Article
Food Science & Technology
Wenchen Yu, Jun Gao, Ruobing Hao, Chenjuan Zhang, Hongwei Liu, Jungang Fan, Jie Wei
Summary: The study investigated the therapeutic effects of Aornia melanocarpa Elliot anthocyanins (AMA) in colitis associated colorectal cancer (CRC) using an azoxymethane (AOM)/dextran sulfate sodium (DSS) mouse model and the Caco-2 cell line. AMA was found to inhibit cell proliferation, alleviate colorectal damages, reduce inflammation, and downregulate the mTORC1 signaling pathway in CRC, suggesting a potential protective mechanism for CRC involving decreased GLS and SLC1A5 expression. This study provides theoretical support for further research on colorectal cancer and offers a new direction for the prevention and individualized treatment of CRC.
Article
Food Science & Technology
Jie Wei, Chenjuan Zhang, Xian Tang, Jinpeng Huang, Hongwei Liu, Yin He, Rugang Zhu, Jun Gao
Summary: In this study, network pharmacology was used to predict the possible targets of Aronia melanocarpa Elliot anthocyanins (AMA) and Aloe Polysaccharides (APs) on alcoholic liver disease (ALD), and animal experiments were conducted to explore their mitigation effect and mechanism. It was found that the combination therapy of AMA and APs showed better results in relieving ALD compared to single administration, providing a theoretical basis for their development and utilization.
Article
Cell Biology
Duo-Yao Cao, Jorge F. Giani, Luciana C. Veiras, Ellen A. Bernstein, Derick Okwan-Duodu, Faizan Ahmed, Catherine Bresee, Warren G. Tourtellotte, S. Ananth Karumanchi, Kenneth E. Bernstein, Zakir Khan
Summary: ACE inhibitors can reduce the bacterial killing ability of neutrophils, leading to increased risk of infection.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Food Science & Technology
Wenchen Yu, Jun Gao, Ruobing Hao, Jing Yang, Jie Wei
Summary: The study found that anthocyanins play an important role in digestion and intestinal fermentation, positively regulating the intestinal microbiota. Anthocyanins have significant effects on antioxidation and promoting the growth of beneficial bacteria.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2021)
Review
Biochemistry & Molecular Biology
Bogdan-Stefan Negreanu-Pirjol, Ovidiu Cristian Oprea, Ticuta Negreanu-Pirjol, Florentina Nicoleta Roncea, Ana-Maria Prelipcean, Oana Craciunescu, Andreea Iosageanu, Victoria Artem, Aurora Ranca, Ludmila Motelica, Anca-Cristina Lepadatu, Madalina Cosma, Dan Razvan Popoviciu
Summary: Lonicera caerulaea L. and Aronia melanocarpa (Michx.) Elliot fruits are rich in bioactive compounds and have numerous health benefits. L. caerulea has higher antioxidant activity and ascorbic acid level compared to commonly consumed berries like blackberries and strawberries. A. melanocarpa is known for its high antioxidants content, surpassing other fruits like currants, cranberries, blueberries, elderberries, and gooseberries. This review aims to highlight the potential health benefits of these fruits and promote their cultivation and processing as nutraceutical sources.
Article
Biochemistry & Molecular Biology
Dean Gilham, Audrey L. Smith, Li Fu, Dalia Y. Moore, Abenaya Muralidharan, St. Patrick M. Reid, Stephanie C. Stotz, Jan O. Johansson, Michael Sweeney, Norman C. W. Wong, Ewelina Kulikowski, Dalia El-Gamal
Summary: The study demonstrates that the most clinically advanced BET inhibitor, apabetalone, can downregulate the expression of cell surface receptors, including ACE2 and DPP4, involved in SARS-CoV-2 entry in susceptible cells. Additionally, apabetalone inhibits SARS-CoV-2 infection in vitro at levels comparable to antiviral agents.
Article
Biochemistry & Molecular Biology
Magdalena Efenberger-Szmechtyk, Ilona Galazka-Czarnecka, Anna Otlewska, Agata Czyzowska, Agnieszka Nowak
Summary: The study investigated the potential of Aronia melanocarpa, Chaenomeles superba, and Cornus mas leaf extracts as natural preservatives for pork meat products. The extracts improved microbial quality, reduced bacterial counts, and extended shelf life of the products. The extracts also impacted bacterial biodiversity and improved meat quality parameters such as lipid oxidation and water-holding capacity.
