Article
Clinical Neurology
Julia Koch, Kira Willemsen, Imis Dogan, Roman Rolke, Joerg B. Schulz, Johannes Schiefer, Kathrin Reetz, Andrea Maier
Summary: The study revealed autonomic dysfunction and somatosensory impairment, along with decreased norepinephrine levels in iRBD patients, which may serve as a possible prodromal marker for developing alpha-synucleinopathy.
JOURNAL OF NEUROLOGY
(2022)
Article
Anesthesiology
Jessica Pinto Martins do Rio, Juliana Valentim Bittencourt, Leticia Amaral Correa, Rainer Freynhagen, Felipe Jose Jandre dos Reis, Tamiris Barbosa de Melo, Diego Galace, Leandro Alberto Calazans Nogueira
Summary: The study translated and cross-culturally adapted the painDETECT questionnaire into Brazilian Portuguese, with good internal consistency for identifying neuropathic components in pain among Brazilian patients.
BRAZILIAN JOURNAL OF ANESTHESIOLOGY
(2022)
Article
Anesthesiology
Maike F. Dohrn, Christina Dumke, Thorsten Hornemann, Stefan Nikolin, Angelika Lampert, Volker Espenkott, Jan Vollert, Annabelle Ouwenbroek, Martina Zanella, Jorg B. Schulz, Burkhard Gess, Roman Rolke
Summary: Small fiber neuropathies (SFNs) are characterized by dysfunction or degeneration of A delta and C fibers, causing significant health burden. In a study of 100 individuals with idiopathic SFN, neuropathic pain was the most common symptom, and 1-deoxy-sphingolipids in plasma were found to be correlated with sensory loss.
Article
Anesthesiology
Janne Gierthmuehlen, Johann Boehmer, Nadine Attal, Didier Bouhassira, Rainer Freynhagen, Maija Haanpaa, Per Hansson, Troels Staehelin Jensen, Jeffrey Kennedy, Christoph Maier, Andrew S. C. Rice, Juliane Sachau, Marta Segerdahl, Soren Sindrup, Thomas Toelle, Rolf-Detlef Treede, Lise Ventzel, Jan Vollert, Ralf Baron
Summary: Neuropathic pain patients can be categorized into sensory loss, mechanical hyperalgesia, and thermal hyperalgesia phenotypes, which have different impacts on mental health, functionality, and quality of life. Sensory loss patients experience higher pain interference, lower self-reported health state, and more problems with mobility, usual activities, and self-care compared to thermal hyperalgesia patients. These results suggest that the somatosensory phenotype should be considered for personalized pain management.
Article
Anesthesiology
Vera Peuckmann-Post, Carolin Hagedorn, Norbert Krumm, Roman Rolke, Frank Elsner
Summary: The study aimed to examine healthcare professionals' perceptions of morphine/opioid administration for symptom control within different care settings, including palliative care and care for COVID-19 patients. Results indicated that some participants expressed personal views and identified deficiencies in the healthcare system, suggesting the need for unified interdisciplinary guidelines, more education, and support from staff confident in symptom control in the future.
Article
Anesthesiology
Vera Peuckmann-Post, Alexandra Scherg, Norbert Krumm, Carolin Hagedorn, Lukas Radbruch, Andras Keszei, Roman Rolke, Frank Elsner
Summary: German Association for Palliative Medicine (DGP) members perceive uncertainty in handling morphine outside of palliative care settings, especially when caring for COVID-19 patients. Most participants express a desire to involve palliative care consultation teams in the future to address this uncertainty. Uniform interdisciplinary guidelines for symptom control and increased education are suggested to improve the use of opioids in medical fields outside of palliative care.
Article
Anesthesiology
Jens Felix Wagner, Henning Cuhls, Martin Muecke, Rupert Conrad, Lukas Radbruch, Roman Rolke
Summary: This study aimed to assess postoperative pain experience in cognitive deficit patients. The results showed no significant differences in postoperative pain intensity among patients with different cognitive impairments. However, quantitative sensory testing revealed mechanical hyperalgesia in the operated area.
