Article
Medicine, General & Internal
Sug Hun Che, Myung-Rae Cho, Patrick Michael Quinn, Suk-Kyoon Song
Summary: This study aimed to identify risk factors for hip fractures in elderly Korean patients, especially in patients with osteoporosis. The retrospective analysis of 168 patients showed that lower body weight, BMI, and BMD Z-scores were associated with a higher incidence of intertrochanteric fractures compared to femoral neck fractures. This suggests that there is a correlation between low body weight, BMI, and BMD Z-scores and an increased risk of intertrochanteric fractures in elderly Korean patients.
Article
Nutrition & Dietetics
Cheng-Feng Li, Yu-Ping Liu, Chun-Ying Liu, Hui-Lian Zhu, Bao-Hua Wu, Bao-Lin Li, Yu-Ming Chen
Summary: This study found a positive association between estimated dietary acid load and the risk of hip fractures in the elderly Chinese population, with a more pronounced effect in participants with a lower body mass index.
Article
Endocrinology & Metabolism
Zohar Yosibash, Nir Trabelsi, Itay Buchnik, Kent W. Myers, Moshe Salai, Iris Eshed, Yiftach Barash, Eyal Klang, Liana Tripto-Shkolnik
Summary: Autonomous finite element analyses (AFE) and machine learning (ML) algorithm were combined to predict the biomechanical response of femurs and the risk of hip fracture based on CT scans. A retrospective clinical study was conducted on CT scans of type 2 diabetic mellitus (T2DM) and non-T2DM patients. The AFE success rate in analyzing CT scans was 91%, and the ML algorithm achieved high prediction accuracy for the risk of hip fracture in both T2DM and non-T2DM populations.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Review
Medicine, General & Internal
Yaqi Hua, Yi Yuan, Xin Wang, Liping Liu, Jianting Zhu, Dongying Li, Ping Tu
Summary: This study systematically evaluated the risk prediction models for postoperative delirium in older adult hip fracture patients. The results showed that the established models had satisfactory predictive performance but there were also issues such as high risk of bias and lack of external validation.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Marcello Covino, Raffaele Vitiello, Giuseppe De Matteis, Nicola Bonadia, Andrea Piccioni, Luigi Carbone, Raffaella Zaccaria, Michele Cauteruccio, Veronica Ojetti, Francesco Franceschi
Summary: This study aimed to evaluate the risk of fracture as a consequence of trauma and its association with kidney function status in a cohort of elderly patients. The results showed that patients with non-end stage chronic kidney disease (CKD) had an increased risk of femur fracture after a fall, which may be associated with increased bone fragility. Active osteoporosis therapy was found to be an effective preventive factor.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2022)
Article
Orthopedics
Fei You, Chaoyang Ma, Fangfang Sun, Lian Liu, Xiuwen Zhong
Summary: Postoperative heart failure is relatively common in elderly patients with hip fracture, with risk factors including age, hypertension, anemia, hypoalbuminemia, and duration of surgery. Peri-operative risk assessment and prevention of related risks are crucial for a good prognosis.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Orthopedics
Hong Cao, Jian Yu, YaRu Chang, Yue Li, Bingqian Zhou
Summary: This study aimed to develop an optimal model for predicting delayed hospital discharge for hip fractures in order to support clinical decision-making. The prediction model was constructed using a Cox proportional hazards regression model and transformed into a nomogram. The model's performance was assessed using the area under the receiver operating characteristic curve, calibration curves, and decision curve analysis. The results showed that the prediction model had high predictive ability and could assist policymakers in developing strategies for the optimal management of hip fracture patients.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Orthopedics
Yue Li, Bo Dong
Summary: This study developed a risk prediction model for respiratory failure in elderly patients with hip fractures. The model showed good performance and can effectively predict the risk of respiratory failure in these patients.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Geriatrics & Gerontology
Bi-Xia Zhong, Hai-Li Zhong, Guan-Qun Zhou, Wen-Qi Xu, Ying Lu, Qian Zhao
Summary: The study aimed to evaluate the association between the risk of hip fracture and score on the Short Physical Performance Battery (SPPB) and handgrip strength in community-dwelling elderly people in China. Overall SPPB score, as well as performance on repeated chair stands and balance tests within the SPPB, were significantly and independently associated with increased hip fracture risk among the elderly Chinese participants. This suggests that these indicators could be useful in predicting hip fracture in clinical settings.
Article
Orthopedics
Timothy E. Hereford, Austin Porter, Jeffrey B. Stambough, Steven M. Cherney, Simon C. Mears
Summary: This study investigated the use of opioids in elderly patients after hip fracture surgery. The results showed a surprisingly high rate of chronic opioid use, with 23% of opioid-naive patients becoming chronic users after surgery. The study highlights the importance of orthopedic surgeons limiting the amount and duration of postoperative opioid prescriptions and monitoring patients for continued use.
