Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 67, Issue -, Pages 134-146Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2015.01.007
Keywords
Aptamer; Aptamer-based microfluidics; Aptamer-functionalized material; Complex sample; Enrichment; Purification; Sample preparation; Solid-phase extraction; Solid-phase microextraction; Surface-affinity extraction
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Funding
- National Natural Science Foundation of China [21265004, 21465008, 21065003]
- Natural Science Foundation from Guangxi Zhuang Autonomous Region [2014GXNSFAA118063]
- Scientific Research Project, Education Department of the Guangxi Zhuang Autonomous Region [201203YB086]
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Aptamer-functionalized materials (AFMs) are promising specific recognition materials in sample-preparation techniques due to the inherently high affinity and selectivity associated with aptamers, so AFMs attract considerable interest and a wide variety of applications to recognize specific target analytes ranging from small molecules to proteins, cells and even tissues. We briefly introduce sample-preparation techniques and potential applications of aptamers in analytical chemistry, and then briefly discuss the preparation of AFMs. We mainly focus on developments and applications of AFMs in sample-preparation techniques, including AF solid-phase extraction, solid-phase microextraction, and microfluidic sample preparation, and other sample-preparation techniques. We also discuss the challenges and the prospects of AFMs in sample preparation in future developments. (C) 2015 Elsevier B.V. All rights reserved.
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