Article
Food Science & Technology
Maria Cinta Roda-Serrat, Behnaz Razi Parjikolaei, Mehrdad Mohammadifakhr, Juncal Martin, Birgir Norddahl, Massimiliano Errico
Summary: This study focused on the extraction and purification of anthocyanins from chokeberry pomace using enzyme-assisted extraction and adsorption-desorption techniques, while stabilizing the extracts through co-pigmentation. The recovery of anthocyanins was high with minimal impact on their concentration and antioxidant activity, showcasing the potential for producing natural food colorants with enhanced properties.
Article
Biochemistry & Molecular Biology
Yishan Fu, Fei Pan, Lei Zhao, Shuai Zhao, Junjie Yi, Shengbao Cai
Summary: This study demonstrates the interfering effects and potential mechanisms of compounds from Lianqiao leaves, particularly forsythoside A, on the bioactivities of key proteins of COVID-19 and its variants. Forsythoside A shows strong binding affinity with the viral proteins and has antiviral properties. It also protects endothelial cells and maintains their integrity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Medicine, Research & Experimental
Mauro G. Silva, Gerardo R. Corradi, Juan Perez Duhalde, Myriam Nunez, Eliana M. Cela, Daniel H. Gonzales Maglio, Ana Brizzio, Martin R. Salazar, Walter G. Espeche, Mariela M. Gironacci
Summary: This study found that COVID-19 patients have higher levels of ACE2 expression and enzymatic activity in their blood compared to healthy individuals, while levels of AngII and Ang-(1-7) are lower. Even when excluding COVID-19 patients under RAS blockade treatment, ACE2 expression and enzymatic activity remain higher in COVID-19 patients, suggesting the involvement of RAS in COVID-19.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
DuoYao Cao, Zakir Khan, Xiaomo Li, Suguru Saito, Ellen A. Bernstein, Aaron R. Victor, Faizan Ahmed, Aoi O. Hoshi, Luciana C. Veiras, Tomohiro Shibata, Mingtian Che, Lei Cai, Ryan E. Temel, Jorge F. Giani, Daniel J. Luthringer, Ajit S. Divakaruni, Derick Okwan-Duodu, Kenneth E. Bernstein
Summary: This study found that increased macrophage ACE expression can enhance macrophage lipid metabolism, cholesterol efflux, and phagocytic function, thereby reducing the incidence of atherosclerosis. This finding has important implications for the treatment of cardiovascular disease.
CARDIOVASCULAR RESEARCH
(2023)
Article
Agriculture, Multidisciplinary
Yuqi Tong, Li Li, Xianjun Meng
Summary: Nano-encapsulation using APNPs stabilizes anthocyanins to deliver them to tissues and enhance their physiological functions.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Geriatrics & Gerontology
Robert MacLachlan, Patrick Gavin Kehoe, J. Scott Miners
Summary: The activity of angiotensin-converting enzyme-1 (ACE-1) is induced in the early stages of Alzheimer's disease (AD), independently from the normal physiological changes in ACE-1 protein during aging.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Plant Sciences
Ayse Esra Karadag, Sevde Nur Biltekin, Betul Demirci, Fatih Demirci, Usman Ghani
Summary: This study evaluates the inhibitory activities of Rosa x damascena and Pelargonium graveolens essential oils, as well as their major constituent geraniol, against various enzymes. Geraniol shows the strongest inhibitory effect on ACE2 enzyme. R. damascena essential oil moderately inhibits cancer cell lines, and P. graveolens essential oil inhibits several cancer cell lines for the first time. Molecular docking reveals that geraniol binds to the active sites of target enzymes similar to known drugs. The findings suggest the potential of geraniol for drug development. The similar biological activities of these essential oils are attributed to their similar phytochemistry.
