Article
Immunology
Chia-En Wong, Chia-Ying Hu, Po-Hsuan Lee, Chi-Chen Huang, Han-Wei Huang, Chih-Yuan Huang, Hsin-Tien Lo, Wentai Liu, Jung-Shun Lee
Summary: This study investigated the therapeutic effect of sciatic nerve stimulation (SNS) on acute neuropathic pain (NP) and its underlying mechanism. The results showed that both 2 Hz and 20 Hz SNS could alleviate pain behavior and hyperactivation of pain conducting pathways, reduce neuroinflammation and inflammatory protein expression, suppress astrocytic gliosis and microglia activation, and enhance the activity of the descending pain modulation pathway.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Cell Biology
Giorgio Rizzi, Zhuoliang Li, Norbert Hogrefe, Kelly R. Tan
Summary: This study explored the involvement of midbrain neurons in conditioned learning and how GABA and glutamate cells affect fear-conditioned learning through specific connections. Inhibiting specific sub-circuits of dmCIN neurons led to varying impairments in learning, with Vglut2-expressing cells and Vgat-positive neurons associating with different stimuli. It suggests that each component of the network carries information relevant to different subdomains of the behavioral strategy.
Article
Biochemistry & Molecular Biology
Daiki Masukawa, Satoshi Kitamura, Rei Tajika, Hiraku Uchimura, Masami Arai, Yuuki Takada, Tetsu Arisawa, Momoyo Otaki, Kaori Kanai, Kenta Kobayashi, Tomoyuki Miyazaki, Yoshio Goshima
Summary: Dopamine (DA) is involved in neurological and physiological functions such as motor control. L-3,4-dihydroxyphenylalanine (L-DOPA), traditionally seen as an inert precursor of DA, is now shown to be a neurotransmitter itself.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Neurosciences
Shin Kurose, Manabu Kubota, Keisuke Takahata, Yasuharu Yamamoto, Hironobu Fujiwara, Yasuyuki Kimura, Hiroshi Ito, Hiroyoshi Takeuchi, Masaru Mimura, Tetsuya Suhara, Makoto Higuchi
Summary: Studies on healthy humans have shown unique structural and functional corticostriatal associations involving D-2 receptors, which appear to be partially independent of the nigrostriatal pathway reflected by striatal DAT.
HUMAN BRAIN MAPPING
(2021)
Article
Psychiatry
Lukasz Smigielski, Diana Wotruba, Valerie Treyer, Julian Roessler, Sergi Papiol, Peter Falkai, Edna Gruenblatt, Susanne Walitza, Wulf Roessler
Summary: This study explored the inverse relationship between dopamine signaling and psychotic-like experiences, as well as the impact of childhood trauma and dopamine-regulating genes on this association. The results suggest that environmental and neurobiological influences play a significant role in the origination of psychosis spectrum symptoms.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Behavioral Sciences
Jiaxin Tang, Chengmei Yang, Mengwen Shi, Weihai Chen
Summary: Conditioned avoidance responses (CAR) behavior is a widely used paradigm for studying aversive conditioning and defensive motivation behavior. This study found that activation of dopamine D-2 receptors in the shell of nucleus accumbens evokes CAR behavior, while activation of dopamine D-1 receptors and dorsolateral striatum does not. This suggests that the shell of nucleus accumbens is the critical brain region for dopamine to elicit CAR behavior, and activation of dopamine D-2 receptors in the shell of nucleus accumbens is sufficient and necessary for triggering CAR behavior.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Behavioral Sciences
Luciana Fernandes, Ralf Kleene, Ludovica Congiu, Sandra Freitag, Matthias Kneussel, Gabriele Loers, Melitta Schachner
Summary: Low doses of quinpirole (0.02 mg/kg body weight) induced hypolocomotion of CHL1+/+ and CHL1-/- males and females, but led to a delayed response in CHL1-/- mice. Sulpiride (1 mg/kg body weight) affected locomotion of CHL1-/- females and social interaction of CHL1+/+ females as well as social interactions of CHL1-/- and CHL1+/+ males. Quinpirole increased novelty-seeking behavior of CHL1-/- males compared to CHL1+/+ males. Vehicle-treated CHL1-/- males and females showed enhanced working memory and reduced stress-related behavior.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Clinical Neurology
Aida Marcotti, Jorge Fernandez-Trillo, Alejandro Gonzalez, Marta Vizcaino-Escoto, Pablo Ros-Arlanzon, Luz Romero, Jose Miguel Vela, Ana Gomis, Felix Viana, Elvira de la Pena
Summary: The study reveals that sigma-1 receptor antagonists can regulate TRPA1 channels in nociceptors, reducing pain in a mouse model of oxaliplatin neuropathy. This finding suggests a novel strategy for the treatment of chemotherapy-induced peripheral neuropathy and offers insights for the development of new therapeutics for neuropathic pain.
