Article
Medicine, General & Internal
Maria-Jose Montoya-Garcia, Merce Giner, Rodrigo Marcos, David Garcia-Romero, Francisco-Jesus Olmo-Montes, Ma Jose Miranda, Blanca Hernandez-Cruz, Miguel-Angel Colmenero, Ma Angeles Vazquez-Gamez
Summary: Fragility fractures are a significant public health issue globally, with hip fractures being most prevalent in women aged 80 and above. Older age and recent fractures were identified as independent risk factors for further fracture events. There was a significant excess mortality rate in individuals aged 80 and above with a previous hip fracture.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Patrick Pflueger, Felix N. Harder, Karoline Mueller, Lukas Willinger, Peter Biberthaler, Moritz Croenlein
Summary: Trimalleolar ankle fractures predominantly affect younger men and older women, with postmenopausal women having lower bone mineral density and a higher risk of fractures. This study aimed to analyze the association between patient characteristics and cortical bone thickness of the distal tibia in trimalleolar ankle fractures. The results showed that older age and female sex were associated with reduced cortical bone thickness and an increased risk of subsequent osteoporotic fractures.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Endocrinology & Metabolism
Umberto Tarantino, Ida Cariati, Chiara Greggi, Riccardo Iundusi, Elena Gasbarra, Giovanni Iolascon, Andreas Kurth, Kristina E. Akesson, Mary Bouxsein, Paolo Tranquilli Leali, Roberto Civinini, Francesco Falez, Maria Luisa Brandi
Summary: Osteoporotic fractures are a major problem in healthcare systems worldwide. Fragility fractures of the hip have a greater impact on morbidity, mortality, and healthcare costs than other fracture sites. There is a lack of awareness of osteoporosis and most high-risk individuals do not receive adequate treatment.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Ebru Koseoglu Tohma, Ozden Ozyemisci Taskiran
Summary: In patients with a cardiac pacemaker, pocket-related complications such as nerve impairment or bone fractures are infrequent, but rare complications like rib fractures several months after implantation may occur. Pacemaker implantation may cause shoulder dysfunction and pectoral tightness, resulting in reduced trunk flexibility and potentially leading to fragility fractures like in the case presented.
ARCHIVES OF OSTEOPOROSIS
(2021)
Review
Orthopedics
Patrick Ziegler, Christian Bahrs, Christian Konrads, Philipp Hemmann, Marc-Daniel Ahrend
Summary: This narrative review summarizes the current concepts for the treatment of ankle fractures in elderly patients. Open reduction and internal fixation is considered as the gold standard for operative care, though individualized treatment decisions based on factors such as soft-tissue status, fracture pattern, mobility, and comorbidities are essential for optimal patient outcomes. Techniques like fibular nails or minimally invasive approaches should be considered to address the high complication rates post-surgery.
