Article
Radiology, Nuclear Medicine & Medical Imaging
Pei-Shan Tsai, Dao-Chen Lin, Ya-Ting Jan, Yu-Peng Liu, Tung-Hsin Wu, Shih-Chieh Huang
Summary: This study found that the quantity of muscle mass in the lower extremities is associated with the severity of vascular stenosis in PAD patients. The muscle mass in the legs of PAD patients is lower and changes earlier than in the abdomen. Age, gender, BMI, and PAD are factors associated with low muscle mass.
EUROPEAN RADIOLOGY
(2023)
Article
Endocrinology & Metabolism
Matthias Walle, Danielle E. Whittier, Denis Schenk, Penny R. Atkins, Michael Blauth, Philippe Zysset, Kurt Lippuner, Ralph Mueller, Caitlyn J. Collins
Summary: This study developed bone mechanoregulation markers and their precision using participants from two cohorts. The results showed that bone formation occurred in high-strain regions and bone resorption occurred in low-strain regions for all participants, indicating a consistent response to mechanical stimuli. This work provides novel and robust bone mechanoregulation markers for designing future clinical studies.
Article
Endocrinology & Metabolism
Kara B. Anderson, Monica C. Tembo, Sophia X. Sui, Natalie K. Hyde, Julie A. Pasco, Mark A. Kotowicz, Kara L. Holloway-Kew
Summary: Peripheral quantitative computed tomography (pQCT) provides information about bone structure and density, which can help in predicting fracture risk. This study found that key pQCT parameters at both the radius and tibia were associated with prior fractures in men, highlighting their potential use in fracture risk prediction.
ARCHIVES OF OSTEOPOROSIS
(2021)
Article
Geriatrics & Gerontology
Alexander Simon, Hannah S. Schafer, Felix N. Schmidt, Julian Stuerznickel, Michael Amling, Tim Rolvien
Summary: This study demonstrated a systemic interaction between muscle strength and bone microarchitecture, primarily with the cortical bone compartment, in a retrospective analysis of data from 230 women at high risk of osteoporosis.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Rheumatology
Rasmus Klose-Jensen, Josephine Therkildsen, Anne-Birgitte Garm Blavnsfeldt, Bente L. Langdahl, Anna Zejden, Jesper Thygesen, Kresten Krarup Keller, Ellen-Margrethe Hauge
Summary: This study compares the accuracy of HR-pQCT and CR in classifying patients as having erosive RA, and the results show that these two methods are comparable.
Article
Endocrinology & Metabolism
Danielle E. Whittier, Elizabeth J. Samelson, Marian T. Hannan, Lauren A. Burt, David A. Hanley, Emmanuel Biver, Pawel Szulc, Elisabeth Sornay-Rendu, Blandine Merle, Roland Chapurlat, Eric Lespessailles, Andy Kin On Wong, David Goltzman, Sundeep Khosla, Serge Ferrari, Mary L. Bouxsein, Douglas P. Kiel, Steven K. Boyd
Summary: This study developed a fracture risk assessment tool based on high-resolution peripheral quantitative compute tomography (HR-pQCT) to evaluate patient-specific fracture risk. The tool, called mu FRAC, outperformed the current Fracture Risk Assessment Tool (FRAX) and models based on bone mineral density (BMD). It provides an alternative approach by utilizing direct measures of bone density and structure.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Orthopedics
Yousun Ko, Youngbin Shin, Yu Sub Sung, Jiwoo Lee, Jei Hee Lee, Jai Keun Kim, Jisuk Park, Hye Sun Ko, Kyung Won Kim, Jimi Huh
Summary: The upper thigh level shows good correlation with the mid-thigh and L3 inferior endpoint level for muscle area measurement. It also exhibits the highest inter-reader agreement, indicating its feasibility as a reliable and robust biomarker for sarcopenia assessment.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Christina L. Brunnquell, Carla Winsor, H. Laura Aaltonen, Scott Telfer
