Article
Medicine, General & Internal
Shannon N. Edd, Patrick Omoumi, Brigitte M. Jolles, Julien Favre
Summary: This study investigated longitudinal changes in femoral cartilage T2 relaxation time and thickness in fast-progressing medial femorotibial osteoarthritis (OA), finding that T2 values increased in the early stages while thickness primarily decreased in the later stages. These results emphasize the importance of T2 relaxation time analysis in early OA.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Orthopedics
Jagdeep Gill, Eric C. Sayre, Ali Guermazi, Savvas Nicolaou, Jolanda Cibere
Summary: Statin use did not show significant impact on MRI incidence/progression of cartilage damage, bone marrow lesions, osteophytes, or effusion in a population-based cohort with predominantly pre-radiographic knee OA.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Editorial Material
Orthopedics
Jason A. Grassbaugh, Edward D. Arrington
Summary: Orthopaedic advancements in the 21st century will focus on chondral restoration to prevent or reverse degenerative processes, requiring new tools to measure treatment effectiveness. Joint space width (JSW) is not sufficient as a surrogate for chondral restoration, and more standardized measures are needed for better clinical outcomes.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2021)
Article
Rheumatology
Dong Jin Go, Dong Hyun Kim, Jie Young Kim, Ali Guermazi, Michel Daoud Crema, David J. Hunter, Hyun Ah Kim
Summary: In elderly community residents without gout, serum UA levels were not associated with knee OA progression but were negatively associated with patellofemoral cartilage loss over time. Further large-scale longitudinal studies are needed to confirm the relationship between UA and cartilage damage in different populations.
Article
Orthopedics
Jennifer Cummings, Kenneth Gao, Vincent Chen, Alejandro Morales Martinez, Claudia Iriondo, Francesco Caliva, Sharmila Majumdar, Valentina Pedoia
Summary: Cartilage thickness change is a biomarker of osteoarthritis pathogenesis, and understanding its patterns in health and disease is important. This study introduces a new analysis method using functional connectivity to explore these patterns. The study analyzes 1186 knees that did not develop osteoarthritis and presents a model of cartilage thickness change related to healthy aging. Differences are observed between males and females, as well as the impact of body mass index (BMI). Variations are also found between knees with and without osteoarthritis, with some differences potentially explained by sex, BMI, and knee alignment. This work highlights the connectome as a useful tool for studying tissue change dynamics.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tom D. Turmezei, Samantha B. Low, Simon Rupret, Graham M. Treece, Andrew H. Gee, James W. MacKay, John A. Lynch, Kenneth E. S. Poole, Neil A. Segal
Summary: Joint space mapping (JSM) of the knee using weight-bearing CT images is reproducible and feasible, showing a relationship between three-dimensional joint space width distribution and structural joint disease. Novice users can learn it reliably, and it can achieve a smallest detectable difference that is at least 50% smaller than that reported in radiography.
Article
Engineering, Biomedical
Masahide Yagi, Masashi Taniguchi, Hiroshige Tateuchi, Tetsuya Hirono, Momoko Yamagata, Jun Umehara, Shusuke Nojiri, Masashi Kobayashi, Noriaki Ichihashi
Summary: This study aimed to investigate the individual forces of quadriceps heads in low-load contractions and their associations with cartilage thickness and symptoms in female knee osteoarthritis patients. The findings showed that maximal strength and vastus lateralis force index were smaller in the knee osteoarthritis group compared to the control group. In the knee osteoarthritis group, vastus medialis and vastus lateralis force indexes were positively correlated with cartilage thickness, while the rectus femoris force index was negatively correlated with cartilage thickness. The vastus lateralis force index was negatively correlated with knee pain.
