Article
Geriatrics & Gerontology
Tiberiu A. Pana, Sheng Hui Kioh, Samuel R. Neal, Maw Pin Tan, Sumaiyah Mat, Alireza Moayyeri, Robert N. Luben, Nicholas J. Wareham, Kay-Tee Khaw, Phyo K. Myint
Summary: This cohort study aimed to determine the association between body fat percentage (BF%), incident fractures and calcaneal broadband ultrasound attenuation (BUA). The results showed that higher BF% is associated with lower risk of fractures in women, while increasing BF% >23% is associated with higher risk of hip fractures in men.
Article
Endocrinology & Metabolism
Carrie Ye, William D. Leslie, Saeed Al-Azazi, Lin Yan, Lisa M. Lix, Piotr Czaykowski, Harminder Singh
Summary: This study assessed post-fracture mortality in cancer patients and found that major fractures (hip, vertebrae, humerus, and forearm) were associated with early and long-term increased all-cause mortality.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Public, Environmental & Occupational Health
S. H. Park, S. R. Yoon, J. Y. Nam, J. Y. Ahn, S. J. Jeong, N. S. Ku, J. Y. Choi, J. -S. Yeom, J. H. Kim
Summary: This nationwide cohort study demonstrated an association between tuberculosis and osteoporosis as well as osteoporotic fractures. Tuberculosis was found to independently increase the incidence of osteoporosis and osteoporotic fractures, particularly hip fractures.
Article
Endocrinology & Metabolism
Henrik Falhammar, Louise Frisen, Angelica Linden Hirschberg, Agneta Nordenskjold, Catarina Almqvist, Anna Nordenstrom
Summary: Patients with congenital adrenal hyperplasia (CAH) have an increased prevalence of fractures, especially those associated with osteoporosis. This highlights the need for regular assessment of fracture risk and optimization of treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Orthopedics
Jianchun Tao, Yun Zhang, Caixia Tan, Wenfu Tan
Summary: This study investigated the association between weight-adjusted waist circumference index (WWI) and fractures among adults. Higher WWI was found to be associated with an increased prevalence of hip fracture and spine fracture, but not wrist fracture.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Health Care Sciences & Services
Dongyeop Kim, Jee Hyun Kim, Tae-Jin Song
Summary: This study found that variability in serum total cholesterol (TC) is associated with the risk of osteoporotic fractures. Higher TC variability was significantly associated with an increased risk of overall osteoporotic fractures, as well as vertebral and hip fractures. Maintaining stable TC levels may help reduce the risk of osteoporotic fractures in the future.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Axel Wester, Nelson Ndegwa, Hannes Hagstrom
Summary: This study analyzed the epidemiological characteristics of alcohol-related cirrhosis in a case-control study and the association between alcohol-related cirrhosis and the risk of fractures and postfracture mortality. The results showed that patients with alcohol-related cirrhosis had a higher incidence of fractures and higher postfracture mortality compared to the control group. Therefore, preventive interventions to reduce modifiable fracture risk factors in this population are justified.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Endocrinology & Metabolism
Xavier Suris, Emili Vela, Montserrat Cleries, Maria-Jesus Pueyo-Sanchez, Esteve Llargues, Marta Larrosa
Summary: This study aimed to estimate the incidence of major osteoporotic fractures in Catalonia, Spain in 2018 and 2019 and their association with age, sex, income, climate, and comorbidities. The results showed that major osteoporotic fractures are frequent in the adult Catalan population, especially in older women and people with low incomes. Hip fracture was the most common type, followed by forearm and vertebral fractures. Smoking, alcohol abuse, and certain comorbidities were associated with a higher incidence of fractures, while obesity was found to be a protective factor.
ARCHIVES OF OSTEOPOROSIS
(2022)
Article
Endocrinology & Metabolism
W. D. Leslie, B. Edwards, S. Al-Azazi, L. Yan, L. M. Lix, P. Czaykowski, H. Singh
Summary: The study found that cancer patients who experience fractures have equally poor post-fracture osteoporosis care as cancer-free individuals, indicating a significant care gap that needs to be addressed in both populations.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Environmental Sciences
Yuan-Yi Pai, Jiaan-Der Wang, Hsin-En Ho, Yi-Jung Chou, Wen-Chao Ho, Wei-Cheng Chan, Wei-Min Chu, Yu-Tse Tsan
Summary: This study investigated the incidence of fractures among patients with hemophilia. The study found that patients with hemophilia had a higher risk of osteoporotic fracture, but there was no significant difference in all-site fractures and repeated fractures compared to the general population. Therefore, screening, prevention, and treatment for osteoporosis and further osteoporotic fractures among patients with hemophilia are essential.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Geriatrics & Gerontology
Nicola Veronese, Francesco Bolzetta, Chiara Cacco, Alberto Cester, Lee Smith, Jacopo Demurtas, Cyrus Cooper, Rene Rizzoli, Maria Gabriella Caruso, Maria Notarnicola, Jean-Yves Reginster, Stefania Maggi, Mario Barbagallo, Mike Trott, Ligia J. Dominguez
Summary: This study is the first to report that high dietary acrylamide may be associated with an increased risk of osteoporotic fractures.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
A. F. Hamad, S. Yang, L. Yan, W. D. Leslie, S. N. Morin, R. Walld, L. L. Roos, L. M. Lix
Summary: The study found that a history of sibling fractures is associated with an increased risk of major osteoporotic fractures, which could be an important factor in predicting fracture risk.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
J. -E. Tarride, J. D. Adachi, J. P. Brown, E. Schemitsch, L. Slatkovska, N. Burke
Summary: The study revealed that in Ontario, the first-year direct healthcare costs of fragility fractures were three times higher for patients with fractures compared to those without fractures. Over 60% of the direct costs were attributed to hospitalization and continuing care, highlighting the significant economic burden fractures pose on the healthcare system.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Johanna Schoenau, Axel Wester, Joern M. Schattenberg, Hannes Hagstrom
Summary: People with PBC have a higher risk of osteoporosis-related fractures and higher postfracture mortality compared to the general population.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Ta-Wei Tai, Jawl-Shan Hwang, Chia-Chun Li, Jason C. Hsu, Chih-Wei Chang, Chih-Hsing Wu
Summary: Hip fracture patients receiving anti-osteoporosis treatment have reduced mortality rates. Oral bisphosphonates, ibandronate, zoledronic acid, and denosumab were associated with lower all-cause mortality rates among these patients.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Morten S. Hansen, Kent Soe, Line L. Christensen, Paula Fernandez-Guerra, Nina W. Hansen, Rachael A. Wyatt, Claire Martin, Rowan S. Hardy, Thomas L. Andersen, Jacob B. Olesen, Bolette Hartmann, Mette M. Rosenkilde, Moustapha Kassem, Alexander Rauch, Caroline M. Gorvin, Morten Frost
Summary: Drugs targeting the GIP receptor have potential as treatments for type-2 diabetes and obesity. GIP can directly act on human bone cells to inhibit bone resorption, increase bone formation, and improve osteoblast survival. Therefore, these drugs may reduce bone resorption while preserving bone formation.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Mohamad Nasser, Jacob Stidsen, Kurt Hojlund, Jens Steen Nielsen, Richard Eastell, Morten Frost
Summary: The study found that bone turnover markers are lower in individuals with type 2 diabetes, and their levels are associated with insulin sensitivity. Among the three phenotypes of type 2 diabetes, individuals with the insulinopenic phenotype have higher levels of bone turnover markers. The conclusion is that bone turnover markers are lower in newly diagnosed individuals with type 2 diabetes characterized by low insulin sensitivity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Medicine, General & Internal
Suzanne M. Jan de Beur, Salvatore Minisola, Wei-Bo Xia, Bo Abrahamsen, Jean-Jacques Body, Maria Luisa Brandi, Roderick Clifton-Bligh, Michael Collins, Pablo Florenzano, Pascal Houillier, Yasuo Imanishi, Erik A. Imel, Aliya A. Khan, M. Carola Zillikens, Seiji Fukumoto
Summary: Tumor-induced osteomalacia (TIO) is a rare condition caused by tumors that secrete fibroblast growth factor 23 (FGF23), leading to bone pain, muscle weakness, and low levels of vitamin D. Limited awareness of TIO among the medical community often leads to delayed diagnosis and poor outcomes. A global guidance document has been developed to improve knowledge and facilitate appropriate diagnosis, referral, and treatment of TIO. Key recommendations include measuring phosphate levels, conducting physical examinations to identify potential tumors, and utilizing functional imaging for tumor localization.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
John A. Kanis, Nicholas C. Harvey, Enwu Liu, Liesbeth Vandenput, Mattias Lorentzon, Eugene McCloskey, Roger Bouillon, Bo Abrahamsen, Lars Rejnmark, Helena Johansson
Summary: Patients with primary hyperparathyroidism have increased incidence of hip and major osteoporotic fractures, even if not referred for parathyroidectomy. The risk of death is also increased, which affects fracture probability. These findings support the need to widen the indications for parathyroidectomy in mild primary hyperparathyroidism.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Michael Kriegbaum Skjodt, Joeri Nicolaes, Christopher Dyer Smith, Cesar Libanati, Cyrus Cooper, Kim Rose Olsen, Bo Abrahamsen
Summary: This study examines the direct healthcare costs of subjects with vertebral fractures available for identification on routine CT scans. The results show that patients with vertebral fractures incur significantly higher healthcare costs compared to those without fractures. The study also found that the healthcare costs per day at risk were higher in the short term for patients with vertebral fractures, although this difference was not statistically significant, and the long-term healthcare costs were similar to the general population.
Review
Endocrinology & Metabolism
Michael Kriegbaum Skjodt, Bo Abrahamsen
Summary: This article summarizes the recent advances in the understanding of vertebral fractures, with a focus on endocrine diseases, prevention, and treatment. It highlights the increased risk of vertebral fractures in patients with endocrine diseases and the current focus on invasive treatments. It also mentions that licensed treatments are effective in reducing the occurrence of vertebral fractures in osteoporosis patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Medicine, General & Internal
Mina Nicole Handel, Isabel Cardoso, Cecilie von Bulow, Jeanett Friis Rohde, Anja Ussing, Sabrina Mai Nielsen, Robin Christensen, Jean-Jacques Body, Maria Luisa Brandi, Adolfo Diez-Perez, Peyman Hadji, Muhammad Kassim Javaid, Willem Frederik Lems, Xavier Nogues, Christian Roux, Salvatore Minisola, Andreas Kurth, Thierry Thomas, Daniel Prieto-Alhambra, Serge Livio Ferrari, Bente Langdahl, Bo Abrahamsen
Summary: This study aimed to review the comparative effectiveness of osteoporosis treatments, including the bone anabolic agents, abaloparatide and romosozumab, on reducing the risk of fractures in postmenopausal women, and to characterize the effect of antiosteoporosis drug treatments on the risk of fractures according to baseline risk factors. The results showed that osteoporosis treatments had a protective effect on reducing fracture risk, and bone anabolic agents were more effective than bisphosphonates.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Biology
Thach Tran, Thao Ho-Le, Dana Bliuc, Bo Abrahamsen, Louise Hansen, Peter Vestergaard, Jacqueline R. Center, Tuan Nguyen
Summary: The concept of "Skeletal Age" is introduced to convey the combined risk of fracture and fracture-associated mortality. Skeletal Age is defined as the sum of chronological age and the number of years of life lost associated with a fragility fracture. The study found that men tend to lose more years of life after a fragility fracture than women, and hip fractures result in the greatest loss of life years.
Article
Clinical Neurology
Carrinna Aviaja Hansen, Martin Thomsen Ernst, Christopher Dyer Smith, Bo Abrahamsen
Summary: This study aimed to characterize the epidemiological risk factors associated with long-term non-cancer opioid use among Danish citizens. The findings revealed that factors such as age, marital status, residence, and medication usage were associated with long-term opioid use. These findings are crucial for future revisions of treatment recommendations.
JOURNAL OF PAIN RESEARCH
(2023)
Article
Endocrinology & Metabolism
Michael Kriegbaum Skjodt, Joeri Nicolaes, Christopher Dyer Smith, Kim Rose Olsen, Cyrus Cooper, Cesar Libanati, Bo Abrahamsen
Summary: We evaluated the risk of subsequent fractures in individuals with vertebral fractures (VFs) identified on routine computed tomography (CT) scans. We found that subjects with VF had a higher risk of major osteoporotic fractures, especially hip fractures, compared to those without VF. This highlights the importance of systematic opportunistic screening and fracture risk management for this high-risk population.
Article
Endocrinology & Metabolism
Joeri Nicolaes, Michael Kriegbaum Skjodt, Steven Raeymaeckers, Christopher Dyer Smith, Bo Abrahamsen, Thomas Fuerst, Marc Debois, Dirk Vandermeulen, Cesar Libanati
Summary: This study developed a machine learning algorithm to identify vertebral fractures in abdominal/chest CT scans and demonstrated its strong performance on an external validation set. It has the potential to support healthcare professionals with the early identification of vertebral fractures and prevention of future fragility fractures.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Sebastian Zanner, Elliott Goff, Samuel Ghatan, Eva Maria Woelfel, Charlotte Ejersted, Gisela Kuhn, Ralph Mueller, Morten Frost
Summary: Clinical studies have shown that microvascular disease (MVD) can affect bone microstructure and decrease bone strength in patients with type 2 diabetes mellitus (T2D). This study collected bone biopsies from T2D patients and found that MVD may alter the morphometric parameters of osteocyte lacunae. Additionally, the study revealed that trabecular bone lacunar density was associated with glycated hemoglobin (HbA1c), independent of MVD.
Article
Endocrinology & Metabolism
Mohamad Nasser, Annika Vestergaard Kvist, Peter Vestergaard, Richard Eastell, Andrea M. Burden, Morten Frost
Summary: The study investigated the trends in fracture incidence rates among men and women with type 1 and type 2 diabetes. The results showed a decrease in fracture incidence rates in men with both types of diabetes and in women with type 2 diabetes, highlighting the need for further attention to the stable trend observed in women with type 1 diabetes.
Article
Health Care Sciences & Services
Helena Kames Kjeldgaard, Kristin Holvik, Bo Abrahamsen, Grethe S. Tell, Haakon E. Meyer, Martin O'Flaherty
Summary: Although the age-standardised hip fracture incidence has declined in many countries, the number of fractures is expected to increase due to population aging. This study found that 91% of the decline in hip fractures can be explained by changes in risk factors and the promotion of osteoporosis treatment.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Correction
Endocrinology & Metabolism
Alexander J. Rodriguez, Bo Abrahamsen