Review
Medicine, Research & Experimental
Benjamin D. D. Lovin, Alex J. J. Wilkinson, Yun Qing, Mike Hernandez, Marc-Elie Nader, Shaan Raza, Franco DeMonte, Paul W. W. Gidley
Summary: This study systematically reviewed and evaluated the potential impact of metformin on vestibular schwannoma (VS) growth. The results suggest that metformin may reduce the odds of VS growth. A randomized trial is needed to determine the unbiased effect of metformin on VS growth.
Article
Otorhinolaryngology
Yin Ren, Kareem O. Tawfik, Bill J. Mastrodimos, Roberto A. Cueva
Summary: Radiographic predictors such as tumor size and extension relative to the internal auditory canal play a significant role in hearing preservation after retrosigmoid resection of vestibular schwannomas. Patients with small intracanalicular tumors and good preoperative hearing have the highest rates of hearing preservation, while tumors extending into the cerebellopontine angle may have worse outcomes if they have greater posterior and caudal extension relative to the internal auditory canal.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Review
Biochemistry & Molecular Biology
Diego Cazzador, Laura Astolfi, Antonio Daloiso, Giulia Tealdo, Edi Simoni, Antonio Mazzoni, Elisabetta Zanoletti, Gino Marioni
Summary: Although there have been improvements in the diagnosis and treatment of vestibular schwannomas (VSs) in recent years, no factors have been identified as predictive of tumor growth. The tumor microenvironment (TME) plays a key role in tumorigenesis, drug response, and treatment outcome. This review aims to assess the current knowledge on TME in sporadic VSs, and highlights the need for further studies to identify TME-related biomarkers and therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Otorhinolaryngology
Sophia Tran, Daniel E. Killeen, Shafeen Qazi, Sanjana Balachandra, Jacob B. Hunter
Summary: This study assessed the impact of medication use, specifically statin, metformin, and aspirin, on the growth of vestibular schwannomas (VSs), and found that metformin is associated with reduced VS growth.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Geriatrics & Gerontology
Xueyun Deng, Lihua Liu, Jiuhong Li, Hui Yao, Shuai He, Zhiwei Guo, Jiayu Sun, Wenke Liu, Xuhui Hui
Summary: Patients with acoustic neuroma show cognitive impairments in various domains, including memory, executive function, attention, and processing speed compared to healthy controls. Changes in the structural brain network, especially the efficiency of subnetworks and fiber connections, are associated with cognitive impairments in these patients. Including neuropsychological aspects in clinical evaluation and appropriate treatments may help improve the life quality of patients with acoustic neuroma.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Clinical Neurology
Max Whitmeyer, Bledi C. Brahimaj, Andre Beer-Furlan, Sameer Alvi, Madeline J. Epsten, Fred Crawford, Richard W. Byrne, R. Mark Wiet
Summary: This study focused on evaluating the outcomes of salvage microsurgery (MS) after stereotactic radiosurgery (SRS) for vestibular schwannomas (VS) based on a review of 20 studies and 300 cases. The primary indication for salvage surgery was tumor growth after an average of 39.4 months post-radiation. The study found no significant differences in outcomes based on surgical approach, but patients who underwent subtotal resection (STR) showed better House-Brackmann outcomes compared to those who had gross-total resection (GTR).
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Jason Gurewitz, Zane Schnurman, Aya Nakamura, Ralph E. Navarro, Dev N. Patel, Sean O. McMenomey, J. Thomas Roland, John G. Golfinos, Douglas Kondziolka
Summary: This study aimed to investigate the relationship between hearing loss and tumor volumetric growth rates in patients with untreated vestibular schwannoma (VS). The results showed that larger initial tumor size and faster tumor growth rates were associated with an elevated risk of loss of class A and serviceable hearing.
JOURNAL OF NEUROSURGERY
(2022)
Review
Clinical Neurology
Mingbin Bao, Yunsen He, Ye Tao, Li Liu, Yuheng Li, Yongjun Zhu, Qinjiang Huang, Mengjun Zhang, Bo Wu, Hao Wang
Summary: This article reports a case of a giant vestibular schwannoma during pregnancy, highlighting the importance of early diagnosis and treatment, and providing insights into the optimal timing for surgery.
FRONTIERS IN NEUROLOGY
(2023)
Review
Clinical Neurology
Paolo di Russo, Arianna Fava, Alberto Vandenbulcke, Akinori Miyakoshi, Michihiro Kohno, Alexander Evins, Vincenzo Esposito, Roberta Morace
Summary: Hydrocephalus can be associated with vestibular schwannoma and may spontaneously resolve after tumor removal. Treatment options vary, but removal of the schwannoma is considered the optimal management approach. Patients with smaller tumors and lower CSF protein levels are at higher risk for persistent hydrocephalus.
NEUROSURGICAL REVIEW
(2021)
Article
Otorhinolaryngology
Yin Ren, Bridget MacDonald, Kareem O. Tawfik, Marc S. Schwartz, Rick A. Friedman
Summary: Clinical predictors of facial nerve outcomes after microsurgical resection of vestibular schwannoma were identified, indicating excellent outcomes can be achieved with this procedure. Gross total resection and >= 100-mu V intraoperative FN electromyographic response were found to predict excellent FN outcomes.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Otorhinolaryngology
Brian Kellermeyer, Erica Haught, Tyler Harper, Stephen Wetmore
Summary: This retrospective study investigated acoustic neuroma patients with vestibular schwannoma (VS) and normal or symmetric hearing loss from 1999 to 2012. The most common presenting symptom in these patients was dizziness, and 40% of them showed tumor growth. The study highlighted the importance of monitoring tumor growth in patients with VS who do not exhibit unilateral hearing loss.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2021)
Review
Oncology
Umberto Tosi, Omri Maayan, Anjile An, Miguel E. Tusa Lavieri, Sergio W. Guadix, Antonio P. DeRosa, Paul J. Christos, Susan Pannullo, Philip E. Stieg, Andrew Brandmaier, Jonathan P. S. Knisely, Rohan Ramakrishna
Summary: Treatment of NF2-associated vestibular schwannomas remains challenging, as stereotactic radiosurgery results in impaired hearing and worse cranial nerve comorbidities.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Kuan-Wei Chiang, Sanford P. C. Hsu, Tsui-Fen Yang, Mao-Che Wang
Summary: This study investigated the impact of the extent of internal acoustic meatus tumor removal on large acoustic neuroma surgery outcomes, finding a correlation with poor postoperative facial function. Younger age, larger tumors requiring radiosurgery, and more extensive tumor removal were associated with better tumor control.
Article
Clinical Neurology
Conrad Josef Villafuerte, David B. Shultz, Normand Laperriere, Fred Gentili, Robert Heaton, Monique van Prooijen, Michael D. Cusimano, Mojgan Hodaie, Michael Schwartz, Alejandro Berlin, David Payne, Suneil K. Kalia, Mark Bernstein, Justin Wang, Gelareh Zadeh, Julian Spears, Derek S. Tsang
Summary: Calibration dose rate and BED were not significantly associated with tumor control or edema post SRS treatment for acoustic neuroma. Salvage SRS and larger tumors were correlated with higher local failure rates, while cystic tumors were associated with lower local failure rates.
WORLD NEUROSURGERY
(2021)
Article
Otorhinolaryngology
Jungho Ha, Hantai Kim, Ga Young Gu, Young Jae Song, Jeong Hun Jang, Hun Yi Park, Yun-Hoon Choung
Summary: Simultaneous cochlear implantation (CI) and intracochlear schwannoma removal can successfully remove the tumor and achieve good hearing performance.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)