Summary: This article reviews the sources and sizes of error in spine and hip BMD estimates from single-energy QCT, as well as the baseline variance expected based on repeatability and reproducibility studies. Understanding the potential sources of error and their size relative to the diagnostic task is crucial for appropriate and meaningful interpretation of reproducible BMD estimates achieved with QCT.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Orthopedics
Constantin Schmidt, Christoph Riedel, Julian Stuerznickel, Herbert Mushumba, Maximilian M. Delsmann, Christian Ries, Sebastian Kleiss, Peter Bannas, Frank Timo Beil, Michael Amling, Klaus Pueschel, Tim Rolvien, Jan Hubert
Summary: This study investigates the association between demographic characteristics and microarchitectural parameters in distal femur fractures. The findings suggest that female sex, advanced age, and low bone mineral density (BMD) are major risk factors for impaired microarchitecture and fracture in this skeletal site.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Endocrinology & Metabolism
Shima Abdelrahman, Mariel Purcell, Timo Rantalainen, Sylvie Coupaud, Alex Ireland
Summary: Osteoporosis is a consequence of spinal cord injury that leads to fragility fractures. This study examined regional bone loss in 13 individuals with SCI, finding that bone loss varies regionally in the tibial diaphysis. Additionally, bone loss at 4 months is a strong predictor of total loss 12 months postinjury.
Article
Radiology, Nuclear Medicine & Medical Imaging
I. Molwitz, M. Leiderer, R. McDonough, R. Fischer, A-K. Ozga, C. Ozden, E. Tahir, D. Koehler, G. Adam, J. Yamamura
Summary: Quantifying fat within skeletal muscle using DECT is feasible and reliable, with excellent correlations between DECT-FF and MR-FF, DECT VNC HU and MR-FF, and DECT-FF and DECT VNC HU. DECT muscle analysis offers a new approach to determine muscle quality, crucial for diagnosing and monitoring sarcopenia as a comorbidity associated with poor clinical outcomes.
EUROPEAN RADIOLOGY
(2021)
Article
Endocrinology & Metabolism
J. P. van den Bergh, P. Szulc, A. M. Cheung, M. Bouxsein, K. Engelke, R. Chapurlat
Summary: HR-pQCT has been developed for imaging bone microarchitecture in peripheral skeletal sites, with increasing clinical research focusing on understanding skeletal fragility and improving fracture prediction. Differentiation and reference data for HR-pQCT variables by age, sex, and race/ethnicity have been provided, along with discussions on fracture risk prediction, monitoring response to anti-osteoporosis therapy, and novel applications in patients with metabolic bone disorders and secondary osteoporosis.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Orthopedics
Balazs Juhasz, Katalin Gulyas, Agnes Horvath, Edit Vegh, Anita Pusztai, Agnes Szentpetery, Zsofia Petho, Nora Bodnar, Attila Hamar, Levente Bodoki, Harjit Pal Bhattoa, Eva Szekanecz, Katalin Hodosi, Andrea Domjan, Szilvia Szamosi, Csaba Horvath, Sandor Szanto, Gabriella Szucs, Hennie G. Raterman, Willem F. Lems, Oliver FitzGerald, Zoltan Szekanecz
Summary: BMD as determined by QCT did not change over one year of anti-TNF treatment. Disease activity, CATHK, RANKL and VITD may be associated with the effects of anti-TNF treatment on QCT BMD changes. RA and AS may differ in this respect.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Simon Lennartz, Anushri Parakh, Jinjin Cao, David Zopfs, Nils Grosse Hokamp, Avinash Kambadakone
Summary: The study investigates the inter-scan and inter-scanner variation of iodine concentration and attenuation in different DECT scanners, finding that the iodine concentration shows higher variation compared to attenuation values. This variation depends on the scanner pairs and organs assessed, highlighting the importance of acknowledging these differences in clinical and scientific DECT applications.
