Letter
Medicine, General & Internal
Isaac W. Leon-acuna, Takeki Suzuki
Summary: Andrade et al. found that initial catheter cryoballoon ablation strategy resulted in lower incidence of persistent atrial fibrillation and lower arrhythmia burden compared to antiarrhythmic drug therapy in patients with paroxysmal atrial fibrillation during 3 years of follow-up. The study builds upon the findings of the EARLY-AF trial and the STOP AF First trial. Due to the relatively small sample size (303 patients) and short follow-up period, it may be difficult to detect mortality benefits of cryoballoon ablation.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Medicine, General & Internal
Oussama M. Wazni, Gopi Dandamudi, Nitesh Sood, Robert Hoyt, Jaret Tyler, Sarfraz Durrani, Mark Niebauer, Kevin Makati, Blair Halperin, Andre Gauri, Gustavo Morales, Mingyuan Shao, Jeffrey Cerkvenik, Rachelle E. Kaplon, Steven E. Nissen
Summary: In this multicenter trial, cryoballoon ablation as initial therapy was found to be superior to drug therapy in preventing atrial arrhythmia recurrence in patients with paroxysmal atrial fibrillation. Serious procedure-related adverse events were uncommon.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Jason G. Andrade, Oussama M. Wazni, Malte Kuniss, Nathaniel M. Hawkins, Marc W. Deyell, Gian-Battista Chierchia, Steven Nissen, Atul Verma, George A. Wells, Ricky D. Turgeon
Summary: Cryoballoon catheter ablation has been shown to significantly improve arrhythmia outcomes, produce clinically meaningful improvements in patient-reported outcomes, reduce subsequent health care resource use, and not increase the risk of serious adverse events compared with initial antiarrhythmic drug therapy in patients with treatment-naive AF.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
J. G. Andrade, M. W. Deyell, L. Macle, G. A. Wells, M. Bennett, V Essebag, J-F Roux, D. Yung, A. Skanes, Y. Khaykin, C. Morillo, U. Jolly, P. Novak, E. Lockwood, G. Amit, P. Angaran, J. Sapp, S. Wardell, S. Lauck, J. Cadrin-Tourigny, S. Kochhaeuser, A. Verma
Summary: This study evaluated the treatment effect of catheter cryoballoon ablation versus antiarrhythmic drug therapy for initial paroxysmal atrial fibrillation. The results showed that in the 3-year follow-up period, the catheter ablation group had a lower incidence of persistent atrial fibrillation and recurrent atrial tachyarrhythmia compared to the drug therapy group. Additionally, the proportion of time in atrial fibrillation was also lower in the ablation group. Therefore, catheter ablation is recommended as the initial treatment for initial paroxysmal atrial fibrillation.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Florian Straube, Janis Pongratz, Alexander Kosmalla, Benedikt Brueck, Lukas Riess, Stefan Hartl, Christian Tesche, Ullrich Ebersberger, Michael Wankerl, Uwe Dorwarth, Ellen Hoffmann
Summary: Cryoballoon ablation is a reasonable strategy for symptomatic persistent AF in the initial AF ablation procedure, with a high acute isolation success rate. Although there are potential complications and recurrence risks, Cryoballoon ablation has shown good outcomes in the treatment of persistent AF.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Jason G. Andrade, George A. Wells, Marc W. Deyell, Matthew Bennett, Vidal Essebag, Jean Champagne, Jean-Francois Roux, Derek Yung, Allan Skanes, Yaariv Khaykin, Carlos Morillo, Umjeet Jolly, Paul Novak, Evan Lockwood, Guy Amit, Paul Angaran, John Sapp, Stephan Wardell, Sandra Lauck, Laurent Macle, Atul Verma
