Review
Oncology
Prince Ahad Mir, Roohi Mohi-Ud-Din, Nazia Banday, Mudasir Maqbool, Syed Naeim Raza, Saeema Farooq, Suhaib Afzal, Reyaz Hassan Mir
Summary: Cancer is a disease characterized by uncontrolled cell division and abnormal growth due to gene mutations, ranking second as a major cause of death. Drug resistance to current anticancer drugs has led to an increase in cancer incidence, raising concerns about finding effective treatments. Thymoquinone, a bioactive compound derived from Nigella sativa L., has gained significant attention from researchers due to its potential for inhibiting various molecular targets involved in cancer, such as apoptosis initiation, cell cycle arrest, generation of ROS, and targeting multiple kinases like tyrosine kinase, MAPK, and Janus kinase.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Prathiba Gnanasekaran, Anitha Roy, Nagabhishek Sirpu Natesh, Varshini Raman, Priyanka Ganapathy, Madan Kumar Arumugam
Summary: In this study, nano thymoquinone (nTQ) was synthesized and characterized. The results showed that biologically synthesized nTQ exhibited higher activity in removing potential microbial pathogens and increasing cancer cell death compared to chemically synthesized nTQ. These findings may support the use of biosynthesis method of nTQ over the chemosynthesis method.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2021)
Review
Plant Sciences
Siti Hajar Adam, Izuddin Fahmy Abu, Datu Agasi Mohd Kamal, Ami Febriza, Mohd Izhar Ariff Mohd Kashim, Mohd Helmy Mokhtar
Summary: Obesity is a global epidemic with various comorbidities. Conventional treatments have limited effectiveness and undesirable side effects, leading to increased interest in alternative therapies. Nigella sativa is believed to have potential in treating obesity and its complications, although further research is needed to confirm its efficacy and safety.
Review
Biochemistry & Molecular Biology
Mohamad Fawzi Mahomoodally, Muhammad Zakariyyah Aumeeruddy, Lesetja J. Legoabe, Domenico Montesano, Gokhan Zengin
Summary: This systematic review provides a comprehensive analysis of the clinical studies on the efficacy, safety, and mechanism of action of Nigella sativa L. and its compound thymoquinone in diabetes management. The review found that Nigella sativa L. is highly potent in lowering blood glucose levels and thymoquinone, when combined with metformin, showed greater effectiveness in reducing HbA1c and blood glucose levels. The study suggests the potential application of Nigella sativa L. in the management of diabetes and highlights the need for further research on the mechanism of action of thymoquinone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Arslan Shaukat, Arsalan Zaidi, Haseeb Anwar, Nadeem Kizilbash
Summary: This review examines the pharmacological and pharmacokinetic properties of Nigella sativa (NS) as a herbal diabetes medication. It discusses the efficacy and safety of NS in diabetes management, as well as its interaction with oxidative stress.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Safialdin Alsanosi, Ryan A. Sheikh, Sultan Sonbul, Hisham N. Altayb, Afnan S. Batubara, Salman Hosawi, Kaltoom Al-Sakkaf, Omeima Abdullah, Ziad Omran, Mahmoud Alhosin
Summary: Nigella sativa oil, commonly known as black seed oil (BSO), contains the active compound thymoquinone (TQ) which inhibits cell proliferation and induces apoptosis by targeting epigenetic factors and proteins. This study compared the effects of BSO and pure TQ on cancer cells and found that both had similar inhibitory and apoptotic effects. Molecular docking and simulation showed that TQ had good binding affinity to UHRF1 and HDAC1, suggesting it as a promising strategy for epigenetic therapy.
Article
Nutrition & Dietetics
Elisabeth Khaikin, Sigrun Chrubasik-Hausmann, Sebahat Kaya, Benno F. Zimmermann
Summary: This study analyzed the TQ content of commercial black seed oils and black seed oil-containing capsules and found variations in TQ content. The highest TQ content was found in a bottled oil, which may be suitable for clinical studies without causing harm to health. It is recommended to regulate the TQ content of black seed products for consumers to purchase supplements with known ingredients.