EUROPEAN RADIOLOGY
(2021)
Article
Medicine, General & Internal
Xu Wang, Beibei Li, Xiaoyu Tong, Yong Fan, Shigeng Wang, Yijun Liu, Xin Fang, Lei Liu
Summary: The purpose of this study was to evaluate the diagnostic accuracy of various base material pairs (BMPs) in dual-energy computed tomography (DECT) and establish diagnostic standards by comparing with quantitative computed tomography (QCT). A total of 469 patients were included in the study, and measurements of bone density and bone mineral density (BMD) were performed. The results showed that using hydroxyapatite (water) in DECT had the highest diagnostic accuracy for osteopenia and osteoporosis.
Article
Medicine, General & Internal
Todd O. McKinley, Paul Childress, Emily Jewell, Kaitlyn S. Griffin, Austin E. Wininger, Aamir Tucker, Adam Gremah, Michael K. Savaglio, Stuart J. Warden, Robyn K. Fuchs, Roman M. Natoli, Karl D. Shively, Jeffrey O. Anglen, Tien-Min Gabriel Chu, Melissa A. Kacena
Summary: This study developed two porcine CSD models using IMN fixation and dual-plate fixation. The porcine models demonstrated relevance in simulating human conditions. BMP-2 was effective in restoring bone healing in both CSD models, with visible effects within the first month after injury.
Article
Endocrinology & Metabolism
S. J. Warden, Z. Liu, R. K. Fuchs, B. van Rietbergen, S. M. Moe
Summary: This study provides reference data for HR-pQCT measures in a population of White adults, revealing differences between ages, sexes, and sites. Excel-based calculators were developed to compute subject-specific percentiles, z-scores, and t-scores and to plot individual outcomes on fitted curves.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Chenxi Yan, Ryan J. Bice, Jeff W. Frame, Stuart J. Warden, Mariana E. Kersh
Summary: Using finite element simulations, strain and strain rate distributions at different locations of the tibia during various activities were calculated for basketball players, with the highest strains and strain rates observed during sprinting and lateral cut activities. While compressive strains predominantly occurred in the posterior tibia, tensile strain locations varied, suggesting different preventative and management strategies for tibial bone stress injuries.
Article
Medicine, General & Internal
Tim Hoenig, Kathryn E. Ackerman, Belinda R. Beck, Mary L. Bouxsein, David B. Burr, Karsten Hollander, Kristin L. Popp, Tim Rolvien, Adam S. Tenforde, Stuart J. Warden
Summary: Bone stress injuries, such as stress fractures, are common overuse injuries in active individuals. These injuries occur when the normal skeletal structure is subjected to excessive repetitive loads. The exact mechanisms for bone stress injuries are not fully understood, but it is believed that an imbalance in bone metabolism leads to microdamage accumulation and inhibits the repair process. Diagnosis is based on patient history, physical examination, and imaging. Treatment depends on the location and risk of healing complications, and may include activity modification, progressive loading, immobilization, medications, or surgery. Understanding the anatomical, biomechanical, and biological risk factors can help improve the prevention and management of these injuries.
NATURE REVIEWS DISEASE PRIMERS
(2022)
Article
Sport Sciences
Stuart J. J. Warden, Austin M. M. Sventeckis, Rachel K. K. Surowiec, Robyn K. K. Fuchs
Summary: The study showed that female collegiate-level cross-country runners who participated in multidirectional sports when younger had stronger bones and reduced risk of bone stress injuries.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Review
Endocrinology & Metabolism
Perla C. Reyes Fernandez, Christian S. Wright, Stuart J. Warden, Julia Hum, Mary C. Farach-Carson, William R. Thompson
Summary: This review discusses the mechanism of action of gabapentinoids and the potential consequences of long-term treatment with these drugs on the musculoskeletal system. It highlights that long-term use of gabapentinoids is associated with detrimental musculoskeletal outcomes, including increased fracture risk. Understanding these potential complications is crucial for clinicians to guide appropriate treatments.
