Article
Endocrinology & Metabolism
Benjamin Tze Keong Ding, Hai Fon Lim, Fadzleen Johari, Remesh Kunnasegaran
Summary: This study evaluates the efficacy of an Orthopaedic Surgeon Led Osteoporosis Model of Care (OSLO-MoC) in improving the care of patients with primary osteoporotic fractures. The study shows that the OSLO-MOC is effective in improving medication compliance and reducing secondary fractures in patients.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Gregory A. Kline, Suzanne N. Morin, Lisa M. Lix, William D. Leslie
Summary: Bone mineral density (BMD) loss shows greater variability at shorter testing intervals, but this variability diminishes over longer intervals. Using reports of rapid BMD loss as an indication for antifracture medication initiation may not be accurate.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Hongli Shi, Xin Jiang, Cuidi Xu, Qun Cheng
Summary: This study investigated the differences in miRNA expression profiles in postmenopausal osteoporosis patients with fragility fractures and identified several miRNAs associated with bone mineral density. The study also explored the potential role of these miRNAs in the pathophysiology of postmenopausal osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ciro Menale, Gaia Tabacco, Anda Mihaela Naciu, Maria Lucia Schiavone, Francesca Cannata, Emanuela Morenghi, Cristina Sobacchi, Andrea Palermo
Summary: The study aimed to assess the association between Dpp3 activity and bone fragility in postmenopausal osteoporosis, as well as the impact of denosumab on the enzymatic activity. The results showed that serum Dpp3 activity was significantly reduced in patients with severe osteoporosis compared to controls and was associated with bone mass. Additionally, there was a negative correlation between Dpp3 activity and specific bone metabolism markers. Dpp3 activity did not change after denosumab injection.
Article
Endocrinology & Metabolism
Karen Burgueno-Aguilar, Francisco Fidencio Cons-Molina, Daniela Garcia-Jimenez, Luis Eduardo Bejarano-Lopez, Marissa Alexandra Gudino-Barroso
Summary: Dysmobility Syndrome (DS) associates sarcopenia and osteoporosis with mobility disturbances, obesity, fractures, and falls. This study found a 74% prevalence of DS in Mexican postmenopausal women, with a close connection to non-vertebral fragility fractures. More research is needed to understand the prevalence and characteristics of DS in Mexican women and populations across the country.
ARCHIVES OF OSTEOPOROSIS
(2021)
Review
Geriatrics & Gerontology
Nicholas Fuggle, Nasser Al-Daghri, Olivier Bock, Jaime Branco, Olivier Bruyere, Enrique Casado, Etienne Cavalier, Bernard Cortet, Maarten de Wit, Andrea Giusti, Philippe Halbout, Nicholas C. Harvey, Mickael Hiligsmann, Jean-Marc Kaufman, Andreas Kurth, Stefania Maggi, Radmila Matijevic, Salvatore Minisola, Santiago Palacios, Regis Pierre Radermecker, Friederike Thomasius, Sansin Tuzun, Nicola Veronese, John A. Kanis, Jean-Yves Reginster, Rene Rizzoli, Cyrus Cooper
Summary: Oral bisphosphonates are important in the treatment of osteoporosis, but poor adherence is a problem. New formulations aim to improve tolerance and adherence, potentially leading to better fracture outcomes.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Orthopedics
Miguel Viana Pereira Filho, Kelly Cristina Stefani, Gabriel Ferraz Ferreira, Monica Paschoal Nogueira
Summary: Insufficiency fractures in the foot and ankle predominantly occur in the metatarsals, with the base of the fifth metatarsal being the most common site. Chronic corticosteroid use and low lumbar bone mineral density were identified as risk factors associated with fracture development.
FOOT & ANKLE INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Carolyn J. Crandall, Rebecca P. Hunt, Andrea Z. LaCroix, John A. Robbins, Jean Wactawski-Wende, Karen C. Johnson, Maryam Sattari, Katie L. Stone, Julie C. Weitlauf, Tanya R. Gure, Jane A. Cauley
Summary: This study prospectively analyzed the association between subsequent fractures in postmenopausal women after initial fractures at different sites. The results showed that different types of initial fractures increased the risk of subsequent fractures of different types, and this risk was observed across all age groups of women.
