Article
Multidisciplinary Sciences
Irma Karabegovic, Eliana Portilla-Fernandez, Yang Li, Jiantao Ma, Silvana C. E. Maas, Daokun Sun, Emily A. Hu, Brigitte Kuhnel, Yan Zhang, Srikant Ambatipudi, Giovanni Fiorito, Jian Huang, Juan E. Castillo-Fernandez, Kerri L. Wiggins, Niek de Klein, Sara Grioni, Brenton R. Swenson, Silvia Polidoro, Jorien L. Treur, Cyrille Cuenin, Pei-Chien Tsai, Ricardo Costeira, Veronique Chajes, Kim Braun, Niek Verweij, Anja Kretschmer, Lude Franke, Joyce B. J. van Meurs, Andre G. Uitterlinden, Robert J. de Knegt, M. Arfan Ikram, Abbas Dehghan, Annette Peters, Ben Schottker, Sina A. Gharib, Nona Sotoodehnia, Jordana T. Bell, Paul Elliott, Paolo Vineis, Caroline Relton, Zdenko Herceg, Hermann Brenner, Melanie Waldenberger, Casey M. Rebholz, Trudy Voortman, Qiuwei Pan, Myriam Fornage, Daniel Levy, Manfred Kayser, Mohsen Ghanbari
Summary: This study found that coffee intake is associated with differential DNA methylation levels at multiple CpGs in a large cohort of European and African-American participants from 15 cohorts.
NATURE COMMUNICATIONS
(2021)
Review
Medicine, General & Internal
Chun-Ching Chen, Yu-Ming Shen, Siou-Bi Li, Shu-Wei Huang, Yi-Jie Kuo, Yu-Pin Chen
Summary: This meta-analysis aimed to investigate the relationship between coffee/tea intake and bone mineral density (BMD) and hip fracture risk. The results showed no association between daily coffee/tea consumption and BMD or hip fracture risk.
MEDICINA-LITHUANIA
(2023)
Review
Endocrinology & Metabolism
Indeevar Beeram, Sharri J. Mortensen, Diana Yeritsyan, Kaveh Momenzadeh, Arvind von Keudell, Ara Nazarian
Summary: This study analyzed the association between combined multivitamin use and hip fracture risk, finding that multivitamin use significantly reduces the risk of osteoporotic hip fractures.
ARCHIVES OF OSTEOPOROSIS
(2021)
Review
Nutrition & Dietetics
Ying Zhu, Chun-Xiang Hu, Xu Liu, Rui-Xia Zhu, Ben-Qiao Wang
Summary: This meta-analysis confirms that coffee and tea consumption is associated with a reduced risk of cognitive disorders, with 2.5 cups of coffee per day minimizing the risk of AD and 1 cup of tea per day leading to an 11% reduction in cognitive deficits.
Article
Orthopedics
Bing-Kuan Chen, Yu-Cheng Liu, Chun-Ching Chen, Yu-Pin Chen, Yi-Jie Kuo, Shu-Wei Huang
Summary: This meta-analysis investigated the correlation between perioperative CRP levels and postoperative mortality in patients undergoing hip fracture surgery. The study found that higher preoperative and postoperative CRP levels were associated with an increased risk of mortality following hip fracture surgery. Further research is needed to confirm the ability of CRP to predict postoperative mortality in patients with hip fracture.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Psychiatry
L. S. Ran, W. H. Liu, Y. Y. Fang, S. B. Xu, J. Li, X. Luo, D. J. Pan, M. H. Wang, W. Wang
Summary: The study found that low alcohol and coffee consumption can reduce the risk of cognitive deficits, while green tea consumption is a significant protective factor for cognitive health.
EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES
(2021)
Article
Thermodynamics
Bruna Rijo, Ana Paula Soares Dias, Marta Ramos, Nicole de Jesus, Jaime Puna
Summary: The pyrolysis of food waste has the environmental advantage of waste management and renewable fuel production. Tea grounds have higher cellulose content and activation energy for pyrolysis compared to coffee grounds, leading to lower liquid product yield. The use of alkaline carbonates as catalysts increases bio-gas production, decreases bio-oil production, and enhances the volatile fraction of bio-oils.