JOURNAL OF ARTHROPLASTY
(2022)
Article
Geriatrics & Gerontology
J. Ahn, J. S. Chang, J. W. Kim
Summary: This study investigated the incidence of postoperative pneumonia and aspiration pneumonia after hip fracture surgery, finding rates of 3.9% and 1.7% respectively. Significant risk factors included postoperative delirium and preoperative serum albumin levels.
JOURNAL OF NUTRITION HEALTH & AGING
(2022)
Article
Medicine, General & Internal
Se-Won Lee, Younghyun Yoon, Junhyuk Kwon, Jun-Young Heu, Jihyo Hwang
Summary: The clinical significance of BMD discordance between the hip and spine for hip fractures was evaluated in this study. The results showed that the rates of BMD discordance and low hip discordance were significantly higher in the hip fracture group than in the non-fracture group, indicating a higher risk of hip fractures.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Geriatrics & Gerontology
Zhicong Wang, Xi Chen, Ling Yang, Hong Wang, Wei Jiang, Yuehong Liu
Summary: This study validated a new preoperative risk score for predicting mortality in elderly hip fracture patients and found that a high-risk score was an independent risk factor for mortality at 30 days, 6 months, and 1 year. Interestingly, each point increase in the risk score was associated with a corresponding increase in mortality risk.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Immunology
Ina Lackner, Birte Weber, Jochen Pressmar, Anna Odwarka, Charles Lam, Melanie Haffner-Luntzer, Ralph Marcucio, Theodore Miclau, Miriam Kalbitz
Summary: Hip fractures may lead to cardiac injury, especially in middle-aged and young mice. Aging and inflammaging are independent risk factors aggravating and accelerating cardiac alterations following hip fracture.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Minmin Chen, Yanping Du, Wenjing Tang, Weijia Yu, Huilin Li, Songbai Zheng, Qun Cheng
Summary: Hip fracture surgery in elderly Chinese patients is associated with high mortality and risk of second fracture within 2 years. Risk factors for mortality include male gender, increased age, preoperative hypoalbuminemia, preoperative pneumonia, and poor activities of daily living (ADL), while factors such as high preoperative hemoglobin, high preoperative eGFR, and high preoperative LVEF are protective. Poor ADL is also a risk factor for second fracture. Postoperative rehabilitation and improving ADL are essential to reduce mortality and second fracture.
JOURNAL OF BONE AND MINERAL METABOLISM
(2022)
Article
Medicine, General & Internal
Chih-Horng Wu, Po-Chin Liang, Chih-Hung Hsu, Fang-Tsu Chang, Yu-Yun Shao, Tiffany Ting-Fang Shih
Summary: The study investigated whether low skeletal muscle mass (LSMM) defined according to different muscle groups on computed tomography (CT) scans are predictive factors of survival for advanced hepatocellular carcinoma (HCC). Muscle area indices such as TSM, PM, and RA can serve as standards for LSMM diagnosis, with LSMM patients exhibiting poorer overall survival.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
I-Lun Shih, Rouh-Fang Yen, Chi-An Chen, Wen-Fang Cheng, Bang-Bin Chen, Yu-Hsuan Chang, Mei-Fang Cheng, Tiffany Ting-Fang Shih
Summary: PET/MRI biomarkers of cervical cancer are associated with tumor stage and survival. SUVmax and ADCmin are independent predictors of PFS and OS, respectively.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Medicine, General & Internal
Chih Horng Wu, Chia Ter Chao, Po Chin Liang, Tiffany Ting Fang Shih, Jenq Wen Huang
Summary: This study evaluated the correlation between computed tomography (CT) based sarcopenia assessment and edema-free lean soft tissue (LST) in patients receiving peritoneal dialysis (PD), as well as its association with patient prognosis. The results showed a strong correlation between LST and CT assessment of muscle mass. After adjusting for clinical and PD-related parameters, only sarcopenia defined by the psoas muscle (PM) index was associated with poorer survival. Sarcopenia assessment based on CT was found to be an important predictor of prognosis in long-term PD patients.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Biochemistry & Molecular Biology
Hwa-Chang Liu, Tzu-Shang Thomas Liu, Yen-Liang Liu, Jyh-Horng Wang, Chih-Hung Chang, Tiffany Ting-Fang Shih, Feng-Huei Lin
Summary: The study demonstrated the safety and efficacy of autologous chondrocyte precursor cell therapy in repairing knee cartilage defects, leading to improved knee function. Long-term follow-up showed no adverse events in patients receiving the CP treatment.
Article
Medicine, General & Internal
Chih-Kai Chang, Tiffany Ting-Fang Shih, Yu-Wen Tien, Ming-Chu Chang, Yu-Ting Chang, Shih-Hung Yang, Mei-Fang Cheng, Bang-Bin Chen
Summary: The study compared metabolites in pancreatic cancer and normal pancreas, finding significantly decreased Glx, NAA, and lipid levels in pancreatic cancer. These metabolites correlated with PET parameters and clinical stages, with lower lipid levels seen in patients with T4 stage.
