Article
Biochemistry & Molecular Biology
Konstantinos D. Rizas, Luisa Freyer, Nikolay Sappler, Lukas von Stuelpnagel, Peter Spielbichler, Aresa Krasniqi, Michael Schreinlechner, Felix N. Wenner, Fabian Theurl, Amira Behroz, Elodie Eiffener, Mathias P. Klemm, Annika Schneidewind, Martin Zens, Theresa Dolejsi, Ulrich Mansmann, Steffen Massberg, Axel Bauer
Summary: The study compared the efficacy of digital smart devices in detecting atrial fibrillation (AF) and found that digital screening technology more than doubled the detection rate of treatment-relevant AF compared to usual care. This technology has the potential for broad applicability and further studies are needed to assess if digital screening for AF leads to better treatment outcomes.
Article
Cardiac & Cardiovascular Systems
Girish M. Nair, David H. Birnie, Pablo B. Nery, Calum J. Redpath, Jean-Francois Sarrazin, Jean-Francois Roux, Ratika Parkash, Martin Bernier, Laurence D. Sterns, John Sapp, Paul Novak, George Veenhuyzen, Carlos A. Morillo, Sheldon M. Singh, Mouhannad M. Sadek, Mehrdad Golian, Andres Klein, Marcio Sturmer, Vijay S. Chauhan, Paul Angaran, Martin S. Green, Jordan Bernick, George A. Wells, Vidal Essebag
Summary: In this study, an augmented double wide-area circumferential ablation (WACA) did not show superiority in preventing recurrent atrial arrhythmias compared to a standard single WACA in patients with paroxysmal AF. The additional ablation did not improve freedom from atrial arrhythmias or safety.
Article
Medicine, General & Internal
Mu Chen, Qunshan Wang, Jian Sun, Peng-Pai Zhang, Wei Li, Bin-Feng Mo, Tai-Zhong Chen, Xiaoli Tang, Yi-Gang Li
Summary: The ASPIRIN LAAO trial aims to evaluate the uncertainty about the risks and benefits of discontinuing aspirin therapy at 6 months postimplantation with a Watchman LAAO device in NVAF patients. The study includes 1120 patients from 12 investigational sites.
Article
Endocrinology & Metabolism
Pokpong Piriyakhuntorn, Adisak Tantiworawit, Mattabhorn Phimphilai, Somdet Srichairatanakool, Waralee Teeyasoontranon, Thanawat Rattanathammethee, Sasinee Hantrakool, Chatree Chai-Adisaksopha, Ekarat Rattarittamrong, Lalita Norasetthada, Kanda Fanhchaksai, Pimlak Charoenkwan
Summary: In this randomized controlled trial, it was found that once-weekly oral Alendronate 70 mg effectively improves bone mineral density at the lumbar spine, reduces serum bone turnover markers, and alleviates back pain in thalassemia patients with osteoporosis. The treatment provides a new therapeutic option.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
David J. Gladstone, Rolf Wachter, Katharina Schmalstieg-Bahr, F. Russell Quinn, Eva Hummers, Noah Ivers, Tamara Marsden, Andrea Thornton, Angie Djuric, Johanna Suerbaum, Doris von Gruenhagen, William F. McIntyre, Alexander P. Benz, Jorge A. Wong, Fatima Merali, Sam Henein, Chris Nichol, Stuart J. Connolly, Jeff S. Healey
Summary: In this study, home-based AF screening with a wearable cECG monitor significantly increased AF detection and anticoagulant therapy initiation, especially in older community-dwelling individuals with hypertension. Intermittent oscillometric screening with a BP monitor was found to be less effective for detecting paroxysmal AF compared to continuous ECG monitoring. Further large trials are needed to evaluate the benefits and risks of AF screening with hard clinical outcomes.