Review
Nutrition & Dietetics
Farzaneh Asoudeh, Fatemeh Dashti, Ahmad Jayedi, Amirhossein Hemmati, Abdulmannan Fadel, Hamed Mohammadi
Summary: This meta-analysis examined the association between dietary caffeine, different types of coffee and tea consumption, and the risk of rheumatoid arthritis (RA). The results showed that higher intake of coffee and decaffeinated coffee was associated with an increased risk of RA, while there was no significant association between caffeinated coffee, tea, or caffeine intake and RA risk.
FRONTIERS IN NUTRITION
(2022)
Article
Emergency Medicine
Jeetinder K. Makkar, Narinder P. Singh, Nidhi Bhatia, Tanvir Samra, Preet Mohinder Singh
Summary: This meta-analysis compared the analgesic efficacy of fascia iliaca block (FICB) performed by non-anesthesiologists with standard of care in geriatric patients with hip fractures. Results showed that FICB provided significant pain relief at rest and on movement, reduced opioid consumption, nausea, vomiting, and hospital stay length. However, the quality of evidence was low, indicating a need for additional trials to confirm the findings.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Review
Surgery
Gonzalo Mariscal, Rafael Lorente, Carlos Barrios
Summary: This study conducted a meta-analysis comparing the safety and efficacy of the U-Blade Gamma 3 nail and the conventional Gamma 3 nail in the surgical treatment of intertrochanteric fractures. The results showed no significant differences between the two groups in terms of radiological outcomes. However, the U-Blade Gamma 3 group had a longer surgery time.
FRONTIERS IN SURGERY
(2022)
Review
Geriatrics & Gerontology
Rafael Llombart, Gonzalo Mariscal, Carlos Barrios, Jose Enrique de la Rubia Orti, Rafael Llombart-Ais
Summary: This study found that vitamin D insufficiency and severe deficiency are associated with increased mortality in patients with hip fracture, but this association was not statistically significant after adjusting for potential confounders. Further research is needed to understand the role of vitamin D deficiency in this population.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Geriatrics & Gerontology
P. Huang, K. Luo, J. Xu, W. Huang, W. Yin, M. Xiao, Y. Wang, M. Ding, X. Huang
Summary: The study found that sarcopenia significantly increases the risk of future hip fractures in older adults, especially in patients who meet the Asian Working Group for Sarcopenia criteria.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Orthopedics
Wenhua Liu, Shaojie Deng, Jinfeng Liang
Summary: This meta-analysis indicated that the use of TXA in hip fracture surgery can significantly reduce the need for blood transfusion and blood loss without increasing the risk of thromboembolic events. Topical application of TXA had a lower transfusion rate compared to controls, but the difference was not statistically significant. TXA showed similar efficacy and safety profiles across different dosage and frequency levels.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2022)
Review
Public, Environmental & Occupational Health
Yanhong Song, Ziyi Wu, Huihui Huo, Ping Zhao
Summary: Frailty can effectively predict adverse outcomes in geriatric hip fracture patients, including postoperative and in-patient complications, inpatient mortality, 6-month mortality, >=1-year mortality, and prolonged hospital stays.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Geriatrics & Gerontology
Willeke M. Ravensbergen, Jeanet W. Blom, Andrew Kingston, Louise Robinson, Ngaire Kerse, Ruth O. Teh, Rolf H. H. Groenwold, Jacobijn Gussekloo
Summary: This study found that in very old individuals, decline in daily functioning already starts before a hip fracture. Therefore, a hip fracture is an indicator of ongoing decline and full recovery should be evaluated with consideration of pre-fracture decline.
Article
Orthopedics
Hui Li, Juyang Jiao, Shutao Zhang, Haozheng Tang, Xinhua Qu, Bing Yue
Summary: The purpose of this study was to develop a predictive model for length of stay (LOS) after total knee arthroplasty (TKA). Risk factors that could affect LOS were identified, and machine learning models were found to have better predictive performance compared to logistic regression models.