Article
Multidisciplinary Sciences
Atila Duque Rossi, Joao Locke Ferreira de Araujo, Tailah Bernardo de Almeida, Marcelo Ribeiro-Alves, Camila de Almeida Velozo, Jessica Maciel de Almeida, Isabela de Carvalho Leitao, Samila Natiane Ferreira, Jessica da Silva Oliveira, Hugo Jose Alves, Helena Toledo Scheid, Debora Souza Faffe, Rafael Mello Galliez, Renata Eliane de Avila, Gustavo Gomes Resende, Mauro Martins Teixeira, Orlando da Costa Ferreira Junior, Terezinha Marta P. P. Castineiras, Renan Pedra Souza, Amilcar Tanuri, Renato Santana de Aguiar, Shana Priscila Coutinho Barroso, Cynthia Chester Cardoso
Summary: ACE2 and TMPRSS2 levels are positively correlated with age, which is strongly associated with respiratory distress. Increased ACE2 levels have a protective effect against this outcome, while the TMPRSS2/ACE2 ratio is associated with risk. In modeling COVID-19 severity, the TMPRSS2/ACE2 ratio outperforms ACE2.
SCIENTIFIC REPORTS
(2021)
Review
Biochemical Research Methods
Pawel Krecisz, Kamila Czarnecka, Leszek Krolicki, Elzbieta Mikiciuk-Olasik, Pawel Szymanski
Summary: Radiolabeled peptides are a versatile and expanding group of radiotracers used in various medical fields, with a focus on oncology. They vary in structure and can be utilized for different therapeutic and diagnostic purposes. In addition to oncology, radiolabeled peptides are increasingly being used in rheumatology, cardiac imaging, and neurology.
BIOCONJUGATE CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Agnieszka Pawlos, Mateusz Niedzielski, Paulina Gorzelak-Pabis, Marlena Broncel, Ewelina Wozniak
Summary: The virus responsible for COVID-19 is SARS-CoV-2, which can progress to ARDS; statin therapy may decrease mortality in COVID-19 patients through various mechanisms, but potential side effects should be considered.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Piotr Hamala, Jaroslaw D. Kasprzak, Anna Binkowska, Kamilla Zawitkowska-Witczak, Marlena Broncel, Anna Piekarska, Karina Wierzbowska-Drabik
Summary: The study revealed that long-term alcohol overuse resulted in left ventricular hypertrophy, diastolic and systolic dysfunction. Diminished strain in endocardial and epicardial layers predicted worsened mid-term prognosis.
KARDIOLOGIA POLSKA
(2021)
Article
Biochemistry & Molecular Biology
Magdalena Markowicz-Piasecka, Karol Sadowski, Johanna Huttunen, Joanna Sikora, Kristiina M. Huttunen
Summary: Transporter-mediated cellular uptake of sulfonamide-based derivatives of metformin exhibited strong cytotoxic effects, inducing apoptosis and cell cycle arrest in breast cancer cells. These results suggest the potential of biguanides as anti-cancer agents through effective intracellular transport.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Marcin Kosmalski, Monika Rozycka-Kosmalska, Joanna Sikora, Tadeusz Pietras
Summary: Diabetes mellitus is not a single disease, but a group of diseases characterized by chronic hyperglycemia and risk of tissue and organ damage. The development of diabetes may be due to disorders of insulin secretion or its effects. Certain psychotropic medications can lead to a specific type of diabetes, and there is a bi-directional relationship between diabetes and psychiatric disorders.
POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ
(2021)
Article
Biochemistry & Molecular Biology
Magdalena Markowicz-Piasecka, Johanna Huttunen, Agnieszka Zajda, Joanna Sikora, Kristiina M. Huttunen
Summary: This study presents the synthesis of eight novel sulfonamide-based biguanides and evaluates their anti-cancer effects on breast cancer cells. The synthesized compounds showed stronger cytotoxic properties compared to metformin, with compound 2 exhibiting the highest activity. Compound 2 induces apoptosis and mitochondrial dysfunction, arrests cell cycle, and inhibits cancer cell migration. The study concludes that chemical modification of the biguanide scaffold can improve its anti-neoplastic potential.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Endocrinology & Metabolism
Magdalena Swistek, Marlena Broncel, Paulina Gorzelak-Pabis, Przemyslaw Morawski, Mateusz Fabis, Ewelina Wozniak
Summary: This study retrospective analyzed the prevalence of euthyroid sick syndrome (ESS) in COVID-19 patients and its association with prognosis and mortality. The results showed that ESS patients had higher levels of inflammatory factors, longer hospitalizations, and a higher risk of intubation. ESS was identified as a potential predictor of poor prognosis in COVID-19 patients.
