Article
Medicine, General & Internal
Xiaoyan Yang, Haishuang Sun, Mei Deng, Yicong Chen, Chen Li, Pengxin Yu, Rongguo Zhang, Min Liu, Huaping Dai, Chen Wang
Summary: Dynamic magnetic resonance imaging (D-MRI) can quantitatively study the characteristic of diaphragm and chest wall motion in Chinese people with normal lung function. The chest wall motion is prominent in the anteroposterior direction during both quiet and deep breathing, with the motions of diaphragm apex and posterior diaphragm more prominent than that of the anterior diaphragm. Smoking may affect respiratory muscle mobility.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Genetics & Heredity
Laurike Harlaar, Pierluigi Ciet, Gijs van Tulder, Alice Pittaro, Harmke A. van Kooten, Nadine A. M. E. van der Beek, Esther Brusse, Piotr A. Wielopolski, Marleen de Bruijne, Ans T. van der Ploeg, Harm A. W. M. Tiddens, Pieter A. van Doorn
Summary: This study aimed to identify early signs of diaphragmatic weakness in Pompe patients using chest MRI. Results showed that even in early-stage Pompe disease, the motion of the diaphragm is reduced and the shape is more curved during inspiration. MRI can be used to detect early signs of diaphragmatic weakness in Pompe patients, which might help to select patients for early intervention.
ORPHANET JOURNAL OF RARE DISEASES
(2021)
Article
Physiology
Simon Ho, Kelly Rock, Odessa Addison, Victoria Marchese
Summary: This study explored the relationships between diaphragm ultrasound (DUS), spirometry, and respiratory mouth pressures in healthy children. The findings suggest that DUS parameters are closely related to spirometry and respiratory mouth pressures, supporting the use of DUS as a noninvasive method of respiratory assessment.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2022)
Article
Neurosciences
Matthew J. J. Fogarty, Obaid U. U. Khurram, Carlos B. B. Mantilla, Gary C. C. Sieck
Summary: The study suggests that chronic TrkB kinase inhibition in TrkB(F616) rats results in a significant worsening of diaphragm neuromuscular transmission, which acute BDNF treatment cannot rescue. Additionally, chronic TrkB kinase inhibition does not affect the apposition of pre-synaptic terminals and post-synaptic endplates at diaphragm NMJs.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Neurosciences
Xiaoman Liu, Ying Yang, Jie Jia
Summary: Respiratory muscle ultrasound is a widely used and feasible technique for studying respiratory dysfunction. However, there is limited evidence on the assessment of extra-diaphragmatic inspiratory muscles. Stroke patients often experience decreased respiratory function, and ultrasound can be used to assess the diaphragm and expiratory muscles.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biophysics
Youngjoo Cha, Chanhee Park, Ilbong Park, Samwon Yoon
Summary: This study aimed to investigate the effect of TECAR therapy on diaphragm movement and chest mobility. The results showed that TECAR therapy significantly improved diaphragm movement and chest mobility in patients, providing innovative evidence for clinical treatment.
JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY
(2023)
Article
Medicine, General & Internal
Saloni Pawar, Amitesh Narayan, Shreekanth D. Karnad, Gopala Krishna Alaparthi, Kalyana Chakravarthy Bairapareddy
Summary: This study aimed to assess respiratory muscle strength in Indian children and found differences in inspiratory and expiratory pressure values between genders, with boys showing higher values. Age, height, weight, and BMI were identified as significant factors influencing respiratory muscle strength, with increases in these factors leading to higher values.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Review
Clinical Neurology
Stephan Wenninger, Harrison N. Jones
Summary: This article summarizes the current aspect of hypoventilation syndrome in neuromuscular disorders, including pathophysiology, clinical symptoms, assessment, and treatments. Recent findings show that new therapeutic agents have positive effects on the respiratory system, while symptomatic therapies like mechanical ventilation and respiratory muscle training are crucial for improving patients' quality of life.
CURRENT OPINION IN NEUROLOGY
(2021)
Review
Respiratory System
S. Souto-Miranda, C. Jacome, A. Alves, A. Machado, C. Paixao, A. Oliveira, A. Marques
Summary: This study reviewed predictive equations for maximum inspiratory and expiratory mouth pressures in adults, finding that most equations were developed from unstandardized procedures. Future research should further explore the applicability of these equations and develop new ones for populations where specific equations are not available.
Article
Physiology
Sarah Rives, Bruno Schmid, Guillaume Chaumet, Fabienne Bregeon, Alain Boussuges
Summary: The study aimed to assess changes in diaphragm function induced by an increase in inspiratory load similar to that experienced by military divers in real life. Ultrasound measurements of diaphragm excursion and thickness showed significant increases under inspiratory load conditions, highlighting the potential impact of respiratory load on diaphragm function.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Neurosciences
Miguel Pareja-Cajiao, Heather M. Gransee, Gary C. Sieck, Carlos B. Mantilla
Summary: The results suggest that TrkB signaling is essential for generating maximal forces by the diaphragm muscle in old mice, consistent with the effects of aging on neuromuscular transmission. In older TrkBF616A mice with inhibited TrkB kinase activity, maximal Pdi was found to be about 20% lower compared to vehicle-treated mice. Treatment with the TrkB agonist 7,8-dihydroxyflavone did not have an impact on Pdi generation in old age.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Physiology
Fanny Gabrysz-Forget, Anne-Catherine Maynard-Paquette, Aileen Kharat, Francois Tremblay, Maite Silviet-Carricart, Annick Lavoie, Martin Girard, Bruno-Pierre Dube
Summary: In patients with cystic fibrosis, diaphragm ultrasound can serve as a reliable and non-invasive marker of disease severity, providing information on respiratory and extra-pulmonary manifestations of the disease and clinical outcomes. Further research is needed to explore its potential as a longitudinal marker of disease progression, response to interventions, or therapeutic target.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Ryan J. Hoffman, Hillary W. Garner, Carlos A. Rojas, Rolf A. Grage, Sushilkumar K. Sonavane, Elizabeth M. Johnson, Patricia J. Mergo, Christopher M. Walker, Justin T. Stowell
Summary: Dyspnea is a common symptom in cardiopulmonary diseases, but it can also be caused by overlooked neuromuscular and chest wall conditions. These conditions affect the structure and function of the respiratory pump, leading to respiratory failure and other complications.
JOURNAL OF THORACIC IMAGING
(2022)
Article
Physiology
Toshiyuki Ohya, Kenta Kusanagi, Jun Koizumi, Ryosuke Ando, Keisho Katayama, Yasuhiro Suzuki
Summary: This study found that high-intensity inspiratory muscle strength training equivalent to 50% MIP can improve MIP and swimming performance in highly trained competitive swimmers, especially under controlled frequency breathing conditions.
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE
(2022)
Article
Clinical Neurology
Mary P. Galea
Summary: The review found that respiratory muscle training may lead to improvements in lung function and respiratory muscle strength in some NMD patients, but there was no clinically significant impact on physical functioning and quality of life in ALS patients. The low certainty of the evidence suggests caution in interpreting the results.
NEUROREHABILITATION
(2021)