JOURNAL OF KNEE SURGERY
(2022)
Article
Engineering, Environmental
Hongtao Yang, Xinhua Qu, Minqi Wang, Houwen Cheng, Bo Jia, Jianfeng Nie, Kerong Dai, Yufeng Zheng
Summary: The study demonstrates the potential of high-strength biodegradable Zn-Li alloy implants for high load-bearing applications in orthopedic surgeries. The implants facilitated complete fracture healing within 6 months, with the osteogenic activity of the Zn-Li alloy validated.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Haozheng Tang, Xinhua Qu, Wenkai Zhang, Xuan Chen, Shutao Zhang, Yang Xu, Hongtao Yang, You Wang, Jianping Yang, Wei-en Yuan, Bing Yue
Summary: In this study, an ultra-micro photosensitizer, AgB nanodots, were used to efficiently clear multidrug-resistant bacteria MRSA through photothermal therapy, photodynamic therapy, and Ag+ ion sterilization. The AgB nanodots were found to enhance host immunogenicity and establish immunological memory in a murine model, providing a novel platform for the effective treatment of postoperative infection and a systematic immunotherapeutic strategy to combat persistent infections, thereby reducing the incidence of recurrence.
ADVANCED MATERIALS
(2022)
Article
Endocrinology & Metabolism
Jingke Du, Zihao He, Mingming Xu, Xinhua Qu, Junqi Cui, Shuangyan Zhang, Shuhong Zhang, Hanjun Li, Zhifeng Yu
Summary: Cold temperature activates the sympathetic nervous system (SNS) to induce bone loss by altering bone remodeling. Brown adipose tissue (BAT), which is influenced by the SNS in cold environments, has been found to have a positive relationship with bone mass. This study showed that bone volume can be restored after cold exposure due to enlarged BAT, which has a beneficial effect on bone mass by facilitating osteogenesis and suppressing osteoclastogenesis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Jialian Xu, Jindou Ji, Juyang Jiao, Liangjun Zheng, Qimin Hong, Haozheng Tang, Shutao Zhang, Xinhua Qu, Bing Yue
Summary: The self-repair of cartilage and subchondral bone is challenging due to the vasculature defects, complex gradients, and layered zonal architecture. However, three-dimensional (3D) printing technology provides a new strategy for bone-cartilage interface regeneration, offering rapid and accurate molding and personalized therapy. Challenges still remain, such as determining the optimal bioink concentrations and finding biomaterials with dual bioactivities.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Bin'en Nie, Shicheng Huo, Xinhua Qu, Jingjing Guo, Xi Liu, Qimin Hong, You Wang, Jianping Yang, Bing Yue
Summary: The bone-and-bacteria dual-targeted nanoparticles show excellent targeting efficacy and antibacterial properties for bone infection treatment.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Shutao Zhang, Xinhua Qu, Juyang Jiao, Haozheng Tang, Minqi Wang, You Wang, Hongtao Yang, Weien Yuan, Bing Yue
Summary: Felodipine has antibacterial effects against MRSA, biofilm, and persisters. It can inhibit the expression of proteins associated with aminoglycoside resistance, eradicate formed biofilms and kill persisters. Felodipine also reduces MRSA virulence and modulates bacterial metabolism. It inhibits the growth of persisters by binding to a protease. In a mouse infection model, felodipine in combination with gentamicin alleviates bacterial burden and inflammation.
BIOACTIVE MATERIALS
(2022)
Article
Surgery
Zhengyu Cai, Xinhua Qu, Yaochao Zhao, Zhiguo Yuan, Liangjun Zheng, Teng Long, Qiuying Yao, Bing Yue, You Wang
Summary: This study conducted a clinical trial of the world's first totally modular polyetheretherketone (PEEK) total knee arthroplasty (TKA) to determine bone density values around the prosthesis, reconstructing a three-dimensional model. Results showed excellent CT compatibility of the PEEK knee joint prosthesis and the ability to assess periprosthetic bone volume changes using Hounsfield units (HU) after CT scans. The assessment may potentially guide future improvements in knee prosthesis alignment techniques and artificial knee prosthesis designs.