ENDOCRINE PRACTICE
(2022)
Editorial Material
Medicine, General & Internal
Maciej Banach, Jaroslaw Kazmierczak, Przemyslaw Mitkowski, Krystian Wita, Marlena Broncel, Mariusz Gasior, Marek Gierlotka, Robert Gil, Piotr Jankowski, Maciej Niewada, Adam Witkowski
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Medicine, Research & Experimental
Paulina Gorzelak-Pabis, Marlena Broncel, Agnieszka Pawlos, Katarzyna Wojdan, Adrian Gajewski, Maciej Chalubinski, Ewelina Wozniak
Summary: This study aimed to assess the effect of dabigatran on the integrity and inflammatory properties of endothelial cells stimulated by 25-hydroxycholesterol. The results showed that dabigatran can restore endothelial cell integrity disrupted by 25-hydroxycholesterol and reduce the expression of inflammatory cytokines and chemokines.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Maria Podsiedlik, Magdalena Markowicz-Piasecka, Joanna Sikora
Summary: The aim of this study was to assess the potency of selected antipsychotic drugs on the main pathological hallmarks of Alzheimer's disease. The tested antipsychotics showed inhibition on acetylcholinesterase and Aβ aggregation, and exhibited antioxidant properties in cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Agnieszka Zajda, Joanna Sikora, Kristiina M. Huttunen, Magdalena Markowicz-Piasecka
Summary: This study assessed the effects of eight new sulfonamide-based derivatives of metformin on plasma parameters, vascular hemostasis, and endothelial and smooth muscle cell function. The results showed that three of the compounds had the most desirable properties, including safety and glucose utilization. These compounds also had beneficial effects on coagulation parameters.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Magdalena Markowicz-Piasecka, Agata Markiewicz, Patrycja Darlak, Joanna Sikora, Santosh Kumar Adla, Sreelatha Bagina, Kristiina M. Huttunen
Summary: One of the greatest challenges in pharmaceutical treatment of central nervous system diseases is delivering drugs to their target locations in the brain. The blood-brain barrier and other factors make it difficult for drugs to penetrate the brain, but there are specific mechanisms by which certain compounds can cross this barrier. However, limited knowledge and tools have hindered the development of successful brain-targeted drugs.
Review
Immunology
Jakub Kulesza, Ewelina Kulesza, Piotr Kozinski, Wojciech Karpik, Marlena Broncel, Marek Fol
Summary: This paper reviews the research on the potential antiviral effect of the BCG vaccine against the novel coronavirus, but there is still no definitive evidence on its effectiveness.
Article
Biochemistry & Molecular Biology
Agnieszka Pawlos, Marlena Broncel, Ewelina Wozniak, Lukasz Markiewicz, Agnieszka Piastowska-Ciesielska, Paulina Gorzelak-Pabis
Summary: This study aimed to evaluate the impact of SGLT2 inhibitors on the integrity of endothelial cells disrupted by 25-OHC and assess the association with changes in VE-cadherin levels. The results showed that SGLT2 inhibitors, when used in conjunction with 25-OHC, significantly increased endothelial integrity and improved the integrity of endothelial cells disrupted by 25-OHC. This effect was associated with significant improvements in VE-cadherin levels.
Article
Medicine, Research & Experimental
Anna Witkowska, Mateusz Staciwa, Iwona Duraj, Ewelina Wozniak, Marlena Broncel, Paulina Gorzelak-Pabis
Summary: This study aimed to measure serum levels of IL-33 and sST2 in patients with acute coronary syndrome (ACS) at the onset and 3 months after revascularization. The results showed that sST2 levels significantly decreased in all ACS patients after 3 months, while IL-33 levels were higher in STEMI patients at the onset and remained high after 3 months. The findings suggest that assessing the baseline and dynamic changes in IL-33 and sST2 concentrations in ACS patients may be important for diagnosis and understanding of immune mechanisms during an ACS event.
ADVANCES IN MEDICAL SCIENCES
(2023)
