ROS and RNS Signaling in Heart Disorders: Could Antioxidant Treatment Be Successful?

Resveratrol: a cardioprotective substance

(2011) Joseph M. Wu et al.   Annals of the New York Academy of Sciences

GSK-3β at the crossroads in the signalling of heart preconditioning: implication of mTOR and Wnt pathways

(2011) François Vigneron et al.   CARDIOVASCULAR RESEARCH

Omega-3 Fatty Acids Prevent Pressure Overload–Induced Cardiac Fibrosis Through Activation of Cyclic GMP/Protein Kinase G Signaling in Cardiac Fibroblasts

(2011) Jinghai Chen et al.   CIRCULATION

Probucol Attenuates Cyclophosphamide-induced Oxidative Apoptosis, p53 and Bax Signal Expression in Rat Cardiac Tissues

(2011) Yousif A. Asiri   Oxidative Medicine and Cellular Longevity

Elevated systemic TGF-β impairs aortic vasomotor function through activation of NADPH oxidase-driven superoxide production and leads to hypertension, myocardial remodeling, and increased plaque formation in apoE−/− mice

(2010) Anna Buday et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Role of arachidonic acid, lipoxygenase, and mitochondrial depolarization in reperfusion arrhythmias

(2010) Robert A. Haworth et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Endothelium-Dependent Coronary Vasodilatation Requires NADPH Oxidase-Derived Reactive Oxygen Species

(2010) Jun Feng et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The contribution of reactive oxygen species and p38 mitogen-activated protein kinase to myofilament oxidation and progression of heart failure in rabbits

(2010) P Heusch et al.   BRITISH JOURNAL OF PHARMACOLOGY

Oxidative Stress Regulates Left Ventricular PDE5 Expression in the Failing Heart

(2010) Zhongbing Lu et al.   CIRCULATION

Upregulation of Nox4 by Hypertrophic Stimuli Promotes Apoptosis and Mitochondrial Dysfunction in Cardiac Myocytes

(2010) Tetsuro Ago et al.   CIRCULATION RESEARCH

Disruption of Rac1 signaling reduces ischemia–reperfusion injury in the diabetic heart by inhibiting calpain

(2010) Limei Shan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death

(2010) Long Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Activation of cAMP-dependent Signaling Induces Oxidative Modification of the Cardiac Na+-K+Pump and Inhibits Its Activity

(2010) Caroline N. White et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ImpairedS-Nitrosylation of the Ryanodine Receptor Caused by Xanthine Oxidase Activity Contributes to Calcium Leak in Heart Failure

(2010) Daniel R. Gonzalez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FoxO Transcription Factors Promote Cardiomyocyte Survival upon Induction of Oxidative Stress

(2010) Arunima Sengupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Is leptin involved in phagocytic NADPH oxidase overactivity in obesity? Potential clinical implications

(2010) Ana Fortuño et al.   JOURNAL OF HYPERTENSION

Angiotensin II induces afterdepolarizations via reactive oxygen species and calmodulin kinase II signaling

(2010) Zhenghang Zhao et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Oral Administration of L-Arginine in Patients With Angina or Following Myocardial Infarction May Be Protective By Increasing Plasma Superoxide Dismutase and Total Thiols With Reduction in Serum Cholesterol and Xanthine Oxidase

(2010) Pratima Tripathi et al.   Oxidative Medicine and Cellular Longevity

Reactive Oxygen Species and Age-Related Genes p66Shc, Sirtuin, FoxO3 and Klotho in Senescence

(2010) Igor Afanas'ev   Oxidative Medicine and Cellular Longevity

Superoxide scavenging and Akt inhibition in myocardium ameliorate pressure overload-induced NF-κB activation and cardiac hypertrophy

(2010) Shawn D. Hingtgen et al.   PHYSIOLOGICAL GENOMICS

NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis

(2010) M. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart

(2010) J. Kuroda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-fat diet increases NF-κB signaling in the prostate of reporter mice

(2010) Eugene V. Vykhovanets et al.   PROSTATE

Tumor necrosis factor induces matrix metalloproteinases in cardiomyocytes and cardiofibroblasts differentially via superoxide production in a PI3Kγ-dependent manner

(2009) Ahmed E. Awad et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

ERK phosphorylation mediates sildenafil-induced myocardial protection against ischemia-reperfusion injury in mice

(2009) Anindita Das et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE−/− mice

(2009) Courtney P. Judkins et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

MCP-1 causes cardiomyoblast death via autophagy resulting from ER stress caused by oxidative stress generated by inducing a novel zinc-finger protein, MCPIP

(2009) Craig W. Younce et al.   BIOCHEMICAL JOURNAL

The cardioprotective effects elicited by p66Shc ablation demonstrate the crucial role of mitochondrial ROS formation in ischemia/reperfusion injury

(2009) Andrea Carpi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The IκB Kinase β/Nuclear Factor κB Signaling Pathway Protects the Heart From Hemodynamic Stress Mediated by the Regulation of Manganese Superoxide Dismutase Expression

(2009) Shungo Hikoso et al.   CIRCULATION RESEARCH

p66Shc Links α 1 -Adrenergic Receptors to a Reactive Oxygen Species-Dependent AKT-FOXO3A Phosphorylation Pathway in Cardiomyocytes

(2009) Jianfen Guo et al.   CIRCULATION RESEARCH

Role of Glycogen Synthase Kinase-3β in Cardioprotection

(2009) Magdalena Juhaszova et al.   CIRCULATION RESEARCH

Potential Mechanisms of Low Sodium Diet–Induced Cardiac Disease

(2009) Nobuhiro Suematsu et al.   CIRCULATION RESEARCH

Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice

(2009) Nagalingam R. Sundaresan et al.   JOURNAL OF CLINICAL INVESTIGATION

δPKC inhibition or ɛPKC activation repairs endothelial vascular dysfunction by regulating eNOS post-translational modification

(2009) Martina Monti et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Nitric oxide and nitric oxide synthase isoforms in the normal, hypertrophic, and failing heart

(2009) Soban Umar et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Role of CuZn superoxide dismutase on carotid body function in heart failure rabbits

(2008) Y. Ding et al.   CARDIOVASCULAR RESEARCH

Heme Oxygenase-1 Regulates Cardiac Mitochondrial Biogenesis via Nrf2-Mediated Transcriptional Control of Nuclear Respiratory Factor-1

(2008) Claude A. Piantadosi et al.   CIRCULATION RESEARCH

Extracellular superoxide dismutase protects the heart against oxidative stress and hypertrophy after myocardial infarction

(2008) Elza D. van Deel et al.   FREE RADICAL BIOLOGY AND MEDICINE

TNF-induced mitochondrial damage: a link between mitochondrial complex I activity and left ventricular dysfunction

(2008) Nithya Mariappan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Crocetin protects against cardiac hypertrophy by blocking MEK-ERK1/2 signalling pathway

(2008) Jun Cai et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Differential roles of p38-MAPK and JNKs in mediating early protection or apoptosis in the hyperthermic perfused amphibian heart

(2008) C. Gaitanaki et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat heart mitochondria

(2007) Qun Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY