Endoplasmic Reticulum Stress and Parkinson’s Disease: The Role of HRD1 in Averting Apoptosis in Neurodegenerative Disease

Protective Effects of 4-Phenylbutyrate Derivatives on the Neuronal Cell Death and Endoplasmic Reticulum Stress

(2012) Seisuke Mimori et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Therapeutic Targeting of the Endoplasmic Reticulum in Alzheimers Disease

(2012) Wayne Chadwick et al.   Current Alzheimer Research

Mitochondria, oxidative stress and neurodegeneration

(2012) Antonio Federico et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Endoplasmic reticulum stress and insulin resistance post-trauma: similarities to type 2 diabetes

(2011) Marc G. Jeschke et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

HRD1 Levels Increased by Zonisamide Prevented Cell Death and Caspase-3 Activation Caused by Endoplasmic Reticulum Stress in SH-SY5Y Cells

(2011) Tomohiro Omura et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Movement disorders in spinocerebellar ataxias

(2011) Judith van Gaalen et al.   MOVEMENT DISORDERS

The endoplasmic reticulum protein folding factory and its chaperones: new targets for drug discovery?

(2010) Martin McLaughlin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Retrotranslocation of a Misfolded Luminal ER Protein by the Ubiquitin-Ligase Hrd1p

(2010) Pedro Carvalho et al.   CELL

Chemical and Pharmacological Chaperones: Application for Recombinant Protein Production and Protein Folding Diseases

(2010) Rahul S. Rajan et al.   CURRENT MEDICINAL CHEMISTRY

Restoring endoplasmic reticulum function by chemical chaperones: an emerging therapeutic approach for metabolic diseases

(2010) F. Engin et al.   DIABETES OBESITY & METABOLISM

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells

(2010) Sonya G. Fonseca et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of HRD1-Mediated Protein Degradation Causes Amyloid Precursor Protein Accumulation and Amyloid-  Generation

(2010) M. Kaneko et al.   JOURNAL OF NEUROSCIENCE

Clinical implications of gene discovery in Parkinson's disease and parkinsonism

(2010) Christian Wider et al.   MOVEMENT DISORDERS

Parkinson's disease: from monogenic forms to genetic susceptibility factors

(2009) S. Lesage et al.   HUMAN MOLECULAR GENETICS

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

(2009) Wataru Satake et al.   NATURE GENETICS

Genome-wide association study reveals genetic risk underlying Parkinson's disease

(2009) Javier Simón-Sánchez et al.   NATURE GENETICS

A chemical chaperone, sodium 4-phenylbutyric acid, attenuates the pathogenic potency in human α-synuclein A30P+A53T transgenic mice

(2009) Kazuhiko Ono et al.   PARKINSONISM & RELATED DISORDERS

Regulation of LRRK2 Stability by the E3 Ubiquitin Ligase CHIP

(2009) Xiaodong Ding et al.   PLoS One

CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity

(2009) Han Seok Ko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synoviolin promotes IRE1 ubiquitination and degradation in synovial fibroblasts from mice with collagen-induced arthritis

(2008) Beixue Gao et al.   EMBO REPORTS

Pael-R transgenic mice crossed with parkin deficient mice displayed progressive and selective catecholaminergic neuronal loss

(2008) Hua-Qin Wang et al.   JOURNAL OF NEUROCHEMISTRY

Novel Functions of Ubiquitin Ligase HRD1 With Transmembrane and Proline-Rich Domains

(2008) Tomohiro Omura et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

OS-9 and GRP94 deliver mutant α1-antitrypsin to the Hrd1–SEL1L ubiquitin ligase complex for ERAD

(2008) John C. Christianson et al.   NATURE CELL BIOLOGY

The PINK1/Parkin pathway regulates mitochondrial morphology

(2008) A. C. Poole et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila

(2008) H. Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA