☆ 4.5 Article Proceedings Paper

Implications of head and neck cancer treatment failure in the neck

OTOLARYNGOLOGY-HEAD AND NECK SURGERY (2010)

Journal

OTOLARYNGOLOGY-HEAD AND NECK SURGERY

Volume 142, Issue 5, Pages 722-727

Publisher

SAGE PUBLICATIONS LTD

DOI: 10.1016/j.otohns.2010.01.026

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Otorhinolaryngology Surgery

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Abstract

OBJECTIVE: Study the survival of patients with cervical lymphatic squamous cell carcinoma recurrence. STUDY DESIGN: Review of tumor registry database. SETTING: Academic health science center. SUBJECTS AND METHODS: Forty-seven isolated neck recurrence patients identified from 224 recurrences from a total of 1291 patients treated between 1998 and 2007. The main outcome measurements were neck lymph nodal recurrence, treatment-specific survival, and overall survival. RESULTS: A total of 47 patients had neck recurrence; 10 of the neck recurrence patients (21.3%) had regional disease (N+) at initial presentation. Median survival for patients with neck recurrence was 14.7 months (95% confidence interval [CI] 8.6-18.1 mo), and five-year survival for this group was five percent (95% CI 0%-30%). Neck dissection salvage therapy for neck recurrence resulted in the best survival. CONCLUSION: Neck dissection as a salvage therapy for neck recurrence resulted in the best survival, and there was no survival benefit in terms of whether a patient had a neck dissection or not as his or her initial therapy. (C) 2010 American Academy of Otolaryngology Head and Neck Surgery Foundation. All rights reserved.

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