Review
Clinical Neurology
Vera Ong, Ashley B. Zhang, Bayard Wilson, Nolan J. Brown, Brian V. Lien, Shane Shahrestani, Isaac Yang
Summary: This study provides a bibliometric analysis of hearing preservation in treating vestibular schwannomas, revealing a lack of prospective studies and novel treatment options in the current literature.
WORLD NEUROSURGERY
(2022)
Article
Otorhinolaryngology
Yin Ren, Kareem O. Tawfik, Bill J. Mastrodimos, Roberto A. Cueva
Summary: Radiographic predictors such as tumor size and extension relative to the internal auditory canal play a significant role in hearing preservation after retrosigmoid resection of vestibular schwannomas. Patients with small intracanalicular tumors and good preoperative hearing have the highest rates of hearing preservation, while tumors extending into the cerebellopontine angle may have worse outcomes if they have greater posterior and caudal extension relative to the internal auditory canal.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Clinical Neurology
Nickalus R. Khan, Turki Elarjani, Aria M. Jamshidi, Stephanie H. Chen, Clifford S. Brown, Josh Abecassis, Michael A. Silva, Victor M. Lu, Eva Wu, Monica Diaz-Kanelidis, Rita Bhatia, Michael E. Hoffer, Adrien A. Eshraghi, Christine T. Dinh, Simon I. Angeli, Fred F. Telischi, Jacques J. Morcos
Summary: This study retrospectively evaluated the clinical and surgical outcomes of a large surgical series of vestibular schwannoma in North America over 20 years. The study found that facial nerve outcomes were correlated with cerebellopontine angle extension, tumor volume, facial nerve stimulation threshold, facial nerve consistency, preoperative facial nerve function, and history of a prior resection. The data supports a continuation of a strategy of gross total resection, modifiable by intraoperative findings and judgment.
WORLD NEUROSURGERY
(2022)
Article
Medicine, Research & Experimental
Christian Scheller, Christian Strauss, Sandra Leisz, Pia Hanel, Ariane Klemm, Simone Kowoll, Iris Boselt, Torsten Rahne, Andreas Wienke
Summary: The study investigated the efficacy and safety of prophylactic nimodipine treatment for hearing preservation in vestibular schwannoma surgery, with potential positive effects on hearing and potential recommendation for routine medication in the future.
Article
Clinical Neurology
Ricardo Ramina, Gustavo S. Jung, Felipe Constanzo, Erasmo Barros da Silva Jr
Summary: The study aimed to evaluate the effect of nerve position within the internal auditory canal on preoperative and postoperative cochlear and facial nerve function in patients with intracanalicular vestibular schwannoma. The study found that patients with tumors located between the vestibular and facial-cochlear nerves had worse outcomes in terms of facial nerve function and hearing preservation after surgery.
JOURNAL OF NEUROSURGERY
(2023)
Review
Clinical Neurology
Amey R. Savardekar, Danielle Terrell, Saudamini J. Lele, Ryan Diaz, Praneeth Reddy Keesari, Krystle Trosclair, Jennifer Kosty, Chiachien Jake Wang, Gale Gardner, Bharat Guthikonda
Summary: A meta-analysis comparing the outcomes of sporadic vestibular schwannoma patients treated with stereotactic radiosurgery (SRS) or microsurgery (MS) revealed comparable results in hearing preservation and tumor control, but a higher occurrence of facial nerve dysfunction in the microsurgery group.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Zane Schnurman, Jason Gurewitz, Eric Smouha, Sean O. McMenomey, J. Thomas Roland, John G. Golfinos, Douglas Kondziolka
Summary: Through propensity score matching, this study found no significant difference in the loss of class A or serviceable hearing between patients managed with SRS or observation alone when controlling for potential confounders.
Article
Clinical Neurology
Akiyoshi Ogino, L. Dade Lunsford, Hao Long, Stephen Johnson, Andrew Faramand, Ajay Niranjan, John C. Flickinger, Hideyuki Kano
Summary: SRS provided sustained tumor control in more than 90% of patients with intracanalicular VS at 10 years and freedom from the need for additional intervention in more than 98% at 10 years. Patients with initially better hearing and smaller VSs had enhanced serviceable hearing preservation during an observation interval up to 10 years after SRS.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Anne Morgan Selleck, Kelli L. Hicks, Kevin D. Brown
Summary: Intralabyrinthine schwannomas differ from intracanalicular schwannomas in the severity of hearing loss at presentation. However, they present in a similar fashion in terms of age, presenting signs and symptoms. Otolaryngologists should have a high suspicion for ILS in patients with asymmetric hearing loss, vertigo, and tinnitus.
OTOLOGY & NEUROTOLOGY
(2022)
Article
Clinical Neurology
Assaf Berger, Juan Diego Alzate, Kenneth Bernstein, Reed Mullen, Sean McMenomey, Daniel Jethanemest, David R. Friedmann, Eric Smouha, Erik P. Sulman, Joshua S. Silverman, J. Thomas Roland, John G. Golfinos, Douglas Kondziolka
Summary: This study evaluates hearing outcomes in patients with vestibular schwannoma (VS) during the modern era of cochlear dose restriction. The results show that factors such as age, baseline GR score, cochlear dose, and biological effective dose are correlated with hearing preservation. Increased tumor-free canal space is associated with better outcomes. Furthermore, patients who meet specific criteria have higher hearing preservation rates compared to the rest of the population.
