Review
Multidisciplinary Sciences
Thilini Sudeshika, Mark Naunton, Louise S. Deeks, Jackson Thomas, Gregory M. Peterson, Sam Kosari
Summary: This review summarizes the characteristics, activities, benefits, barriers, and facilitators of including pharmacists in general practices in Australia. The study shows that general practice pharmacists are well accepted by stakeholders and can engage in patient-centered activities to benefit patients. However, more robust research is needed to explore the patient and economic outcomes related to clinical activities that pharmacists can perform in general practice, in order to develop an appropriate and sustainable funding model.
Review
Oncology
Noraisyah Mohd Sani, Zoriah Aziz, Rema Panickar, Adeeba Kamarulzaman
Summary: Pharmacists' knowledge and perceptions of biosimilars vary and are limited, especially regarding interchangeability and substitution, efficacy, safety, and indication extrapolation. Increasing pharmacists' understanding of biosimilars can help them encourage prescribers' acceptance of biosimilars.
Review
Public, Environmental & Occupational Health
Adam C. Livori, Adaire Prosser, Bianca Levkovich
Summary: Pharmacists play a role in the care of cardiac patients in ambulatory settings, but there is a lack of consensus on how to assess the impact of pharmacist care. This systematic review examines the assessments used and the outcomes of pharmacist interventions in cardiology ambulatory care.
RESEARCH IN SOCIAL & ADMINISTRATIVE PHARMACY
(2023)
Review
Pharmacology & Pharmacy
Kohei Yamaura, Anna Laura Nelson, Haruki Nishimura, Joan C. Rutledge, Sudheer K. Ravuri, Chelsea Bahney, Marc J. Philippon, Johnny Huard
Summary: Fisetin, a natural flavonoid, shows promising pharmaceutical potential for treating or delaying the progression of osteoporosis and osteoarthritis. Studies have demonstrated the beneficial effects of fisetin on osteoporosis and osteoarthritis in preclinical and animal studies.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Iva Buzancic, Ingrid Kummer, Margita Drzaic, Maja Ortner Hadziabdic
Summary: Community-based pharmacists play a crucial role in providing continuing care for chronic multi-morbid patients, and their involvement in deprescribing interventions has been found to be successful in discontinuing medications. Different types of interventions led by community-based pharmacists result in greater medication discontinuation compared to usual care, but the short follow-up periods limit assessment of long-term sustainability.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Review
Immunology
Oluwafemifola Oyedeji, Jill M. Maples, Samantha Gregory, Shaunta M. Chamberlin, Justin D. Gatwood, Alexandria Q. Wilson, Nikki B. Zite, Larry C. Kilgore
Summary: The cost, insurance coverage, and reimbursement of the HPV vaccine were commonly reported barriers. Barriers to adolescent HPV vaccination were related to parental concerns, beliefs, and insufficient knowledge about the vaccine. Personal barriers perceived by pharmacists were related to lack of information and knowledge about the HPV vaccine. System/organization level barriers included lack of time/staff/space, difficulty in series completion, tracking and recall of patients, perceived competition with providers, and prioritization of other responsibilities/vaccines.
Review
Clinical Neurology
John Dimar, Erica F. Bisson, Sanjay Dhall, James S. Harrop, Daniel J. Hoh, Basma Mohamed, Marjorie C. Wang, Praveen Mummaneni
Summary: Osteoporosis is a common bone disease in the elderly, and preoperative diagnosis and treatment are crucial for postoperative outcomes. Experts recommend preoperative testing for osteoporosis through dual-energy X-ray absorptiometry scan, computed tomography scan, and serum vitamin D3 level to predict an increased risk of adverse events after surgery.
Review
Nutrition & Dietetics
Yuhe Wang, Xu Han, Jingru Shi, Zeqi Liao, Yuanyue Zhang, Yuanyuan Li, Miao Jiang, Meijie Liu
Summary: This systematic review and meta-analysis investigated the distinct metabolites in patients with osteopenia (ON) and osteoporosis (OP). The results show that certain metabolites were associated with ON and OP, indicating their potential as predictors for OP.
Review
Gastroenterology & Hepatology
Nanfu Deng, Niharika Mallepally, Frederick B. Peng, Aleem Kanji, Marco Marcelli, Ruben Hernaez
Summary: Low serum testosterone is associated with increased morbidity and mortality in cirrhosis patients. Testosterone supplementation improved intermediate endpoints, but there was no conclusive data on clinical outcomes.
