Review
Endocrinology & Metabolism
David P. P. Bray, Sai Mannam, Rima S. S. Rindler, Joseph W. W. Quillin, Nelson M. M. Oyesiku
Summary: Acromegaly is a disease caused by excessive levels of growth hormone, usually due to hormone-secreting pituitary adenomas, leading to adverse effects in multiple systems. Diagnosis involves measuring serum growth hormone and IGF-1 levels and obtaining an MRI to evaluate pituitary adenoma function. Complete surgical resection of the growth hormone-secreting adenoma is the preferred treatment for acromegaly, aiming for biochemical remission. Medical and radiation therapies are available if biochemical cure is not achieved after surgery.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, Research & Experimental
Bita Naimi, Alexander Duffy, Emily Garvey, Zachary Urdang, Douglas Farquhar, Patrick Kelly, Christopher Farrell, Mindy Rabinowitz, Marc Rosen, Elina Toskala, James Evans, Gurston Nyquist
Summary: This study investigates national trends in transsphenoidal approaches to pituitary tumors and compares the outcomes of microscopic approach (MA) and endoscopic approach (EA) from 2010 to 2021. The results show an increasing adoption of EA since 2013, and overall improved complication rates for EA compared to MA, potentially due to improving surgeon familiarity and experience.
Article
Clinical Neurology
Marco Ceraudo, Luigi Maria Cavallo, Diego Criminelli Rossi, Domenico Solari, Pasquale Anania, Frank Rikki Canevari, Alessandro Prior, Paolo Cappabianca, Gianluigi Zona
Summary: The study found that anterior nasal packing is commonly adopted in certain conditions, especially when extensive nasal dissection is performed. The choice to use anterior nasal packing should be tailored based on specific conditions, such as acromegaly and Cushing disease. It is an important factor in reducing postoperative sinonasal complications of EESB.
WORLD NEUROSURGERY
(2021)
Article
Medicine, General & Internal
Chao Tao, Gang Cheng, Yunxiang Chen, Peiyuan Gu, Weixing Hu
Summary: This study retrospectively reviewed the tumor characteristics and surgical outcomes of a consecutive series of endoscopic endonasal approach pituitary adenomas resection mainly performed by a single author between March 2018 and June 2019. The results demonstrated that EEA is an effective and safe approach for resecting pituitary adenomas with satisfactory gross total resection rate, near-total resection rate, and endocrinological remission rate, while maintaining minimal nasal injury.
Article
Endocrinology & Metabolism
Hani J. Marcus, Danyal Z. Khan, Anouk Borg, Michael Buchfelder, Justin S. Cetas, Justin W. Collins, Neil L. Dorward, Maria Fleseriu, Mark Gurnell, Mohsen Javadpour, Pamela S. Jones, Chan Hee Koh, Hugo Layard Horsfall, Adam N. Mamelak, Pietro Mortini, William Muirhead, Nelson M. Oyesiku, Theodore H. Schwartz, Saurabh Sinha, Danail Stoyanov, Luis Syro, Georgios Tsermoulas, Adam Williams, Mark J. Winder, Gabriel Zada, Edward R. Laws
Summary: The purpose of surgical workflow analysis is to systematically break down operations into hierarchical components, facilitating education, training, and understanding of surgical variations. Through an international expert panel consensus, a detailed surgical workflow including 40 steps and 4 phases has been generated.
Article
Clinical Neurology
Joseph A. Carnevale, Christopher S. Babu, Jacob L. Goldberg, Reginald Fong, Theodore H. Schwartz
Summary: Visual deterioration after endoscopic endonasal transsphenoidal surgery (EETS) is a rare but serious complication that can be effectively treated if diagnosed and intervened in a timely manner. This study analyzed 1200 cases of EETS and found that early postoperative visual deterioration is most commonly associated with craniopharyngioma. Timely intervention restored vision in 81% of patients.
JOURNAL OF NEUROSURGERY
(2022)
Article
Clinical Neurology
Ryan Delport, James King, Mendel Castle-Kirszbaum, Tony Goldschlager, Carmela Caputo, Yi Yuen Wang
Summary: This study aimed to determine if resection of pituitary adenomas via the endoscopic endo-nasal approach (EEA) improves headaches and investigate factors that may be associated with headaches in patients with pituitary adenoma. The results showed that surgery using this method can significantly improve headaches and patients with cavernous sinus invasion are more likely to experience improvement in headaches.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Iyan Younus, Mina Gerges, Theodore H. Schwartz, Rohan Ramakrishna
Summary: Patients with Medicaid insurance undergoing endonasal endoscopic transsphenoidal surgery for pituitary adenoma tend to have larger tumor diameter, longer postoperative length of stay, higher rate of complications, and increased likelihood of long-term cranial neuropathy. However, there were no statistically significant differences in baseline comorbidities, apoplexy, endocrine outcome, vision outcome, or 30-day readmission.