CLINICAL BIOMECHANICS
(2022)
Article
Orthopedics
Anthony Teoli, Melissa Cloutier-Gendron, Shirley Y. K. Ho, Susan Gu, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Shawn M. Robbins
Summary: The relationship between knee moments and markers of knee osteoarthritis progression varies between nontraumatic and posttraumatic knee osteoarthritis subtypes, suggesting different mechanical influences on articular cartilage in these patient groups.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Orthopedics
G. B. Joseph, C. E. McCulloch, M. C. Nevitt, T. M. Link, J. H. Sohn
Summary: In this study, a machine learning-based prediction model for incident radiographic osteoarthritis (OA) of the knee over 8 years was developed. The results showed that a 10-predictor model including MRI parameters and other relevant factors could effectively predict the occurrence of osteoarthritis over 8 years.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Orthopedics
Liyi Zhang, Chutong Lin, Qiang Liu, Jiaxiang Gao, Yunfei Hou, Jianhao Lin
Summary: This study aimed to explore the incidence and risk factors for radiographic knee osteoarthritis in a suburban area of China. The results showed that older age, female gender, being overweight, less range of motion, and KL grade 1 at baseline were associated with an increased risk of incident ROA. The annual cumulative incidence of ROA was 3.6% at knee level and 5.7% at patient level in the study population.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Medicine, General & Internal
Ruei-Shyuan Chien, Cheng-Pang Yang, Chun-Ran Chaung, Chin-Shan Ho, Yi-Sheng Chan
Summary: The study evaluated the radiographic and functional outcomes of arthroscopy-assisted lateral open-wedge distal femur osteotomy (LOWDFO) for patients with lateral compartment osteoarthritis and valgus knees. The results show that this surgical procedure can significantly improve mechanical correction and patient function, with a good treatment outcome.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Orthopedics
Shogo Okada, Masashi Taniguchi, Masahide Yagi, Yoshiki Motomura, Sayaka Okada, Yoshihiro Fukumoto, Masashi Kobayashi, Kyoseki Kanemitsu, Noriaki Ichihashi
Summary: This study aimed to investigate whether altered cartilage echo intensity is associated with knee osteoarthritis (OA) severity and whether the alteration occurs before thinning of the femoral cartilage.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Article
Biochemistry & Molecular Biology
Luz Herrero-Manley, Ana Alabajos-Cea, Luis Suso-Marti, Enrique Viosca-Herrero, Isabel Vazquez-Arce
Summary: The study aimed to test the practicality of the existing diagnostic criteria for early knee osteoarthritis (EKOA) and evaluate the clinical progression of both healthy subjects at risk and patients diagnosed with EKOA. The participants were classified into EKOA and healthy subjects based on disability, pain, and self-reported variables. Most participants remained in their original classification, although some were reclassified during the follow-ups. The current diagnostic criteria could lead to misdiagnosis due to fluctuations in patients' conditions.
Article
Orthopedics
Ziyuan Shen, Yining Wang, Xing Xing, Graeme Jones, Guoqi Cai
Summary: Our findings from two independent cohorts consistently showed that smoking was not associated with knee cartilage loss in older adults.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Engineering, Biomedical
Liping Liu, Nan Chang, Shihong Li, Peipei Gong, Junhua Wang
Summary: This study investigated the rehabilitation nursing of football players' ACL injury using lateral cutting and running combined with an optical microscope based on the medical Internet of Things. The results showed that the systematic rehabilitation training significantly improved the joint contraction performance of the hamstrings/quadriceps in the athletes.
APPLIED BIONICS AND BIOMECHANICS
(2022)
Article
Orthopedics
W. Wirth, S. Maschek, A. C. A. Marijnissen, A. Lalande, F. J. Blanco, F. Berenbaum, L. A. van de Stadt, M. Kloppenburg, I. K. Haugen, C. H. Ladel, J. Bacardit, A. Wisser, F. Eckstein, F. W. Roemer, F. P. J. G. Lafeber, H. H. Weinans, M. Jansen
Summary: The study aims to investigate the test-retest precision of cartilage thickness and report longitudinal changes in the IMI-APPROACH cohort. The machine-learning-estimated structural progression score (s-score) was not predictive of cartilage thickness loss.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Orthopedics
Mylene P. Jansen, Frank W. Roemer, Anne Karien C. A. Marijnissen, Margreet Kloppenburg, Francisco J. Blanco, Ida K. Haugen, Francis Berenbaum, Floris P. J. G. Lafeber, Paco M. J. Welsing, Simon C. Mastbergen, Wolfgang Wirth
Summary: The study investigated the correlations between longitudinal weight-bearing radiographic joint space width and non-weight-bearing MRI-based cartilage thickness changes. The results showed weak but statistically significant correlations between changes in medial femorotibial cartilage thickness and changes in medial joint space width. These correlations varied significantly based on cartilage quality and meniscal extrusion.