LIVER INTERNATIONAL
(2021)
Review
Chemistry, Medicinal
Sophia Ogechi Ekeuku, Kok-Lun Pang, Kok-Yong Chih
Summary: Caffeic acid, a metabolite of hydroxycinnamate and phenylpropanoid, acts as an antioxidant to reduce osteoclastogenesis and bone resorption. However, in some cases, it may have no effect on bone resorption or even impair bone mechanical properties in normal rats.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Review
Nutrition & Dietetics
Zhaoli Dai, Joanne E. McKenzie, Sally McDonald, Liora Baram, Matthew J. Page, Margaret Allman-Farinelli, David Raubenheimer, Lisa A. Bero
Summary: This study found considerable variability in recommendations for vitamin D and calcium in bone health guidelines, as well as differences in guideline development methods. Efforts are needed to strengthen the methodological rigor of guideline development and utilize the best available evidence to support nutrition recommendations in evidence-based guidelines on bone health.
Review
Food Science & Technology
Taylor C. Wallace, Regan L. Bailey, Joan Lappe, Kimberly O. O'Brien, Ding Ding Wang, Shivani Sahni, Connie M. Weaver
Summary: The role of dairy products in long-term bone health and fracture prevention remains controversial, with some studies suggesting potential risks associated with dairy consumption. Evidence supports a moderate effect of dairy consumption on bone density in middle-aged to older adults, while insufficient evidence exists for its effects on other age groups. Further research is needed to better understand the impact of dairy consumption on bone health across different age groups and ethnicities.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Review
Endocrinology & Metabolism
Catherine Laird, Helen Benson, Kylie A. Williams
Summary: Pharmacist interventions have shown to be effective in improving osteoporosis management by increasing investigation and treatment commencement, as well as improving adherence to therapy.
OSTEOPOROSIS INTERNATIONAL
(2023)
Review
Food Science & Technology
Emma O. Billington, Amita Mahajan, Jamie L. Benham, Maitreyi Raman
Summary: This systematic review examined the effects of probiotic interventions on bone health in postmenopausal women. The findings showed inconsistent effects of probiotics on bone mineral density and bone turnover markers. Further high-quality studies are needed to determine the role of probiotics in maintaining bone health in humans.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Social Issues
Nujud Alsufyani, Asif Qumer Gill
Summary: This paper addresses the research need for understanding the impact of digitalisation on organisational performance. It provides performance indicators, measures, and evaluation tools to help researchers and practitioners study this impact.
TECHNOLOGY IN SOCIETY
(2022)
Letter
Rheumatology
Shahab Abtahi, Johanna H. M. Driessen, Andrea M. Burden, Patrick C. Souverein, Joop P. van den Bergh, Tjeerd P. van Staa, Annelies Boonen, Frank de Vries
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Shahab Abtahi, Johanna H. M. Driessen, Andrea M. Burden, Patrick C. Souverein, Joop P. van den Bergh, Annelies Boonen
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Shahab Abtahi, Johanna H. M. Driessen, Andrea M. Burden, Patrick C. Souverein, Joop P. van den Bergh, Tjeerd P. van Staa, Annelies Boonen, Frank de Vries
Summary: Low-dose oral glucocorticoid therapy does not increase the overall risk of osteoporotic fractures in patients with RA, but is associated with an increased risk of clinical vertebral fractures.
Article
Public, Environmental & Occupational Health
Dominik Staempfli, Birgit A. Winkler, Simona Berardi Vilei, Andrea M. Burden
Summary: This study describes the utilization and symptom resolving rate of decision trees for triaging in Swiss community pharmacies. The findings show that pharmacist-led triaging services play an important role in minimizing the burden on other primary health care providers.
RESEARCH IN SOCIAL & ADMINISTRATIVE PHARMACY
(2022)
Article
Endocrinology & Metabolism
Annika Vestergaard Kvist, Mohamad I. Nasser, Peter Vestergaard, Morten Frost, Andrea M. Burden
Summary: A study in Denmark from 1997 to 2017 found that the incidence rates of fractures were higher in patients with type 1 and type 2 diabetes compared to those without diabetes, except for foot fractures. The incidence of hip fractures decreased by 35.2%, 47.0%, and 23.4% in patients with type 1 diabetes, type 2 diabetes, and without diabetes, respectively, over the last 5 years. However, vertebral fractures increased by 14.8%, 18.5%, and 38.9% in the same groups. After age adjustment, patients with type 1 diabetes still had a higher risk of fractures compared to those without diabetes, while patients with type 2 diabetes had a risk similar to those without diabetes.
