Article
Engineering, Biomedical
S. Gamsjaeger, P. Fratzl, E. P. Paschalis
Summary: The study investigated the association between mineral maturity/crystallinity of the youngest crystallites and subsequent mineral accumulation at forming trabecular surfaces in post-menopausal osteoporosis patients. Results indicated differences in crystal size, accumulation rate, and maturation between patients receiving vitamin D and calcium supplementation and treatment-naive patients, which may provide insights into mechanisms contributing to decreased mineral content in post-menopausal osteoporosis.
ACTA BIOMATERIALIA
(2021)
Article
Geriatrics & Gerontology
Dazhi Yang, Jie Tan, Yufeng Long, Kang Huang, Weidong Han, Min Wang, Shizhuang Zhu, Shutong Zeng, Weihong Yi
Summary: A short-sequential treatment of teriparatide followed by alendronate was more effective in preventing refracture and elevating bone mineral density in osteoporotic patients after percutaneous vertebroplasty, compared to the therapy of alendronate alone.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Chemistry, Physical
Michael Kovalev, Alena Nastulyavichus, Ivan Podlesnykh, Nikita Stsepuro, Victoria Pryakhina, Evgeny Greshnyakov, Alexey Serdobintsev, Iliya Gritsenko, Roman Khmelnitskii, Sergey Kudryashov
Summary: The absorption of light in the near-infrared region by Au-hyperdoped Si is observed. Current silicon photodetectors in this range have low efficiency. Through laser hyperdoping of thin amorphous Si films, we characterize the composition, chemical, structural, and IR spectroscopic properties of hyperdoped Si with gold and demonstrate several promising regimes. It is found that the optimal efficiency of impurity-hyperdoped Si materials has not been achieved yet.
Article
Endocrinology & Metabolism
Mei Li, Zhenlin Zhang, Qingyun Xue, Qifu Li, Xiaolan Jin, Jin Dong, Qun Cheng, Li You, Hua Lin, Hai Tang, Lin Shen, Xin Gao, Ji Hu, Aijun Chao, Pengqiu Li, Rui Shi, Shuhui Zheng, Ying Zhang, Xiaojiang Xiong, Wei Yu, Weibo Xia
Summary: The efficacy of generic teriparatide is similar to that of alendronate in improving BMD at the lumbar spine in patients with osteoporosis, providing a new treatment option for the Chinese population.
ARCHIVES OF OSTEOPOROSIS
(2022)
Article
Engineering, Environmental
Zhourui Liu, Manisha Mukherjee, Yichao Wu, Qiaoyun Huang, Peng Cai
Summary: Nano-sized iron oxide minerals, especially goethite, in soil have been found to reduce the viability of E. coli O157:H7, helping to control the spread of human pathogens. Micro-sized goethite exhibited more effective antibacterial activity against the bacteria compared to nano-sized goethite. The antibacterial mechanisms of the two particle sizes differed, with nano-sized goethite causing RNA damage and cell membrane destruction, while micro-sized goethite induced severer membrane damage and less oxidative stress.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Engineering, Biomedical
Lucas Becker, Chuan-En Lu, Ivonne A. Montes-Mojarro, Shannon L. Layland, Suzan Khalil, Ali Nsair, Garry P. Duffy, Falko Fend, Julia Marzi, Katja Schenke-Layland
Summary: Fibrosis is the excessive deposition of collagen type I (COL I) that replaces healthy tissue structures, often caused by chronic inflammation. This study used Raman spectroscopy to identify a spectroscopic biomarker, the subpeak at 1608 cm-1 in the amide I region of COL I Raman spectra, to discriminate fibrotic and non-fibrotic tissues. These findings offer a potential diagnostic approach for non-invasive tracking and monitoring of fibrosis progression.
ACTA BIOMATERIALIA
(2023)
Article
Spectroscopy
Rekha Gautam, Rafay Ahmed, Ezekiel Haugen, Mustafa Unal, Sean Fitzgerald, Sasidhar Uppuganti, Anita Mahadevan-Jansen, Jeffry S. Nyman
Summary: This study investigated the feasibility of using spatially offset Raman spectroscopy (SORS) to acquire Raman bands related to bone fracture resistance. The results showed that autoclaving of femur mid-shafts reduced the yield stress of cortical beams. Autoclaving also affected the Raman characteristics of the organic matrix, but changes in Raman properties related to bone strength could still be detected with SORS.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Biochemical Research Methods
Ali Jaafar, Roman Holomb, Anton Y. Sdobnov, Zsombor Ocskay, Zoltan Jakus, Valery V. Tuchin, Miklos Veres
Summary: The study investigated the effect of tissue optical clearing (TOC) on ex vivo porcine dura mater using confocal Raman microspectroscopy (CRM) to increase probing depth and observe in-depth structure. It found that the TOC process involves three main steps, including tissue dehydration, glycerol penetration, and collagen dissociation, with glycerol significantly affecting collagen hydration. This study is the first to introduce the TOC technique in assisting CRM of ex vivo dura mater in-depth probing.