Article
Health Care Sciences & Services
C. Bausewein, F. Hodiamont, N. Berges, A. Ullrich, C. Gerlach, K. Oechsle, B. Pauli, J. Weber, S. Stiel, N. Schneider, N. Krumm, R. Rolke, C. Gebel, M. Jansky, F. Nauck, U. Wedding, B. van Oorschot, C. Roch, L. Werner, M. Fischer, M. Schallenburger, M. C. Reuters, J. Schwartz, M. Neukirchen, A. Guelay, K. Maus, B. Jaspers, L. Radbruch, M. Heckel, I. Klinger, C. Ostgathe, U. Kriesen, C. Junghanss, E. Lehmann, D. Gesell, S. Gauder, C. Boehlke, G. Becker, A. Pralong, J. Strupp, C. Leisse, K. Schloesser, R. Voltz, N. Jung, S. T. Simon
Summary: In the context of the COVID-19 pandemic, general and specialist Palliative Care (PC) play a crucial role in providing symptom control, psycho-social support, and assistance with complex decision making. This study aims to develop a national pandemic plan for the care of seriously ill and dying adults and their informal carers, including guidance for generalist and specialist palliative care, information material for an online platform, and identification of research questions on palliative care in pandemics. The project will utilize mixed-methods research approaches to explore the experiences and challenges faced by patients and their relatives, as well as healthcare professionals and decision makers during the pandemic.
BMC PALLIATIVE CARE
(2022)
Article
Clinical Neurology
Andrea Maier, Romina Kapfenberger, Istvan Katona, Joachim Weis, Jorg B. Schulz, Roman Rolke
Summary: In this retrospective analysis of autoimmune autonomic neuropathy (AAN) patients, it was found that neuropathic pain was not as common as sensory loss. Sensory loss was widely distributed, mainly affecting cold and warm detection thresholds and the thermal sensory limen. Serostatus was not a significant predictor of small fiber deficit in AAN.
JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Sebastian Scheliga, Thilo Kellermann, Angelika Lampert, Roman Rolke, Marc Spehr, Ute Habel
Summary: In this study, a meta-analysis was conducted using multiple sensory modalities to identify a common brain network for multisensory integration. The results revealed the involvement of several brain regions, including the superior temporal gyrus, middle temporal gyrus, thalamus, insula, and inferior frontal gyrus, in this network.
REVIEWS IN THE NEUROSCIENCES
(2023)
Article
Medicine, General & Internal
Norbert Krumm, Cordula Gebel, Lars Kloppenburg, Roman Rolke, Ulrich Wedding
Summary: The study developed a questionnaire based on 33 PALLPAN recommendations, piloted its implementation in nursing homes, and received positive feedback. Facilities found the questionnaire helpful, with feedback highlighting the need for realistic requirements, impracticality of creating a pandemic plan solely for palliative care, and challenges in implementing psychosocial support for staff.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Denver Igharo, Joana C. Thiel, Roman Rolke, Merve Akkaya, Joachim Weis, Istvan Katona, Joerg B. Schulz, Andrea Maier
Summary: This study aimed to investigate the pathophysiological mechanisms of small fiber neuropathy and autonomic neuropathy in hypermobile Ehlers-Danlos Syndromes (hEDS). Skin biopsy, quantitative sensory testing, tilt-table testing, the painDetect, Small Fiber Neuropathy Screening List, and the COMPASS-31 questionnaire were used to assess 31 hEDS patients and 31 healthy controls. The results revealed that 61% of hEDS patients were diagnosed with small fiber neuropathy and 32% fulfilled the criteria for postural tachycardia syndrome (PoTS). Skin biopsy showed significantly reduced nerve fiber density in both proximal and distal regions of hEDS patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Primary Health Care
Sophie Peter, Anna Maria Volkert, Lukas Radbruch, Roman Rolke, Raymond Voltz, Holger Pfaff, Nadine Scholten
Summary: German GPs are generally satisfied with the quality of care provided by specialised PHC teams, but they do not always perceive the cooperation as optimal. There is a need to improve the involvement of GPs in specialised PHC.
EUROPEAN JOURNAL OF GENERAL PRACTICE
(2022)
Article
Neurosciences
Tabea M. Dyong, Burkhard Gess, Christina Dumke, Roman Rolke, Maike F. Dohrn
Summary: Myopathies, specifically muscle pain, are often overlooked rare diseases with limited treatment options. This study retrospectively analyzed the response to carbamazepine treatment for muscle pain in 54 individuals with various myopathies. The results showed that carbamazepine significantly reduced pain levels but was associated with side effects and discontinuation in some patients.
Article
Clinical Neurology
Denver Igharo, Joana C. Thiel, Roman Rolke, Merve Akkaya, Joachim Weis, Istvan Katona, Joerg B. Schulz, Andrea Maier
Summary: This study aimed to understand the pathophysiological mechanisms of small fiber neuropathy and autonomic neuropathy in hypermobile Ehlers-Danlos syndromes. By observing and testing 31 patients with hEDS and 31 healthy controls, it was found that SFN was common in patients with hEDS, with accompanying autonomic dysfunctions. Quantitative sensory testing and skin biopsy results supported SFN as an important underlying mechanism.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