Article
Environmental Sciences
Claudio Ripamonti, Lucia Lisi, Jacopo Ciaffi, Angela Buffa, Renata Caudarella, Francesco Ursini
Summary: This study demonstrates that combining LS-BMD and TBS can improve the diagnostic ability for vertebral fragility fractures, with a significant probability of absence of fractures.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Endocrinology & Metabolism
K. Kerschan-Schindl, M. Hackl, E. Boschitsch, U. Foeger-Samwald, O. Naegele, S. Skalicky, M. Weigl, J. Grillari, P. Pietschmann
Summary: This study aimed to investigate and evaluate the diagnostic accuracy of osteomiRs for osteoporosis, revealing their potential application in the prevention and diagnosis of osteoporosis.
CALCIFIED TISSUE INTERNATIONAL
(2021)
Article
Nutrition & Dietetics
Antonino Catalano, Federica Bellone, Domenico Santoro, Peter Schwarz, Agostino Gaudio, Giorgio Basile, Maria Carmela Sottile, Sabrina Atena Stoian, Francesco Corica, Nunziata Morabito
Summary: Vitamin D supplementation can increase bone density in postmenopausal women, especially after discontinuation of alendronate. Changes in 25-hydroxyvitamin D levels are associated with changes in bone mineral density.
Article
Endocrinology & Metabolism
E. McCloskey, J. Rathi, S. Heijmans, M. Blagden, B. Cortet, E. Czerwinski, P. Hadji, J. Payer, K. Palmer, R. Stad, J. O'Kelly, S. Papapoulos
Summary: This study conducted in 8 European countries revealed a significant treatment gap in osteoporosis-related fracture risk management for elderly women in primary care, mainly due to the lack of osteoporosis diagnosis.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Eugene McCloskey, Jeetandera Rathi, Stephane Heijmans, Mark Blagden, Bernard Cortet, Edward Czerwinski, Peyman Hadji, Juraj Payer, Kerry Palmer, Robert Stad, James O'Kelly, Socrates Papapoulos
Summary: This study examines whether elderly women at risk for fractures receive primary care treatment to prevent fracture. The findings show that women at risk are often not identified across Europe, and less than half of them receive appropriate treatment. Furthermore, women diagnosed with osteoporosis are more likely to receive treatment.
ARCHIVES OF OSTEOPOROSIS
(2022)
Article
Endocrinology & Metabolism
Jacopo Antonino Vitale, Veronica Sansoni, Martina Faraldi, Carmelo Messina, Chiara Verdelli, Giovanni Lombardi, Sabrina Corbetta
Summary: The study investigated the relationship between osteocalcin (OC) and body composition, risk of fall, and bone-muscle crosstalk in osteoporotic postmenopausal women. Results showed that serum cOC levels correlated with skeletal muscle mass and function, acting as a mediator in the bone-muscle crosstalk. Circulating levels of cOC and uOC may be differentially regulated in fractured and unfractured osteoporotic women, indicating potential differences in bone metabolism.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Nicholas R. Fuggle, Beth Curtis, Michael Clynes, Jean Zhang, Kate Ward, Muhammad Kassim Javaid, Nicholas C. Harvey, Elaine Dennison, Cyrus Cooper
Summary: Despite significant progress in understanding osteoporosis over the past three decades, there is still a treatment gap where many high-risk individuals go untreated. This review highlights the patient, physician, and policy-related factors contributing to this gap, and focuses on discussing the efficacy and adverse effects of bisphosphonates in osteoporosis treatment, as well as strategies to improve prevention pathways for the disorder.
