Journal
TOXICOLOGY IN VITRO
Volume 30, Issue 1, Pages 552-560Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tiv.2015.09.004
Keywords
Uranium; RedOx; Localization; Low-dose; HepG2
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Funding
- Institute for Radioprotection and Nuclear Safety (IRSN)
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This study aimed to compare the cell stress effects of low and high uranium concentrations and relate them to its localization, precipitate formation, and exposure time. The time-course analysis shows that uranium appears in cell nuclei as a soluble form within 5 min of exposure, and quickly induces expression of antioxidant and DNA repair genes. On the other hand, precipitate formations began at the very beginning of exposure at the 300-mu M concentration, but took longer to appear at lower concentrations. Adaptive response might occur at low concentrations but are overwhelmed at high concentrations, especially when uranium precipitates are abundant. (C) 2015 Elsevier Ltd. All rights reserved.
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