Review
Clinical Neurology
Marina Neves Cavada, Michael Fook-Ho Lee, Nicholas Emmanuel Jufas, Richard John Harvey, Nirmal P. Patel
Summary: This study conducted a systematic review and meta-analysis on the management of intracanalicular vestibular schwannoma, including 71 studies. The primary outcome revealed that serviceable hearing preservation rates were 31% in the observation group, 56% in the radiotherapy group, and 51% in the surgery group. Facial nerve function was found to be best preserved in both observation and radiotherapy groups.
OTOLOGY & NEUROTOLOGY
(2021)
Article
Clinical Neurology
Kareem O. Tawfik, Marin McDonald, Yin Ren, Omid Moshtaghi, Marc S. Schwartz, Rick A. Friedman
Summary: The study found that preoperative cochlear FIESTA/CISS signal intensity may impact hearing outcomes after surgery for acoustic neuroma. Lower FIESTA/CISS signal ratios were associated with greater declines in hearing, suggesting a potential predictive value for postoperative hearing loss.
OTOLOGY & NEUROTOLOGY
(2021)
Review
Clinical Neurology
Elie Massaad, Nima Hamidi, Jacalynn Goetz, Varun Padmanaban, Christine Mau, Derek Tsang, Fabio Y. de Moraes, Caroline Chung, Brad E. Zacharia, Alireza Mansouri
Summary: The evidence collected demonstrates that radiosurgery for cystic vestibular schwannomas exhibits effective tumor control probabilities similar to solid counterparts. It is necessary to establish consensus definitions and standard criteria in the future to better understand tumor growth patterns, treatment response, as well as long-term neurological and functional outcomes following radiosurgery for cystic vestibular schwannomas.
WORLD NEUROSURGERY
(2021)
Article
Medicine, Research & Experimental
Katherine P. Wallerius, Robert J. Macielak, Skye K. Lawlor, Christine M. Lohse, Brian A. Neff, Jamie J. Van Gompel, Colin L. W. Driscoll, Michael J. Link, Matthew L. Carlson
Summary: The study showed that tumor size is the strongest predictor of hearing preservation after microsurgical resection of sporadic vestibular schwannomas. Approximately 10% of patients with tumors >= 15 mm of cerebellopontine angle extension will retain serviceable hearing after microsurgery, indicating the importance of preoperative assessment and patient counseling.
Article
Clinical Neurology
Olivia A. La Monte, Kareem O. Tawfik, Usman Khan, Marc Schwartz, Rick Friedman
Summary: This study aims to investigate the effect of preoperative hearing on hearing preservation after middle cranial fossa (MCF) approach for resection of vestibular schwannoma (VS) and the impact of hearing preservation on disease-specific quality of life. The results showed that patients with better preoperative hearing had higher rates of hearing preservation, and postoperatively, patients with preserved hearing reported better hearing-related quality of life scores compared to those with hearing loss.
OTOLOGY & NEUROTOLOGY
(2022)
Article
Audiology & Speech-Language Pathology
Nicholas Giuliani, Marlan R. Hansen
Summary: This case study found that for patients with well-preserved hearing and poor performance with a hybrid cochlear implant device, switching back to bilateral hearing aid use can result in better auditory outcomes.
INTERNATIONAL JOURNAL OF AUDIOLOGY
(2022)
Article
Otorhinolaryngology
Kristen L. Seligman, A. Eliot Shearer, Kathy Frees, Carla Nishimura, Diana Kolbe, Camille Dunn, Marlan R. Hansen, Bruce J. Gantz, Richard J. H. Smith
Summary: Comprehensive genetic testing was performed on patients undergoing cochlear implantation, with 28% testing positive for genetic causes of hearing loss. A total of 44 causative genes were identified, with pediatric patients having a higher diagnostic rate. This study sets the foundation for future research on the relationship between genetic variation and cochlear implant performance.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Neurosciences
Viral D. Tejani, Hyejin Yang, Jeong-Seo Kim, Helin Hernandez, Jacob J. Oleson, Marlan R. Hansen, Bruce J. Gantz, Paul J. Abbas, Carolyn J. Brown
Summary: Acoustic hearing can be preserved after cochlear implant surgery, but a delayed loss of residual hearing may occur in some patients, possibly due to increases in electrode impedances associated with intracochlear inflammation/fibrosis. Access resistance rather than polarization impedance appears to drive the increase in total impedances seen with loss of hearing. Studies suggest that intracochlear inflammation may contribute to loss of acoustic hearing in EAS CI users.
JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
(2022)
Article
Medicine, Research & Experimental
Megan J. Jensen, Heba Isaac, Helin Hernandez, Jacob Oleson, Camille Dunn, Bruce J. Gantz, Marlan R. Hansen
Summary: Long-term low frequency hearing preservation is achievable for recipients of Cochlear implants, regardless of gender or device type. Older recipients may experience poorer initial hearing outcomes, but there is no significant difference in the rate of hearing loss over time between older and younger patients. Early hearing loss after implantation does not serve as an indicator for long-term hearing loss.
Article
Otorhinolaryngology
Allan M. Henslee, Christopher R. Kaufmann, Matt D. Andrick, Parker T. Reineke, Viral D. Tejani, Marlan R. Hansen
Summary: An ECochG-guided robotics-assisted CI insertion system was developed to detect real-time drops in ECochG signals during electrode array insertions and immediately alter the insertion motion. This system provides surgeons with a means to monitor and reduce CI insertion-related trauma, potentially improving CI hearing outcomes.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Clinical Neurology
Thomas Lenarz, Andreas Buechner, Bruce Gantz, Marlan Hansen, Viral D. Tejani, Robert Labadie, Brendan O'Connell, Craig Alan Buchman, Carla V. Valenzuela, Oliver F. Adunka, Michael S. Harris, William J. Riggs, Douglas Fitzpatrick, Kanthaiah Koka
Summary: This study compared the intraoperative intra-cochlear electrocochleography (ECochG) with hearing preservation outcomes in cochlear implant (CI) subjects. The results showed a moderate positive correlation between the size of the ECochG drop and the magnitude of pure tone average change. This information can be useful for surgical decision-making regarding electrode insertion and hearing preservation.
OTOLOGY & NEUROTOLOGY
(2022)
Article
Audiology & Speech-Language Pathology
Alexander D. Claussen, Rene Vielman Quevedo, Jonathon R. Kirk, Timon Higgins, Brian Mostaert, Muhammad Taifur Rahman, Jacob Oleson, Reyna Hernandez, Keiko Hirose, Marlan R. Hansen
Summary: This study examined the contributions of surgical trauma, foreign body response, and electrical stimulation to intracochlear fibrosis and the innate immune response to cochlear implantation. The results showed that surgical trauma and the presence of a foreign body can induce an innate immune response and contribute to the development of intracochlear fibrosis.
Review
Audiology & Speech-Language Pathology
Bruce J. Gantz, Marlan Hansen, Camille C. Dunn
Summary: Preservation of residual acoustic hearing is an important concept for individuals with residual low frequency hearing undergoing cochlear implantation. Acoustic plus electric speech processing improves hearing outcomes in quiet, enables melody recognition, preserves spatial hearing if there is acoustic hearing in both ears, and significantly improves hearing in noise.
Review
Audiology & Speech-Language Pathology
Muhammad T. Rahman, Divya A. Chari, Gail Ishiyama, Ivan Lopez, Alicia M. Quesnel, Akira Ishiyama, Joseph B. Nadol, Marlan R. Hansen
Summary: Cochlear implants provide effective auditory rehabilitation for patients with severe to profound sensorineural hearing loss. This article reviews the impact of the inflammatory/foreign body response (FBR) on cochlear implants, the factors affecting the response, and therapeutic strategies to mitigate it. The understanding of the FBR has the potential to improve current cochlear implants and facilitate the development of neural prostheses.
Article
Medicine, Research & Experimental
Armine Kocharyan, Amanda M. Schaefer, Richard J. H. Smith, Marlan R. Hansen
Article
Audiology & Speech-Language Pathology
Osama Tarabichi, Tatiana Correa, Emre Kul, Stacia Phillips, Bahaa Darkazanly, Samuel M. Young Jr, Marlan R. Hansen
Summary: Viral vector gene therapy using Helper-dependent adenoviral vectors (HdAd) shows potential for treating hearing loss. HdAd vectors can express large or multiple genes in a cell-type specific manner. Two HdAd vectors, HdAd5 and a chimeric HdAd 5/35, were created and delivered into mice to evaluate their efficacy in inner ear gene therapy. Both HdAd vectors successfully transduced multiple cell types in the cochlea, suggesting their promise in treating hearing loss.
Article
Audiology & Speech-Language Pathology
Jae-Hee Lee, Hwan Shim, Bruce Gantz, Inyong Choi
Summary: This study investigates the mechanism of speech comprehension in noise for cochlear implant users. By quantifying the attentional modulation of cortical auditory responses and comparing it with speech-in-noise performance, the results show a significant correlation between attentional modulation strength and speech-in-noise performance, suggesting that attentional modulation may serve as a neural marker for predicting the success of cochlear implant users in speech-in-noise listening tests.
Article
Otorhinolaryngology
Alexander D. Claussen, Bruce J. Gantz
Summary: Recent evidence shows that cochlear implantation in advanced otosclerosis leads to consistent, excellent auditory outcomes, but facial nerve stimulation risk may be higher in this population. Pre-operative high resolution CT or MRI imaging can help anticipate surgical challenges and post-operative complications, improving surgical success rates.
CURRENT OTORHINOLARYNGOLOGY REPORTS
(2022)