian Domenico Iannetti, Troels S. Jensen, Timo Kauppila, Turo J. Nurmikko, Andew S. C. Rice, Michael Rowbotham, Jordi Serra, Claudia Sommer, Blair H. Smith, Rolf-Detlef Treede
Article
Anesthesiology
Miroslav 'Misha'' Backonja, Nadine Attal, Ralf Baron, Didier Bouhassira, Mark Drangholt, Peter J. Dyck, Robert R. Edwards, Roy Freeman, Richard Gracely, Maija H. Haanpaa, Per Hansson, Samar M. Hatem, Elena K. Krumova, Troels S. Jensen, Christoph Maier, Gerard Mick, Andrew S. Rice, Roman Rolke, Rolf-Detlef Treede, Jordi Serra, Thomas Toelle, Valeri Tugnoli, David Walk, Mark S. Walalce, Mark Ware, David Yarnitsky, Dan Ziegler
Review
Anesthesiology
Per Hansson
Article
Anesthesiology
Ralf Baron, Misha M. Backonja, Paul Eldridge, Robert Levy, Kris Vissers, Nadine Attal, Eric Buchser, Giorgio Cruccu, Jose De Andres, Per Hansson, Marilyn Jacobs, John D. Loeser, Joshua P. Prager, Michael Stanton Hicks, Antoine Regnault, Carine Van den Abeele, Rod S. Taylor
Article
Clinical Neurology
Monika Samuelsson, Ann-Sofie Leffler, Per Hansson
SCANDINAVIAN JOURNAL OF PAIN
(2011)
Article
Clinical Neurology
Asa H. Landerholm, Per T. Hansson
SCANDINAVIAN JOURNAL OF PAIN
(2011)