JOURNAL OF BIOPHOTONICS
(2022)
Article
Pharmacology & Pharmacy
Yujun Qi, Wenyuan Wang, Wenlin Sun, Qiuyin Pan
Summary: The study compared the effects of teriparatide and alendronate in Chinese patients with osteoporosis, finding that teriparatide showed significantly greater improvements in BMD and bone formation biomarkers compared to alendronate, as well as a lower incidence of new fractures. The results suggest that teriparatide is superior to alendronate in increasing BMD, bone formation, and reducing fractures in both male and female patients with osteoporosis.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2021)
Article
Biology
Guillaume Falgayrac, Raffaele Vitale, Yann Delannoy, Helene Behal, Guillaume Penel, Cecile Olejnik, Ludovic Duponchel, Thomas Colard
Summary: This study assessed the early stages of diagenetic processes by monitoring bone composition changes over 12 months using Raman microspectroscopy. The results showed that minerals undergo dissolution-recrystallization and collagen fibers undergo fragmentation.
Article
Geochemistry & Geophysics
Qiuli Yan, Guanghai Shi
Summary: A unique low-crystallinity chalcedony was discovered in the Late Jurassic Zhangjiakou Formation in Longhua County, Hebei Province, China. It is distinct from other chalcedony deposits and occurs as fillings along fragile fractures in the host rock. The chalcedony exhibits specific physical properties and compositional features, with a growth structure that transitions from crystalline to cryptocrystalline, indicating a formation process under low temperature conditions.
Article
Multidisciplinary Sciences
Hartmut H. Malluche, Daniel L. Davenport, Florence Lima, Marie-Claude Monier-Faugere
Summary: This study found that starting osteoporosis treatment with an antiresorber in all patients may not be optimal. Some patients have low bone formation, indicating the need for different treatment strategies.
Article
Environmental Sciences
Anja Giese, Jutta Kerpen, Felix Weber, Juergen Prediger
Summary: The packaging material of bottled water is suspected to be a source of microplastics (MP). This preliminary study focused on the screw cap system in particular for its potential release of microplastics. The results showed that with increased opening and closing of the bottles, there was a significant increase in the release of PP particles, while the concentrations of PE and PET particles remained relatively stable.
Review
Anesthesiology
Marie-Eva Pickering, Rose-Marie Javier, Sandrine Malochet, Gisele Pickering, Jules Desmeules
Summary: This scoping review explores the potential of anti-osteoporosis drugs to provide pain relief in OP management. The findings suggest that these drugs may have analgesic effects due to their local action on bone and modulation of pain sensitization. However, the heterogeneity in study design, endpoints, methodology, comparators, and follow-up duration indicates a need for more rigorous trials and larger real-life studies to optimize pain improvement in OP patients.
EUROPEAN JOURNAL OF PAIN
(2023)
Article
Endocrinology & Metabolism
John G. Damrath, Sharon M. Moe, Joseph M. Wallace
Summary: Chronic kidney disease affects bone quality, and treatment with calcimimetics improves tissue-level bone material properties to prevent bone deterioration.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Chung-Hwan Chen, Abdulaziz H. Elsalmawy, Sophia Ish-Shalom, Seung-Jae Lim, Nadia S. AlAli, Joao L. Cunha-Borges, Huilin Yang, Noemi Casas, Lale Altan, Zhanna Belaya, Fernando Marin, Thomas Moll, Sirel Gurbuz, Alan Brnabic, Imre Pavo, Sandra Florez
Summary: The ALAFOS study evaluated the occurrence of clinical fractures and changes in health status in postmenopausal women treated with teriparatide in Asia, Latin America, and the Middle East. Results showed a significant reduction in new clinical fragility fractures after 6 months of teriparatide treatment, along with improvements in back pain and health-related quality of life.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
J. Vaculik, L. Wenchich, M. Bobelyak, K. Pavelka, J. J. Stepan
Summary: This study confirms the decrease in serum levels of active vitamin D after elective hip replacement surgery by examining the association of changes in calcitriol production. The study also identifies significant correlations between the percent change in the conversion rate of 25(OH)D to 1,25(OH)(2)D, intact to C-terminal FGF23 ratio, and serum iron.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2022)
Article
Endocrinology & Metabolism
E. P. Paschalis, S. Gamsjaeger, D. B. Burr
Summary: This study demonstrates that treatment with clinically relevant doses of PTH can reverse the effects of ovariectomy on bone quality, and these beneficial effects can be sustained even after discontinuation of treatment for six months.