Article
Medicine, General & Internal
Bang-Bin Chen, Yu-Yun Shao, Zhong-Zhe Lin, Chih-Hung Hsu, Ann-Lii Cheng, Chiun Hsu, Po-Chin Liang, Tiffany Ting-Fang Shih
Summary: The study found that in patients with advanced hepatocellular carcinoma, higher slope, K-ep, and ADC values were associated with longer progression-free survival (PFS); smaller tumor size, higher slope, ADC, and f values were associated with longer overall survival (OS).
Article
Medicine, General & Internal
Chih-Horng Wu, Yu-Hsin Lee, Po -Chin Liang, Rey-Heng Hu, Tiffany Ting -Fang Shih, Ming-Chih Ho
Summary: The study investigated the clinical factors associated with changes in preoperative tumor stage between dynamic CT and EOB-MRI. The results showed that 20.2% of patients had changes in tumor staging between the two modalities.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Oncology
Bang-Bin Chen, Zhong-Zhe Lin, Yu-Yun Shao, Chiun Hsu, Chih-Hung Hsu, Ann-Lii Cheng, Po-Chin Liang, Tiffany Ting-Fang Shih
Summary: In patients with advanced hepatocellular carcinoma (HCC) after progression from 1st-line sorafenib treatment, early changes in DCE-MRI biomarkers may predict survival outcomes during 2nd-line targeted therapy. Participants with high reductions in Delta Peak and Delta AUC on days 3 and 14 of treatment had better progression-free survival (PFS) rates. High reductions in Delta Peak, Delta AUC, and Delta K-trans on day 14 were associated with higher PFS and overall survival (OS) values, indicating the potential of DCE-MRI biomarkers as predictive tools for treatment outcomes.
Article
Medicine, Research & Experimental
Yan-Jhen Lu, Ssu-Yuan Chen, Ying-Chuen Lai, Pakaratee Chaiyawat, Yuan-Hung Chao, Lee-Ming Chuang, Tiffany Ting-Fang Shih, Hsing-Kuo Wang
Summary: This study investigated the role of impaired oxygen extraction on peak oxygen uptake using noninvasive and indirect methods in participants with type 2 diabetes mellitus (T2DM) and control group. The study found that T2DM patients had lower values in peak oxygen uptake, peak workload, peak heart rate, peak minute ventilation, and muscle oxygenation compared to the control group. The study also observed a correlation between changes in muscle oxygenation and peak oxygen uptake.
METABOLIC SYNDROME AND RELATED DISORDERS
(2022)
Article
Clinical Neurology
Chien-Feng Lee, Yunn-Jy Chen, Wen-Chi Huang, Jen-Wen Hou, Yu-Ting Liu, Tiffany Ting-Fang Shih, Pei-Lin Lee, Chong-Jen Yu
Summary: The study showed that in treatment-naive patients with moderate-severe OSA, the supine-predominant phenotype and lower CPAP pressure were associated with the MAD response, while the sleep stage dependency phenotype was not. Utilizing a CPAP level >14 cmH(2)O could be a sensitive measure to identify nonresponders.
NATURE AND SCIENCE OF SLEEP
(2022)
Article
Medicine, General & Internal
Yu-Chen Wang, Tiffany Ting -Fang Shih, Chih-Wei Yu, Yunn-Jy Chen
Summary: This study used kinematic magnetic resonance imaging to explore the mandibular condylar movements in patients with TMJ disorders. The results showed a significant correlation between condylar translation and rotation in all TMJs, regardless of the disc status.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Po-Ting Chen, Tiffany Ting Fang Shih
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Microbiology
Yeh-Sheng Chien, Feng-Jui Chen, Han-Chieh Wu, Chieh-Hua Lin, Wen-Chiung Chang, David Perera, Jyh-Yuan Yang, Min-Shi Lee, Yu-Chieh Liao
Summary: This study proposes a cost-effective approach for generating complete enterovirus genome sequences using the Oxford Nanopore MinION sequencer. It can differentiate co-infections from viral isolates and generate protein sequences that affect virus infection.
MICROBIOLOGY SPECTRUM
(2023)
Article
Acoustics
Ming-Wei Wang, Wei-Ning Lee, Chih-Chien Hung, Jung-Hsien Hsieh, Yueh-Hsia Chen, Tiffany Ting -Fang Shih, Jyh-Horng Wang, Nai-Hao Yin, Hsing-Kuo Wang
Summary: This study used a 2-D radiofrequency-based ultrasound speckle tracking algorithm (UST) to quantify the gliding of finger flexor tendons (FFT) after repair and evaluate tendon recovery. The results showed that the affected side had less gliding and smaller active range of motion compared to the healthy side. Additionally, a significant correlation between tendon gliding and passive range of motion was only found on the healthy side.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Bang-Bin Chen, Po-Chin Liang, Tiffany Ting-Fang Shih, Tsung-Hao Liu, Ying-Chun Shen, Li-Chun Lu, Zhong-Zhe Lin, Chiun Hsu, Chih-Hung Hsu, Ann-Lii Cheng, Yu-Yun Shao
Summary: Sarcopenia and myosteatosis are independent prognostic factors in patients who received immunotherapy for advanced HCC.
EUROPEAN RADIOLOGY
(2023)