SKELETAL RADIOLOGY
(2023)
Review
Orthopedics
Wolfgang Wirth, Christoph Ladel, Susanne Maschek, Anna Wisser, Felix Eckstein, Frank Roemer
Summary: This review summarizes the current status of cartilage morphometry in osteoarthritis research, providing insights into future study design and clinical trials. It covers aspects related to acquiring suitable MRI images for cartilage morphometry, analyzing techniques for deriving quantitative measures, quality assurance for reliable cartilage measurement, and appropriate participant recruitment criteria.
SKELETAL RADIOLOGY
(2023)
Article
Endocrinology & Metabolism
Rafael Heiss, Jean -Denis Laredo, Wolfgang Wirth, Mylene P. Jansen, Anne C. A. Marijnissen, Floris Lafeber, Agnes Lalande, Harrie H. Weinans, Francisco J. Blanco, Francis Berenbaum, Margreet Kloppenburg, Ida K. Haugen, Klaus Engelke, Frank W. Roemer
Summary: Objective: Osteoarthritis (OA) is a highly prevalent chronic condition, and the subchondral bone plays an important role in its onset and progression. This study aimed to investigate the changes in periarticular bone mineral density (BMD) in OA and its relation to meniscal coverage and meniscal extrusion at the knee.
Article
Biochemistry & Molecular Biology
Michael Seiberl, Julia Feige, Patrick Hilpold, Wolfgang Hitzl, Lukas Machegger, Arabella Buchmann, Michael Khalil, Eugen Trinka, Andrea Harrer, Peter Wipfler, Tobias Moser
Summary: This study investigated the impact of cladribine on serum neurofilament light chain (sNfL) and its potential as a predictor of long-term treatment response. The results showed that cladribine significantly reduced sNfL levels, but baseline and 12-month sNfL assessments failed to predict clinical and radiological treatment response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Ambrish Singh, Alison Venn, Leigh Blizzard, Lyn March, Felix Eckstein, Graeme Jones, Wolfgang Wirth, Flavia Cicuttini, Changhai Ding, Benny Antony
Summary: This study aims to describe the associations between MRI markers and knee symptoms in young adults. The results showed that bone marrow lesions and cartilage defects were positively associated with knee symptoms, while cartilage volume and thickness were weakly and negatively associated with knee symptoms.
Article
Medicine, General & Internal
Julia Hanne Niebauer, Christina Binder-Rodriguez, Ahmet Iscel, Sarah Schedl, Christophe Capelle, Michael Kahr, Simona Cadjo, Simon Schamilow, Roza Badr-Eslam, Michael Lichtenauer, Aurel Toma, Alexander Zoufaly, Rosmarie Valenta, Sabine Hoffmann, Silvia Charwat-Resl, Christian Krestan, Wolfgang Hitzl, Christoph Wenisch, Diana Bonderman
Summary: We aimed to identify the long-term cardiopulmonary effects of severe COVID-19 disease and the predictors of Long-COVID. A prospective registry included 150 hospitalized patients who were followed up six months after discharge. The study found that a majority of patients fulfilled the criteria for Long-COVID, and various cardiopulmonary abnormalities were detected, including impaired pulmonary function, reduced GLS, and diastolic dysfunction. Predictors of Long-COVID included length of in-hospital stay, admission to the intensive care unit, and higher NT-proBNP levels.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mylene P. Jansen, Wolfgang Wirth, Jaume Bacardit, Eefje M. van Helvoort, Anne C. A. Marijnissen, Margreet Kloppenburg, Francisco J. Blanco, Ida K. Haugen, Francis Berenbaum, Cristoph H. Ladel, Marieke Loef, Floris P. J. G. Lafeber, Paco M. Welsing, Simon C. Mastbergen, Frank W. Roemer
Summary: In the IMI-APPROACH knee osteoarthritis study, machine learning models were trained to predict the probability of structural progression. The study found that approximately 1/6 to 1/3 of participants showed structural progression over a 2-year follow-up period. KL scores were observed to be a better predictor of progression than machine-learning-based s-scores.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Health Care Sciences & Services
Clemens Huettenbrink, Wolfgang Hitzl, Florian Distler, Jascha Ell, Josefin Ammon, Sascha Pahernik