Article
Public, Environmental & Occupational Health
Maria Luisa Faquetti, Adrian Martinez-De la Torre, Theresa Burkard, Guillaume Obozinski, Andrea M. M. Burden
Summary: This study used the Apriori algorithm to analyze patients with polypharmacy who were first-time users of metformin. The most frequently co-prescribed drug with metformin was atorvastatin. Women and older patients were more likely to receive polypharmacy. The results of this study indicate the need to optimize polypharmacy to minimize drug-drug interactions and adverse drug reactions.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2023)
Article
Rheumatology
Rasmus Westermann, Rene Lindholm Cordtz, Kirsten Duch, Lene Mellemkjaer, Merete Lund Hetland, Andrea Michelle Burden, Lene Dreyer
Summary: This study examined the risk of first primary cancer in patients with rheumatoid arthritis (RA) treated with janus kinase inhibitors (JAKi) compared to those treated with biologic disease-modifying antirheumatic drugs (bDMARDs) in a real-world setting. The results showed that JAKi treatment was not associated with a statistically significant increased risk of first primary cancer compared to bDMARDs treatment in RA patients.
Article
Pharmacology & Pharmacy
Dominik Stampfli, Rebecca Dommrich, Sharon Orbach-Zinger, Andrea M. Burden, Michael Heesen
Summary: This study analyzed the adverse drug events and haemodynamic profile of oxytocin and carbetocin using data from the World Health Organization's pharmacovigilance database. The results showed that carbetocin had a higher reporting of adverse hypertension, hypotension, and tachycardia compared to oxytocin. Therefore, clinicians should be cautious of their patients' susceptibility and the potential haemodynamic deterioration when using these drugs.
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
(2023)
Article
Biochemical Research Methods
Maria Kalweit, Andrea. M. H. Burden, Joschka Boedecker, Thomas H. Hugle, Theresa Burkard
Summary: Machine learning techniques were used to identify five distinct patient groups with rheumatoid arthritis (RA) based on sex, disease burden/duration, and concomitant traditional RA treatment use. The results suggest that different RA patient clusters have different responses to first-line b/tsDMARD treatment.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Natalia Konstantelos, Andrea M. Burden, Angela M. Cheung, Sandra Kim, Paul Grootendorst, Suzanne M. Cadarette
Summary: This study aimed to compare fracture rates estimated using different definitions and found that coding decisions have a significant impact on fracture outcome definitions. The study highlights the importance and impact of coding decisions on fracture outcome identification and emphasizes the need for further research to inform best practice in fracture outcome identification.
Article
Multidisciplinary Sciences
Maria Luisa Faquetti, Enriqueta Vallejo-Yague, Rene Cordtz, Lene Dreyer, Andrea M. Burden
Summary: Janus Kinase inhibitors (JAKis) are important synthetic drugs used to treat rheumatoid arthritis (RA) patients. However, there have been debates regarding the safety concerns associated with JAKi use, including increased risk for venous thromboembolism (VTE), serious viral infection, and major adverse cardiovascular events (MACE). This study aims to enrich the safety profile of JAKis using real-world data from the Danish DANBIO registry.
Article
Medicine, General & Internal
Stefan Russmann, Fabiana Martinelli, Franziska Jakobs, Manjinder Pannu, David F. F. Niedrig, Andrea Michelle Burden, Martina Kleber, Markus Bechir
Summary: Potential medication errors and related adverse drug events (ADE) are challenging in clinical medicine. Clinical decision support systems (CDSSs) can help identify preventable prescription errors but often lack specificity. In this study, CDSS performance was analyzed using two systems (pharmaVISTA and MediQ) to evaluate drug-drug interactions and other factors. Automated analyses produced an average of 15.5 alerts per patient, but expert evaluation resulted in only 0.8 recommendations per patient. Co-factors such as comorbidities and laboratory results were decisive for classifying CDSS alerts as clinically relevant.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Mohamad Nasser, Annika Vestergaard Kvist, Peter Vestergaard, Richard Eastell, Andrea M. Burden, Morten Frost
Summary: The study investigated the trends in fracture incidence rates among men and women with type 1 and type 2 diabetes. The results showed a decrease in fracture incidence rates in men with both types of diabetes and in women with type 2 diabetes, highlighting the need for further attention to the stable trend observed in women with type 1 diabetes.
Article
Rheumatology
Theresa Burkard, Enriqueta Vallejo-Yague, Kim Lauper, Axel Finckh, Thomas Hugle, Andrea M. Burden
Summary: The study found that an increase in BMI may not result in changes in DAS28-esr in patients receiving infliximab, but may lead to a decrease in joint erosions.