EFORT OPEN REVIEWS
(2023)
Article
Cardiac & Cardiovascular Systems
Iacopo Chiodini, Agostino Gaudio, Andrea Palermo, Nicola Napoli, Fabio Vescini, Alberto Falchetti, Daniela Merlotti, Cristina Eller-Vainicher, Vincenzo Carnevale, Alfredo Scillitani, Giuseppe Pugliese, Domenico Rendina, Antonio Salcuni, Francesco Bertoldo, Stefano Gonnelli, Ranuccio Nuti, Vincenzo Toscano, Vincenzo Triggiani, Simone Cenci, Luigi Gennari
Summary: The risk of bone fragility in type 2 diabetes patients should not be underestimated. Diagnoses and treatments should consider diabetes-specific factors and stratify risk based on individual profiles.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Review
Biochemistry & Molecular Biology
Giuseppe Rinonapoli, Valerio Pace, Carmelinda Ruggiero, Paolo Ceccarini, Michele Bisaccia, Luigi Meccariello, Auro Caraffa
Summary: Obesity leads to higher bone mineral density, but also an increased risk of fracture due to multiple factors such as metabolic issues and a higher risk of falls.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Orthopedics
Ludwig Oberkircher, Julia Lenz, Benjamin Buecking, Daphne Eschbach, Rene Aigner, Christopher Bliemel, Carsten Schoeneberg, Steffen Ruchholtz, Juliana Hack
Summary: This study aimed to describe specific characteristics of patients with pelvic fragility fractures and evaluate factors influencing treatment decisions. Results showed that fracture type, mobility level, and pain level were key factors influencing the decision for surgical treatment. Patients with B2 fractures benefited in terms of mobility level with surgical treatment at discharge.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Endocrinology & Metabolism
Salvador Israel Macias-Hernandez, Miriam Macarena Degollado-Rodriguez, Horacio Maldonado-Sanchez, Andrea Olascoaga-Gomez de Leon, Roberto Coronado-Zarco, Tania Ines Nava-Bringas, Esperanza Ramirez-Perez, Eva Cruz-Medina, Rolando Espinosa-Morales, Juan Daniel Morones-Alba
Summary: This study highlights the diagnostic and therapeutic gap for osteoporosis in patients with fragility fractures in Mexico, showing a higher rate of failure to diagnose and treat osteoporosis compared to other countries. Measures should be taken to reduce this gap and improve care for these patients.
ARCHIVES OF OSTEOPOROSIS
(2021)
Review
Endocrinology & Metabolism
Manju Chandran, Katherine Brind'Amour, Saeko Fujiwara, Yong-Chan Ha, Hai Tang, Jawl-Shan Hwang, James Tinker, John A. Eisman
Summary: Robust data on osteoporosis in the Asia Pacific region can improve healthcare decision-making. Osteoporosis affects 10-30% of women aged 40 + and up to 10% of men in 7 developed economies in the Asia Pacific. Fractures affect 500-1000 adults aged 50 + per 100,000 person-years. Policymakers and clinicians must address this problem.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Bailey J. Ross, Austin J. Ross, Olivia C. Lee, Timothy L. Waters, McCayn M. Familia, William F. Sherman
Summary: Patients with multiple sclerosis are more likely to develop osteoporosis and receive treatment following primary fragility fractures, but they have higher rates of falls.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Camilla Bergh, Michael Moller, Jan Ekelund, Helena Brisby
Summary: Limited information is available on age-related mortality across fractures in different anatomical regions. This study aimed to investigate mortality rates at 30 days and 1 year post-fracture within four different age groups. The findings showed that older age groups had higher mortality rates, and fractures of the femur and humerus diaphysis were associated with the highest mortality rates. Additionally, pelvic, acetabulum, spine, and tibia fractures had moderately high mortality rates across all age groups.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Hiroki Iida, Yoshihito Sakai, Taisuke Seki, Tsuyoshi Watanabe, Norimitsu Wakao, Hiroki Matsui, Shiro Imagama
Summary: The study investigates the impact of bisphosphonate (BP) on mortality post osteoporotic vertebral fracture (OVF), and finds that BP medication is significantly associated with reduced all-cause mortality after OVF.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Hongli Shi, Xin Jiang, Cuidi Xu, Qun Cheng
Summary: This study investigated the differences in miRNA expression profiles in postmenopausal osteoporosis patients with fragility fractures and identified several miRNAs associated with bone mineral density. The study also explored the potential role of these miRNAs in the pathophysiology of postmenopausal osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Patrice Fardellone, L. Barnieh, N. Quignot, G. Gusto, D. A. Kahangire, G. Worth, J. O'Kelly, A. Khachatryan, G. Desamericq
Summary: This study found that subsequent fractures among osteoporotic patients with an initial fracture result in increased clinical mortality and high healthcare resource use. Therefore, emphasis should be placed on the prevention of recurrent fractures.
ARCHIVES OF OSTEOPOROSIS
(2021)