Summary: In patients with symptomatic, paroxysmal atrial fibrillation, catheter cryoballoon ablation was associated with a significantly lower rate of atrial fibrillation recurrence compared to antiarrhythmic drug therapy. The ablation group also had better outcomes in terms of atrial tachyarrhythmia occurrence and atrial fibrillation burden.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Alvise Del Monte, Luigi Pannone, Antonio Bisignani, Thiago G. Osorio, Saverio Iacopino, Gian-Battista Chierchia, Carlo de Asmundis
Summary: This article provides an overview of the clinical relevance of neuromodulation during pulmonary vein isolation (PVI) with cryoballoon catheter ablation (CB-A) and the relationship between the intrinsic cardiac nervous system (ICNS) and atrial fibrillation (AF) pathophysiology.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Francesco Santoro, Natale Daniele Brunetti, Andreas Rillig, Bruno Reissmann, Christine Lemes, Tilman Maurer, Thomas Fink, Naotaka Hashiguchi, Alessandra Leopizzi, Adriana Mallardi, Shibu Mathew, Feifan Ouyang, Karl-Heinz Kuck, Roland R. Tilz, Andreas Metzner, Christian H. Heeger
Summary: Stroke after catheter ablation of atrial fibrillation is a potential complication with long term consequences. The incidence of stroke after cryoablation is low, with a relative higher prevalence during the first 3 months after the procedure. EHRA score may be an independent predictor of stroke or LAA thrombi.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2021)
Article
Cardiac & Cardiovascular Systems
Yibo Ma, Lanyan Guo, Miaoyang Hu, Qun Yan, Haitao Liu, Fu Yi
Summary: This study compared the efficacy and safety of left atrial appendage occlusion combined with cryoballoon ablation and radiofrequency ablation in high-risk atrial fibrillation patients. The results showed similar peri-device leaks and safety outcomes between the two groups, but the procedure time was significantly reduced in the cryoballoon ablation group.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Lukas Urbanek, Stefano Bordignon, David Schaack, Shaojie Chen, Shota Tohoku, Tolga Han Efe, Ramin Ebrahimi, Francesco Pansera, Jun Hirokami, Karin Plank, Alexander Koch, Britta Schulte-Hahn, Boris Schmidt, Kyoung-Ryul Julian Chun
Summary: This study compared the efficacy and long-term outcomes of cryoballoon (CB) and pulsed field ablation (PFA) in patients with atrial fibrillation (AF). The results showed that PFA had shorter procedure time and no cases of phrenic nerve palsy compared to CB. Importantly, the 12-month success rates were similar for both techniques.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jun Oikawa, Hidehira Fukaya, Takuya Wada, Jun Kishihara, Tetsuro Sato, Gen Matsuura, Hironori Nakamura, Naruya Ishizue, Chikatoshi Katada, Satoshi Tanabe, Shinichi Niwano, Chika Kusano, Junya Ako
Summary: The study investigated the incidence of esophagogastric complications in patients undergoing radiofrequency and cryoballoon catheter ablation for atrial fibrillation. The results showed a higher prevalence of esophageal ulcers in the radiofrequency group compared to the cryoballoon group, with no significant difference in other complications.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Andreea Motoc, Maria-Luiza Luchian, Esther Scheirlynck, Bram Roosens, Hadischat Chameleva, Maxim Gevers, Xavier Galloo, Berlinde von Kemp, Robbert Ramak, Juan Sieira, Carlo de Asmundis, Gian-Battista Chierchia, Julien Magne, Caroline Weytjens, Steven Droogmans, Bernard Cosyns
Summary: Assessment of LA function using strain echocardiography provides additional predictive value for AF recurrence after CBA, especially in patients with non-dilated LA.