Summary: The prediction of radiation exposure is crucial for therapy modality selection and informed consent. Implementing a trained machine learning model in a real-time computer system allows surgeons and patients to assess personal radiation risk. Factors influencing radiation exposure include age, gender, weight, stone size, surgeon experience, number of stones, stone density, use of flexible endoscope, and preoperative stone position.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Health Care Sciences & Services
Kim Loose, Sophie Pennekamp, Wolfgang Hitzl, Maximilian Willauschus, Johannes Ruether, Sandeep Silawal, Philipp Schuster, Hermann Josef Bail, Michael Millrose, Markus Gesslein
Summary: In this retrospective study, patients with patellar tendinopathy (PT) were compared with a control group in terms of patient data and MRI characteristics. The study found significant differences in patellar height and patella-patellar tendon angle between the PT patient group and the control group. The thickness of different parts of the patellar tendon was also significantly increased in patients with PT. Persistence of symptoms over 6 months was associated with increased signal intensity in MRI. These findings can help in understanding PT and identifying suitable surgical candidates.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Dermatology
Ralph Bertram, Hans-Theodor Naumann, Vanessa Bartsch, Wolfgang Hitzl, Martina Kinzig, Golo-Sung Haarmeyer, Matthias Baumgaertel, Arnim Geise, Dorothea Muschner, Jens Nentwich, Stefan John, Fritz Soergel, Joerg Steinmann, Rainer Hoehl
Summary: This study aimed to determine the plasma concentrations of isavuconazole in ICU patients with COVID-19 and invasive fungal infection, and evaluate the factors contributing to sub-therapeutic drug levels. The results showed that patients' risk factors and supportive therapies can negatively affect the plasma levels of isavuconazole.
Article
Orthopedics
T. Schnitzer, M. Pueyo, H. Deckx, E. van der Aar, K. Bernard, S. Hatch, M. van der Stoep, S. Grankov, D. Phung, O. Imbert, D. Chimits, K. Muller, M. C. Hochberg, H. Bliddal, W. Wirth, F. Eckstein, P. G. Conaghan
Summary: This study aimed to evaluate the efficacy and safety of the anti-catabolic ADAMTS-5 inhibitor S201086/GLPG1972 for the treatment of symptomatic knee osteoarthritis. The results showed that S201086/GLPG1972 did not significantly reduce rates of cartilage loss or modify symptoms in adults with knee osteoarthritis.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Editorial Material
Orthopedics
Wolfgang Wirth
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Medicine, General & Internal
Francesco Pollari, Wolfgang Hitzl, Magnus Rottmann, Ferdinand Vogt, Miroslaw Ledwon, Christian Langhammer, Dennis Eckner, Juergen Jessl, Thomas Bertsch, Matthias Pauschinger, Theodor Fischlein, Omer Dzemali
Summary: This study used various machine learning models to predict the 1-year survival of patients undergoing transcatheter aortic valve implantation (TAVI). The models showed good predictive power and high accuracy in determining patients' survival rates.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mylene P. Jansen, Wolfgang Wirth, Jaume Bacardit, Eefje M. van Helvoort, Anne C. A. Marijnissen, Margreet Kloppenburg, Francisco J. Blanco, Ida K. Haugen, Francis Berenbaum, Cristoph H. Ladel, Marieke Loef, Floris P. J. G. Lafeber, Paco M. Welsing, Simon C. Mastbergen, Frank W. Roemer
Summary: In this study, machine learning models were used to predict structural progression in knee osteoarthritis patients over a 2-year period. Different radiographic and MRI structural parameters were evaluated for their ability to predict progression. The results showed that between 1/6 and 1/3 of patients showed structural progression during the follow-up period. The machine learning models performed less effectively than the Kellgren-Lawrence grading system, suggesting a need for further development of more accurate prediction models.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