Article
Multidisciplinary Sciences
Wen-Ling Dai, Yi-Ni Bao, Ji-Fa Fan, Bin Ma, Shan-Shan Li, Wan-Li Zhao, Bo-Yang Yu, Ji-Hua Liu
Summary: The study demonstrates that D1DR and D2DR antagonists reduce NMDAR-mediated spinal neuron activation, alleviate bone cancer pain, and act through the Gq protein and Src pathways.
JOURNAL OF ADVANCED RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Kavya Prasad, Erik F. J. de Vries, Philip H. Elsinga, Rudi A. J. O. Dierckx, Aren van Waarde
Summary: Adenosine and dopamine interact antagonistically in living mammals via adenosine A(2A) and dopamine D-2 receptors. These interactions mainly occur in striatal neurons and astrocytes, and may have therapeutic potential for Parkinson's disease, schizophrenia, substance abuse, and attention deficit-hyperactivity disorder.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Meei-Ling Sheu, Liang-Yi Pan, Jason Sheehan, Meng-Yin Yang, Hung-Chuan Pan
Summary: Neuropathic pain is reduced by AhR activation and aggravated by AhR deletion, indicating the neuroprotective effects of AhR. AhR expression is increased after nerve injury, and AhR agonist omeprazole attenuates nerve damage and inflammation. AhR agonists may have potential in neuropathic pain treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Shi-Hao Gao, Yong Tao, Yang Zhu, Hao Huang, Lin-Lin Shen, Chang-Yue Gao
Summary: The activation of dopamine D2 receptors to reduce excitability of lateral entorhinal cortex fan cells may be a strategy for treating chronic inflammatory pain.
NEUROSCIENCE BULLETIN
(2022)
Article
Neurosciences
Linghua Xie, Hui Wu, Qing Chen, Fang Xu, Hua Li, Qi Xu, Cuicui Jiao, Lihong Sun, Rahim Ullah, Xinzhong Chen
Summary: This study reveals the crucial roles of specific midbrain GABAergic subpopulations in the modulation of pain and anxiety. The sensitivity to pain and anxiety can be altered by manipulating the activity of these neurons. These findings provide new insights into cell type-targeted or subregion-targeted therapies for pain management.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Roger L. Albin, Prabesh Kanel, Teus van Laar, Sygrid van der Zee, Stiven Roytman, Robert A. Koeppe, Peter J. H. Scott, Nicolaas Bohnen
Summary: This study examined the association between regional brain [F-18]FEOBV PET binding and the use of dopamine D2-like receptor agonist drugs in subjects with Parkinson's disease (PD). The results showed that chronic use of D2-like dopamine agonists in PD subjects did not lead to significant alterations in regional brain [F-18]FEOBV binding.
