Journal
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
Volume 139, Issue 2, Pages 195-197Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.otohns.2008.05.013
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OBJECTIVE: To prospectively evaluate the risks of vial contamination after routine clinical use of multiple-dose vials for immunotherapy. STUDY DESIGN: Prospective observational study of immunotherapy vial cultures from June 2007 to January 2008. SETTING: Tertiary care outpatient otolaryngology clinic. RESULTS: Over an 8-month period, 136 consecutive vials were cultured for aerobic and anaerobic bacteria at the 3-month expiration date after regular use in an outpatient allergy clinic and dispensation of multiple doses of injection immunotherapy from each vial. All vials had negative cultures. CONCLUSION: Immunotherapy vials are at low risk to undergo contamination in routine use. Important factors include aseptic technique, bacteriostatic agents, and expiration dating. (C) 2008 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved.
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