Article
Geriatrics & Gerontology
Maria Butylina, Ursula Foeger-Samwald, Sonja Gamsjaeger, Katharina Wahl-Figlash, Michael Kothmayer, Eleftherios P. Paschalis, Oliver Pusch, Peter Pietschmann
Summary: This study investigates the bone properties of Nothobranchius furzeri, a potential model for age-related osteoporosis. The results show gender differences in bone structure and remodeling, as well as the impact of age on bone properties.
Article
Endocrinology & Metabolism
Nadja Fratzl-Zelman, Markus A. Hartmann, Sonja Gamsjaeger, Stamatia Rokidi, Eleftherios P. Paschalis, Stephane Blouin, Jochen Zwerina
Summary: This study analyzed the effect of Burosumab on bone material properties in XLH patients, finding that it can decrease highly mineralized regions, increase mineralized bone volume, and improve osteomalacia symptoms.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Eleftherios P. Paschalis, Sonja Gamsjaeger, Klaus Klaushofer, Elizabeth Shane, Adi Cohen, Jan Stepan, Imre Pavo, Erik F. Eriksen, Kathleen A. Taylor, David W. Dempster
Summary: The study aimed to assess the effects of TPTD treatment on bone quality indices in postmenopausal osteoporosis patients. The results showed that TPTD treatment can restore the quality of bone mineral and organic matrix.
Article
Multidisciplinary Sciences
Roman Thaler, Farzaneh Khani, Ines Sturmlechner, Sharareh S. Dehghani, Janet M. Denbeigh, Xianhu Zhou, Oksana Pichurin, Amel Dudakovic, Sofia S. Jerez, Jian Zhong, Jeong-Heon Lee, Ramesh Natarajan, Ivo Kalajzic, Yong-hui Jiang, David R. Deyle, Eleftherios P. Paschalis, Barbara M. Misof, Tamas Ordog, Andre J. van Wijnen
Summary: The primary function of vitamin C in bone is not just as a cofactor for collagen synthesis, but also as a global regulator of osteogenesis through epigenetic mechanisms. Deficiency in vitamin C disrupts bone integrity and affects osteogenic differentiation. Vitamin C's epigenetic functions are essential for osteoblastogenesis and bone formation.
NATURE COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
S. Gamsjaeger, F. Rauch, F. H. Glorieux, E. P. Paschalis
Summary: Bone material and compositional properties play a significant role in bone quality and strength. Raman spectroscopic analysis can provide information on the quantity and quality of mineral, organic matrix, and tissue water in bone tissue. This study aimed to establish normative reference data for bone material and compositional properties in the cortical compartment of children and young adults. The findings contribute to the understanding of healthy bone quality and serve as a valuable tool for identifying bone alterations in pediatric diseases.
Review
Biochemistry & Molecular Biology
Ljubomir Vitkov, Jeeshan Singh, Christine Schauer, Bernd Minnich, Jelena Krunic, Hannah Oberthaler, Sonja Gamsjaeger, Martin Herrmann, Jasmin Knopf, Matthias Hannig
Summary: The break of the epithelial barrier of gingiva has been a neglected topic despite its significant role in periodontal pathology and transitory bacteraemia. Mechanically induced bacterial translocation in gingiva has been disregarded despite the knowledge of mechanical force effects on tight junctions in other epithelial tissues. In this review, the bacterial, immune, and mechanical factors responsible for the increased permeability and break of the epithelial barrier of inflamed gingiva are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Zuzana Jackova, Jan J. Stepan, Stepan Coufal, Martin Kostovcik, Natalie Galanova, Zuzana Reiss, Karel Pavelka, Laszlo Wenchich, Hana Hruskova, Miloslav Kverka
Summary: Ovarian hormone deficiency increases the risk of osteoporosis and bone fractures in women, but this study found no specific gut microbiota signature associated with hormone levels. Hormonal therapy after oophorectomy prevented bone loss but had only marginal effects on gut microbiota composition.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Wen Qian, Sonja Gamsjaeger, Eleftherios P. Paschalis, Laura A. Graeff-Armas, Robert R. Recker, Mohammed P. Akhter
Summary: The incidence of diabetes mellitus and its complications is increasing globally, posing a significant burden on healthcare systems and negatively impacting patients' quality of life. The study investigates the relationship between bone quality and fracture risk in type 1 diabetes patients, focusing on material behavior and compositional properties. The findings show differences in mineral maturity, glycosaminoglycan content, and advanced glycation endproducts between type 1 diabetes and control groups, suggesting a deterioration of material strength and compositional properties in type 1 diabetes.
Meeting Abstract
Endocrinology & Metabolism
Eleftherios Paschalis, Sonja Gamsjaeger, Klaus Klaushofer, Elizabeth Shane, Adi Cohen, Jan Stepan, Imre Pavo, Erik Eriksen, Kathleen Taylor, David Dempster
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)