Article
Chemistry, Analytical
Yi-Fan Shieh, Fu-Mei Hung, Szu-Ning Yeh, Li-Ting Kao, Jen-Chi Chen, Fu-En Liao, Jenpang Huang, Chin-Hsiung Wang, Chi-Yang Lee, Jentaie Shiea
Summary: A derivatization-free HILIC-MS/MS method was developed to quantify low levels of alendronate in human plasma. The method is simpler, safer, and more environmentally friendly than the conventional LC-MS/MS method.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Medicine, General & Internal
Joshua Buron Feinberg, Michael Hecht Olsen, Axel Brandes, Llan Raymond, Walter Bjorn Nielsen, Emil Eik Nielsen, Frank Stensgaard-Hansen, Ulrik Dixen, Ole Dyg Pedersen, Uffe Jakob Ortved Gang, Christian Gluud, Janus Christian Jakobsen
Summary: The study aims to investigate the impact of lenient vs strict rate control strategy on quality of life in patients with persistent or permanent atrial fibrillation. It will be a two-group, superiority randomised clinical trial involving 350 outpatients from four hospitals in Denmark. The primary outcome will be quality of life assessed using the SF-36 questionnaire (physical component score) at 1 year after randomisation.
Article
Cardiac & Cardiovascular Systems
Carina Blomstrom-Lundqvist, Gerald Naccarelli, David S. McKindley, Gregory Bigot, Mattias Wieloch, Stefan H. Hohnloser
Summary: This post hoc analysis showed that dronedarone reduced the progression of atrial fibrillation/flutter to permanent AF/AFL and increased the regression to sinus rhythm compared to placebo. The estimated burden of AF/AFL was also lower in the dronedarone group.
Article
Cardiac & Cardiovascular Systems
Michelle Samuel, Paul Khairy, Jean Champagne, Marc W. Deyell, Laurent Macle, Peter Leong-Sit, Paul Novak, Mariano Badra-Verdu, John Sapp, Jean-Claude Tardif, Jason G. Andrade
Summary: This study analyzed the association between the change in atrial fibrillation burden and quality of life following ablation, finding that a reduction in AF burden postablation was associated with a meaningful improvement in quality of life.
Article
Medicine, General & Internal
Jennifer L. Reed, Tasuku Terada, Sol Vidal-Almela, Heather E. Tulloch, Matheus Mistura, David H. Birnie, George A. Wells, Girish M. Nair, Harleen Hans, Kimberley L. Way, Daniele Chirico, Carley D. O'Neill, Andrew L. Pipe
Summary: This study compared the effects of 12 weeks of high-intensity interval training (HIIT) and moderate to vigorous intensity continuous training (MICT) on functional capacity and quality of life in patients with atrial fibrillation (AF). The results showed that both HIIT and MICT had similar effects in improving functional capacity, quality of life, resting heart rate, and physical activity levels in patients with persistent and permanent AF.
Article
Medicine, Research & Experimental
Ying Xiao, Xinyi Wang, Jin Yang, Keke Liu, Mianmian Li, Zilin Ma, Bing Deng, Lin Shen, Yihong Wei, Shuai Zhang, Na Zhang, Ping Zhao, Chen Zhu, Meijiao Mao, Nuo Tang, Qiong Wu
Summary: This study aims to evaluate the efficacy and safety of HTDJ combined with western medicine in treating atrial fibrillation (qi deficiency and phlegm opacities), providing medical evidence for the short-term and medium-term clinical efficacy of integrating traditional and western medicine in the treatment of atrial fibrillation and laying the foundation for further clinical development and application.
Article
Cardiac & Cardiovascular Systems
Avi Sabbag, Anat Berkovich, Ehud Raanani, David Volvovitch, William F. McIntyre, Yigal Kassif, Alexander Kogan, Michael Glikson, Roy Beinart
Summary: Postoperative atrial fibrillation (POAF) is a common complication of cardiac surgery, associated with increased mortality and thrombo-embolism. The rates of recurrence and optimal management remain unclear. This study aimed to evaluate the incidence of recurrent atrial fibrillation in patients with POAF following cardiac surgery.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Emma Svennberg, Leif Friberg, Viveka Frykman, Faris Al-Khalili, Johan Engdahl, Marten Rosenqvist
Summary: A randomized controlled trial in Sweden showed that systematic screening for atrial fibrillation in older populations can reduce mortality and morbidity compared to no screening.
Article
Endocrinology & Metabolism
Rikke Viggers, Zheer Al-Mashhadi, Jakob Starup-Linde, Peter Vestergaard
Summary: The study found a negative association between the use of alendronate and the risk of developing type 2 diabetes, with a dose-response relationship observed.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Gregory F. Michaud, William G. Stevenson
Summary: A 63-year-old healthy male with atrial fibrillation presents with symptoms of dyspnea and irregular heartbeat. Physical examination reveals high blood pressure, irregular pulse, and ECG confirms atrial fibrillation. Further evaluation and treatment plan are needed.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)