Article
Endocrinology & Metabolism
Leanne M. Ward, Jinhui Ma, Marie-Eve Robinson, Maya Scharke, Josephine Ho, Kristin Houghton, Adam Huber, Rosie Scuccimarri, Julie Barsalou, Johannes Roth, Nazih Shenouda, Mary Ann Matzinger, Brian Lentle, Jacob L. Jaremko, Khaldoun Koujok, Karen Watanabe Duffy, Robert Stein, Anne Marie Sbrocchi, Celia Rodd, Paivi M. Miettunen, Claire M. A. LeBlanc, Maggie Larche, Roman Jurencak, Elizabeth A. Cummings, Robert Couch, David A. Cabral, Stephanie Atkinson, Nathalie Alos, Elizabeth Sykes, Victor N. Konji, Frank Rauch, Kerry Siminoski, Bianca Lang
Summary: This study tracked children with rheumatic disorders who were treated with glucocorticoids for six years, revealing a high incidence of fractures, especially vertebral fractures, with some children experiencing complete vertebral body reshaping, but bone mineral density remained low despite treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Kim Phung, Laura McAdam, Jinhui Ma, Hugh J. McMillan, Stefan Jackowski, Maya Scharke, Mary-Ann Matzinger, Nazih Shenouda, Khaldoun Koujok, Jacob L. Jaremko, Nagwa Wilson, Scott Walker, Colleen Hartigan, Nasrin Khan, Marika Page, Marie-Eve Robinson, David S. Saleh, Kevin Smit, Frank Rauch, Kerry Siminoski, Leanne M. Ward
Summary: This study investigated factors associated with incident vertebral fractures (VFs) in Duchenne muscular dystrophy patients. The results showed that spinal deformity index, non-fracture indicators, and bone age delay were all associated with incident VFs. Therefore, preventing first fractures is necessary in high-risk populations.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Rheumatology
Luca Seitz, Lisa Christ, Fabian Loetscher, Godehard Scholz, Adela-Cristina Sarbu, Lukas Buetikofer, Florian Kollert, Wolfgang A. Schmidt, Stephan Reichenbach, Peter M. Villiger
Summary: The study found that glucocorticoid pulse therapy resulted in a transient decrease in IMT in the temporal and axillary/subclavian arteries of GCA patients. Subsequent monotherapy with Tocilizumab led to a slow and steady decrease in IMT of the temporal arteries and had a smaller and delayed effect on the axillary/subclavian arteries.
Article
Endocrinology & Metabolism
Emely Loscalzo, Julia See, Sonum Bharill, Nazanin Yousefzadeh, Ethan Gough, Malinda Wu, Janet L. Crane
Summary: The use of glucocorticoids in Duchenne and Becker muscular dystrophy can prolong ambulation but also cause significant skeletal toxicity. Growth hormone and testosterone have been found to have a stronger effect on reducing the risk of vertebral fractures compared to bisphosphonates alone in children with dystrophinopathies on chronic glucocorticoids.
OSTEOPOROSIS INTERNATIONAL
(2023)
Review
Medicine, General & Internal
Madalina Cristina Sorohan, Catalina Poiana
Summary: This study reviewed the literature on the evaluation of bone density in patients with acromegaly and found that these patients have a significant loss of bone mineral density. The study suggests that regular monitoring and assessment of bone density are important for these patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Francois-Matthieu Seuvic, Romain Gillet, Matthias Louis, Edouard Germain, Charles Lombard, Alain Blum, Pedro Augusto Gondim Teixeira
Summary: This study investigated the relationship between opportunistic CT bone density measurements and the occurrence of new vertebral fractures after percutaneous vertebral cementoplasty (PVC) for osteoporotic vertebral compression fractures (OVCF). The results showed that low opportunistic vertebral density measurements were associated with a higher risk of recurrent OVCF and fracture cascades after PVC.
EUROPEAN RADIOLOGY
(2023)
Article
Orthopedics
Qiujiang Li, Xingxia Long, Yinbin Wang, Xiaomin Fang, Donggeng Guo, Jinhan Lv, Xuehua Hu, Lijun Cai
Summary: A nomogram was developed to predict NVCFs after vertebral augmentation in patients with OVCFs. The model showed good discrimination and calibration in both the training and validation cohorts, providing a useful tool for identifying high-risk patients for postoperative VCFs. Postoperative management strategies should be considered for patients identified as high risk by this nomogram.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Review
Clinical Neurology
Gaylene Pron, Matthew Hwang, Roger Smith, Angela Cheung, Kieran Murphy
Summary: This study is a systematic review of peer-reviewed studies evaluating the cost-effectiveness of vertebral augmentation procedures, such as vertebroplasty (VP) or balloon kyphoplasty (BK), for osteoporotic vertebral fractures (OVFs). The results show that both VP and BK are cost-effective alternatives to conservative management for OVFs, with earlier health gains and shorter hospital stays.