Article
Chemistry, Medicinal
Masoumeh Fadishei, Mahboobeh Ghasemzadeh Rahbardar, Mohsen Imenshahidi, Ahmad Mohajeri, Bibi Marjan Razavi, Hossein Hosseinzadeh
Summary: The study found that BPA can lead to abnormalities in blood pressure, lipid profile, hepatic enzymes, and insulin, while supplementation with NSO or TQ can reduce these abnormalities and increase the level of glutathione, providing a certain control over metabolic disorders.
PHYTOTHERAPY RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Amin F. Majdalawieh, Sarah M. Yousef, Imad A. Abu-Yousef
Summary: Atherosclerosis is a prevalent chronic arterial disease characterized by dyslipidemia and inflammation, with Thymoquinone (TQ) from Nigella sativa seeds showing potential as a natural therapeutic agent for its anti-atherosclerotic effects. Studies support TQ's ability to combat key hallmarks of atherosclerosis, such as hyperlipidemia and inflammation, while also preventing foam cell formation. Experimental evidence suggests TQ could be a safe and natural therapeutic option against atherosclerosis and its complications.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Nutrition & Dietetics
Siti Hajar Adam, Noor Mohd Nasri, Mohd Izhar Ariff Mohd Kashim, Erny Haslina Abd Latib, Muhammad Amirul Aiman Ahmad Juhari, Mohd Helmy Mokhtar
Summary: This review gathers and summarizes up-to-date information on the potential health benefits of Nigella sativa on diabetes mellitus and its complications, highlighting its multifactorial activities and therapeutic potential.
FRONTIERS IN NUTRITION
(2022)
Article
Medicine, Research & Experimental
Hilal Alkis, Elif Demir, Mehmet Resit Taysi, Suleyman Sagir, Seyithan Taysi
Summary: Ionizing radiation leads to the release of free radicals into the systemic circulation, causing oxidative stress in distant organs. Naturally occurring antioxidant agents such as Nigella sativa oil (NSO) and thymoquinone (TQ) exhibit protective and antioxidant effects against oxidative damage in the kidney tissue of rats exposed to cranial irradiation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Abdullah Algaissi, Heena Tabassum, Elhan Khan, Sonam Dwivedi, Mohtashim Lohani, Nizar A. Khamjan, Abdullah Farasani, Iffat Zareen Ahmad
Summary: The 5th day germinated sprouts of N. sativa seeds have been found to exhibit HDAC inhibition and antioxidant activity, showing potential as an anticancer agent. The bioactive compound thymoquinone from N. sativa also demonstrated strong binding affinity with HDAC protein.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biology
Rana A. Alamoudi, Soha A. Alamoudi, Ruaa A. Alamoudi
Summary: This study evaluated the antimicrobial efficacy, chelating efficacy, and dissolving capability of the bioactive agent thymoquinone from the Nigella sativa plant. The findings showed that thymoquinone solution exhibited excellent antibacterial effect on endodontic pathogens and did not affect the organic and inorganic tissue inside the root canal. However, its chelating and dissolving effects were relatively weak.
Review
Biochemistry & Molecular Biology
Abdalsalam Kmail, Omar Said, Bashar Saad
Summary: This review examines the latest research on how thymoquinone accelerates wound healing and the mechanisms behind its effectiveness. Thymoquinone has antimicrobial, anti-inflammatory, and antineoplastic activities, making it a potential remedy for skin pathologies. There is sufficient evidence to support the effectiveness of thymoquinone in promoting wound healing, but there is no consensus on the most effective concentrations.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Chemistry, Analytical
Fatemeh Nejabati, Homeira Ebrahimzadeh
Summary: Thymoquinone (TQ), the main constituent of Nigella sativa, was extracted using electrospun nanofibers as a sorbent and detected using a nonenzymatic electrochemical biosensor. The biosensor showed a linear range of 50-1000 mu M and a detection limit of 4.85 mu M, and was successfully applied to human blood serum samples.
MICROCHEMICAL JOURNAL
(2023)
