Article
Immunology
Tatsuma Okazaki, Momoko Matashiro, Gaku Kodama, Takeshi Tshubota, Yoshihito Furusawa, Shin-Ichi Izumi
Summary: Four female Japanese patients with secondary lower limb lymphedema developed cellulitis at their lymphedema lesion following COVID-19 mRNA vaccinations, but no adverse effects were observed at the vaccination site. Three patients developed cellulitis following the first vaccination, with the onset of cellulitis occurring within 0 to 21 days. All patients were treated with oral antibiotics and recovered, but two patients experienced recurrent cellulitis. Therefore, intensive skincare and antibiotic treatment should be considered for prevention and immediate management of cellulitis in lymphedema patients during vaccination.
Article
Infectious Diseases
Diogo de Sousa, Joana Frade, Joao Patrocinio, Joao Borges-Costa, Paulo Filipe
Summary: This study presents two cases of patients with MPX infection complicated by deep skin infection, highlighting the significance of this complication and providing prevention advice.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Virology
Katrin Hartmann, Herman Egberink, Karin Moestl, Diane D. Addie, Sandor Belak, Corine Boucraut-Baralon, Tadeusz Frymus, Albert Lloret, Regina Hofmann-Lehmann, Fulvio Marsilio, Maria Grazia Pennisi, Severine Tasker, Etienne Thiry, Uwe Truyen, Margaret J. Hosie
Summary: Vaccine-associated adverse events (VAAEs), such as feline injection-site sarcomas (FISSs), are rare but can be severe. The European Advisory Board on Cat Diseases (ABCD) provides a comprehensive review on VAAEs in cats, summarizing existing knowledge and filling gaps with expert opinions. The causes of VAAEs include immune reactions, local reactions, administration errors, and manufacturing failures. FISS, the most severe VAAE, can occur after vaccinations or other injections. It is important to understand and minimize the risks associated with vaccination.
Article
Chemistry, Multidisciplinary
Chu-Xin Li, Yongdan Qi, Yingge Chen, Yu Zhang, Bin Li, Jun Feng, Xian-Zheng Zhang
Summary: Morphology tuning is a powerful strategy to modulate the physiological effects of synthetic biomaterials. This study explores the possibility of morphology tuning in microbe-based biochemicals, using Escherichia coli as an example. The results show that adjusting bacterial morphology can enhance immunogenicity and improve delivery profiles, offering a potential strategy for developing more effective vaccines and carriers.
Article
Immunology
Natalia G. C. Vasileiou, Daphne T. Lianou, Charalambia K. Michael, George C. Fthenakis, Vasia S. Mavrogianni
Summary: This review discusses the use of vaccination for preventing bacterial mastitis in ewes, particularly staphylococcal mastitis. The timing of vaccination during the final stage of pregnancy is important for protecting ewes during lambing. Vaccination can bring several benefits including reduced incidence risk of mastitis, increased milk production, and decreased use of antibiotics in flocks.
Review
Ophthalmology
Dayakar Yadalla, Rajagopalan Jayagayathri, Karthikeyan Padmanaban, Rajkumar Ramasamy, Ram Rammohan, Sonam Poonam Nisar, Viji Rangarajan, Vikas Menon
Summary: Infections of the orbit and periorbita are common and can cause significant morbidity. The main causes include infection from neighboring sinuses, trauma, foreign bodies, dental infections, dental procedures, surgeries, and retinal procedures. Gram-positive, Gram-negative organisms, and anaerobes are the main culprits, with Staphylococcus aureus and Streptococcus species being common in children. Orbital cellulitis requires prompt medical attention and imaging tests like CT and MRI to evaluate complications. The loss of vision and systemic sequelae can occur if not treated appropriately.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Medicine, General & Internal
Orapan Aryasit, Supachaya Aunruan, Nuttha Sanghan
Summary: This study aimed to identify predictive factors associated with surgical intervention and visual outcomes of orbital cellulitis. Sinusitis was the most common predisposing factor, and abscess volume strongly predicted surgical intervention. Pre-treatment poor vision and the presence of a relative afferent pupillary defect were significant predictors of worse visual outcomes. Early detection of optic nerve dysfunction and prompt treatment could improve visual prognosis.
