Article
Clinical Neurology
Stefan Evers
Summary: Martin Luther reported experiencing headache and vertigo attacks. His headache attacks may be diagnosed as migraine, but further evidence is needed. His vertigo attacks may fulfill the criteria for Meniere's disease or vestibular migraine, but more information is required to confirm the diagnoses.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Roberto Teggi, Marco Familiari, Omar Gatti, Mario Bussi
Summary: Meniere's disease (MD) is an inner ear disorder characterized by cochlear symptoms and episodic vertigo. Vestibular migraine (VM) is also a cause of episodic vertigo. Clinical features such as photo-phonophobia, migrainous headache, and positive positional tests can help differentiate between MD and VM.
NEUROLOGICAL SCIENCES
(2021)
Article
Audiology & Speech-Language Pathology
James G. Naples, Drew Soda, Kahlil Rahman, Michael J. Ruckenstein, Kourosh Parham
Summary: This study evaluated the role of prestin and otolin-1 as biomarkers and found differences in their levels between Meniere's disease and vestibular migraine patients. Furthermore, prestin levels were correlated with word recognition scores in Meniere's disease patients, suggesting a potential role as a marker for inner ear function.
Review
Clinical Neurology
Jing-Yu Chen, Zhao-Qi Guo, Jun Wang, Dan Liu, E. Tian, Jia-Qi Guo, Wei-Jia Kong, Su-Lin Zhang
Summary: Meniere's disease is a vertigo disorder characterized by recurrent vertigo, fluctuating hearing loss, tinnitus, or ear fullness. It is important to accurately differentiate Meniere's disease from vestibular migraine for effective treatment. Advances in examination technologies have improved the diagnostic accuracy of differentiating vertigo diseases.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Nese Celebisoy, Aysin Kisabay Ak, Huseyin Nezih Ozdemir, Figen Gokcay, Gulsum Saruhan Durmaz, Dilek Top Karti, Hulya Ertasoglu Toydemir, Vildan Yayla, Ayse Ilksen Colpak Isikay, Irem Erkent, Pinar Ozcelik, Gulden Akdal, Ceyla Atac, Sebnem Bicakci, Eylem Ozaydin Goksu, Feray Gulec Uyaroglu
Summary: This study evaluated demographic and clinical features of 415 patients with vestibular migraine (VM) using a structured questionnaire and clinical examination. The results showed that younger patients experienced more severe headache attacks, while older patients had more severe vertigo attacks. BPPV and MD were commonly associated with VM, and VM/MD patients had higher rates of aural and autonomic symptoms compared to pure VM patients. More than half of the patients had a history of motion sickness, and a family history of migraine was associated with younger onset of migraine headaches and vertigo attacks.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2022)
Article
Otorhinolaryngology
John S. Phillips, Jacob L. Newman, Stephen J. Cox
Summary: This study aims to develop a new technology that can measure key physiological parameters in patients experiencing dizziness, leading to better diagnosis of the symptoms. The authors have been funded and have conducted preliminary research, with promising prospects for the future.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Clinical Neurology
Roeland B. van Leeuwen, Carla Colijn, Babette F. F. van Esch, Tjard R. Schermer
Summary: This study compared the course of vertigo attacks in patients with BRV, MD, and VM over a 3-year follow-up period. The results showed no significant differences in attack-free rates among the three groups, with 67-70% of patients being free of vertigo attacks after the follow-up. MD patients had higher HADS scores compared to BRV patients. The findings suggest that BRV may be a milder variant of VM and MD rather than a separate disease entity.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Julia Dlugaiczyk, Thomas Lempert, Jose Antonio Lopez-Escamez, Roberto Teggi, Michael von Brevern, Alexandre Bisdorff
Summary: Despite the progress in understanding and classifying vestibular disorders, there are still patients with recurrent symptoms that do not fit into recognized syndromes like Meniere's disease or vestibular migraine. These patients with nonspecific symptoms have a clinical presentation more similar to vestibular migraine, with a variety of symptoms and attack durations. However, they do not show a female preponderance seen in vestibular migraine and often have milder vertigo attacks compared to other disorders.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Sun-Uk Lee, Hyo-Jung Kim, Jeong-Yoon Choi, Byung-Jo Kim, Ji-Soo Kim
Summary: Right-beating horizontal nystagmus is usually associated with clockwise torsional nystagmus. This study aimed to determine the etiologies and mechanisms of discordant horizontal-torsional nystagmus. The findings suggest that selective damage may be responsible for the discordant nystagmus.