Article
Clinical Neurology
Hiroyuki Inose, Tsuyoshi Kato, Shoichi Ichimura, Hiroaki Nakamura, Masatoshi Hoshino, Daisuke Togawa, Toru Hirano, Yasuaki Tokuhashi, Tetsuro Ohba, Hirotaka Haro, Takashi Tsuji, Kimiaki Sato, Yutaka Sasao, Masahiko Takahata, Koji Otani, Suketaka Momoshima, Kunihiko Takahashi, Masato Yuasa, Takashi Hirai, Toshitaka Yoshii, Atsushi Okawa
Summary: Women with fresh OVF are at higher risk for subsequent vertebral fracture within the next year. Severe low back pain and use of soft braces are associated with higher risk of subsequent vertebral fractures. Therefore, more attention may be needed for the occurrence of subsequent vertebral fractures in patients treated with these risk factors after OVFs.
EUROPEAN SPINE JOURNAL
(2021)
Article
Medicine, General & Internal
Yang Jiang, Wei Zhang, Shihao Huang, Qing Huang, Haoyi Ye, Yurong Zeng, Xin Hua, Jinhui Cai, Zhifeng Liu, Qingyu Liu
Summary: This study aimed to develop a radiomics nomogram for the preoperative prediction of new vertebral fractures (NVFs) after vertebral augmentation (VA). The radiomics features were extracted from MRI images and combined with the presence of intravertebral cleft and number of previous vertebral fractures to develop a predictive model. The nomogram showed good predictive performance, successfully categorizing patients into high- or low-risk subgroups.
Article
Endocrinology & Metabolism
Julie-Catherine Coll, Elodie Garceau, William D. Leslie, Mathieu Genest, Laetitia Michou, S. John Weisnagel, Fabrice Mac-Way, Caroline Albert, Suzanne N. Morin, Remi Rabasa-Lhoret, Claudia Gagnon
Summary: The prevalence of vertebral fractures is comparable between individuals with well-controlled T1D and nondiabetic controls, but T1D patients have lower bone density and trabecular bone score.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Roberto Luigi Cazzato, Teodora Bellone, Marco Scardapane, Pierre De Marini, Pierre-Alexis Autrusseau, Pierre Auloge, Julien Garnon, Jack W. Jennings, Afshin Gangi
Summary: In comparison to NSM, the study shows that VP/BKP can reduce the 12-month risk of all-cause mortality and morbidity in patients with OVCFs by 19% and 36%, respectively. Furthermore, VP/BKP reduces the 12-month risk of infection from any origin by 77%.
EUROPEAN RADIOLOGY
(2021)
Article
Anesthesiology
Lei Ning, Jungao Zhu, Shen Tian, Ziang Hu, Chao Liu, Xiangde Zhao, Xiang Li, Shunwu Fan, Shuanglin Wan
Summary: The main cause of refracture after percutaneous kyphoplasty (PKP) is osteoporosis. Elderly women are more susceptible to refracture than elderly men. Patients with a history of previous fractures, previous osteoporosis, stomach ulcers, and ovariectomy are more likely to experience refractures. Antiosteoporosis treatment (calcium + vitamin D or zoledronate) after PKP can reduce the risk of refracture.
Review
Medicine, General & Internal
Athanasios D. Anastasilakis, Polyzois Makras, Julien Paccou, Ilias Bisbinas, Stergios A. Polyzos, Socrates E. Papapoulos
Summary: The management of patients with RVFx requires a multidisciplinary approach, including pain relief, medication administration, back protection, early mobilization, and appropriate exercise.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Michael Kriegbaum Skjodt, Joeri Nicolaes, Christopher Dyer Smith, Cesar Libanati, Cyrus Cooper, Kim Rose Olsen, Bo Abrahamsen
Summary: This study examines the direct healthcare costs of subjects with vertebral fractures available for identification on routine CT scans. The results show that patients with vertebral fractures incur significantly higher healthcare costs compared to those without fractures. The study also found that the healthcare costs per day at risk were higher in the short term for patients with vertebral fractures, although this difference was not statistically significant, and the long-term healthcare costs were similar to the general population.