JOURNAL OF NEUROSURGERY
(2021)
Article
Otorhinolaryngology
Fabio Ferreli, Chiara Lasagna, Luca Canali, Ali Baram, Beatrice C. Bono, Maria Pia Tropeano, Francesca Pirola, Emanuela Morenghi, Giuseppe Mercante, Giuseppe Spriano, Davide Milani, Giovanni Lasio, Giovanni Colombo
Summary: The study compared the sinonasal morbidity and quality of life outcomes in patients undergoing endonasal approach and trans-septal approach for pituitary adenoma surgery. The results showed comparable improvements in sinonasal morbidity and general quality of life for both surgical approaches, allowing surgeons to choose based on their preference.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Clinical Neurology
Moritz Ueberschaer, Sophie Katzendobler, Annamaria Biczok, Michael Schmutzer, Tobias Greve, Joerg-Christian Tonn, Jun Thorsteinsdottir, Walter Rachinger
Summary: The transsphenoidal approach is the standard for treating pituitary adenomas, and using synthetic materials for CSF leak repair and sellar closure can significantly reduce the risk of CSF fistulas and meningitis.
NEUROSURGICAL FOCUS
(2022)
Article
Oncology
Xiaoyu Ji, Xinyu Zhuang, Siyuan Yang, Kai Zhang, Xiaozhe Li, Kun Yuan, Xiaofeng Zhang, Xuebo Sun
Summary: The purpose of this study was to analyze and predict the likelihood of visual field recovery after endoscopic transsphenoidal surgery (ETSS) in patients with pituitary adenoma. The study investigated factors that affect the improvement of visual field defects (VFD) and built a predictive nomogram model based on these risk factors. The study also identified specific recovery regions of the visual field associated with VFD improvement.
FRONTIERS IN ONCOLOGY
(2023)
Article
Endocrinology & Metabolism
In-Ho Jung, Seonah Choi, Cheol Ryong Ku, Sang-Guk Lee, Eun Jig Lee, Sun Ho Kim, Eui Hyun Kim
Summary: This study evaluated the reliability of IGF-1 levels as an alternative for disease monitoring after surgical treatment of acromegaly. The results showed that IGF-1 levels can serve as a reliable alternative to OGTT and play a valuable role in monitoring acromegaly status.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Oncology
Mingjian Lin, Wenbo Wang, Lejian Tang, Yunxiang Zhou, Wencai Li, Jing Xiao, Zhizhu Peng, Xuewei Xia
Summary: The suprasellar extension (SSE) value on sagittal MRI can predict the risk of intracranial infection in patients with suprasellar extended pituitary adenoma after endoscopic endonasal transsphenoidal resection (EETA). Neurosurgeons should pay attention to the imaging characteristics of pituitary adenomas and select appropriate treatment plans based on intraoperative conditions to reduce the incidence of intracranial infection.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Endocrinology & Metabolism
Juan Manuel Canelo Moreno, Elena Dios Fuentes, Eva Venegas Moreno, Pablo Jesus Remon Ruiz, Cristina Munoz Gomez, Ana Pinar Gutierrez, Eugenio Cardenas Valdepenas, Ariel Kaen, Alfonso Soto Moreno
Summary: This study aimed to investigate the prevalence and predictive factors of water and electrolyte disturbances in patients undergoing surgery with an extended endoscopic endonasal approach. The study found a high prevalence of electrolyte disturbances, with most cases being transient hypotonic polyuria and a smaller proportion being transient or permanent diabetes insipidus.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Otorhinolaryngology
Zaid Al-Qurayshi, Douglas M. Bennion, Jeremy D. W. Greenlee, Scott M. Graham
Summary: This study provides a national epidemiological perspective on transsphenoidal approach for pituitary tumors surgery in the United States. The risk of postoperative cerebrospinal fluid (CSF) leak appears to be associated with intrinsic patient factors rather than hospital volume and teaching status.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)