JOURNAL OF NEUROLOGY
(2022)
Review
Medicine, Research & Experimental
Wandi Xu, Xiaofei Li, Yongdong Song, Ligang Kong, Na Zhang, Jiahui Liu, Guorong Li, Zhaomin Fan, Yafeng Lyu, Daogong Zhang, Haibo Wang, Na Li
Summary: In this review, the association between allergies and Meniere's disease (MD) is discussed from an immunology, pathophysiology, and immunotherapy perspective, highlighting the characteristics in patients and animal models.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Clinical Neurology
Gabor M. Halmagyi, Guelden Akdal, Miriam S. Welgampola, Chao Wang
Summary: Much has changed in the field of neuro-otology since our last review 7 years ago. However, there is still a shortage of practicing neuro-otologists, leading to the reliance on neurologists for the evaluation and treatment of patients with vestibular problems. This review focuses on the common areas that neurologists should be able to manage, such as acute and recurrent spontaneous vertigo, and the future developments in vestibular monitoring and diagnosis using machine learning.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
John S. Phillips, Jacob Newman, Stephen Cox
Summary: This study developed a vestibular telemetry system to aid in the diagnosis of vertigo, showing its ability to differentiate between different inner-ear causes of dizziness such as Meniere's disease, vestibular migraine, and Benign Paroxysmal Positional Vertigo. By analyzing nystagmus data, automated diagnoses can be made based on features like attack frequency, nystagmus duration, and onset triggers.
OTOLOGY & NEUROTOLOGY
(2021)
Article
Neurosciences
Jiake Zhong, Xin Li, Jia Xu, Wenjing Chen, Juanjuan Gao, Xingxing Lu, Sichao Liang, Zhenping Guo, Manlin Lu, Yunshuo Li, Haijin Yi
Summary: Recent research suggests a link between vestibular dysfunction and cognitive impairment. Meniere's disease, a common vestibular disorder, is often associated with hearing loss and emotional stress, which could mediate the relationship between vestibular dysfunction and cognition. This study followed up with MD patients after treatment and found that cognitive decline improved with effective therapy, particularly in relation to the severity of vertigo and its impact on function and physical well-being. These results support the idea that vestibular dysfunction is a potentially modifiable risk factor for cognitive decline.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Ricardo Wegmann-Vicuna, Raquel Manrique-Huarte, Diego Calavia-Gil, Eduardo Martin-Sanz, Pedro Marques, Nicolas Perez-Fernandez
Summary: The reduction in vestibulo-ocular reflex (VOR) gain measured with the video head-impulse test (vHIT) 1 month after the first intratympanic injection can predict the need for additional injections to control vertigo spells in patients with intractable Meniere's disease (MD). Single intratympanic treatment with gentamicin is effective and has limited impact on hearing in MD patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, Research & Experimental
Xiaofei Li, Yafeng Lyu, Yawei Li, Huirong Jian, Jing Wang, Yongdong Song, Ligang Kong, Zhaomin Fan, Haibo Wang, Daogong Zhang
Summary: This study aimed to compare the long-term efficacy of semicircular canal plugging (SCP) with labyrinthectomy in the treatment of advanced Meniere's disease (MD). A retrospective analysis was conducted on 116 MD patients, including auditory and vestibular function tests. The results showed that SCP had a higher rate of hearing preservation and faster vestibular compensation compared to labyrinthectomy.