FRONTIERS IN SURGERY
(2022)
Article
Chemistry, Multidisciplinary
Xinhua Qu, Minqi Wang, Miaochen Wang, Haozheng Tang, Shutao Zhang, Hongtao Yang, Weien Yuan, You Wang, Jianping Yang, Bing Yue
Summary: This study proposes a novel antimicrobial system to address the challenges of refractory Staphylococcus aureus-related implant infection. The system provides a continuous, prolonged antibacterial effect at the site of infection and significantly reduces immunosuppression, thereby restoring the antimicrobial immune response.
ADVANCED MATERIALS
(2022)
Review
Biotechnology & Applied Microbiology
Zhen Liu, Weiwei Xin, Jindou Ji, Jialian Xu, Liangjun Zheng, Xinhua Qu, Bing Yue
Summary: Three-dimensional (3D) printing has been used in medical research and practice for several years. Hydrogels, as the most advantageous biological raw materials for 3D printing, have shown significant potential in orthopedics. They can promote tissue repair and prevent infection. However, there are still some challenges associated with hydrogel materials that need to be addressed through a multi-disciplinary approach.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Yihan Wang, Shutao Zhang, Bin'en Nie, Xinhua Qu, Bing Yue
Summary: This review summarizes the modification strategies to biofunctionalize PEEK for antibacterial purposes, including surface-coating modifications, controlled release of antimicrobials, blending modifications, and 3D printing technology. The aim is to provide an in-depth understanding and optimize the design of PEEK orthopedic implants.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Bo Jia, Zechuan Zhang, Yifu Zhuang, Hongtao Yang, Yu Han, Qiang Wu, Xiufeng Jia, Yanhui Yin, Xinhua Qu, Yufeng Zheng, Kerong Dai
Summary: Implant-related infections caused by drug-resistant bacteria are a major challenge in orthopedic surgery. This study focuses on the antibacterial and osteogenic properties of Zn alloys, specifically the Zn-Li-Ag ternary alloy, which showed significant bactericidal effects on MRSA and improved mechanical properties. In vivo experiments on a rat femoral model demonstrated the alloy's effectiveness in controlling infection and promoting bone retention.
Article
Engineering, Biomedical
Hongtao Yang, Bo Jia, Xinhua Qu, Kerong Dai, Yufeng Zheng
Summary: The addition of a small amount of gadolinium can modify the degradation behavior and microstructure of zinc, leading to more uniform degradation and improved bone regeneration and implant integration.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Orthopedics
Haozheng Tang, Jialian Xu, Wei'en Yuan, You Wang, Bing Yue, Xinhua Qu
Summary: This study aimed to evaluate and unify diagnostic criteria for periprosthetic joint infection (PJI) and found that laboratory-based synovial alpha-defensin and synovial calprotectin are the two best independent preoperative diagnostic tests for PJI. A cut off of 70% for synovial PMN% and tighter cut-offs for synovial WBC and serum CRP could have a better diagnostic accuracy for non-IA patients with chronic PJI.
ORTHOPAEDIC SURGERY
(2022)
Article
Biotechnology & Applied Microbiology
Juyang Jiao, Qimin Hong, Dachen Zhang, Minqi Wang, Haozheng Tang, Jingzhou Yang, Xinhua Qu, Bing Yue
Summary: Porous tantalum scaffolds with three different porosities (60%, 70%, and 80%) were prepared using laser powder bed fusing technique to investigate the effects on the adhesion, proliferation, and osteogenic differentiation of rat mesenchymal stem cells in vitro. The in vivo bone ingrowth and osseointegration effects of each scaffold were evaluated in a rat femoral bone defect model. The results showed that scaffolds with 70% and 80% porosity exhibited better osteogenic proliferation and differentiation capacity, as well as bone ingrowth, suggesting that the 3D printed trabecular tantalum scaffold with 70% porosity could be the optimal choice for implant design.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)