Journal
TOXICON
Volume 105, Issue -, Pages 10-12Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.toxicon.2015.08.027
Keywords
Zearalenone; Mycotoxin; MCF-7; E-screen assay; Estrogenicity; Isomerization
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Zearalenone and its cis-isomer, cis-zearalenone, are nonsteroidal mycotoxins that elicit an estrogenic response upon binding to the estrogen receptor. This study compares the estrogenicity of eleven congeners including novel metabolites as 15-OH-zearalenone, zearalenone-14-sulfate, alpha-cis-zearalenol and beta-cis-zearalenol using the E-Screen assay. Overall, a change in the configuration from trans to cis retains significant estrogenic activity. In contrast, alterations of the aromatic moiety including hydroxylation and sulfation showed a markedly decreased estrogenicity when compared to zearalenone. (C) 2015 Elsevier Ltd. All rights reserved.
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