Meeting Abstract
Rheumatology
S. J. Bartlett, O. Schieir, M. F. Valois, G. Boire, G. Hazlewood, C. Thorne, D. Tin, C. Hitchon, J. Pope, E. Keystone, L. Bessette, V. Bykerk
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Meeting Abstract
Rheumatology
W. P. Maksymowych, L. Bessette, R. G. Lambert, A. Carapellucci, C. T. Appleton
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Meeting Abstract
Rheumatology
L. Gossec, L. Bessette, R. Xavier, E. G. Favalli, A. Ostor, M. H. Buch
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Letter
Rheumatology
Louis Bessette, Cassandra D. Kinch
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Health Care Sciences & Services
Susan J. Bartlett, Vivian P. Bykerk, Orit Schieir, Marie-France Valois, Janet E. Pope, Gilles Boire, Carol Hitchon, Glen Hazlewood, Louis Bessette, Edward Keystone, Carter Thorne, Diane Tin, Clifton O. Bingham
Summary: This study investigated the perception of disease activity change in rheumatoid arthritis (RA) patients and physicians, and estimated minimal and meaningful change thresholds. The results showed that the thresholds varied depending on the anchor used. These findings provide guidance for the assessment and decision-making in the management of RA.
QUALITY OF LIFE RESEARCH
(2023)
Article
Rheumatology
Louis Bessette, Mohammad Movahedi, George Reed, Joel M. Kremer, Kevin Kane, Edward Keystone
Summary: This study evaluated the response to a second TNFi or non-TNFi in patients failing their initial TNFi treatment. The results showed that patients with secondary failure were more likely to achieve treatment goals compared to patients with primary failure, regardless of the choice of second treatment.
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2023)
Correction
Rheumatology
R. Fleischmann, E. Mysler, L. Bessette
Article
Rheumatology
Walter P. Maksymowych, Robert D. Inman, Louis Bessette, Proton Rahman, Emmanouil Rampakakis, Odalis Asin-Milan, Meagan Rachich, Anne Marilise Marrache, Allen J. Lehman
Summary: A study found that sustained disease activity states, as measured by BASDAI and ASDAS, impact function in axial spondyloarthritis patients. Characteristics predicting sustained low functional impairment were evaluated in this prospective cohort study.
ARTHRITIS RESEARCH & THERAPY
(2023)
Article
Rheumatology
Louis Bessette, Boulos Haraoui, Emmanouil Rampakakis, Joanna Dembowy, Marc-Olivier Trepanier, Janet Pope
Summary: A study compared the effects of a treat-to-target approach and routine care in patients with rheumatoid arthritis and found that treat-to-target approach resulted in faster achievement of therapeutic goals.
ARTHRITIS RESEARCH & THERAPY
(2023)
Meeting Abstract
Rheumatology
Louis Bessette, Adriana Kakehasi, Neil Basu, David A. Walsh, Andra Balanescu, Clifton Bingham, Andrew Garrison, Ivan Lagunes, Sander Strengholt, Ralph Lippe, Maxime Dougados
ARTHRITIS & RHEUMATOLOGY
(2022)
Meeting Abstract
Rheumatology
Louis Bessette, Proton Rahman, John Kelsall, Jane Purvis, Emmanouil Rampakakis, Allen J. Lehman, Meagan Rachich, Francois Nantel, A. Marilise Marrache, Odalis Asin-Milan
ARTHRITIS & RHEUMATOLOGY
(2022)
Meeting Abstract
Rheumatology
Louis Bessette, Georg Pongratz, Luca Navarini, Rodrigo Garcia Salinas, Tianming Gao, Marie-Claude laliberte, Ralph Lippe, Philip J. Mease
ARTHRITIS & RHEUMATOLOGY
(2022)
Meeting Abstract
Rheumatology
Elaine Husni, Sona Kamat, Keri Stenger, Rebecca Bolce, Thorsten Holzkaemper, Cameron Helt, So Young Park, Jeffrey Lisse, Luca Idolazzi, Louis Bessette
JOURNAL OF RHEUMATOLOGY
(2022)
Meeting Abstract
Rheumatology
Walter Maksymowych, Robert Inman, Louis Bessette, Proton Rahman, Emmanouil Rampakakis, Odalis Asin-Milan, Meagan Rachich, Marilise Marrache, Allen Lehman
JOURNAL OF RHEUMATOLOGY
(2022)
Meeting Abstract
Rheumatology
Wen Qi, Antoine Robert, Narcisse Singbo, Lucie Ratelle, Louis Bessette, Paul Fortin, Jacques Brown, Laetitia Michou
JOURNAL OF RHEUMATOLOGY
(2022)