Article
Engineering, Electrical & Electronic
Wen Hong, Mengfei Xu, Zhejun Guo, Longchun Wang, Mu Qin, Jingquan Liu
Summary: Compared to traditional radiofrequency ablation, a new cryoablation treatment for atrial fibrillation has shown advantages such as lower re-ablation rate, fewer thrombus, higher efficiency, and increased safety. However, the commercial cryoablation balloon currently requires complex monitoring using an extra guide wire and thermocouples, resulting in errors. In this study, a stretchable and flexible array with electrodes and temperature sensors attached to the cryoballoon's surface is proposed for improved monitoring and feedback during the cryoablation process, simplifying catheterization and facilitating interventional operations.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
Article
Cardiac & Cardiovascular Systems
Ayman Almousa, J. Hunter Mehaffey, Lawrence M. Wei, Amy Simsa, J. W. Awori Hayanga, Chris Cook, J. Scott Rankin, Vinay Badhwar
Summary: This study reports a single-therapy robotic approach to the Cox maze for persistent atrial fibrillation. Longitudinal follow-up showed that this method achieved more than 90% 1-year freedom from stroke, oral anticoagulation, repeat ablation, and recurrent AF without the need for antiarrhythmic drugs.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Alexis Hermida, Jacqueline Burtin, Maciej Kubala, Floriane Fay, Pierre-Marc Lallemand, Otilia Buiciuc, Audrey Lieu, Mustafa Zaitouni, Christophe Beyls, Jean-Sylvain Hermida
Summary: This study compared the effectiveness and complications of cryoballoon pulmonary vein isolation (cryo-PVI) in men and women with atrial fibrillation (AF). It found that a single cryo-PVI procedure for paroxysmal AF had significantly lower success rates in female patients compared to male patients, and female patients were also more likely to experience complications.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Jun Liu, Pihua Fang, Yue Liu, Guoying Lu, Zhi Li, Xiaofeng Li, Yushan Wang
Article
Cardiac & Cardiovascular Systems
H. Wang, J. Liu, P. Fang, S. Lei, X. Li, Y. Hou, S. Zhang
Article
Cardiac & Cardiovascular Systems
Jun Liu, Pi-hua Fang, Yu Hou, Xiao-feng Li, Yue Liu, Yu-shan Wang, Shu Zhang
JOURNAL OF ELECTROCARDIOLOGY
(2010)
Article
Cardiac & Cardiovascular Systems
Jun Liu, Pi-Hua Fang, Samer Dibs, Yu Hou, Xiao-Feng Li, Shu Zhang
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2011)
Article
Cardiac & Cardiovascular Systems
Jun Liu, Yu Xia, Hao Zhang, Xiaofeng Li, Shu Zhang, Pihua Fang
Summary: The study investigated the safety and efficacy of using a second-generation CBA catheter for pulmonary vein isolation and a left atrial appendage closure device in patients with AF. Results showed that the combination procedure was effective in achieving PVI and LAAC, with a reduced rate of AF recurrence in long-term follow-up despite some acute complications during the procedures. Further larger randomized studies are needed to evaluate the overall safety and efficacy of this combined approach.
Article
Cardiac & Cardiovascular Systems
Jun Liu, Hong Yang, Ying Liu, Xiaofeng Li, Hao Zhang, Yu Xia, Yuhe Jia, Pihua Fang, Min Tang, Shu Zhang
JOURNAL OF ELECTROCARDIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Miao Yu, Jun Liu, Hao Zhang, Yu Xia, Xiaofeng Li, Pihua Fang
AMERICAN JOURNAL OF CARDIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Jun Liu, Wenchi Guan, Jinrui Guo, Xiaofeng Li, Yu Xia, Guodong Niu, Yan Yao
Summary: This study investigated the optimal range of quantitative ablation index (AI) value during radiofrequency catheter ablation (RFCA) for superior vena cava (SVC) electrical isolation. The target AI value range of 350-400 was found to be safe and effective for complete SVC isolation, as demonstrated in both the development and validation cohorts.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Hao Zhang, Miao Yu, Yu Xia, Xiaofeng Li, Jun Liu, Pihua Fang
JOURNAL OF ARRHYTHMIA
(2020)
Article
Cardiac & Cardiovascular Systems
Yu Xia, Xiaofeng Li, Hao Zhang, Li Liu, Lijuan Fu, Wei Yan, Qingxia Li, Yukun Zhang, Miao Yu, Jun Liu, Pihua Fang
Meeting Abstract
Cardiac & Cardiovascular Systems
Jun Liu, JinHong, Gerds-Li
Meeting Abstract
Cardiac & Cardiovascular Systems
Yu Hou, Pi-Hua Fang, Yuan Wu, Xiao-Feng Li, Jun Liu, Zhi Li, Sen Lei, Shu Zhang