Article
Chemistry, Physical
Giovanni Di Liberto, Luis A. Cipriano, Gianfranco Pacchioni
Summary: This article investigates the relationship between metal atoms and their surrounding environment in single atom catalysts (SACs). The numerical experiments reveal that changing the active site or the surrounding environment can lead to significant variations in catalytic activity. The implications of this conclusion for modeling studies of SACs are discussed.
Article
Immunology
Izabela Jeskowiak, Benita Wiatrak, Patrycja Grosman-Dziewiszek, Adam Szelag
Summary: Vaccination is key in limiting the spread of COVID-19, with Poland implementing a National Vaccination Program to ensure safe and effective vaccination among its citizens. Research suggests the need to verify GIS statistical data on post-vaccination reactions, as healthcare workers and individuals with previous COVID-19 infections may experience more severe side effects after vaccination.
Article
Nanoscience & Nanotechnology
Mukarram Mudjahid, Firzan Nainu, Rifka Nurul Utami, Anwar Sam, Ardiyah Nurul Fitri Marzaman, Tri Puspita Roska, Rangga Meidianto Asri, Achmad Himawan, Ryan F. Donnelly, Andi Dian Permana
Summary: One of the challenges in infectious disease treatment is the difficulty of delivering antibacterial drugs to underskin wound tissue. This research combines dissolving microneedles and bacteria-sensitive microparticles to enhance the penetration and targeted delivery of chloramphenicol. The findings show improved antibacterial activity and longer retention duration compared to conventional cream formulation.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Multidisciplinary Sciences
Jiarong Zhou, Nishta Krishnan, Zhongyuan Guo, Christian J. Ventura, Maya Holay, Qiangzhe Zhang, Xiaoli Wei, Weiwei Gao, Ronnie H. Fang, Liangfang Zhang
Summary: This study investigates the effectiveness of a biomimetic nanotoxoid vaccine in protecting immunodeficient animals from Pseudomonas aeruginosa infection. The nanotoxoids utilize a macrophage membrane coating to sequester and present bacterial virulence factors, providing rapid and long-lasting immunity. The nanovaccine can be administered through multiple routes and effectively protects against lethal infections in pneumonia and septicemia models.
Article
Surgery
Stephane Vignes, Florence Poizeau, Alain Dupuy
Summary: This study retrospectively analyzed cellulitis frequency and associated risk factors in patients with limb lymphedema, identifying different risk factors for cellulitis in patients with primary or secondary lymphedema. Recognizing these factors is important for timely treatment of lymphedema patients.
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2022)
Review
Microbiology
Linda A. Lieberman
Summary: Outer membrane vesicles (OMVs) derived from Gram-negative bacteria have various important roles and applications, including bacterial pathogenesis, cell-to-cell communication, gene transfer, quorum sensing, and maintenance of bacterial fitness. OMVs can be modified to express antigens, making them suitable for immunization and potential drug delivery. This review highlights the manipulation of OMVs, their use as vaccines, and novel engineering approaches to expand their applications.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Zheng Quan Toh, Rachel A. Higgins, Nadia Mazarakis, Elysia Abbott, Jordan Nathanielsz, Anne Balloch, Kim Mulholland, Paul V. Licciardi
Summary: Encapsulated bacteria like Streptococcus pneumoniae, Haemophilus influenzae type b, and Neisseria meningitidis cause significant morbidity and mortality in young children, despite available vaccines. Highly specific antibodies are crucial for protection against invasive diseases, and robust assays measuring functional antibodies are essential for vaccine evaluation and data comparison between clinical studies. This review highlights the importance of functional antibody assays in measuring protective immunity.
Review
Veterinary Sciences
James W. Herrmann, Ralph E. Hamor, Caryn E. Plummer
Summary: Retrospective study of thirty-eight dogs diagnosed with retrobulbar cellulitis or abscess from 2007 to 2017 revealed that most cases were medically managed, with common bacterial organisms cultured being gram-negative bacilli, Corynebacterium sp., and alpha-hemolytic Streptococci sp. Antibiotics with highest susceptibility patterns included gentamicin and amoxicillin/clavulanic acid, while no bacteria were susceptible to cefovecin. Three previously unreported organisms associated with orbital cellulitis were identified in this study - Corynebacterium sp., Bacillus sp., and Micrococcus sp.
VETERINARY OPHTHALMOLOGY
(2021)