MOLECULAR PHARMACEUTICS
(2022)
Review
Pharmacology & Pharmacy
Jazlyn P. Borges, Katrina Mekhail, Gregory D. Fairn, Costin N. Antonescu, Benjamin E. Steinberg
Summary: Chronic pain is a major public health issue that is often resistant to conventional analgesics. Recent studies have implicated the epidermal growth factor receptor (EGFR) signaling pathway in chronic pain, suggesting potential therapeutic targets for this devastating condition.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Zuyue Chen, Hong Wei, Boriss Sagalajev, Ari Koivisto, Antti Pertoyaara
PHARMACOLOGICAL REPORTS
(2019)
Article
Neurosciences
Jing Lei, Gang Ye, Antti Pertovaara, Hao-Jun You
Article
Neurosciences
Hanna Viisanen, Tuomas O. Lilius, Boriss Sagalajev, Pekka Rauhala, Eija Kalso, Antti Pertovaara
JOURNAL OF NEUROPHYSIOLOGY
(2020)
Article
Neurosciences
Jing Lei, Gang Ye, Antti Pertovaara, Hao-Jun You
Article
Pharmacology & Pharmacy
Hong Wei, Zuyue Chen, Ari Koivisto, Antti Pertovaara
Summary: The study demonstrated that spinal pronociceptive mechanisms activated by endogenous sphingolipids include TRPM3, gap junction coupling, the sigma(1) and NMDA receptors, and DAAO.
PHARMACOLOGICAL REPORTS
(2021)
Article
Clinical Neurology
Meritxell Llorca-Torralba, Carmen Camarena-Delgado, Irene Suarez-Pereira, Lidia Bravo, Patricia Mariscal, Jose Antonio Garcia-Partida, Carolina Lopez-Martin, Hong Wei, Antti Pertovaara, Juan Antonio Mico, Esther Berrocoso
Summary: There is a strong comorbidity between chronic pain and depression. The activation of noradrenergic locus coeruleus neurons is closely related to pain and depression. The time of injury also affects the symptoms, with early injury causing sensory hypersensitivity and long-term pain leading to depressive-like behavior.
Article
Biochemistry & Molecular Biology
Hong Wei, Liisa Ailanen, Miguel Morales, Ari Koivisto, Antti Pertovaara
Summary: This study found that Netrin-1 induces mechanical hypersensitivity through its actions on spinal TRPA1 receptors and pronociceptive RVM ON-like neurons. These findings are important for further understanding the mechanism of action of Netrin-1 in pain processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Behavioral Sciences
Hao-Jun You, Jing Lei, Antti Pertovaara
Summary: The thalamic mediodorsal (MD) and ventromedial (VM) nuclei play crucial roles in discriminating noxious and innocuous peripheral afferents, promoting and inhibiting nociception. Enhancing thalamic VM nucleus activity or reducing thalamic MD nucleus-induced facilitation may be a promising approach for controlling pathological pain effectively.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Neurosciences
Hong Wei, Zuyue Chen, Jing Lei, Hao-Jun You, Antti Pertovaara
Summary: In this study, we investigated the role of spinal neurotransmitter mechanisms in the reduction of mechanical hypersensitivity and ongoing pain-like behavior. Our findings suggest that the CeA contributes to this hyperresponse and that the involvement of certain neurotransmitter systems differs between males and females.
Article
Neurosciences
Hong Wei, Zuyue Chen, Jing Lei, Hao-Jun You, Antti Pertovaara
Summary: In this study, we investigated the potential association between the sex-related difference in mechanical hypersensitivity induced by neuropathy and the discharge rate of medullary pain control neurons. Our experiments were conducted in male and female rats with the spared nerve injury (SNI) model of peripheral neuropathy. We found that the mechanical hypersensitivity induced by SNI was significantly stronger in females than in males, and the discharge rates of pronociceptive RVM ON-like neurons were higher in SNI females while those of antinociceptive RVM OFF-like neurons were lower.
NEUROSCIENCE LETTERS
(2023)
Article
Physiology
Z. Gao, H. Wei, Z. Chen, N. Jalava, A. Koivisto, A. Pertovaara
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2019)
Meeting Abstract
Physiology
Hong Wei, Chen Zuyue, Hugh Chapman, Niina Jalava, Ari Koivisto, Antti Pertovaara
Article
Physiology
N. Bourbia, A. Pertovaara
PHYSIOLOGICAL RESEARCH
(2018)
Review
Chemistry, Medicinal
Ari Koivisto, Niina Jalava, Raymond Bratty, Antti Pertovaara
Article
Pharmacology & Pharmacy
Zuyue Chen, Hong Wei, Antti Pertovaara, Jianhong Wang, Synnove Carlson
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2018)