CURRENT OSTEOPOROSIS REPORTS
(2022)
Editorial Material
Sport Sciences
Stuart J. Warden, Tim Hoenig, Austin M. Sventeckis, Kathryn E. Ackerman, Adam S. Tenforde
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Review
Sport Sciences
Tim Hoenig, Julian Eissele, Andre Strahl, Kristin L. Popp, Julian Stuerznickel, Kathryn E. Ackerman, Karsten Hollander, Stuart J. Warden, Karl-Heinz Frosch, Adam S. Tenforde, Tim Rolvien
Summary: This systematic review examines the prognostic role of injury location on return-to-sport and treatment complications after bone stress injuries (BSIs) of the lower extremity and pelvis. The findings suggest that the anatomical site of BSIs influences the timelines for return to sport and the risk of complications.
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Review
Orthopedics
S. L. Coburn, K. M. Crossley, J. L. Kemp, S. J. Warden, T. J. West, A. M. Bruder, B. F. Mentiplay, A. G. Culvenor
Summary: This systematic review examines the immediate and delayed effects of running on hip and knee cartilage. The study finds that running leads to immediate decreases in cartilage thickness, volume, and relaxation times in the knee, but these changes are small and appear to be temporary, suggesting that a single bout of running is not detrimental to knee cartilage.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Endocrinology & Metabolism
Rachel K. Surowiec, Elizabeth A. Swallow, Stuart J. Warden, Matthew R. Allen
Summary: This study describes a technique to evaluate individual cortical pore dynamics in aging females over one year using HR-pQCT imaging and determines whether formation and expansion of pores would exceed contraction and infilling of pores.
Article
Multidisciplinary Sciences
Charalampos Lyssikatos, Zhiying Wang, Ziyue Liu, Stuart J. Warden, Marco Brotto, Lynda Bonewald
Summary: The study found that exercise leads to increased levels of L-BAIBA and D-BAIBA, and these levels are associated with physical performance. Specifically, L-BAIBA is positively correlated with BMI, fat mass, and bone mineral density in females, but not in males. On the other hand, D-BAIBA is positively correlated with age and gait speed, but the associations vary in different genders and performance levels.
SCIENTIFIC REPORTS
(2023)
Review
Sport Sciences
Sally L. L. Coburn, Kay M. M. Crossley, Joanne L. L. Kemp, Stuart J. J. Warden, Tom J. J. West, Andrea M. M. Bruder, Benjamin F. F. Mentiplay, Adam G. G. Culvenor
Summary: This study summarized the impact of activity-related joint loading on knee and hip cartilage in healthy adults. It found that certain joint loading activities can lead to a decrease in cartilage, but also provided information on the recovery time of knee cartilage.
SPORTS MEDICINE-OPEN
(2023)
Article
Endocrinology & Metabolism
Sonia Afshariyamchlou, Michelle Ng, Asmaa Ferdjallah, Stuart J. Warden, Paul Niziolek, Imranul Alam, Lynda E. Polgreen, Erik A. Imel, Paul Orchard, Michael J. Econs
Summary: This article presents a case study of male siblings with autosomal recessive osteopetrosis who underwent hematopoietic stem cell transplant (HSCT) and survived into adulthood. Despite improvements in clinical parameters, the patients continued to have significantly elevated bone density and decreased marrow space. The study suggests that the cortical bone may be particularly sensitive to the resorptive activity of transplanted osteoclasts, leading to increased cortical porosity. Moreover, high-resolution peripheral quantitative computed tomography (HR-pQCT) was identified as a potentially useful modality for imaging and assessing the therapeutic effects on bone in individuals with osteopetrosis.
Meeting Abstract
Orthopedics
S. L. Coburn, K. M. Crossley, J. L. Kemp, S. J. Warden, T. J. West, A. M. Bruder, A. G. Culvenor
OSTEOARTHRITIS AND CARTILAGE
(2022)
Meeting Abstract
Anthropology
Osbjorn M. Pearson, Ian J. Wallace, Tea Jashashvili, Kristian J. Carlson, Stuart J. Warden, John G. Fleagle
AMERICAN JOURNAL OF BIOLOGICAL ANTHROPOLOGY
(2022)